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Parkinson’s & Depression: Connections, Signs, & Treatments

Published: February 1, 2022 Updated: January 26, 2023
Published: 02/01/2022 Updated: 01/26/2023
Headshot of Iris Waichler MSW, LCSW
Written by:

Iris Waichler

MSW, LCSW
Headshot of Pat F Bass III, MD, MS, MPH
Reviewed by:

Pat Bass III

MD, MS, MPH
  • The Connection Between Parkinson’s & DepressionConnection
  • Risk Factors for Parkinson’s DepressionRisk Factors
  • Ways to Cope With Parkinson’s & DepressionCoping
  • Treatment for Parkinson’s DepressionTreatment
  • How to Get Help for Depression While Dealing With Parkinson’s DiseaseGet Help
  • What Caregivers Can Do to HelpFor Caregivers
  • Final ThoughtsConclusion
  • Additional ResourcesResources
Headshot of Iris Waichler MSW, LCSW
Written by:

Iris Waichler

MSW, LCSW
Headshot of Pat F Bass III, MD, MS, MPH
Reviewed by:

Pat Bass III

MD, MS, MPH

Depression frequently occurs with people who have chronic illnesses like Parkinson’s Disease (PD). The Parkinson’s Foundation reports that mood, depression, and anxiety have an even greater impact on health status than the motor impairments commonly associated with the disease.1 Fortunately, with proper mental healthcare, medical treatment, and a system of support, people can learn to manage and cope with Parkinson’s depression.

Connect with a therapist that specializes in treating depression in people with chronic health conditions. BetterHelp has over 20,000 licensed therapists who provide convenient and affordable online therapy. BetterHelp starts at $60 per week. Complete a brief questionnaire and get matched with the right therapist for you.

Choosing Therapy partners with leading mental health companies and is compensated for marketing by BetterHelp

Visit BetterHelp

The Connection Between Parkinson’s & Depression

Depression is closely connected to many medical diagnoses and can directly impact your quality of life and ability to function. Researchers found this to be true with Parkinson’s Disease, reporting that depression occurs in this population with a prevalence of 30%-40%.2 Additionally, if depression is left untreated, there is an increased risk for greater disability and reduced quality of life.2

Many times when people have a serious progressive medical illness, the attention is given to the physical symptoms. Parkinson’s patients naturally monitor their mobility and movement above all else. This can be true of their doctors as well, and the patient’s emotional reaction can be overlooked.

Another complicating factor in diagnosing depression alongside a serious medical condition is that the symptoms can overlap, making it difficult to differentiate between the two. Depression can intensify the symptoms of Parkinson’s Disease.1

Risk Factors for Parkinson’s Depression

Some research has found that the prevalence of depression in relation to PD is biphasic, with a peak early in the illness and another gradual increase as the illness reaches its latter stages. Depression also appears to be more common in people with rapidly progressive Parkinson’s, and may be a precursor to the onset.4,5

Additional risk factors for Parkinson’s depression include:3

  • Age
  • Sex (women are statistically more at risk for depression)
  • History of anxiety or depression before PD diagnosis
  • Severity of motor symptoms
  • Disease duration
  • Disease stage
  • Extent of limitations to activities and daily living
  • Non-motor symptoms such as sleep disturbance, anxiety, hallucinations, and memory issues

5 Ways to Cope With Parkinson’s & Depression

To cope with Parkinson’s and depression, arm yourself with knowledge, create short and long term goals, and build and rely upon your support system of loved ones, caregivers, and healthcare professionals. Don’t feel shame or embarrassment for needing help; remember that depression is a common reaction to Parkinson’s Disease.

Here are five ways to cope with Parkinson’s and depression:

1. Learn All You Can About Parkinson’s Disease

Educating yourself will help you understand what to expect when it comes to Parkinson’s  and depression. It will also help you anticipate and prepare for future changes, and make realistic expectations and goals for yourself.

2. Create Short-Term Goals Based On Realistic Expectations 

Create manageable goals and celebrate when those goals are achieved. Don’t berate yourself if you are unable to do something on a particular day. Set a new goal for tomorrow and keep moving forward.

3. Maintain Social Connections & Relationships

Make time to spend with your close family and trusted friends. These connections are more important than ever. They’re particularly useful for reducing feelings of isolation, which can contribute to depression.

4. Connect With People Who Have Also Been Diagnosed

Connecting with other people who have been diagnosed with Parkinson’s can help you feel less alone and more understood. It can also reaffirm your feelings regarding your illness. They may even be able to offer tips and resources that you can use to promote your own well-being.

5. Openly Discuss Your Fears & Feelings

Identify a trusted loved one, caregiver, friend, or healthcare professional to speak with about your fears for the future and other more difficult feelings. Talking can offer emotional relief, and expression is a good tool to combat depression.

Help For Depression

Talk Therapy – Get help from a licensed therapist. Betterhelp offers online therapy starting at $60 per week. Get matched With A Therapist


Virtual Psychiatry – Get help from a real doctor that takes your insurance. Talkiatry offers medication management and online visits with top-rated psychiatrists. Take the online assessment and have your first appointment within a week. Free Assessment

Choosing Therapy partners with leading mental health companies and is compensated for marketing by BetterHelp and Talkiatry.

Treatment for Parkinson’s Depression

The treatment of depression for patients with Parkinson’s should begin with an assessment of your emotional status. Parkinson’s disease changes brain function and chemistry, causing an imbalance that can lead to mood disorders like depression. After the initial assessment, there are other treatments available.

Antidepressant Medication

Medication for depression has been found to be both safe and well tolerated. Efficacy has been demonstrated for nortriptyline, venlafaxine extended release, desipramine, citalopram, and paroxetine.6 Ask your physician or psychiatrist about the interaction between antidepressants and medication for Parkinson’s Disease.

Psychotherapy

Therapy for depression can be especially effective if doctors determine that medication management may not be appropriate. Cognitive Behavioral Therapy (CBT) is often used, which focuses on changing negative thoughts. It helps you create a more positive mental framework, teaches coping skills, and enhances self-awareness.

Electroconvulsive Therapy (ECT)

ECT is a brief electrical stimulation used to produce a generalized seizure while the patient is under general anesthesia. Some people have difficulty tolerating certain side effects, especially if they already have muscle aches or problems processing information or memory. However, it can be effective for people with severe depression.7

Holistic or Mindfulness Techniques 

These include techniques in yoga, meditation, relaxation, and other forms of exercise. They offer a way to increase control over your body and mind. Consult your physician about what is recommended and safe for you.

How to Get Help for Depression While Dealing With Parkinson’s Disease

Inform the doctor treating your Parkinson’s and a general practitioner that you’re experiencing depression and ask for a referral to a mental health professional. One simple way to find a mental health professional in your area is to use an online therapist directory where you can search based on specialty, price, experience, language, and more. Therapist profiles show open appointments and enable you to immediately schedule an appointment.

Counseling can help patients navigate and understand their depression. Family therapy and group counseling may also be beneficial to combat depressive emotions that grow with time within a family unit. Ideally, seek out a counselor who has expertise or special knowledge of working with people with chronic illnesses that can alter cognitive function, body function, and lifestyle.

What Caregivers Can Do to Help

In their effort to provide care and support, caregivers should try to be positive and realistic. They may be called upon to offer ongoing physical help and emotional support, which can be challenging, especially for extended periods of time. Sometimes, caregiving can lead to burnout, so if possible, be sure you have enough support that you can take breaks when necessary.

Here are seven tips for caregivers to help your loved one dealing with Parkinson’s and depression:

1. Be Realistic

In terms of the help you can offer, it’s important to be realistic. For example, if ongoing physical help becomes problematic, give yourself permission to ask for help. It is in the best interest of you and your loved one to have someone with the skills and abilities necessary.

2. Remember Your Attitude Impacts Your Loved One’s Resolve

Try to maintain a delicate balance between optimism and realism. Encourage your loved one to create goals, and help them celebrate when those goals are met. Be supportive when they struggle and keep a positive attitude whenever possible.

3. Practice Good Communication 

Listen without imposing any judgement, and try to encourage candid discussions about how Parkinson’s and depression are impacting your loved one’s relationships and lifestyle.

4. Nurture Yourself

Make time to relax, reenergize, and experience comfort on a regular basis. Pick the things you enjoy doing like taking a walk, reading a book, or cooking a nice meal and incorporate them into your life on a regular basis.

5. Identify a Trusted Person to Talk With

It’s important to have someone you can trust to talk with about your loved one’s medical and mental health struggles. It may be a friend, family member, healthcare professional, or spiritual/religious guide.

6. Seek Individual Support

You may benefit from attending in-person or online support groups offered for family members and caregivers of people diagnosed with Parkinson’s Disease. This can be a good source of  comfort, information, education, and resources.

7. Assume an Advocacy Role

Sometimes patients may not be fully aware of their own depression, or they may be in denial. If this is the case, you can reach out to healthcare practitioners on their behalf. Essentially, advocacy requires your trusted and undivided support of their well-being in public and in private.

Final Thoughts

Your experience with Parkinson’s and depression is unique to you, but you are not alone. There are universal feelings associated with this life-altering diagnosis, and while there may be moments of struggle, isolation, loss of control, and uncertainty, there also can be shared humanity, strengthening of relationships, intimacy, and achievement. If you don’t know where to start, reaching out to a loved one, trusted individual, support group, or healthcare professional can be your first step toward feeling a sense of relief.

Additional Resources

Education is just the first step on our path to improved mental health and emotional wellness. To help our readers take the next step in their journey, Choosing Therapy has partnered with leaders in mental health and wellness. Choosing Therapy may be compensated for marketing by the companies mentioned below.

Talk Therapy 

Online-Therapy.com – Get support and guidance from a licensed therapist. Online-Therapy.com provides 45 minute weekly video sessions and unlimited text messaging with your therapist for only $64/week. Get Started

Online Psychiatry

Hims / Hers – If you’re living with anxiety or depression, finding the right medication match may make all the difference. Get FDA approved medication prescribed by your dedicated Hims / Hers Healthcare Provider and delivered right to your door. Plans start at $25 per month (first month). Get Started

Learn Anti-Stress & Relaxation Techniques

Mindfulness.com – Change your life by practicing mindfulness. In a few minutes a day, you can start developing mindfulness and meditation skills. Free Trial

Choosing Therapy Directory 

You can search for therapists by specialty,  experience, insurance, or price, and location. Find a therapist today.

Choosing Therapy partners with leading mental health companies and is compensated for marketing by Online-Therapy, Hims / Hers, and Mindfulness.com

For Further Reading

  • Mental Health America
  • National Alliance on Mental Health
  • MentalHealth.gov
7 sources

Choosing Therapy strives to provide our readers with mental health content that is accurate and actionable. We have high standards for what can be cited within our articles. Acceptable sources include government agencies, universities and colleges, scholarly journals, industry and professional associations, and other high-integrity sources of mental health journalism. Learn more by reviewing our full editorial policy.

  • Parkinson’s Foundation. Depression. Retrieved from https://www.parkinson.org/Understanding-Parkinsons/Symptoms/Non-Movement-Symptoms/Depression

  • Pasquale G. Frisina, Joan C. Borod, Nancy S. Foldi, Harriet R. Tenenbaum. (2008) Depression in Parkinson’s Disease: Health Risks, etiology, and treatment options. Journal of Neuropsychiatric Disease and Treatment. Feb; 4(1):81-91. Doi: 10.2147/ndt.s1453 Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515908/

  • Yang-Pei Chang, Min-Sheng Lee, Da-Wei Wu, Jui-Hsiu Tsai, Pei-Shan Ho, Chun-Hung Richard Lin, Hung-Yi Chuang. (2020) Risk Factors for depression in patients with Parkinson’s Disease: A Nationwide nested case-control study. Public Library of Science One. July 27, 2020. Retrieved from https://doi.org/10.1371/journal.pone.0236443

  • Flemming M. Nilsson, MD, Lars. V. Kessing (2002) Depression as a Risk Factor for Parkinson’s Disease? Neurology Journal. Retrieved from https://n.neurology.org/content/depression-risk-factor-parkinsons-disease

  • H Rickards. (2005) Depression in Neurological disorders: Parkinson’s disease, multiple sclerosis, and stroke. Journal of Neurology, Neurosurgery, and Psychiatry. dx.doi.org/10.1136/jnnp.2004.060426. Retrieved from https://jnnp.bmj.com/content/76/suppl_1/i48

  • Laura Marsh, MD (2013) Depression and Parkinson’s Disease: Current Knowledge. Current Neurology and Neuroscience Reports. 2013. Dec; 13 (12):409. Doi: 10.1007/s11910–013–0409-5. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878671/

  • Cleveland Clinic. (2015) Depression: Overview and its Role in Parkinson’s Disease: Management and Treatment. Retrieved from https://my.clevelandclinic.org/health/diseases/9379-depression-overview-and-its-role-in-parkinsons-disease/management-and-treatment

update history

We regularly update the articles on ChoosingTherapy.com to ensure we continue to reflect scientific consensus on the topics we cover, to incorporate new research into our articles, and to better answer our audience’s questions. When our content undergoes a significant revision, we summarize the changes that were made and the date on which they occurred. We also record the authors and medical reviewers who contributed to previous versions of the article. Read more about our editorial policies here.

  • Originally Published: April 6, 2021
    Original Author: Iris Waichler, MSW, LCSW
    Original Reviewer: Pat F. Bass III, MD, MS, MPH

  • Updated: February 1, 2022
    Author: No Change
    Reviewer: No Change
    Primary Changes: Updated for readability and clarity. Reviewed and added relevant resources.

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Headshot of Iris Waichler MSW, LCSW
Written by:

Iris Waichler

MSW, LCSW
Headshot of Pat F Bass III, MD, MS, MPH
Reviewed by:

Pat Bass III

MD, MS, MPH
  • The Connection Between Parkinson’s & DepressionConnection
  • Risk Factors for Parkinson’s DepressionRisk Factors
  • Ways to Cope With Parkinson’s & DepressionCoping
  • Treatment for Parkinson’s DepressionTreatment
  • How to Get Help for Depression While Dealing With Parkinson’s DiseaseGet Help
  • What Caregivers Can Do to HelpFor Caregivers
  • Final ThoughtsConclusion
  • Additional ResourcesResources
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