Ozempic Side Effects: Everything You Need to Know

What Is Ozempic (Semaglutide) & How Is it Used?

Ozempic belongs to the GLP-1 receptor agonist class and is prescribed to assist in managing blood sugar for individuals with type 2 diabetes.¹ Semaglutide, the active ingredient in this injectable medication, mimics a natural hormone in the body. This action promotes insulin release, reducing excess glucose production and slowing down the stomach’s release of food to the intestines.

As an FDA-approved medication for diabetes type 2 control, Ozempic has demonstrated several benefits. It is effective at lowering blood sugar levels as well as reducing cardiovascular events like strokes and heart attacks in diabetic patients.

A possible side effect of Ozempic is weight loss, and providers may prescribe it for this effect. However, using Ozempic specifically for weight loss is not FDA-approved. Ozempic use for weight loss is referred to as “off-label” use, meaning it is being utilized for a purpose outside the scope of its initial FDA approval. Another medication called Wegovy also contains the active drug semaglutide, and it is FDA-approved for weight loss in certain people.

How Does Ozempic Make You Feel?

Ozempic can make some people feel enhanced emotional well-being and experience a sense of stability and balance in their daily lives as a result of better controlling their diabetes. However, it’s also important to note ongoing investigations into reported concerns about mood swings and suicidal behavior associated with Ozempic.²

This effect is particularly important in light of the fact that Wegovy, which shares the same pharmaceutical active ingredient as Ozempic (semaglutide), has been linked to increased suicidal behavior and suicide attempts. Patients should communicate openly with their healthcare providers to address any mood-related concerns or changes.

Common Side Effects of Ozempic

Common side effects of Ozempic are important to be aware of, as individuals may experience symptoms during their treatment. These effects are typically mild and may include symptoms like nausea, vomiting, diarrhea, and abdominal discomfort.^{3, 4} While many individuals tolerate the medication well, it should be noted that some side effects may necessitate medical attention. Users are advised to consult with their healthcare providers if they encounter persistent or severe side effects to receive appropriate guidance and support.

Common side effects of Ozempic include:

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Loss of appetite
• Constipation
• Indigestion

*All medications, including Ozempic, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.

Serious Side Effects of Ozempic

Ozempic users can experience potentially serious side effects that necessitate prompt medical attention. Serious adverse reactions include, but are not limited to, conditions such as pancreatitis, thyroid tumors, and severe allergic reactions.^{3, 5} Recognizing these potential complications is imperative for users and healthcare providers to ensure swift intervention in case of an emergency. It is also important to note that Wegovy, which uses the same active ingredient as Ozempic (semaglutide) has a risk of suicidal behavior and attempts.

Serious side effects of Ozempic include:

• Pancreatitis
• Thyroid tumors
• Hypoglycemia (low blood sugar)
• Kidney problems
• Allergic reactions
• Gallbladder problems
• Vision changes or loss

*All medications, including Ozempic, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.

Ozempic Long-Term Side Effects

Long-term use of Ozempic should involve considerations for potential long-term side effects. Continuous monitoring is essential to assess any extended impacts on the body. While many users tolerate the medication well, healthcare providers typically conduct regular check-ups to evaluate aspects such as kidney function, thyroid health, and any signs of pancreatitis.

Because of Wegovy’s concern with suicidal behavior, patients on Ozempic should also be monitored for depression and suicidal behavior. Long-term use has also been associated with intestinal paralysis, increased heart rate, and gallbladder issues.³ Timely communication between users and their healthcare team ensures that any emerging long-term side effects are promptly identified and managed.

Ozempic Warnings & Precautions

Ozempic use comes with certain warnings and precautions, underlining the need for users to be mindful of potential risks. Some of these risks include the risk of thyroid tumors, pancreatitis, kidney problems, and the potential for allergic reactions is important.³ Patient awareness of these warnings can help seek prompt medical attention when necessary. Open communication with healthcare providers allows users to navigate these warnings effectively.

Warnings and precautions for taking Ozempic address people with: 

• Increased risk of thyroid tumors: Ozempic carries a boxed warning due to a potential increase in the risk of thyroid tumors. Regular monitoring of thyroid function should be considered to detect any abnormalities.
• Pancreatitis risk: There is a risk of pancreatitis associated with Ozempic. Users should be vigilant for symptoms such as persistent severe abdominal pain and seek medical attention if any signs occur.
• Kidney problems: Individuals with kidney issues should use Ozempic cautiously, as the medication may impact kidney function. Regular monitoring of kidney function is important for those at risk.
• Hypoglycemia risk: Ozempic may cause low blood sugar levels, especially when combined with other antidiabetic medications like insulin or sulfonylureas. Users should be cautious to prevent, recognize, and manage low blood sugar levels.
• Allergic reactions: Users may experience allergic reactions to Ozempic, and immediate medical attention is necessary if symptoms like rapid swelling, rash, dizziness, or difficulty breathing occur.
• Gallbladder problems: Ozempic may contribute to gallbladder issues that require urgent medical attention. Individuals with a history of gallbladder disease should exercise caution.
• Vision changes or loss: Some users may experience changes in vision or even vision loss, specifically those who already have vision issues due to diabetes (diabetic retinopathy). This requires immediate medical attention.

What are the New Warnings for Ozempic?

This article centers on Ozempic, containing the active ingredient semaglutide, which is also found in Wegovy (prescribed for weight loss) and Rybelsus (an oral version). Ozempic and Wegovy share similar side effect profiles, but Wegovy includes an additional warning about potential suicidal thoughts and behavior.^{6, 7}

While this specific warning is not present for Ozempic,³ recent post-marketing data is under investigation, suggesting a potential risk. Concerns about intestinal paralysis have also emerged after Ozempic’s market introduction.³ Ozempic’s drug label has been updated, stating intestinal paralysis as a rare but serious side effect. Patients should stay informed about these new developments and consult their healthcare providers for the latest information and guidance.

Allergic Reactions to Ozempic

Potential allergic reactions to Ozempic can occur in users of this medication. While such reactions are generally rare, patients should be aware of the signs and symptoms. Allergic responses can vary in severity, ranging from mild to severe, and some may necessitate immediate medical attention.

Symptoms may include skin manifestations like hives or rashes, swelling, itching, or tingling sensations, especially around the injection site. Although many users tolerate Ozempic well, individuals should remain vigilant and promptly communicate any unusual or severe symptoms to their healthcare providers.

• Hives or Rash
• Swelling
• Difficulty Breathing
• Itching or Tingling
• Dizziness
• Mental status changes
• Passing out 

If someone experiences allergic reactions to Ozempic, seek immediate medical attention. These symptoms can be serious, and prompt intervention is necessary to ensure a swift and appropriate response. Users should not hesitate to contact their healthcare providers if they observe any signs of an allergic reaction. Call 911 if symptoms are serious, such as difficulty breathing.

Interactions That May Exacerbate Ozempic Side Effects

Certain drugs and dietary factors can influence how Ozempic functions, potentially amplifying the risk of side effects. For instance, Ozempic’s interaction with diabetes medications that help the pancreas secrete insulin, or with insulin injections may elevate the risk of experiencing low blood sugar. When starting Ozempic, adjusting the dose of insulin secretors (like sulfonylureas) or insulin injections is recommended to reduce this risk.

Additionally, Ozempic’s impact on slowing stomach emptying raises caution when taking oral medications at the same time. While clinical trials suggest no significant impact on oral medication absorption, prudence is advised. Patients should communicate their complete medication regimen to healthcare providers to navigate potential interactions and minimize the risk of side effects during Ozempic use.

This is not a comprehensive discussion of the possible interactions with Ozempic. You should talk with your healthcare provider and your pharmacist about all prescription and over-the-counter medications, herbs, and supplements you take before starting Ozempic.

How to Manage Ozempic Side Effects

Managing common side effects of Ozempic often involves simple strategies. For instance, nausea can be alleviated by taking Ozempic with a meal, and staying hydrated helps minimize the risk of dehydration. Dizziness or fatigue may improve with adequate rest. If injection site reactions occur, users can rotate injection sites and ensure proper technique. Open communication with healthcare providers enables personalized guidance to address and manage side effects effectively.

Injection Site Reactions

Some individuals may experience injection site reactions while using Ozempic. These reactions, such as redness, pain, or irritation at the injection site, can be managed effectively. Rotating injection sites with each dose can help distribute the impact and minimize discomfort. Ensuring proper injection techniques, such as using the correct needle size and injecting at the recommended depth, can help prevent these side effects.

Do not share Ozempic needles with others. Being attentive to injection practices and promptly addressing any concerns with a healthcare professional can contribute to a better experience with Ozempic.

Gastrointestinal Side Effects

Ozempic may occasionally lead to gastrointestinal side effects, including constipation, diarrhea, indigestion, vomiting, and abdominal pain/discomfort. Maintaining a well-balanced diet with adequate fiber intake can assist with constipation, while staying hydrated helps with diarrhea.

Eating smaller, more frequent meals and avoiding spicy or rich foods can ease indigestion. If vomiting occurs, it’s essential to stay hydrated and consult a healthcare provider if the symptom persists. Addressing abdominal pain may involve adjusting dietary habits and discussing with a healthcare provider for personalized guidance.

Lifestyle Tips to Reduce Ozempic Side Effects

Implementing lifestyle adjustments can play a big part in minimizing potential side effects when taking Ozempic. Individuals can explore dietary changes, emphasizing a well-balanced and fiber-rich diet to address gastrointestinal symptoms like constipation or indigestion. Engaging in regular physical activity not only supports overall well-being but can also alleviate symptoms such as fatigue.

Maintaining consistent meal times and portion control may help manage potential side effects like nausea. Staying adequately hydrated is essential, especially for those prone to vomiting or experiencing diarrhea. Collaborating with healthcare providers to customize these lifestyle adjustments ensures a personalized approach most effective for you.

Questions to Ask Your Healthcare Provider About Ozempic Side Effects

It’s useful to discuss Ozempic side effects with your healthcare provider, especially when initiating the medication or experiencing persistent symptoms. Ask your doctor about potential side effects, their frequency, and when to seek medical attention. Inquire about lifestyle adjustments that may alleviate common side effects.

Additionally, discuss any existing medical conditions or medications that could interact with Ozempic. Open communication ensures a comprehensive understanding, empowering individuals to navigate their treatment effectively and minimize any potential challenges.

Questions to ask your care team about Ozempic side effects:

• How long is the adjustment period typically for individuals starting Ozempic?
• Are there specific interactions with other medications I’m currently taking that might increase the risk of side effects?
• What lifestyle adjustments can I make to minimize side effects?
• Are there any dietary considerations or restrictions while on Ozempic?
• What are the common side effects I might expect, and how can they be managed?
• Can Ozempic affect my mood or behavior?
• How will I know if a side effect is severe and requires immediate medical attention?
• How can I prevent Ozempic face?
• If I experience gastrointestinal side effects, what dietary or lifestyle changes can I consider?
• Will the side effects diminish over time as my body adjusts to Ozempic?
• Are there any specific health conditions that might increase the likelihood or severity of side effects?
• Can you recommend any over-the-counter remedies or strategies to alleviate common side effects?
• How frequently should I check in with my care team to discuss my experience with Ozempic and address any concerns?
• How do side effects of Trulicity compare to those of Ozempic?
• What are some Ozempic alternatives to consider?
• What are the risks of taking Ozempic during pregnancy?