Common antidepressant side effects include nausea, fatigue, changes in sleep and appetite, and sexual dysfunction. Serious side effects require medical attention such as a risk of suicidal thoughts, symptoms of mania, and allergic reactions.
One of the most common reasons people want to stop taking a medication is the occurrence of side effects. If antidepressant side effects persist beyond the first few weeks, a prescriber can help you determine next steps, which may include a change in dosage, timing of dosage, or to a different medication.
If you are considering an antidepressant or want to discuss your current medication treatment with a provider, online psychiatry platforms, such as Talkiatry and Brightside Health are a good place to start. Their providers offer assessments and prescription consultation, and can answer any questions you have about antidepressant side effects.
Key Takeaways
Common antidepressant side effects can impact your digestive system, sleep patterns, appetite, and sexual functioning. There is also a risk of serious side effects that require medical attention.
If antidepressant side effects persist longer than a few weeks, your provider can help you determine next steps, which may include a change in dosage, timing of dosage, or medication.
There are several ways to cope with antidepressant side effects, including self care practices, medication adjustments, and therapy.
If you are considering an antidepressant or an alternative, a good place to start is with an evaluation from a medical provider. Many online psychiatry platforms offer online assessments and medication management, such as Talkiatry, or Circle Medical.
Concerned About Medication Side Effects? Ask a Doctor
Talkiatry can match you with a real psychiatrist who takes your insurance and is seeing new patients. They’re in-network with major insurers and offer medication management. Get started with a short online assessment
What Are Common Antidepressant Side Effects?
Antidepressants can cause various side effects. Each person responds differently, making side effects unpredictable. While some symptoms are temporary, others may require medical attention.
Here are some of the common types of antidepressant side effects:1
- Digestive symptoms: Dry mouth, nausea, constipation, appetite changes
- Changes in sleep: Insomnia, drowsiness, fatigue
- Sexual dysfunction: Reduced sex drive, erectile dysfunction, difficulties with orgasm
- Mood changes: Increased anxiety, restlessness, agitation
- Cardiovascular symptoms: Rapid heartbeat, irregular heart rhythms, blood pressure changes
- Additional symptoms: Excessive sweating, weight changes
*All medications, including antidepressants, can cause side effects that can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and understand the potential side effects and benefits of any medication.
Common SSRI & SNRI Side Effects
Individuals taking SSRIs and SNRIs may experience common side effects that impact their digestive system, sleep, appetite, and sexual functioning. Selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs) are safer and have fewer side effects than older antidepressants. Some side effects may require medical attention. And while many side effects often resolve on their own, they may persist for as long as a person takes the medication.
Common side effects of SSRIs and SNRIs may include:*2, 3
- Nausea
- Diarrhea
- Sleep changes
- Headache
- Sexual dysfunction
- Fatigue
- Increased sweating
- Dry mouth
- Weight changes
- Anxiety/restlessness
*All medications, including SSRIs and SNRIs, can cause side effects that can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and understand the potential side effects and benefits of any medication.
Serious SSRI & SNRI Side Effects
There is a risk for SSRI and SNRI side effects to be severe or persistent. If these side effects appear, it is important to seek immediate medical attention.
Serious side effects of SSRIs and SNRIs that require immediate medical attention include:*2, 4, 5, 6
- Suicidal thoughts or actions
- Increased or unusual bleeding
- Symptoms of mania or hypomania
- Seizures or convulsions
- Allergic reactions
- Changes in heart rate or rhythm
- Muscle rigidity, fever, tremors, and/or seizures (Could be a sign of serotonin syndrome)
*All medications, including SSRIs and SNRIs, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.
Common Atypical Antidepressant Side Effects
Common side effects from taking atypicaI antidepressants are typically mild and may go away on their own after a few weeks. However, some may persist for as long as a person takes the medication. Side effects will vary for each individual and depend on the specific medication being taken.
Common side effects of atypical antidepressants may include:*7, 8
- Insomnia
- Drowsiness
- Dry mouth
- Constipation
- Weight changes
- Sweating
*All medications, including atypical antidepressants, can cause side effects that can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and understand the potential side effects and benefits of any medication.
Serious Atypical Antidepressant Side Effects
There is a risk for atypical antidepressant side effects to be severe or persistent. If these side effects appear, seek medical care right away. Because atypical antidepressants all work differently, serious side effects are unique to each medication. Your provider can help you understand which medication may be most appropriate for you.
Serious side effects of atypical antidepressants include:*7, 8, 9
- Suicidal thoughts or behaviors
- Severe allergic reactions
- Changes in heart rate or rhythm
- Seizures
- Serotonin syndrome
- Unusual or increased bleeding
- Urinary retention, incontinence, or urgency
*All medications, including atypical antidepressants, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.
Common TCA Side Effects
Tricyclic and tetracyclic antidepressants (TCAs) are older medications that are known to be effective for depressive symptoms. However, they come with a higher likelihood of side effects than newer antidepressants and are not used as primary depression treatments anymore.10 Some side effects may require medical attention. And while many side effects often resolve on their own, they may persist for as long as a person takes the medication.
Common side effects of TCAs may include:*11, 12, 13
- Drowsiness
- Dry mouth
- Nausea
- Dizziness
- Constipation
- Urinary retention
- Increased heart rate
- Confusion
- Weight changes
*All medications, including TCAs, can cause side effects that can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and understand the potential side effects and benefits of any medication.
Serious TCA Side Effects
TCAs are associated with the risk of serious side effects, including some to look out for when starting or changing doses. Seek medical attention right away if you are taking a TCA and experience any serious side effects.
Serious side effects of TCAs include:*11, 12, 13
- Suicidal thoughts or behaviors
- Severe allergic reactions
- Cardiovascular problems
- Potential harm to kidneys and liver
- Seizures
- Serotonin syndrome
- TCA-induced mania
*All medications, including TCAs, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.
Common MAOI Side Effects
Common side effects when taking monoamine oxidase inhibitors (MAOIs) usually occur when starting treatment or when changing doses. MAOIs are among the first medications approved to treat depression, but they are no longer primary treatments due to their risk of side effects. And while many side effects often resolve on their own, they may persist for as long as a person takes the medication and some may require medical attention.
Common side effects of MAOIs may include:*14
- Drowsiness
- Fatigue
- Headache
- Low blood pressure upon standing (orthostatic hypotension)
- Drowsiness
- Weight changes
- Appetite changes
- Insomnia
- Nausea
- Sexual dysfunction
*All medications, including MAOIs, can cause side effects that can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and understand the potential side effects and benefits of any medication.
Serious MAOI Side Effects
There is a risk for MAOI side effects to be severe or persistent. Serious side effects can happen at any time during treatment, so it’s important to remain watchful for them throughout your treatment. If these side effects appear, seek medical care right away.
Serious side effects of MAOIs include:*14, 15, 16
- Suicidal thoughts or behaviors
- Dangerously high blood pressure (hypertensive crisis)
- Severe allergic reactions
- Seizures
- Potential harm to the liver or kidneys
- Serotonin syndrome
- Risk of manic episodes
- Interactions with tyramine-rich foods
*All medications, including MAOIs, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.
Concerned About Medication Side Effects? Ask a Doctor
Talkiatry can match you with a real psychiatrist who takes your insurance and is seeing new patients. They’re in-network with major insurers and offer medication management. Get started with a short online assessment
What Are the Risks & Warnings for Antidepressants?
Suicidal Thoughts & Behaviors
All antidepressants have a black box warning, the most serious kind of warning from the FDA for a risk of suicidal thoughts and behaviors in certain people. This risk may be present particularly in the early stages of treatment. You should talk with your doctor about these risks before starting this medication.
Mania or Hypomania
In individuals with bipolar disorder, antidepressants may induce manic or hypomanic episodes. Providers will closely monitor individuals for this risk, and the use of mood stabilizers may be considered in such cases.
Serotonin Syndrome
Serotonin syndrome is a potentially life-threatening condition that can occur when there is an excess of serotonin in the body. This can result from the use of certain antidepressants, especially when combined with other medications that affect serotonin levels. Symptoms include agitation, hallucinations, rapid heartbeat, and increased body temperature.
Increased Bleeding
Some antidepressants may elevate the risk of bleeding, particularly when used in combination with anticoagulant medications or nonsteroidal anti-inflammatory drugs (NSAIDs). Tell your provider if you have a history of bleeding disorders before considering antidepressant medications.
Abnormal Heart Rhythms
Certain antidepressants may cause abnormal heart rhythms, such as prolonged QT interval. This may potentially lead to a serious heart rhythm condition known as torsades de pointes. This risk is more pronounced at higher doses and in individuals with pre-existing heart conditions.
Hyponatremia (Low Sodium Levels)
Hyponatremia occurs when sodium levels in the blood are too low. This is a rare but serious side effect associated with antidepressant use, especially for older adults and those taking diuretics.
Liver Damage
Some antidepressants carry a risk of harming the liver, potentially causing liver damage. Regular liver function tests may be recommended, especially in individuals with pre-existing liver conditions.
Weight Changes
Antidepressants may be associated with weight changes, including both weight gain and weight loss. Monitoring dietary habits and discussing any significant weight changes with healthcare providers can help minimize these effects.
Antidepressant Discontinuation Syndrome
Abruptly stopping antidepressant medications can lead to withdrawal symptoms, also known as antidepressant discontinuation syndrome. Symptoms may include dizziness, irritability, and flu-like symptoms. If needed, your medical provider will advise you on tapering off these medications safely.
Sexual Dysfunction
Sexual dysfunction is a common side effect of some antidepressants, especially SSRIS and SNRIs. Sexual side effects may include changes in libido, difficulty achieving or maintaining an erection, and difficulty with orgasm.
*This is not a comprehensive list of all warnings and precautions for antidepressants. You should talk with your doctor about any questions you have and to understand the potential warning and precautions of any medication.
Immediate vs. Long-Term Effects
Antidepressant medications can elicit both immediate and long-term side effects. Immediate side effects typically develop shortly after initiating treatment and may include symptoms such as nausea, dizziness, or insomnia. These initial reactions are often temporary and tend to resolve as the body adjusts to the medication.
On the other hand, long-term side effects are those that persist or develop after prolonged use of antidepressants. These effects can include weight changes, sexual dysfunction, or changes in bone density.17 While immediate side effects are often manageable and may lessen over time, long-term effects may require ongoing monitoring and adjustment of the treatment plan to address persistent or new issues. It is important to note that side effects can vary across medications and individuals.
Individual Considerations for Antidepressant Side Effects
Individual responses to antidepressants can vary, influenced by factors such as genetics, dosage, and the specific class of medication. What works well for one person may not be suitable for another, and finding the right dosage often requires careful adjustment.
- Genetics: Genetic variations can impact how the body metabolizes drugs, influencing both the efficacy and side effect profile of antidepressants. Some individuals may also be more susceptible to certain side effects due to their genetic makeup.
- Dosage: Each person’s response to medication can differ based on whether they are taking a low or high dose.
- Type of antidepressant: Some people may tolerate selective serotonin reuptake inhibitors (SSRIs) better than tricyclic antidepressants, and vice versa.
Important Things to Know About Taking Antidepressants
Before starting antidepressants, it’s important to understand what to expect during your first weeks of treatment. Your prescriber will discuss your dosage, how to take your medication, precautions for the medication, potential side effects you may experience, and what to do if side effects become a problem.
How Long Does It Take for Antidepressants to Work?
Antidepressants can take about 4-8 weeks to become fully effective, though this may vary depending on the medication. Some individuals may start to feel better after the first week or two. Each person may have a different response time based on how their body absorbs and processes the medication.
Can Antidepressants Worsen Symptoms at First?
Yes, some people starting an antidepressant may experience uncomfortable side effects such as insomnia, nausea, and fatigue. Antidepressants can also increase the risk of suicidal thoughts and behaviors in some people. If you experience worsened symptoms or side effects of any kind, contact your provider immediately.
What Happens If I Miss a Dose?
If you forget to take your antidepressant dose, take it as soon as you remember. If your next dose is due soon, skip the missed one and take your next scheduled dose. Never take two doses at once, and continue taking your medication as prescribed unless your prescriber directs you to do otherwise.4, 5, 8, 13, 15
Who Experiences Side Effects More?
Some patients may experience side effects from antidepressants more than others. While predicting who will respond poorly is difficult, specific patient populations should be cautious with antidepressants.
Populations who are at an increased risk for experiencing side effects include those who are or have:3
- Susceptibility to nausea and vomiting
- Suicidal ideations (current or history)
- Adolescents and young adults (elevated risk for suicidal ideations)
- A history of serotonin syndrome
- Currently taking medications that may increase serotonin levels in the brain
- Bipolar disorder
- Prior allergic reactions to antidepressants
- Prior vision issues such as glaucoma
- A history of seizures
How to Cope With Common Antidepressant Side Effects
There are ways to cope with the most common antidepressant side effects*. Many may go away on their own during the first few weeks. Contact your provider if side effects persist or worsen.
Digestive Symptoms
Taking an antidepressant can cause digestive side effects such as nausea, stomach upset, diarrhea, and loss of appetite. To reduce these, follow meal timing recommendations for your medications. Also, drink plenty of water, eat smaller, more frequent meals, and avoid spicy foods. You may also try ginger or peppermint teas, but talk with your healthcare provider before taking any prescription or over-the-counter medicine or using supplements such as tea.
Increased Sweating
Several types of antidepressants can cause increased sweating. Wearing loose clothing and using topical antiperspirants can help. Your provider may also make an adjustment or change of medication if the sweating interferes with your daily life. Be aware that excessive sweating is a symptom of serotonin syndrome. This is a rare but potentially life-threatening complication with antidepressants that requires immediate medical care.18
Sleep Changes
Sleep changes such as drowsiness and insomnia may occur when taking antidepressants. If you experience drowsiness, avoid doing activities that require alertness, such as driving or operating machinery. Your provider may also recommend taking your medication at a certain time of the day or using sleep aids.
Tremors
While not a common side effect, antidepressants may cause tremors for some who take them. Your provider may adjust or change your medication. But if the tremor is mild and does not interfere with your daily activity, you may not need any treatment or medication changes. Speak to your provider so they can determine the best course for you.19
Anxiety & Agitation
Some may feel anxiety or agitation when starting an SSRI medication. The exact cause of this side effect is not clear and may fade on their own as your body adjusts to the medication. If your anxiety persists or worsens, contact your provider as agitation is a symptom of serotonin syndrome, a serious condition that requires immediate medical care.2, 4, 20
Sexual Side Effects
Men taking SSRIs and SNRIs may experience erectile dysfunction, decreased sex drive, and delayed ejaculation. Women may have problems with orgasms and decreased sex drive. Scheduling sexual activity before taking a dose may also reduce the risk or impact of sexual side effects. These effects may go away after the first few weeks, but if these effects are bothersome or persistent, your provider may consider a change of dosage or medication.4, 5
*All medications, including antidepressants, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.
More Ways to Manage Antidepressant Side Effects
Here are more ways to cope with and reduce the impact of antidepressant side effects.
Practice Good Sleep Hygiene
Following good sleep hygiene practices can help you get better sleep while your body adjusts to the medication. Try to wake up and go to bed about the same time each day, and make sure your sleeping environment is relaxing and comfortable to you. Keeping a sleep diary to track patterns and get daily light exposure can also help. Getting 30 minutes of exercise during the day can improve your sleep quality, but avoid intense activity before bed.
Healthy Lifestyle Activities
Eating well, sleeping enough, and getting adequate exercise are all parts of a healthy lifestyle. These activities are important for all aspects of your physical and mental health and can help you endure the impact of side effects.
Follow a Daily Routine
Following your normal routine is important whether or not the medication is working yet. Doing your regular daily activities can keep life more predictable and reduce stress as you adjust to the medication. Also, be sure you are taking your medication as prescribed and at a consistent time each day.
Consider Therapy
Psychotherapy can support you by addressing the impact of side effects and helping you develop strategies to manage them. For in-person treatment, your primary care provider or insurance company can provide a referral, or you may get one from family or friends.
To find an online therapist, an online therapist directory is a great starting point. Many online psychiatry platforms, such as Talkiatry and Brightside Health, also offer therapy services.
Should I Stop Taking My Antidepressant If I Start Feeling Side Effects?
Do not stop taking your antidepressant medication unless you have been advised to do so by your provider. Stopping on your own can cause uncomfortable symptoms, including dizziness, fatigue, irritability, and nausea. If you have been taking antidepressants for a long time, abruptly stopping can lead to antidepressant discontinuation syndrome, also known as antidepressant withdrawal.
If you are experiencing side effects from your medication, tell your provider. They will help you determine the best course for continued treatment, which may include changing your dosage, the time for your dosage, or your medication. If your doctor determines discontinuing your medication is the best option, they will provide a plan for stopping your medication gradually, which can minimize your risk of developing withdrawal symptoms.
When Should I Call My Doctor About Antidepressant Side Effects?
Side effects are one of the most common reasons people choose to stop taking medication. While some effects can be managed and may fade away, some do not go away unless a person stops taking the medication. Side effects can occur even if you are taking your medication correctly.
Contact your provider as soon as possible if side effects persist or become hard to tolerate so you can consider other treatment options. While not common, some people taking antidepressants may experience serious side effects. These effects often require immediate medical care and some may be life-threatening. If you notice any of the serious side effects listed above, seek medical care immediately.
Popular Choices for Online Psychiatry
Talkiatry – Safe, virtual mental health care from doctors who take insurance. Most psychiatry visits cost patients $30 or less* Take a short assessment.
Circle Medical – anxiety and depression treatment. Meet with an online doctor today! All prescriptions are based on necessity determined by a medical professional. Diagnosis and prescription over video. Insurance accepted. No membership or hidden fees. Same day appointments. Visit Circle Medical
*Includes copayment, deductible, coinsurance, and $0 Visits. Excludes no shows. **On average. Actual appointment times vary by state and individual patient.
When Should I Seek an Alternative Antidepressant or Medication Due to Side Effects?
Initial side effects from antidepressants typically subside after a few weeks. If after some time you are looking to change your medication due to continued side effects, work with a doctor to find an alternative. All classes of antidepressants can help reduce depression symptoms, though potential risks and benefits can vary.
SNRIs and SSRIs are typically the first type of antidepressants and alternatives considered because of their safety and effectiveness. Atypical antidepressants work differently to improve symptoms and don’t fit into a formal category.
Tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs) are older medications with more side effects. However, they may be helpful for those who need to avoid or can’t tolerate other types of antidepressants.
How to Get a Prescription for Antidepressants or Alternative Medications
To get a prescription for antidepressants or an alternative in person, start with an evaluation for your symptoms. Your primary care provider, who may be a physician, nurse practitioner, or physician assistant, can help you get the process started. They may make a referral to a psychiatrist or specialist to determine if a prescription for antidepressants or alternatives should be included in your treatment plan.
To get an online prescription for an antidepressant or alternative medication, you will also start by getting evaluated by an online psychiatric provider. We have thoroughly reviewed platforms like Talkiatry or Circle Medical that prescribe non-controlled substances such as antidepressants and some anti-anxiety medications.
Benzodiazepines are controlled substances that may be used to treat anxiety symptoms. To get prescribed benzodiazepines, you must do your evaluation with an online psychiatry provider that can and will prescribe controlled substances.
We have thoroughly evaluated online providers like Talkiatry that can and will prescribe benzodiazepines and found them each to be a good place to get started with an evaluation. If your provider feels a benzodiazepine is a good fit for your anxiety symptoms, they may offer you a benzodiazepine prescription online.
Concerned About Medication Side Effects? Ask a Doctor
Talkiatry can match you with a real psychiatrist who takes your insurance and is seeing new patients. They’re in-network with major insurers and offer medication management. Get started with a short online assessment
Questions to Ask Your Provider
It is important to discuss the potential side effects of antidepressants with your doctor, psychiatrist, or therapist you may experience immediately after starting the treatment. Ask them whether these side effects will go away on their own or if any intervention is needed.
Also, many online psychiatry services are available with convenient access to mental health care for depression and anxiety problems. Individuals may even change prescribers and get a mental health evaluation, diagnosis, and personalized treatment plan.
Questions to ask your care team about antidepressant side effects may include:
- How long will it take for me to adjust to taking an antidepressant?
- How quickly can an antidepressant cause side effects?
- What are the first days of antidepressant side effects like?
- What is the best dosage to ensure fewer side effects, especially in the first week?
- When should I reach out to you if I am experiencing side effects?
- If I’m not able to tolerate the side effects, are there antidepressant alternatives to consider?
- How should I cope with side effects?
- What to do if the side effects do not disappear after the first few weeks?
- Can I skip or lower a dose to avoid the side effects?
- Can I switch the drug if the side effects last longer or get worse?
- What to do if I have serious side effects?
Prescriber’s Tips
Your prescriber will share important information about your antidepressant prescription. They will explain how to take and store your medication, what to avoid when taking it, and what to do about side effects. Follow these tips for safe and effective use of antidepressants.
- Take your medication as prescribed, do not change your dose or stop taking it unless your prescriber tells you to. Keeping a consistent dosing schedule reduces the chance of unwanted side effects. When taking antidepressants, this approach can prevent withdrawal symptoms such as dizziness, brain zaps, and flu-like symptoms.18
- Take your medication at the same time each day. Doing so can help you remember to take it, making it as effective as possible. Your healthcare provider can help determine the optimal timing based on your sleep patterns and initial medication response.
- Tell your prescriber right away if you or your child have any worsening mental health symptoms. Antidepressants have a boxed warning for increased risk of suicidal thoughts and behaviors in children under age 18 and young adults.
- Ask your doctor whether it is safe to drink alcohol while taking antidepressants.
- Tell your prescriber about all medications and supplements you take, including over-the-counter treatments. Many over-the-counter medications and supplements can interact with prescription medications. This is because they are processed by the same gut enzymes, cytochrome P450 (CYPs). These interactions can lead to unwanted side effects or reduce the effectiveness of your prescription medication.21
Frequently Asked Questions
What Are Antidepressants & What Are They Used to Treat?
Antidepressants are FDA-approved to treat many mental health conditions such as major depression, anxiety disorders, PTSD, OCD, and other conditions in adults and children.
What Do Antidepressants Do?
Antidepressant medications work in the brain to increase levels of certain brain chemicals, which can lead to an improvement in symptoms for some people. Dopamine, serotonin, and norepinephrine are neurotransmitters (chemical messengers) that are most closely associated with depression. They affect mood, energy, and motivation.22 People with depression are often found to be deficient in one or more of these chemicals, which at least partially explains their depression symptoms.
How Do Antipressants Make You Feel During the First Week?
During the first week of taking an antidepressant, the medication is building up in your body. This may trigger side effects for some people. It can take several weeks for antidepressants to start working and you may not notice any difference in your symptoms yet.
Which Antidepressants Cause the Fewest Side Effects?
SSRIs and serotonin norepinephrine reuptake inhibitors (SNRIs) are antidepressants that cause the fewest side effects. These are newer classes of antidepressants and are often preferred for their milder side effects.
Which Antidepressants Cause the Most Side Effects?
Monamine oxidase inhibitors (MAOIs), tetracyclic, and tricyclic antidepressants (TCAs) cause the most side effects. These are older classes of medication and are not first-line treatments for depression because they have more side effects than newer antidepressants.
Should I Stop Taking My Antidepressants If I Experience Side Effects?
Do not stop taking your antidepressants unless you have been advised to do so by your provider. Doing so can lead to antidepressant discontinuation syndrome, also known as antidepressant withdrawal. This can cause uncomfortable symptoms, including dizziness, fatigue, irritability, and nausea.
ChoosingTherapy.com strives to provide our readers with mental health content that is accurate and actionable. We have high standards for what can be cited within our articles. Acceptable sources include government agencies, universities and colleges, scholarly journals, industry and professional associations, and other high-integrity sources of mental health journalism. Learn more by reviewing our full editorial policy.
-
Santarsieri, D., & Schwartz, T. L. (2015). Antidepressant efficacy and side-effect burden: a quick guide for clinicians. Drugs in context, 4, 212290. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630974/
-
Celexa- citalopram tablet, film coated. (November 13, 2023). DailyMed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
-
Santarsieri, D., & Schwartz, T. (2015). Antidepressant efficacy and side-effect burden: a quick guide for clinicians. Drugs in Context, 4, 1–12. Retrieved from https://doi.org/10.7573/dic.212290
-
ZOLOFT- sertraline hydrochloride tablet, film coated. (August 8, 2023). DailyMed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
-
Effexor XR- venlafaxine hydrochloride capsule, extended release. (August 15, 2023). Dailymed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
-
Cymbalta- duloxetine hydrochloride capsule, delayed release. (November 6, 2024). Dailymed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
-
Remeron- mirtazapine tablet, film coated. (April, 2024). Dailymed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
-
Wellbutrin XL- bupropion hydrochloride tablet, extended release. (March 1, 2024). Dailymed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
-
Trazodone hydrochloride tablet, film coated. (March 28, 2024). Dailymed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
-
Carvalho, A. F., Sharma, M. S., Brunoni, A. R., Vieta, E., & Fava, G. A. (2016). The safety, tolerability and risks associated with the use of newer generation antidepressant drugs: a critical review of the literature. Psychotherapy and psychosomatics, 85(5), 270-288. Retrieved from https://karger.com/pps/article/85/5/270/282974/The-Safety-Tolerability-and-Risks-Associated-With-the-Use-of-Newer-Antidepressant-Drugs
-
Amitriptyline hydrochloride tablet, coated. (May 24, 2024). Dailymed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
-
Clomipramine hydrochloride capsule. (December 10, 2024). Dailymed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
-
Imipramine hydrochloride tablet, film coated. (December 19, 2024). Dailymed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
-
Wimbiscus, M., Kostenko, O., & Malone, D. (2010). MAO inhibitors: risks, benefits, and lore. Cleveland Clinic journal of medicine, 77(12), 859–882. https://doi.org/10.3949/ccjm.77a.09103
-
Nardil – phenelzine sulfate tablet, film coated. (December 9, 2024). Dailymed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
-
Marplan- isocarboxazid tablet. (July 17, 2023). DailyMed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
-
Mercurio, M., de Filippis, R., Spina, G., De Fazio, P., Segura-Garcia, C., Galasso, O., & Gasparini, G. (2022). The use of antidepressants is linked to bone loss: A systematic review and metanalysis. Orthopedic reviews, 14(6), 38564. Retrieved from https://doi.org/10.52965/001c.38564
-
A.D.A.M. Medical Encyclopedia [Internet]. (2024). Serotonin syndrome. Medlineplus.gov. Retrieved from https://medlineplus.gov/ency/article/007272.htm
-
Drug-induced tremors. (2024). MedlinePlus.gov. Retrieved from https://medlineplus.gov/ency/article/000765.htm
-
Scotton WJ, Hill LJ, Williams AC, Barnes NM. (2019, Sep 9). Serotonin Syndrome: Pathophysiology, Clinical Features, Management, and Potential Future Directions. International Journal of Tryptophan Research. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734608/
-
Marken, P. A., & Munro, J. S. (2000). Selecting a Selective Serotonin Reuptake Inhibitor: Clinically Important Distinguishing Features. Primary Care Companion to the Journal of Clinical Psychiatry. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC181142/
-
Pandya, M., Altinay, M., Malone, D. A., Jr, & Anand, A. (2012). Where in the brain is depression?. Current psychiatry reports, 14(6), 634–642. https://doi.org/10.1007/s11920-012-0322-7
We regularly update the articles on ChoosingTherapy.com to ensure we continue to reflect scientific consensus on the topics we cover, to incorporate new research into our articles, and to better answer our audience’s questions. When our content undergoes a significant revision, we summarize the changes that were made and the date on which they occurred. We also record the authors and medical reviewers who contributed to previous versions of the article. Read more about our editorial policies here.
Author: No Change
Reviewer: No Change
Primary updates: Added “Key Takeaways” feature. Edited for clarity. Added new section “What Are Common Antidepressant Side Effects?”. Removed the intro paragraphs for the SSRI/SNRI, TCAs, MAOIs, and Atypical Antdepressants sections. Replaced “Antidepressant Warnings & Precautions” sections with new “Warnings & Risks” feature. Removed “Allergic Reactions to Antidepressants”, and “Interactions That May Exacerbate Antidepressant Side Effects”, condensed the info and added it to each drug class Serious Side Effect section. Added new sections “Who Experiences Side Effects More?”, “Important Things to Know About Taking Antidepressants”, “How to Cope With Common Antidepressant Side Effects”, “Should I Stop Taking My Antidepressant If I Start Feeling Side Effects?”, “When Should I Seek an Alternative Antidepressant or Medication Due to Side Effects?”, “How to Get a Prescription for Antidepressants or Alternative Medications” and all included subsections. Revised and retitled “How to Manage Antidepressant Side Effects” to “More Ways to Manage Antidepressant Side Effects”. Removed “Signs of Serious Side Effects That Require Immediate Attention”. Retitled “Questions to Ask Your Health Team” to “Questions to Ask Your Provider”. Replaced “Final Thoughts” with “Prescriber’s Tips” feature. Removed “For Further Reading”, Added FAQs.
Author: Alejandro Figueroa, MD, PharmD
Medical Reviewer: Dena Westphalen, PharmD
Your Voice Matters
Can't find what you're looking for?
Request an article! Tell ChoosingTherapy.com’s editorial team what questions you have about mental health, emotional wellness, relationships, and parenting. Our licensed therapists are just waiting to cover new topics you care about!
Leave your feedback for our editors.
Share your feedback on this article with our editors. If there’s something we missed or something we could improve on, we’d love to hear it.
Our writers and editors love compliments, too. :)
Concerned About Medication Side Effects? Ask a Doctor
Talkiatry can match you with a real psychiatrist who takes your insurance and is seeing new patients. They’re in-network with major insurers and offer medication management. Get started with a short online assessment
Additional Resources
To help our readers take the next step in their mental health journey, ChoosingTherapy.com has partnered with leaders in mental health and wellness. ChoosingTherapy.com is compensated for marketing by the companies included below.
Virtual Psychiatry
Circle Medical – Anxiety and Depression Treatment. Meet with an online doctor today! All prescriptions are based on necessity determined by a medical professional. Diagnosis and prescription over video. Insurance accepted. No membership or hidden fees. Same day appointments. Visit Circle Medical
Talkiatry – Get help from a real doctor that takes your insurance. Talkiatry offers medication management and online visits with expert psychiatrists. Take the online assessment and have your first appointment in days. Free Assessment
Therapy for Anxiety & Medication Management
Brightside Health – develops personalized plans that are unique to you and offers 1 on 1 support from start to finish. Brightside Health accepts United Healthcare, Anthem, Cigna, and Aetna. Appointments in as little as 24 hours. Start Free Assessment
Talk Therapy
BetterHelp – Get support and guidance from a licensed therapist. BetterHelp has over 30,000 therapists who provide convenient and affordable online therapy. BetterHelp starts at $65 per week and is FSA/HSA eligible by most providers. Take a Free Online Assessment and get matched with the right therapist for you. Take free assessment
Anxiety Newsletter
A free newsletter from the experts at ChoosingTherapy.com for those impacted by anxiety. Get helpful tips and the latest information. Sign Up
Online Anxiety Test
A few questions from Talkiatry can help you understand your symptoms and give you a recommendation for what to do next.
Best Online Psychiatry Services
Online psychiatry, sometimes called telepsychiatry, platforms offer medication management by phone, video, or secure messaging for a variety of mental health conditions. In some cases, online psychiatry may be more affordable than seeing an in-person provider. Mental health treatment has expanded to include many online psychiatry and therapy services. With so many choices, it can feel overwhelming to find the one that is right for you.
