Abilify Weight Gain: What You Need to Know

Why Does Abilify Cause Weight Gain?

Atypical antipsychotics, such as Abilify, are associated with weight gain. However, the weight gain typically seen with Abilify is much less in comparison to other atypical antipsychotic medications. Also, weight changes will vary from person to person, and not everyone will experience this side effect. Atypical antipsychotics are associated with metabolic changes, including increased blood sugar levels, increased lipid/fats in the blood, and weight gain.

It is unclear why Abilify can cause weight gain in some individuals. Several factors may play a role, including changes in metabolism and increased appetite. Studies have shown that weight gain may be more common in children and adolescents when compared to adults.³ The weight gain typically occurs over a short period of time and may be noticed after a few weeks. The weight changes become less significant, at least in adults, when taken for a longer period of time.

Here are some ways Abilify may cause weight gain:

• Changes in the body’s response to blood sugar and insulin
• Changes in the body’s metabolism of lipids/fats
• Increased appetite

Abilify May Increase Your Appetite

One factor that may contribute to weight gain associated with Abilify is the drug’s potential to increase appetite. Dopamine is a chemical that can impact appetite. Abilify alters the activity of dopamine, which can lead to appetite changes. The extent of an increased appetite can vary, and some individuals may experience a decreased appetite.

Abilify May Affect Your Metabolism

Another factor contributing to weight gain with Abilify is its potential to impact metabolism. The drug may alter the metabolism processes of the body, altering how it stores and manages calories. These changes can impact blood glucose, insulin, and lipids, making it easier for individuals to gain weight.

*All medications, including Abilify, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.

How Much Weight Could I Gain With Abilify?

The amount of weight gain varies from person to person and may change depending on how long you are on the medication. For example, studies in adults have shown that the average weight gain was only around 0.6 pounds after three weeks.

However, up to 8% of adults on Abilify experienced a weight gain of more than 7% of their body weight.¹ In children, these numbers are even higher. The average weight gain in children was around 3.5 pounds after six weeks, and as much as 26% may experience a weight gain of more than 7% of their body weight.¹

How to Avoid Weight Gain on Abilify

There are many options to consider to avoid weight gain when taking Abilify, including regular exercise to support both physical and mental health, engaging in open discussions with your healthcare provider about your Abilify dosage and concerns, and following a balanced diet. A comprehensive strategy works best to address potential weight changes while taking Abilify.

Here are 5 ways to avoid weight gain while taking Abilify:

1. Exercise regularly: Incorporating physical activity into your routine can help mitigate weight gain associated with Abilify.
2. Talk to your prescriber about your dosage: Engage in open dialogue with your healthcare provider regarding your medication dosage. While you should never adjust your dose independently, it is important to discuss your concerns with your healthcare provider.
3. Adopt a balanced diet: Maintaining a healthy, well-balanced diet can help with weight gain associated with Abilify.
4. Manage stress: Stress can contribute to weight gain. By engaging in stress-reduction techniques, you may be able to help with the weight gain associated with Abilify. Examples include medication, yoga, and deep breathing exercises.
5. Monitor your weight: Regularly tracking your weight can help you and your healthcare provider detect any changes early, allowing for timely adjustments to your treatment plan if needed.

Will I Lose Weight After Stopping Abilify?

Weight changes after discontinuing Abilify can vary from person to person, and this has not been well studied. Some individuals may experience a gradual weight loss once they stop taking the medication.⁴ However, others may not observe significant changes in their weight.

Are There Abilify Alternatives That Don’t Cause Weight Gain?

There are alternatives to Abilify that may have a lower risk of causing weight gain. However, the weight gain caused by Abilify is typically less frequent and less severe than for most other antipsychotics.³ Also, the body weight changes can vary significantly from person to person. Below is a chart showing the average weight gain associated with different antipsychotic medications.

The chart below shows the relative risk of gaining weight while taking atypical antipsychotics:⁵

Questions to Ask Your Healthcare Team About Abilify Weight Gain

Individuals considering Abilify as part of their treatment should discuss potential weight gain concerns with their healthcare team. They can start by asking their doctor, psychiatrist, and therapist about the expected benefits of Abilfiy in managing their specific condition. It is important to ask about the risk of weight gain and strategies to help with weight management.

Questions to ask your care team about Abilify weight gain include:

1. How can I tell if it is the medication causing weight gain?
2. How long will the weight gain from Abilify last?
3. Am I at risk for increased weight gain or weight gain if I take other medications, such as antidepressants or anxiety medications?
4. Will a previous history of weight gain or weight gain make me more susceptible?
5. What is the best dosage to reduce the risk of weight gain?
6. Are there drugs I am taking that increase the risk of weight gain when taking Abilify?
7. When should I reach out to you if I am noticing significant weight gain?
8. Are there other medications that may have less impact on my weight?
9. What lifestyle changes can help mitigate potential weight gain?
10. Are there any dietary changes I should consider to help prevent weight gain?
11. How long does it take for abilify to work?

For Further Reading

• Bipolar Disorder Diet: Foods to Eat & Avoid
• Abilify Side Effects Sexually: What You Need to Know
• Abilify Withdrawal Symptoms: All You Need to Know
• Abilify & Alcohol: What Are the Risks?
• Latuda Weight Gain: Everything You Need to Know