Effexor Weight Gain: Everything You Need to Know

What Is Effexor (Venlafaxine)?

Effexor (venlafaxine) is FDA-approved for the treatment of depression, anxiety disorders, and other mental health conditions.¹ Effexor belongs to the serotonin and norepinephrine reuptake inhibitors (SNRIs) class of medications that plays an important role in regulating serotonin and norepinephrine levels in the brain. In turn, a person can experience improvements in their overall mood and mental well-being.

Why Does Effexor Cause Weight Gain?

Like many other antidepressants, Effexor may cause weight gain. It’s important to note that the extent of weight gain varies from individual to individual and can be influenced by several factors, including one’s diet, exercise habits, genetics, and other medications being taken. However, it is believed that Effexor increases a person’s appetite and influences their desire for carbohydrate-rich foods. This will likely influence their weight over time. Conversely, for some individuals, taking Effexor can result in the opposite effect, resulting in decreased appetite and weight loss.

Do Other Antidepressants Cause Weight Gain?

Many antidepressants are associated with weight gain. For example, both Effexor and other SNRIs or SSRIs work in the same way to improve a person’s depression or anxiety symptoms. Improving an individual’s mood can contribute to an increased appetite. If depression had caused weight loss, that weight might be regained as depression is treated.

Short-Term vs. Long-Term Impacts on Weight Gain

Both short- and long-term use of Effexor can result in weight gain. As one’s body adjusts to the medication, they are likely to experience some increase in weight. Long-term treatment with Effexor may lead to longer-lasting mood improvements, but this depends on the person and the duration of their medication plan.

Other Reasons for Weight Gain While Taking Effexor

Effexor is not the sole contributor to weight gain. Many other factors can influence a person’s weight. However, it is possible to curb weight gain and maintain a healthy diet while remaining on medication. Eating excessively without increasing physical activity will likely increase the risk of weight gain while taking Effexor.

Ways to Manage Effexor Weight Gain

Unhealthy levels of weight gain while taking Effexor can be concerning, especially if this continues well into treatment. However, there are healthy ways to limit this side effect while taking Effexor. Being sure to stay active and eat a nutritious diet will help you stay on track and in shape.

Below are ways to manage weight gain while taking Effexor:

• Adjust your dosage: If weight gain becomes persistent, talk with your doctor. Your physician can help taper your Effexor dosage if needed.
• Try another medication: If Effexor does not work for you and significantly affects your weight, your doctor can offer an alternative medication, such as Lexapro.
• Maintain a healthy diet: Eating healthy foods, such as vegetables and fruits, can help you manage your weight.³
• Stay physically active: A lack of exercise can lead to fat buildup in the body and further weight gain. Regular exercise burns excess calories and helps you stay in shape.²
• Work with a dietician: A dietician can help you determine a nutrition plan that works well for you and ensures you are able to maintain a healthy weight.

Other Side Effects of Effexor

Besides weight gain, Effexor can result in other side effects, including nausea, drowsiness, and headaches.³ However, if side effects become severe, it is important to seek immediate medical attention. The severity of adverse reactions typically depends on factors such as the individual’s age or pre-existing health conditions.

Common side effects of Effexor include:¹

• Sweating
• Weight changes
• Dry mouth
• Sexual dysfunction
• Nervousness/restlessness
• Drowsiness
• Dizziness
• Headache
• Vomiting
• Sleeping problems
• Indigestion
• Nausea

Severe side effects of Effexor that may require immediate medical attention include:¹

• Worsening anxiety symptoms
• Seizures
• Manic episodes
• Serotonin syndrome
• Vision problems
• Tremors
• Excessive bleeding
• Hyponatremia
• Suicidal thoughts and behaviors

Alternatives to Effexor

Most SSRIs, SNRIs, tricyclic antidepressants, and monoamine oxidase inhibitors can lead to weight gain in users. However, certain medications may be less likely to result in appetite, metabolism, and weight changes. A doctor can recommend alternatives to Effexor that work similarly, such as Lexapro (escitalopram), Pristiq (desvenlafaxine), or Trintellix (vortioxetine).

Questions to Ask Your Healthcare Team

Discuss your medical history with your doctor before taking any medication. This increases your chance of remaining safe while receiving treatment and that you are well-informed of any associated risks or side effects beforehand. Your doctor will determine which prescription suits your individual needs. However, it’s important to ask questions about your prescription so you can remain informed about healthy medication practices.

Questions to ask your care team about Effexor include:

• Am I at risk of increased weight gain if I am already taking other anxiety/depression medications?
• Will a previous history of weight gain on other medications make me more susceptible?
• What is the best dose of Effexor to limit weight gain?
• Are there substances I am taking that could interact with Effexor?
• When should I reach out to you about weight gain?
• How often should I come in for checkups while taking Effexor?
• Does insurance cover my medication?
• Is it possible to mix Effexor with other medications?

Final Thoughts

While every person reacts to medication differently, taking Effexor may result in weight gain. If you are unhappy with the side effects of Effexor or another antidepressant, discuss alternatives with your doctor. Your prescriber can recommend medications that may have a smaller impact on your weight.