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  • Considering Phentermine AlternativesConsidering Phentermine Alternatives
  • Prescription DrugsPrescription Drugs
  • Over-the-Counter OptionsOver-the-Counter Options
  • Herbal RemediesHerbal Remedies
  • Lifestyle ChangesLifestyle Changes
  • Questions to AskQuestions to Ask
  • In My ExperienceIn My Experience
  • Additional ResourcesAdditional Resources

Phentermine Alternatives Compared

Headshot Max Ruvinov PharmD MBA

Author: Max Ruvinov, PharmD, MBA

Headshot Max Ruvinov PharmD MBA

Max Ruvinov PharmD, MBA

Max Ruvinov is an accomplished pharmacist and an expert in medication management for multiple mental health conditions. His areas of expertise include weight loss, sexual health, and mood disorders.

See My Bio Editorial Policy
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Medical Reviewer: Heidi Moawad, MD Licensed medical reviewer

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Heidi Moawad MD

Heidi Moawad, MD is a neurologist with 20+ years of experience focusing on
mental health disorders, behavioral health issues, neurological disease, migraines, pain, stroke, cognitive impairment, multiple sclerosis, and more.

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Published: March 5, 2024
  • Considering Phentermine AlternativesConsidering Phentermine Alternatives
  • Prescription DrugsPrescription Drugs
  • Over-the-Counter OptionsOver-the-Counter Options
  • Herbal RemediesHerbal Remedies
  • Lifestyle ChangesLifestyle Changes
  • Questions to AskQuestions to Ask
  • In My ExperienceIn My Experience
  • Additional ResourcesAdditional Resources
Generic name:
Phentermine
Brand name:
Adipex-P, Lomaira
Is the generic available:
Yes
Class of drug:
Appetite Suppressant
FDA-approved treatments:
Weight loss, short-term
Common Off-label Uses (non-FDA approved):
Weight loss, long-term
Common alternatives:

Ozempic, Wegovy, Mounjaro

View Drug Class, FDA-Approved Uses, Off-Label Uses, and more

*An off-label use of a medication is a use that is not FDA-approved. Prescribers can decide to use a medication off-label because, in their professional judgment, they believe it may offer a benefit to someone.

When seeking alternatives to phentermine for weight loss, individuals may explore a range of options, including prescription weight loss medications, over-the-counter treatments, and natural remedies. Each alternative varies in its mechanism of action and potential side effects, offering individuals options for weight management beyond phentermine.

Phentermine is a controlled substance, which means that it’s more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.

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Reasons to Consider a Phentermine Alternative

Many individuals explore alternatives to phentermine due to concerns about reported side effects affecting various bodily systems, such as the heart, nervous system, stomach, allergies, and hormones.1

The range of reported adverse events prompts some to seek safer options, especially if they have pre-existing medical conditions incompatible with phentermine use. Additionally, those inclined towards a more natural weight loss approach may turn to alternatives that offer a gentler impact on the body while still aiding in effective weight management.

Prescription Phentermine Alternatives

Newer prescription alternatives to phentermine may help some patients lose weight, but potential side effects are possible for all medications. If you are considering alternatives, consulting with your healthcare provider can help you understand your options.

Here are some common phentermine alternative prescription medications to consider:2, 3, 4

Medication FormCommon Side EffectsSpecial Considerations
Semaglutide (Wegovy)self-injection

  • Dizziness or light-headedness

  • Sweating

  • Shakiness

  • Blurred vision

  • Slurred speech

  • Weakness

  • Anxiety



Wegovy slows down stomach emptying, which might affect the absorption of oral medications. Please use it with caution.

Tirzepatide (Mounjaro)self-injection

  • Nausea

  • Diarrhea

  • Decreased appetite

  • Vomiting

  • Constipation

  • Indigestion





This medication hasn't been studied in people who had pancreatitis before. It's not suggested for those with type 1 diabetes.

Alli (orlistat)capsule

  • Abdominal or stomach pain or discomfort

  • Back pain

  • Difficulty with moving

  • Inability to hold bowel movements





Do not use if taking cyclosporine, diagnosed with food absorption issues, or are not overweight.
Liraglutide (Saxenda)self-injection

  • Nausea and vomiting

  • Diarrhea

  • Constipation

  • Headache

  • Increased heart rate


Patients should monitor for symptoms of pancreatitis, such as severe abdominal pain.
Not recommended for individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2
Bupropion-naltrexone (Contrave)tablet

  • Nausea

  • Constipation

  • Headache

  • Dry mouth

  • Dizziness


It may raise blood pressure and heart rate, so monitoring these vitals is advised during treatment.

*All medications can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and understand the potential side effects and benefits of any medication.

How Effective Are Prescription Alternatives to Phentermine?

Prescription alternatives like semaglutide (Wegovy) and tirzepatide (Mounjaro) have proven effective for weight loss. semaglutide, initially designed for diabetes, has shown significant weight reduction, and tirzepatide, acting on certain hormones, also helps in shedding pounds. Keep in mind that everyone responds differently, so it’s important to chat with your doctor to find the best prescription alternative based on your health needs.

How to Get a Prescription for Phentermine Alternative Medications

To obtain a prescription for phentermine alternative medications, consult a healthcare professional, such as a primary care physician or a specialized weight management doctor. The prescription process often involves a comprehensive health assessment, considering factors like medical history, existing conditions, and lifestyle.

Your healthcare provider may conduct physical exams, assess your weight loss goals, and discuss potential risks and benefits to determine if a prescription weight loss medication is a suitable and beneficial treatment for you.

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Over-the-Counter Phentermine Alternatives

For those exploring over-the-counter alternatives to phentermine, Alli may be an effective option. Alli is a 60-milligram over-the-counter version of the ingredient orlistat, which is also available as a prescription drug (Xenical) at a higher dosage of 120 milligrams. Both Alli and Xenical are designed to complement a weight-loss plan that includes a low-calorie, low-fat diet and regular physical activity.5

Alli works by inhibiting the absorption of dietary fat in the intestines, aiding in weight loss. However, individuals considering over-the-counter alternatives should be aware of potential side effects and consult with a healthcare professional to ensure these options align with their overall health goals and needs.

How Effective Are Over-the-Counter Alternatives to Phentermine?

Commonly used over-the-counter weight loss options include caffeine-based supplements, green tea extract, and appetite suppressants. Caffeine, known for its metabolism-boosting properties, can be found in many over-the-counter weight loss supplements. Green tea extract is often included for its potential fat-burning effects and antioxidant benefits.

Appetite suppressants, which may contain ingredients like glucomannan or garcinia cambogia, aim to reduce food intake. While individual responses vary, incorporating these alternatives into a healthy lifestyle, including a balanced diet and regular exercise, can enhance their effectiveness in promoting gradual and sustainable weight loss. Always consult with a healthcare professional before starting any weight loss regimen.

Herbal Remedies & Supplements as Phentermine Alternatives

Some may prefer to use herbal remedies and supplements as alternatives to phentermine for weight loss. Green tea extract, garcinia cambogia, berberine, and curcumin may each offer natural benefits for some. However, these natural substances are not regulated and do not come without risk.

The composition and strength may vary with different brands, and these supplements might come in formulations that are mixed with other components that also have effects on your health. Consult your healthcare provider before using any supplement intended to prompt weight loss and management.

Herbal remedies and supplement alternatives to phentermine for weight loss include:6

  • PhenQ supplement: PhenQ is a blend of ingredients thought to aid weight loss through increased metabolism and reduced appetite, but evidence supporting its effectiveness is limited.
  • Dietary fiber: Found in fruits and grains, dietary fiber promotes fullness, regulates blood sugar, and aids digestion, supporting weight loss efforts. Psyllium husk is another form of dietary fiber that comes in capsules, tablets, or powder form.
  • Berberine: This extract may regulate metabolism and improve insulin sensitivity, potentially aiding in weight loss.
  • Green tea extract: Known for antioxidants, green tea extract might boost metabolism and fat burning, though scientific consensus is mixed.
  • Lotus leaf with taurine: Thought to have diuretic properties, aiding weight loss by reducing water retention, but research is limited.
  • Ginger: Ginger’s anti-inflammatory properties may enhance digestion and control appetite, supporting weight management.
  • Turmeric: Turmeric’s active compound, curcumin, has anti-inflammatory properties that could indirectly aid in weight management.
  • Grapefruit: Low in calories and potentially metabolism-boosting, grapefruit might reduce calorie intake, though individual responses vary.

How Effective Are Herbal Remedies & Supplement Alternatives to Phentermine?

The effectiveness of herbal remedies and supplement alternatives to phentermine for weight loss varies. While some, like green tea extract and garcinia cambogia, have shown potential in supporting metabolism, others, including berberine and turmeric, require more research. Individual responses differ, emphasizing the importance of cautious exploration and consultation with healthcare professionals for personalized and effective weight management strategies.

Lifestyle Changes as Phentermine Alternatives

Embracing lifestyle changes is a holistic approach to weight loss, offering alternatives to phentermine. A balanced diet, rich in whole foods and portion control, plays a pivotal role. Regular exercise, combining cardiovascular workouts with strength training, enhances metabolism and supports sustainable weight loss.

Acupuncture, a traditional Chinese medicine practice, is believed to aid weight management by addressing imbalances in the body. Stress management techniques, such as mindfulness and meditation, contribute to a healthier lifestyle, as stress can influence weight gain. Integrating these lifestyle changes fosters a comprehensive and personalized strategy for effective, long-term weight loss.

How Effective Are Lifestyle Changes as an Alternative to Phentermine?

Lifestyle changes serve as an effective alternative to phentermine for weight loss. A balanced diet, regular exercise, acupuncture, and stress management may all be beneficial for individuals looking for better weight management. Using several strategies together can promote sustainable weight management. Unlike medications, lifestyle changes can address the root causes of weight gain, fostering long-term success and overall well-being.

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Questions to Ask Your Healthcare Team About Phentermine Alternatives

Consider exploring alternatives to phentermine if you experience adverse effects, have contraindications, or seek a more natural approach to weight loss. When discussing alternatives with your healthcare team, inquire about potential prescription alternatives, their mechanisms of action, and side effects. Collaborate with your healthcare team to create a personalized plan that aligns with your health goals, preferences, and potential challenges.

Questions to ask your care team about phentermine alternatives include:

  1. Is it safe to take weight loss medication alongside my current medications?
  2. Are there potential interactions or side effects when combining weight loss medications with antidepressants?
  3. Which weight loss medications have fewer side effects and may be more suitable for me?
  4. Can my weight loss symptoms improve without the need for medication?
  5. What lifestyle changes or non-pharmacological options do you recommend for weight management?
  6. How long should I expect to take weight loss medications, and are there long-term effects to consider?
  7. Are there specific dietary or exercise guidelines to enhance the effectiveness of weight loss interventions?
  8. Should I consult with a nutritionist or dietitian for personalized dietary advice?
  9. How frequently should I schedule follow-up appointments to monitor my progress and discuss any concerns?
  10. Are there support groups or counseling services available to address the psychological aspects of weight loss?
  11. Can you provide information on potential risks and benefits associated with specific weight loss medications?
  12. Are there alternative therapies, such as acupuncture or herbal supplements, that could complement weight loss efforts?
  13. Could Adderall be compared to phentermine as an alternative treatment for weight loss?

In My Experience

“In my experience, patients using phentermine for weight loss have experienced a variety of outcomes. Some have had successful but temporary results, and others have had challenges sustaining their progress. Real-life stories highlight the need for personalized approaches. Share these important experiences, including any side effects, with your doctor.”

Headshot Max Ruvinov PharmD MBA Max Ruvinov, PharmD, MBA
Sources

ChoosingTherapy.com strives to provide our readers with mental health content that is accurate and actionable. We have high standards for what can be cited within our articles. Acceptable sources include government agencies, universities and colleges, scholarly journals, industry and professional associations, and other high-integrity sources of mental health journalism. Learn more by reviewing our full editorial policy.

  • National Institutes of Health. (2023). DailyMed – phentermine hydrochloride capsule. U.S. National Library of Medicine. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm

  • National Institutes of Health. (2023). DailyMed – Wegovy- semaglutide injection, solution. U.S. National Library of Medicine. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm

  • National Institutes of Health. (2023). DailyMed – mounjaro- tirzepatide injection, solution. U.S. National Library of Medicine. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm

  • National Institutes of Health. (2023). DailyMed – Alli- Orlistat capsule. U.S. National Library of Medicine. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm

  • Tchang, B. G., Aras, M., Kumar, R. B., & Aronne, L. J. (2021). Pharmacologic treatment of overweight and obesity in adults. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK279038/

  • Sun, N.-N., Wu, T.-Y., & Chau, C.-F. (2016). Natural dietary and herbal products in anti-obesity treatment. Molecules (Basel, Switzerland). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273667/

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