*An off-label use of a medication is a use that is not FDA-approved. Prescribers can decide to use a medication off-label because, in their professional judgment, they believe it may offer a benefit to someone.
Rybelsus is sometimes prescribed off-label for the treatment of obesity. Like other medications in its class, it may cause side effects such as nausea, diarrhea, and vomiting. It contains semaglutide, the same active ingredient as Ozempic and Wegovy. Rybelsus is in the application process for weight loss, showing clinically meaningful weight loss results in research studies.
Boxed Warning: Semaglutide – Risk of Thyroid C-Cell Tumors
Semaglutide, the active ingredient in Ozempic, has a black box warning. These are the most serious types of warnings from the Food and Drug Administration (FDA). Semaglutide has a risk of thyroid c-cell tumors. Your healthcare provider will evaluate your health history and risk for thyroid tumors to decide if semaglutide is safe for you.
Medication to Help with Weight Loss
Get weight loss medication prescribed online by licensed doctors on Klarity. For only $99, connect instantly with weight loss experts to receive a personalized plan, including options like Semaglutide, Ozempic, Wegovy, Phentermine, and more. Free consultation is available!
What Is Rybelsus?
Rybelsus (semaglutide) is a prescription medication FDA-approved to be used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes. FDA approval means that medication has been reviewed and determined that it is both effective and safe for that indication. The use of Rybelsus for weight loss is an off-label use. This means that this indication has not been reviewed by the FDA but is prescribed by a doctor, using their professional judgment, with the belief that there is potential benefit.
Rybelsus belongs to a class of medications called GLP-1 receptor agonists, which works by stimulating insulin secretion and lowering blood sugar, and helps to make you feel fuller after food. This medication is currently not available as a generic.1, 2
How Does Rybelsus Work for Weight Loss?
Rybelsus helps to promote weight loss by mimicking a natural hormone called glucagon-like peptide 1 (GLP-1) that keeps blood sugar levels in check and slows down digestion.2 The slower digestion can lead to decreased appetite and, in combination with other weight loss efforts like nutrition and exercise, can result in weight loss.
FAQs About Rybelsus for Weight Loss
Rybelsus can help promote weight loss, and you may have questions about it. Here are some FAQs about Rybelsus and how it may help.
How Long Does it Take for Rybelsus to Start Working?
It takes about 4 weeks for a patient to start seeing benefits from taking Rybelsus. Initially, Rybelsus is started at 3 mg to let a patient’s body get used to the medication and reduce the likelihood of side effects involving the GI tract.
Is Rybelsus or Ozempic Better for Weight Loss?
The effectiveness of Rybelsus and Ozempic can vary and depends on individual factors. At the end of a 68-week study about Rybelsus, a medication similar to Ozempic, patients had an average weight loss of about 15% or 35 lbs. In this study, participants were given either a placebo or a 50 mg dose of Rybelsus, an orally administered form of semaglutide. 50 mg is higher than the usual maximum of 14 mg dose used for controlling blood sugar.3, 4 Other factors may impact which is better for a patient, such as if they want an oral or injectable medication or if they would prefer taking their medication daily or once weekly, respectively.
How Much Weight Can You Lose With Rybelsus?
Potential weight loss from Rybelsus can vary for each individual. According to a 6-month study on adults with type 2 diabetes, patients lost around 8 lbs compared to the 3 lbs of the placebo group. In the previously mentioned 68-week study, 89.2% of patients who received the 50 mg dose of Rybelsus saw a meaningful amount of weight loss at 68 weeks. Those who received the Rybelsus achieved a bodyweight loss of 17.4%.4, 5
Who Might Benefit from Rybelsus for Weight Loss?
Rybelsus may be beneficial to those who are already managing their weight with diet and exercise, but may need extra help with maintaining their weight. Specifically, it is ideal for people with type 2 diabetes looking to lose weight since Rybelsus is approved for blood sugar control in this population. Others who may benefit from this medication include those who would like to use a GLP medication but are unable to utilize the injection features of others within this class.
Weight Loss With Circle Medical
Medically Managed Weight Loss. Our expert team of online weight loss doctors and providers has only one goal: helping you find a way to live your healthiest life in a way that actually works for you. Most Insurance Accepted. Same day online appointments available.
Side Effects of Rybelsus for Weight Loss
As with all medications, Rybelsus may cause side effects due to how it works in the body. Side effects may range from mild to severe, sometimes requiring medical intervention. A patient may also experience temporary effects. These effects typically are seen when a person first starts the medication and may go away as the body gets used to it. The side effects associated with Rybelsus are gastrointestinal (GI) side effects, and severe effects can relate to diabetic complications as well as pancreatitis and kidney injury.
Common Side Effects of Rybelsus
Medications in the same medication class share similar side effects. GLP agonists are known for their GI side effects, especially when the dosage is increased too rapidly. This may lead some patients to experience symptoms such as constipation, diarrhea, nausea, and other similar effects. Typically, these side effects do not require medical intervention, but if symptoms worsen or persist, contact your doctor for further advice.
Common side effects of Rybelsus include:1, 2
- Nausea
- Abdominal pain
- Diarrhea
- Decreased appetite
- Vomiting
- Constipation
*All medications, including Rybelsus, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.
Serious Side Effects of Rybelsus
While not common, serious side effects may occur while taking Rybelsus. Warnings and precautions about Rybelsus are based on reports of inflammation of the pancreas, kidney injuries, gallbladder problems, diabetic complications, and allergic reactions. These reactions can be serious, and it is important to seek immediate medical care should they occur.
Serious side effects of Rybelsus include:1, 2
- Severe abdominal pain, sometimes radiating to the back, with or without vomiting
- Vision changes
- Yellowing of skin or eyes
- Allergic reactions
- Low blood sugar
*All medications, including Rybelsus, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.
Rybelsus Warnings & Precautions
The warnings associated with Rybelsus are related to its medication class of GLP-agonists. This class carries a warning of the risk of thyroid cancer, pancreatitis, and complications with diabetes. If you are concerned about any of these warnings, consult your doctor or pharmacist.
Warnings and precautions for taking Rybelsus include:1, 2
- Risks of thyroid cancer: In animal studies, there was an increased incidence of thyroid cancer developing in mice and rats. It is unknown whether Rybelsus causes thyroid cancer, but patients with medullary thyroid carcinoma or a family history of it should not start Rybelsus.
- Allergic reactions: Some may be sensitive to Rybelsus or its components, potentially resulting in an allergic reaction. Symptoms of a serious allergic reaction, include: swelling of the face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; very rapid heartbeat.
- Pancreatitis: Inflammation of the pancreas has been reported as a serious adverse event in those treated with Rybelsus. Signs and symptoms of pancreatitis include persistent severe abdominal pain that sometimes radiates to the back, sometimes accompanied by vomiting.
- Diabetic retinopathy: Patients with a history of diabetic retinopathy should be monitored since rapid blood sugar control has been associated with temporary worsening of this condition.
- Hypoglycemia with combined usage of diabetic medications: Rybelsus, in combination with other medications meant to control blood sugar, such as insulin or sulfonylurea, can increase the risk of low blood sugar. Patients should be informed of the risk and be able to identify the signs and symptoms of hypoglycemia.
- Kidney injury: In postmarketing reports, there were sudden kidney injuries as well as worsening of chronic kidney failure.
- Gallbladder disease: Sudden events of gallbladder problems such as gallstones or inflammation of the gallbladder have been reported during trials and after.
Interactions With Rybelsus
Rybelsus can interact with several substances. These interactions may affect how Rybelsus works in the body, creating unintended and potentially unsafe effects. Depending on the interaction, effects can range from mild to severe in its effects, sometimes requiring medical attention. It is important to inform your doctor and pharmacist if you intend to start new medications or substances to avoid potentially harmful interactions.
3 substances you should avoid while taking Rybelsus include:1, 2
- Combined use with other diabetic medications: Rybelsus combined with other medications meant to control blood sugar, such as insulin or sulfonylurea, can increase the risk of low blood sugar. This includes severe hypoglycemia.
- Beta-blockers: While Rybelsus may cause symptoms of low blood sugars, beta-blockers may mask these symptoms, making them harder to identify.
- Oral medications: Rybelsus can delay when your stomach empties, affecting the absorption of medications that are taken by mouth. For drugs with narrow windows of therapeutic effect, such as digoxin or lithium, doctors may consider closely monitoring its effects.
Medication to Help with Weight Loss
Get weight loss medication prescribed online by licensed doctors on Klarity. For only $99, connect instantly with weight loss experts to receive a personalized plan, including options like Semaglutide, Ozempic, Wegovy, Phentermine, and more. Free consultation is available!
Rybelsus Dosages for Weight Loss
When Rybelsus is prescribed, it is usually started at its lowest dose and slowly increased to avoid GI side effects. Rybelsus is supplied as a 3 mg, 7 mg, and 14 mg oral tablet. Weight loss is an off-label indication for Rybelsus, so there is no official dosage range for this purpose.
In a 6-month study, weight loss was seen in patients at 7 mg and 14 mg, but the company that makes Rybelsus is seeking approval for using 50 mg for the purpose of weight loss.4 It should be noted that dosages may vary from person to person depending on personal factors such as your health conditions, other medications you may be taking, and your age.
How Do I Take Rybelsus?
Rybelsus should be taken exactly as prescribed by your doctor. It is important to follow these instructions to ensure your therapy is effective and safe. This medication should be taken on an empty stomach when you first wake up with a sip of plain water, but no more than 4 ounces. Rybelsus should be swallowed whole and should not be split, crushed, or chewed. After 30 minutes, you can eat, drink, or take other oral medications.1, 2 If you have questions on how to take Rybelsus to fit into your lifestyle, contact your doctor or pharmacist.
What Happens If I Miss a Dose of Rybelsus?
If you miss a dose of Rybelsus, skip the missed dose and go back to your regular schedule. It is important that you do not take an extra dose to make up for any missed doses. Taking extra doses outside of a doctor’s advice can result in an increased risk of side effects.
What Should I Know About Stopping Rybelsus?
If you are thinking of stopping Rybelsus, contact your doctor before doing so. When stopped, Rybelsus will no longer be managing your blood sugar. This may lead to complications, especially if you have diabetes. Your doctor will be able to help you assess what is the safest and best option for you if you wish to stop Rybelsus.
Can I Take Rybelsus With Food?
Rybelsus should be taken on an empty stomach. This is important because if you eat or take anything else with Rybelsus, it can affect how it is absorbed in the body. Less absorption in the body can result in the medication not working as intended, resulting in a less effective dose.
How to Get Rybelsus for Weight Loss
Only an authorized prescriber can write a prescription for Rybelsus. This medication does not have official approval for weight loss, so the doctor will ask you questions to see if it is a good fit for you, weighing the risks and benefits of using Rybelsus off-label. They may ask you about your diet and exercise plans as well as if you have any other conditions that may affect your weight or therapy. Your doctor may also go over other weight loss options, both behavioral and medication, and how Rybelsus may fit into your lifestyle.
Weight Loss With Circle Medical
Medically Managed Weight Loss. Our expert team of online weight loss doctors and providers has only one goal: helping you find a way to live your healthiest life in a way that actually works for you. Most Insurance Accepted. Same day online appointments available.
Rybelsus Vs. Other Weight Loss Methods
Three oral options for weight loss medications would be Qsymia (phentermine/topiramate), Xenical (orlistat), and Contrave (bupropion/naltrexone). Xenical is a medication that helps to promote weight loss by preventing the absorption of dietary fats which may lead to potential side effects like loose stools, oil spotting in underwear or clothing, and oily flatulence. The average weight loss is about 5%, and there is also a weaker strength available over the counter named Alli.6
Qsymia and Contrave are both medications that help to control one’s appetite, with Qsymia containing a stimulant and Contrave being a non-stimulant medication, containing an antidepressant and medication meant to treat substance abuse. Contrave had an average weight loss of 3.7-8.1% compared to placebo, with the most dramatic weight loss occurring after 4 months.7 At 56 weeks, patients on the recommended dose of Qsymia saw an average weight loss of 24 lbs.8 This medication carried side effects like altered sense of taste, insomnia, and tingling or prickling of the extremities.
Wegovy (semaglutide) and Saxenda (liraglutide) are injectables approved for weight loss that belong to the same medication class as Rybelsus. They all share similar side effects, commonly causing GI side effects like Rybelsus. Wegovy, the version of Ozempic approved for weight loss, is injected weekly, and on average, adults lose about 15% (about 35 lbs) of their weight compared to placebo.3
Saxenda studies showed that about 85% of people lost some weight with Saxenda, where 3 out of 5 people experienced an average weight loss of about 5% or more (about 12 lbs).9 The bottom line is that weight-loss medications are not magic pills that will solve a person’s weight issue. They often require lifestyle changes to help facilitate meaningful change.
Rybelsus in Combination With Lifestyle Changes
Rybelsus may prompt weight loss for some patients, but diet management and exercise are also necessary. Another drawback is that it does take 4 weeks each time you want to increase the dosage because of side effects that may occur. This may be frustrating to those who want more rapid results.
Rybelsus does have the benefit of being an oral medication. This differs from other medications sharing its active ingredients, Ozempic and Wegovy, as they are injectable medications. Its status as an oral medication may be a drawback for some, though, because of its specific instructions of taking it separate from food and other medications.
Questions to Ask Your Healthcare Provider About Rybelsus of Weight Loss
When starting a new medication, it is best to go to your appointment with a list of questions to ask your doctor. Together, you can find the answers and find what option works best for you to help you with your goals. Rybelsus is but one of many possible options for weight loss you may discuss with your doctor.
Questions to ask your care team about Rybelsus for weight loss include:
- How safe is Rybelsus for weight loss?
- How long will it take for me to adjust to taking Rybelsus for weight loss?
- Am I at risk for more serious symptoms if I am already taking other medications?
- Will Rybelsus allow me to lose weight and keep it off long-term?
- Are there other weight loss options available to me?
- Do I take Rybelsus long-term?
- Can I take any over-the-counter medications to help with side effects if I get them?
- What should my diet and exercise consist of to help with weight loss on Rybelsus?
- What other peptides for weight loss may be effective?
How to Know if Rybelsus for Weight Loss Is Right for You
When considering if Rybelsus is right for you, there are several factors to take into account. You will have to consider a diet and exercise plan to supplement the weight loss you may experience on Rybelsus. You should also consider if you have any conditions or medications that would make Rybelsus a less attractive option for weight loss. Overall, a discussion with your doctor can help you find your answers.
In My Experience
Additional Resources
To help our readers take the next step in their mental health journey, Choosing Therapy has partnered with leaders in mental health and wellness. Choosing Therapy is compensated for marketing by the companies included below.
Medication to Help with Weight Loss
Get weight loss medication prescribed online by licensed doctors on Klarity. For only $99, connect instantly with weight loss experts to receive a personalized plan, including options like Semaglutide, Ozempic, Wegovy, Phentermine, and more. Free consultation is available!
Medically Managed Weight Loss With Circle Medical
Their expert team of online weight loss doctors and providers has only one goal: helping you find a way to live your healthiest life in a way that actually works for you. Most insurance accepted. Same day online appointments available.
Henry - Take Semaglutide Orally, No Injections!
New compounded oral Semaglutide. Convenient and affordable, without injections! Once a day under the tongue doses make it easy to start your weight management journey! Only $249 per month, everything included. No insurance needed. Get Started
Plushcare – Medical Weight Loss Programs Available Online
Get access to online weight loss consultations with a doctor, ongoing treatment monitoring, and prescription weight management medication as medically necessary. Covered by many insurance plans. Visit Plushcare
Semaglutide: Uses, Side Effects, Interactions, & More
Understanding the complexities of medications like semaglutide is crucial for anyone seeking effective treatment. It’s important to acknowledge that semaglutide is extensively used in managing type 2 diabetes and obesity, with potential benefits in weight loss and cardiovascular risk reduction.
Mounjaro Weight Loss: Safety, Side Effects, & More
Mounjaro is a relatively new medication that is within a class of medications known for their control of blood sugar and potential for managing weight. It’s unique in that it has two different ways of working in the body. It is generally recommended that patients make lifestyle choices alongside any medications used for weight management.