*An off-label use of a medication is a use that is not FDA-approved. Prescribers can decide to use a medication off-label because, in their professional judgment, they believe it may offer a benefit to someone.
Common Vyvanse side effects include loss of appetite, insomnia, and nausea. Serious side effects require medical attention such as a risk of suicidal thoughts and behaviors, symptoms of mania, and allergic reactions.
Many people consider stopping their medication due to side effects. If your Vyvanse side effects last longer than the first few weeks, talk to your provider. They can help you understand your treatment options, which may include a change in dosage, timing of dosage, or switching your medication.
If you are considering Vyvanse or want to discuss your current medication treatment with a provider, online psychiatry platforms, such as Circle Medical are a good place to start. The providers on these platforms can do assessments and consult you about your prescription. They can answer any questions you have about Vyvanse’s side effects and other risks.
Boxed Warning: Lisdexamfetamine dimesylate (Vyvanse) – Risk of medication misuse or abuse
Lisdexamfetamine dimesylate, the active ingredient in Vyvanse, has a black box warning. These are the most serious types of warnings from the Food and Drug Administration (FDA). Lisdexamfetamine dimesylate has a risk of misuse (abuse) which can lead to dependence on the medication.
Vyvanse is a controlled substance, which means that it’s more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
Key Takeaways
Common Vyvanse side effects include loss of appetite, insomnia, dry mouth, and a fast heart rate. Serious side effects requiring medical attention can also occur.
If Vyvanse side effects last longer than a few weeks, your provider can help you determine next steps, which may include a change in dosage, timing of dosage, or medication.
There are several ways to cope with Vyvanse side effects, including self care practices, medication adjustments, and therapy.
If you are considering Vyvanse or an alternative, a good place to start is with an evaluation from a medical provider. Many online psychiatry platforms offer online assessments and medication management, such as Talkiatry or Circle Medical.
Concerned About Medication Side Effects? Ask a Doctor
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Common Vyvanse Side Effects
Vyvanse can cause several common side effects affecting the heart, digestive system, and sleep. Some may require medical attention but many often improve on their own.
Common side effects of Vyvanse may include:*1
- Dry mouth
- Insomnia
- Decreased appetite
- Increased heart rate
- Constipation
- Feeling jittery
- Anxiety
*All medications, including Vyvanse, can cause side effects that can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and understand the potential side effects and benefits of any medication.
Serious Vyvanse Side Effects
Some side effects of Vyvanse may become severe or persistent. If you experience any of the serious side effects listed below, seek immediate medical care.
Serious side effects of Vyvanse that require immediate medical care include:*1
- Allergic reactions include rash, itching, swelling, severe dizziness, or difficulty breathing
- Signs of heart problems such as chest pain
- Increased blood pressure
- Rapid heartbeat or significantly increased heart rate
- Worsened tics or Tourette syndrome
- Serotonin syndrome
- Symptoms of mania or psychosis
- Signs of circulation problems, such as numbness, discoloration, or coldness in the extremities
*All medications, including Vyvanse, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.
Long-term Vyvanse Side Effects
In addition to common and severe side effects, there are risks associated with Vyvanse use when taken for long periods of time. It is important to have regular check-ins with your provider to reevaluate your health risks and any lingering side effects. Some may require immediate medical attention.
Long-term side effects of Vyvanse include:1
- Physical dependence: High doses or prolonged use of Vyvanse can also result in tolerance, requiring higher doses to achieve the same effect.
- Growth suppression in children: Taking Vyvanse can lead to weight loss or a general slowing of growth in children, requiring careful monitoring during treatment.
Each person taking Vyvanse will experience different side effects, if at all. It is important to understand your risk and know what to do if a particular side effect occurs. Work with your doctor to have a plan and seek medical help immediately if you experience severe side effects.
What Are the Risks & Warnings for Vyvanse?
Misuse & Dependence
Vyvanse and other stimulants have a high risk of abuse and dependence, especially in those with a history of abuse. Symptoms of abuse may include increased heart rate and breathing rate, high blood pressure, hyperactivity, vomiting, dilated pupils, and tremors. In extreme cases, this can lead to overdose and death. If you think you or your loved one is showing signs of addiction to stimulant medication, such as Vyvanse, seek professional help as soon as possible.
Changes in Cognitive Functions
When first taking a stimulant medication like Vyvanse, use caution when performing tasks that require increased mental alertness. It may take time to understand the effects this medication can have on your cognitive functions, such as your reflexes. Until you know how Vyvanse affects you, do not drive, operate machinery, or participate in other dangerous activities.
Manic Episodes
Vyvanse and other stimulants can cause patients with bipolar disorder to experience a manic episode. Mania is serious and requires medical help immediately.
Growth Suppression in Children
Vyvanse and other stimulants can cause weight loss and slowing of growth weight in children between 6 and 12. Studies have shown that this risk is dose related. Your provider will carefully monitor your child’s growth patterns throughout treatment.
Worsened Pre-existing Heart Conditions
Stimulants, such as Vyvanse, can exacerbate existing heart conditions. Sudden death in those with heart abnormalities has been reported.
Worsened High Blood Pressure
As a stimulant medication, Vyvanse will cause both increased blood pressure and heart rate. This can be especially harmful to those who already have high blood pressure prior to starting stimulant medication.
Blood Circulation Problems
Vyvanse are associated with potential circulation problems in fingers and toes, like Raynaud’s phenomenon. Seek medical care if you or your child experiences numbness, pain, skin color change, or sensitivity to temperature in fingers or toes.
Worsened Tics or Tourette Syndrome
Some stimulant medications, such as Vyvanse, may worsen physical and verbal tics and Tourette syndrome. Tell your provider if you have a history of this condition.
Serotonin Syndrome
For people who are already taking a medication that can increase the amount of serotonin available in your body, taking Vyvanse can induce serotonin syndrome. Symptoms of serotonin syndrome can include mental status change, increased heart rate, seizures, muscle rigidity, etc. This can become life-threatening and requires immediate medical care.
Pregnancy
Vyvanse and other stimulants can have many negative side effects on you and the fetus. Vyvanse can cause a decrease in placental perfusion, can cause premature delivery, and increase the risk of low birth weight. Taking Vyvanse while pregnant should be a serious decision between you and your doctor.
Breastfeeding
Vyvanse can pass into the breast milk and to your baby if you are breastfeeding while taking Vyvanse. Consult your provider on safe ways to breastfeed along with your treatment plan.
Allergic Reactions
While rare, an allergic reaction to Vyvanse may occur. This kind of reaction may become life-threatening.
Severe allergic reactions to Vyvanse can include:
- Breathing problems
- Swelling
- Rash/hives
If you experience wheezing, difficulty breathing, or swelling in the throat, seek immediate medical help.
Drug Interactions
Taking certain medications, herbs, or supplements alongside Vyvanse can change how Vyvanse works in your body or increase the risk for serious side effects. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.
Substances you should avoid using while taking Vyvanse include:
- Other stimulant medications
- SSRIs, SNRIs, and other medications affecting serotonin levels
- Medications that affect the liver enzyme CYP2D6
- Monoamine oxidase inhibitors (MAOIs)
- Tricyclic antidepressants (TCAs)
- Medications affecting pH balance (Acids and alkalines)
This is not a comprehensive list of medications that interact with Vyvanse. Be sure to talk with your doctor or pharmacist about any prescription or over the counter medications you take, as well as supplements, herbs, and teas.
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Important Things to Know About Taking Vyvanse
Before you begin taking Vyvanse, it’s important to understand how it may affect you. While side effects can occur at any time while taking a medication, it’s common for them to appear during the first few weeks of treatment.
Your prescriber will discuss how to take Vyvanse, your dosage, precautions and warnings, and side effects that may occur. They will also discuss what to do if side effects don’t go away on their own and which ones may require medical care.
How Long Does It Take for Vyvanse to Work?
Vyvanse starts working within 2 hours of taking the dose and may last up to 12 hours.1 It may also take some a little more time for some to feel the effects of Vyvanse as everyone’s response to medication is unique.
Can Vyvanse Make You Feel Worse at First?
Yes, some people starting Vyvanse may start feeling side effects. These may include trouble sleeping, a faster or more noticeable heartbeat, and decreased appetite.1 Vyvanse also has a risk of rare but serious side effects, including circulation problems in fingers and toes causing numbness, discoloration, or feeling cold. Chest pain and allergic reactions are also possible. If you experience any of these or other serious side effects, get medical help right away.
What Happens If I Miss a Dose?
If you miss a dose of Vyvanse, do not catch up by taking any extra doses. Take the missed dose as soon as you remember it. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Never take a double dose.1
Do not abruptly stop Vyvanse or make a change to your dosage without discussing it first with your provider.
What Are the Side Effects of Vyvanse in Children Vs. Adults?
The most notable side effects of Vyvanse are experienced by adults and children alike. Specifically, children and adolescents (ages 6-17) using the medication for extended periods are at risk for slowed growth. This is due to loss of appetite, a common side effect of Vyvanse.
Since adults have typically finished growing, this serious effect is mostly observed in children. While Vyvanse can still cause weight loss in adults, the risk of malnutrition is greater in children.1
Who Experiences Side Effects More?
Some who take Vyvanse are more likely to experience side effects than others. While side effects may develop for anyone, those with certain risks should be cautious with Vyvanse, possibly avoiding it.
Discuss any health conditions for yourself or your child with your provider when considering treatment with Vyvanse. This information will help them select the most suitable medication for you.
Those with a history of certain health concerns have a higher risk of side effects, such as:
- Substance misuse or dependence
- Heart problems, including high blood pressure and abnormal heart rhythms
- Tics or Tourette syndrome
- Psychosis, bipolar disorder, mania, or depression
- Suicidal thoughts or behaviors
- Pregnancy or breastfeeding
- Prior allergic reactions to Vyvanse or its components
Vyvanse can have harmful interactions with medications. This may include serious reactions requiring medical care or reduced effectiveness of Vyvanse, the other medication, or both.
Those taking certain medications or treatments also have a higher risk of side effects, such as:
- Monoamine oxidase inhibitors (MAOIs), such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate)
- Medications that affect the liver enzyme CYP2D6
- Antidepressant medications, such as selective serotonin reuptake inhibitors (SSRIs)
- Tricyclic antidepressants
- Other stimulant medications
- Herbs, herbal remedies, and over-the-counter treatments
This is not a complete list of possible interactions with Vyvanse. Consult with your healthcare provider before combining Vyvanse with any over-the-counter medications, prescription medications, or herbal supplements to ensure safety and effectiveness.
How to Cope With Common Vyvanse Side Effects
Some side effects of Vyvanse, such as anxiety, insomnia, and weight loss, can be managed through lifestyle changes or timing of your dose. Talk to your medical provider if you have difficulty managing these symptoms on your own or if they become severe.
Anxiety
For some, Vyvanse may cause feelings of nervousness and worry. If you already have anxiety, Vyvanse may intensify your symptoms, such as sweating, shaking, chest pain, and shortness of breath.2
You can manage anxiety caused by Vyvanse with lifestyle changes. Meditation can help you relax and decrease the amount of stress you feel. Regular exercise can improve your stress levels and prevent health problems. Decreasing the amount of caffeine you consume can reduce your risk for anxiety since it is also a stimulant. Talk to your doctor if you are not able to manage these symptoms, as therapy and changes in medications can also help.2
Insomnia
Taking your Vyvanse dose later in the day can interfere with sleep, causing insomnia, daytime drowsiness, and problems with memory and learning. 3 To reduce the risk of insomnia, take your dose earlier in the day.
Lifestyle changes can also help, such as limiting your screen time a couple of hours before bed, blocking out light, avoiding lying in bed when it’s not bedtime, and avoiding caffeine and nicotine.3
Dry Mouth
Dry mouth is another potential side effect of Vyvanse. To manage dry mouthfeel, sip water frequently and use sugar-free lozenges or gum. This promotes saliva production and can reduce discomfort. Avoiding caffeine and alcohol can also help alleviate dry mouth symptoms.4
Reduced Appetite
Vyvanse can cause decreased appetite, possibly resulting in unplanned weight loss. If this occurs, try eating more when you do have an appetite. Your appetite may be stronger in the morning before the medication begins to work or in the evening as it wears off. You can also manage weight loss with frequent snacking.5
Nausea
For some, Vyvanse can cause feelings of nausea. To lessen this, follow the meal timing instructions for your medication. Also, drink plenty of water and eat smaller, more frequent meals. Talk with your provider first if you want to try soothing teas with peppermint or other herbal remedies. Over-the-counter treatments and supplements, including tea, may interact with Vyvanse.edical care.
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More Ways to Manage Vyvanse Side Effects
Here are more ways to cope with and reduce the impact of Vyvanse side effects.
Practice Good Sleep Habits
Vyvanse can disrupt sleep if you take it too late in the day. Reduce the risk of sleep problems by taking it earlier in the day and following your provider’s instructions.
Your sleep habits can make a difference when adjusting to your new medication. Try waking up and going to bed at the same time every day. Make sure your sleep environment is dark and comfortable as well. If you struggle with sleep, be cautious when doing activities that require you to be alert, such as driving. Or avoid them until you understand how Vyvanse affects your sleep patterns.
Healthy Lifestyle Activities
Healthy lifestyle habits can also provide much-needed support for your body as it begins adjusting to a new medication. Focus on eating well, getting enough sleep, and staying physically active to maintain well-being.
Follow Your Daily Routine
Staying with your normal daily routine while starting your new Vyvanse prescription can be helpful in several ways. It may not feel like your medication is working right away, or a few side effects may emerge in the first few days of taking it. Keeping a predictable schedule will reduce stress on your body and mind during this transition. Also, be sure you’re following your provider’s instructions for taking your medication and take it at the same time each day.
Consider Therapy
With psychotherapy, you can develop strategies to manage the impact of side effects. For in-person therapy, your primary care provider or insurance company can provide referrals in your local area. Or, family members and friends may recommend someone to you.
To find an online therapist, an online therapist directory is a great starting point. Many online psychiatry platforms, such as Talkiatry and Brightside Health, also offer therapy services.
Should I Stop Taking Vyvanse If I Start Feeling Side Effects?
Do not stop taking Vyvanse if you start feeling side effects. Stopping abruptly can lead to withdrawal symptoms or a sudden return of your mental health symptoms. If you need to stop taking Vyvanse or change your dosage, your provider will tell you how to safely reduce your dose.1
When Should I Call My Doctor About Vyvanse Side Effects?
Side effects often lead people to stop taking a medication. While some side effects can be managed and may fade on their own, some will persist for as long as a person takes the medication. Even when taken correctly, medications may still cause side effects for some.
Talk with your provider if side effects persist or you can’t tolerate them anymore. They will discuss your treatment options and your next steps. While serious side effects from Vyvanse are rare, they can occur for some people. Some of these side effects may become life-threatening and require immediate medical care.
When Should I Seek an Alternative to Vyvanse Due to Side Effects?
After the first few weeks, many of Vyvanse’s initial side effects go away on their own. If your side effects continue and you’re considering a change in your medication, talk with your provider. There are many Vyvanse alternatives available and they can help you determine which one may be a good fit. Stimulant and non-stimulant medications can help reduce ADHD symptoms, though it’s important to understand the potential risks and benefits of each option.
Stimulants, such as Adderall, Ritalin, and Concerta, are often the primary medications used to treat ADHD. While they can be effective, there are risks to consider with each of these medications.
If stimulant medications aren’t a good fit, many non-stimulant alternatives are available. Strattera and Qelbree are two FDA-approved non-stimulants for treating ADHD. These medications are thought to work by increasing levels of the norepinephrine in the brain, which may improve attention and focus for some.
Some antidepressants have shown to be effective ADHD treatments. Wellbutrin, Effexor XR, imipramine, and desipramine are the most widely studied antidepressants for treating ADHD symptoms.They may be helpful for those who need to avoid or can’t tolerate stimulant medications.
How to Get a Prescription for Vyvanse or Alternative Medications
The first step of getting a prescription for Vyvanse or an alternative in person is getting an evaluation of your symptoms. Your primary care provider, whether a physician, nurse practitioner, or PA, can get the process started. They’ll also determine if a referral to a specialist may be helpful. Based on their assessment, they’ll decide if Vyvanse or another medication should be part of your treatment plan.
To get an online prescription for a Vyvanse or an alternative, you’ll also begin with an evaluation from a platform that prescribes stimulants. After a careful review, we have determined that Circle Medical is a good place for such an evaluation. This online platform can prescribe controlled substances such as Vyvanse, offering both assessments and prescription management.
Non-stimulant medications are also effective for treating ADHD symptoms and may be considered as alternatives to Vyvanse. These include medications like Strattera, Qelbree, and also some antidepressants. We have carefully reviewed online psychiatry platforms such as Talkiatry and Circle Medical, which can prescribe non-stimulant medications for ADHD.
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Questions to Ask Your Provider
Your doctor, psychiatrist, or therapist can discuss possible side effects of Vyvanse with you, especially those that may occur at the beginning of your treatment. Ask them whether these side effects will go away on their own and what to do if they persist or become difficult to manage.
Also, many online psychiatry services make accessing mental health care for ADHD convenient. You get a mental health evaluation, diagnosis, and personalized treatment plan. Some platforms also allow you to change providers, if needed.
Questions to ask your care team about Vyvanse side effects may include:
- What does it mean that Vyvanse is a controlled substance?
- Can I use Vyvanse along with therapy to treat ADHD symptoms?
- How is Vyvanse different from other stimulants?
- How long will it take for me to adjust to taking Vyvanse?
- Am I at risk for more severe side effects if I am already taking medication for anxiety, depression, or other mental health conditions?
- Will a previous history of addiction make me more susceptible to dependency?
- What is the best dosage to ensure fewer side effects?
- Will my dose change over time?
- Are there drugs I am taking that could have negative interactions?
- When should I reach out to you if I am experiencing side effects?
- Is there anything I should tell my therapist about this new medication?
- Are there any potentially serious or rare side effects of Vyvanse that I should be aware of?
- Are there any long-term or permanent side effects associated with Vyvanse that I should be aware of?
- Are there any specific side effects that are more common in certain age groups or populations?
- Can Vyvanse interact with any other medications or substances I am currently taking, potentially increasing the risk of side effects?
Frequently Asked Questions
What Is Vyvanse & What Is It Used to Treat?
How Does Vyvanse Work?
The exact mechanism of how Vyvanse helps to treat attention-deficit hyperactivity disorder (ADHD) symptoms and binge eating disorder (BED) is not fully understood. Vyvanse is a prodrug, meaning it is not active until it is broken down in the body, also known as metabolism.
Vyvanse’s active ingredient, lisdexamfetamine, is broken down into another substance, dextroamphetamine. This substance is the active ingredient, providing the medication’s action in the body. Vyvanse works by increasing the levels of norepinephrine, dopamine, and serotonin, which are chemicals in the brain. These chemical changes help stimulate the central nervous system.1
How Does Vyvanse Make You Feel During the First Week?
Some people starting Vyvanse may experience side effects such a faster or more noticeable heartbeat, insomnia, and nausea.1 Vyvanse may also cause circulation problems in fingers and toes causing numbness, discoloration, or feeling cold. This is a rare but serious side effect that requires medical attention right away. If you experience side effects that persist or get worse, contact your provider as soon as possible.
How Long Do Vyvanse Side Effects Last?
The timing of Vyvanse side effects can differ for each person. Mild side effects tend to improve after the first few weeks and often go away on their own. But when they persist or get worse, medical care is likely needed. Individual response, dosage, and overall health can all affect how long Vyvanse side effects may last.
What Are the Long-term Side Effects of Vyvanse?
Prolonged use of Vyvanse may affect growth in children, making regular monitoring of height and weight important during treatment. Long-term use can also lead to tolerance, which means that higher doses may be needed to achieve the same effectiveness.
How Do the Side Effects of Vyvanse & Adderall Compare?
Because Vyvanse and Adderall are both stimulant medications, they affect the body in similar ways. They share many common side effects as well, including reduced appetite, weight loss, headaches, and sleep problems. Increased blood pressure is more common in Adderall XR than Vyvanse and is worse with a higher dosage. Many of these side effects can be managed with the timing or adjustment of the dose.1, 3, 6, 7
Can Vyvanse Affect My Sleep?
Yes, insomnia is a common side effect of Vyvanse. To reduce the chance of sleep problems, take Vyvanse earlier in the day.
Should I Stop Taking Vyvanse If I Experience Side Effects?
No, do not stop taking Vyvanse unless your provider tells you to do so. Stopping Vyvanse abruptly may cause withdrawal symptoms, which can include excessive fatigue or even symptoms of depression.
ChoosingTherapy.com strives to provide our readers with mental health content that is accurate and actionable. We have high standards for what can be cited within our articles. Acceptable sources include government agencies, universities and colleges, scholarly journals, industry and professional associations, and other high-integrity sources of mental health journalism. Learn more by reviewing our full editorial policy.
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Vyvanse-lisdexamfetamine dimesylate capsule; Vyvanse- lisdexamfetamine dimesylate tablet, chewable. October 13, 2023). DailyMed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
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Chand SP, Marwaha R. Anxiety. [Updated 2023 Apr 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK470361/
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NIN.gov. (2022) Living With Insomnia. Retrieved from https://www.nhlbi.nih.gov/health/insomnia/living-with
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Talha, B., & Swarnkar, S. A. (2020). Xerostomia. PubMed; StatPearls Publishing. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK545287/
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Tefft, A. (2022). ADHD medications and your child’s appetite. Ohioline.osu.com. Retrieved from https://ohioline.osu.edu/factsheet/fcs-1002
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Adderall- dextroamphetamine saccharate, amphetamine aspartate, dextroamphetamine sulfate, and amphetamine sulfate tablet. (May 29, 2024). DailyMed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
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Adderall XR- dextroamphetamine sulfate, dextroamphetamine saccharate, amphetamine sulfate and amphetamine aspartate capsule, extended release. (March 13, 2025). DailyMed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
We regularly update the articles on ChoosingTherapy.com to ensure we continue to reflect scientific consensus on the topics we cover, to incorporate new research into our articles, and to better answer our audience’s questions. When our content undergoes a significant revision, we summarize the changes that were made and the date on which they occurred. We also record the authors and medical reviewers who contributed to previous versions of the article. Read more about our editorial policies here.
Author: No Change
Reviewer: No Change
Primary updates: Added “Key Takeaways” feature. Edited for clarity. Condensed “What is Vyvanse?” and moved to FAQs. Revised sections covering common, serious, and long-term side effects. Revised and moved content from “Allergic Reactions”, “Interactions With Vyvanse”, and “Other Warnings & Precautions for Taking Vyvanse” sections with new “What Are the Warnings & Risks of Vyvanse?” feature. Revised and expanded “Who Experiences Side Effects More?” Revised and moved FAQ section to the end. Added new sections “Important Things to Know About Taking Vyvanse”, “How to Manage Side Effects” to “How to Cope With Common Vyvanse Side Effects”, added new sections, “More Ways to Manage Vyvanse Side Effects”,“When Should I Call My Doctor About Vyvanse Side Effects?”, “When Should I Seek an Alternative to Vyvanse Due to Side Effects?”, “How to Get a Prescription for Vyvanse or Alternative Medications” and all included subsections. Revised and retitled “Vyvanse Withdrawal” to “Should I Stop Taking Vyvanse If I Start Feeling Side Effects?”. Retitled “Questions to Ask Your Health Team” to “Questions to Ask Your Provider”. Replaced “Final Thoughts” with “Prescriber’s Tips” feature. Removed “For Further Reading”
Author: Zachary Reale, PharmD
Medical Reviewer: Heidi Moawad, MD
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