*An off-label use of a medication is a use that is not FDA-approved. Prescribers can decide to use a medication off-label because, in their professional judgment, they believe it may offer a benefit to someone.
Buspirone is not typically associated with a risk for sexual side effects and may be prescribed to help reduce sexual side effects from selective serotonin reuptake inhibitors (SSRIs). However, it is possible to experience changes in libido and other sexual side effects from buspirone.
If these effects occur, your healthcare provider may recommend a change in dosage, timing for taking the medication, or to another medication. Additional coping strategies, such as talking to your partner and therapy, can help you cope with these side effects.
If you are considering buspirone or want to discuss your current medication treatment with a provider, online psychiatry platforms, such as Talkiatry and Brightside Health are a good place to start. Their providers offer assessments and prescription consultation, and can answer any questions you have about buspirone sexual side effects.
Key Takeaways
Buspirone is not typically associated with a risk for sexual side effects and may be prescribed to help reduce sexual side effects from SSRIs. However, it is possible to experience changes in libido and other sexual side effects from buspirone.
Your provider may offer several recommendations for managing sexual side effects from buspirone. These may include a dosage adjustment or switching to a different medication. Do not make changes with your medication or stop taking it without specific guidance from your provider.
There are several ways to cope with buspirone side effects, including self care practices, medication adjustments, and therapy.
If you are considering an alternative to buspirone, a good place to start is with an evaluation from a medical provider. Many online psychiatry platforms offer online assessments and medication management, such as Talkiatry, or Circle Medical.
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Does Buspirone Have Sexual Side Effects?
Unlike some medications for anxiety treatment such as SSRI antidepressants, buspirone has a lower risk of causing sexual side effects. While SSRIs are known to potentially decrease libido and cause other sexual issues, buspirone has a more favorable effect on sexual functioning.
However, the positive impact of buspirone on sexual function may not be immediate and may vary from person to person. The effects can persist as long as the person continues to take buspirone but may fluctuate or fade over time as well.
All medications, including buspirone, can cause side effects that can be mild or serious. This is not a comprehensive discussion of all possible side effects. You should talk with your doctor about any questions you have and understand the potential side effects and benefits of any medication.
Sexual Side Effects of Buspirone in Females
The sexual side effects of buspirone in women are not clear, though the medication may cause changes in libido.* In some cases, it has been found to help improve sexual dysfunction caused by certain antidepressants like SSRIs.
The positive effect was more evident in women and occurred early during treatment. It may reverse the sexual difficulties caused by SSRIs in women without making their anxiety worse.1
Sexual Side Effects of Buspirone in Males
Male patients taking buspirone have reported some sexual side effects. But these effects are infrequent or rare, occurring in 1% or fewer female or male patients during clinical trials.
Buspirone sexual side effects in men include:*2
- Decreased sex drive
- Inability to get or keep an erection
- Delayed ejaculation
*The use of terms females, males, women, or men are used to describe the sex assigned at birth. Talk with your healthcare provider if you are a different gender than your sex assigned at birth to understand what you can expect from using any medicine.
What Causes Buspirone’s Potentially Positive Effect on Sexual Functioning?
Buspirone’s positive effect on sexual functioning may be attributed to its specific pharmacological properties. Buspirone works by affecting serotonin and dopamine levels in the brain, which may also contribute to its positive effect on sexual functioning.2
While research provides insights into the positive impact of buspirone on sexual functioning, it is important to consider individual variations. Talk to your healthcare professional for personalized advice and management of sexual side effects.
Can You Take Buspirone to Treat Sexual Dysfunction from Antidepressants?
Yes, buspirone can help treat sexual dysfunction caused by taking SSRI antidepressants. One study showed that adding buspirone to antidepressant treatment can significantly reduce sexual dysfunction caused by antidepressant medications in both men and women.1
How Soon Will I Start Feeling Buspirone Sexual Side Effects?
Sexual side effects may develop soon after starting buspirone. These effects may fade after the first several weeks, but some may experience sexual dysfunction for as long as they take buspirone.
How Long Do Sexual Side Effects Last With Buspirone?
Some people may experience sexual side effects from buspirone during the first few weeks of their treatment or when changing doses. The duration of these effects may vary depending on several factors, such as the dose, duration, and individual sensitivity of the person taking it.
What If My Side Effects Persist?
If your side effects continue and they are impacting your overall quality of life, speak with your doctor. They may help you consider a change in dosage, timing of dosage, medication, or possibly adding another medication.
Should I Stop Taking Buspirone If I Have Sexual Side Effects?
Do not stop taking buspirone unless you have been advised to do so by your provider. Buspirone is generally not associated with significant withdrawal symptoms when used as prescribed. Unlike other medications used to treat anxiety (such as benzodiazepines and barbiturates), buspirone does not cause the same effects on the brain that lead to dependency.
However, it is still possible that if stopped abruptly, individuals may experience symptoms such as dizziness, headaches, and nervousness.
Can You Reduce Sexual Side Effects of Buspirone?
Depending on your personal experience, it may be possible to reduce or eliminate sexual side effects caused by buspirone. Take note of how your sexual health has changed since starting buspirone and speak to your prescriber about your options.
Here are possible recommendations for reducing the sexual side effects of buspirone:
Wait for Side Effects to Improve
Side effects may occur for anyone taking medication, and some initial side effects may be due to your body adjusting to the medication. These initial side effects may go away after the first several weeks or they may persist for as long as a person takes the medication. A healthcare provider may advise you to wait for a few weeks before making medication adjustments to see if sexual side effects improve.
Make a Dosage Adjustment
If you are experiencing sexual side effects from taking buspirone, talk to your doctor about whether a lower dose would be right for you. Do not adjust your dose on your own. Your healthcare provider will give you guidance to help you avoid any complications from an adjusted dose. Scheduling sexual activity before taking that dose may reduce the risk or impact of sexual side effects.
What Anti-anxiety Medications Have the Fewest Sexual Side Effects?
Buspirone is among the anti-anxiety medications with fewer reported sexual side effects. However, if you find them intolerable, you may discuss switching to a different medication with your prescriber.
Before recommending a different anti-anxiety medication, your provider will account for many factors, including your condition, health history, and the specific sexual side effects you’re experiencing. They will also recommend a plan for transitioning from one medication to another. This can help you avoid uncomfortable symptoms that may occur when stopping your medication.
Anti-anxiety medications with the least reported sexual side effects include:
- Hydroxyzine (Vistaril): Hydroxyzine is an antihistamine that can be used to manage anxiety. It is sometimes prescribed as a non-addictive alternative to benzodiazepines.
- Amitriptyline (Elavil)*: Amitriptyline is an older tricyclic antidepressant that may be considered as a buspirone alternative. However, it’s important to note that while it may have a lower association with sexual side effects, it can have other adverse effects that should be taken into consideration.3
- Bupropion (Wellbutrin XL, Wellbutrin SR)*: Wellbutrin is an antidepressant medication that belongs to the class of medications known as norepinephrine and dopamine reuptake inhibitors (NDRI). Wellbutrin helps anxiety symptoms while causing less sexual dysfunction compared to other antidepressants, such as selective serotonin reuptake inhibitors (SSRIs).
*These medications have a black box warning, the most serious kind of warning from the FDA for the risk of suicidal thoughts and behaviors in certain people. You should talk with your doctor about these risks before starting this medication.
When Should I Call My Doctor About Buspirone Sexual Side Effects?
Side effects are one of the most common reasons people choose to stop taking medication. While some effects can be managed and may fade away, some do not go away unless a person stops taking the medication. Side effects can occur even if you are taking your medication correctly.
Contact your provider as soon as possible if side effects persist or become hard to tolerate so you can consider other treatment options.
How to Cope With Sexual Side Effects of Buspirone
Buspirone sexual side effects are not common and may only last a few weeks for some, but they may feel disruptive to a person’s typical sexual activity. It is also possible for these side effects to be long-term. If you notice changes in your sexual functioning while taking buspirone, contact your healthcare provider for guidance.
Here are ways to cope with sexual side effects of buspirone:
Talk to Your Partner
Talking to your partner can help you better understand the sexual side effects that may occur and how they may affect your relationship. Consider meeting with your provider together to ask questions and learn what your options are if sexual side effects become a problem.
Adjust Routines & Expectations
Changing your sexual routines and adjusting your expectations for sexual activity may help. Plan your sexual activity at times of the day when sexual side effects are less bothersome. You may also find that these changes break you and your partner out of your typical patterns, which may help raise interest in sexual activity.
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Get Good Sleep
Fatigue and sleep deprivation can contribute to a loss of libido. Insomnia may increase the risk for sexual dysfunction, and a lack of sleep or having disrupted sleep patterns has been linked to having a higher risk of erectile dysfunction.4 To maintain better sleep, keep a relaxing schedule in the evenings, limit phone time before bed, set the temperature comfortably, and limit disruptions.
Exercise Regularly
Regular exercise has sexual health benefits for both men and women. It can improve sexual functioning in men experiencing erectile dysfunction and those at risk for it.5 Exercise may also increase sexual arousal in women.6
Focus on Being Sensual
Sensual sex includes focusing more on pleasure than on performance. It encourages partners to slow down and take the time to connect more intimately.
Also consider non-penetrative sex, or outercourse. Take time to cuddle on the couch or in the bed, hold hands, or massage each other’s shoulders–even when sex isn’t the main goal. These physical connections throughout the day or the week can keep you emotionally and physically connected.
Keep a Consistent Daily Schedule
Following a consistent daily or weekly schedule can keep life more predictable and reduce stress as you adjust to the medication. Also, be sure you are taking your medication as prescribed and at the same time each day. Doing so can limit uncomfortable effects from adjusting to the medication, which may also affect your interest in sex.
Consider Therapy
Psychotherapy can support you and your partner by addressing the impact of sexual dysfunction and helping you develop strategies to manage the side effects. Sex therapy may also be helpful for addressing sexual side effects of buspirone. For in-person treatment, your primary care provider or insurance company can provide a referral, or you may get one from family or friends.
To find an online therapist, an online therapist directory is a great starting point. Many online psychiatry platforms, such as Talkiatry and Brightside Health, also offer therapy services.
When to Seek an Alternative to Buspirone Due to Side Effects
Initial side effects of buspirone typically subside after a few weeks. Sexual side effects are not commonly reported when taking buspirone, but they can occur. If after some time you are looking to change your medication due to continued side effects, work with a doctor to find an alternative. There are many buspirone alternatives available to help reduce anxiety symptoms with a low risk of sexual side effects, though potential risks and benefits can vary.
Hydroxyzine is an antihistamine FDA-approved as an anxiety treatment for short-term symptoms. It is nonaddictive and works to reduce anxiety quickly but can lead to drowsiness and decreased alertness.
Several antidepressants with low risk of sexual side effects can be used as non-FDA-approved (off-label) treatments for anxiety symptoms. This includes Viibryd, an SSRI, and atypical antidepressants, such as Wellbutrin, Remeron, and Trintellix.
Other antidepressants and benzodiazepines are more commonly used to treat anxiety symptoms, but these medications come with a higher risk of sexual side effects.
Many SSRIs and serotonin norepinephrine reuptake inhibitors (SNRIs) are FDA-approved first-line treatments for anxiety. Benzodiazepines are prescribed as short-term anxiety treatments due to their risk of tolerance, dependence, and withdrawal symptoms.
How to Get a Prescription for Buspirone or an Alternative
If you are looking to start buspirone, or are considering an alternative due to side effects, start by speaking with a prescriber. To get a prescription for a buspirone alternative in person, start with an evaluation for your symptoms. Your primary care provider, who may be a physician, nurse practitioner, or physician assistant, can help you get the process started. They may make a referral to a psychiatrist or specialist to determine if prescription buspirone alternatives should be included in your treatment plan.
To get an online prescription for buspirone or an alternative, you will also start by getting evaluated by an online psychiatric provider. We have thoroughly reviewed platforms like Talkiatry or Circle Medical that prescribe non-controlled substances such as antidepressants and some anti-anxiety medications.
Also, Talkiatry can and will prescribe benzodiazepines, which are controlled substances that are sometimes used to treat anxiety symptoms. Your provider may offer a prescription if they feel it may be a good fit for your symptoms.
Questions to Ask Your Provider
Your prescriber will share important information about your buspirone prescription. They will explain how to take and store your medication, what to avoid when taking it, and what to do if you experience sexual side effects from buspirone. Follow these tips for safe and effective use of buspirone.
Questions to ask your care team about the sexual side effects of buspirone include:
- Why does buspirone help sexual functioning for some people?
- If buspirone doesn’t usually cause sexual side effects, could it still happen to me?
- Is there any relationship between buspirone and erectile dysfunction?
- After how long after starting buspirone can sexual side effects start?
- What is the best dosage to get fewer sexual side effects?
- When should I contact you if I am experiencing sexual side effects?
- How could buspirone affect my libido?
- What other side effects should I look out for once I start my buspirone dose?
Prescriber’s Tips
Your prescriber will share important information about your buspirone prescription. They will explain how to take and store your medication, what to avoid when taking it, and what to do about sexual side effects. Follow these tips for safe and effective use of buspirone.
- Take your medication as prescribed, do not change your dose or stop taking it unless your prescriber tells you to. Keeping a consistent dosing schedule reduces the chance of unwanted side effects, including sexual side effects.
- Limit alcohol and eat a balanced diet to minimize sexual dysfunction and ensure your body can experience and enjoy sex. This is because drinking alcohol can make it hard for your brain to send and receive signals to feel different parts of your body during sex. It can also make it harder for men and women to reach orgasm when having sex. Your healthcare provider can help to determine what is a safe amount of alcohol for you to drink and the best-balanced diet for you.
- Take your medication at the same time each day. Doing so can help you remember to take it, making it as effective as possible. Your healthcare provider can help determine the optimal timing based on your sleep patterns and initial medication response.
- Some anti-anxiety medications can cause drowsiness and may affect your decision making. Talk to your doctor about how taking one of these medications may affect your ability to drive, operate heavy machinery, or do other dangerous activities safely.
- Tell your prescriber about all medications and supplements you take, including over-the-counter treatments. Many over-the-counter medications and supplements can interact with prescription medications.
Frequently Asked Questions
What Is Buspirone & How Is It Used?
Buspirone is an FDA-approved medication for the treatment of anxiety disorders in adults and children. It is an anti-anxiety medication that works by mimicking the brain chemical serotonin. Buspirone interacts with brain cells and promotes a sense of calmness, particularly in areas of the brain associated with anxiety and fear. This leads to a reduction in feelings of worry, tension, and uneasiness. Additionally, buspirone blocks certain functions of dopamine, contributing to improved mood regulation.2
Does Buspirone Affect Sex Drive?
While it’s possible, changes in sex drive appear to be infrequent with buspirone.
Does Buspirone Cause Erectile Dysfunction?
Not usually. While it is possible, buspirone is rarely reported to cause erectile dysfunction. Buspirone can be used to help treat.
Can Buspirone Help With Sexual Dysfunction Caused by Antidepressants?
Yes, buspirone is known to have positive effects on sexual functioning. The medication can be used to help with erectile dysfunction caused by taking antidepressants.
Which Anti-anxiety Medications Cause the Fewest Sexual Side Effects?
Anti-anxiety medications with the fewest reported sexual side effects include bupropion (Wellbutrin XL and SR), buspirone, amitriptyline (Elavil), and hydroxyzine (Vistaril).
Which Anti-anxiety Medications Cause the Most Sexual Side Effects?
Antidepressants that increase serotonin levels include selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are first-line treatments for anxiety. They also tend to cause more sexual side effects than other medications for anxiety.3
Should I Stop Taking Buspirone If I Experience Sexual Side Effects?
Do not stop taking buspirone unless you have been advised to do so by your provider. If you are experiencing sexual side effects from buspirone, your provider will tell you how to manage these effects or stop taking your medication safely, if needed.
Do Sexual Side Effects From Buspirone Go Away on Their Own?
Many initial side effects from medications go away on their own. But if some effects persist, speak to your prescriber so they can adjust your treatment plan.
Is Buspirone Similar to Viagra?
No. Buspirone can be used to reduce sexual side effects caused by SSRIs, but it works differently than Viagra.
Choosing Therapy strives to provide our readers with mental health content that is accurate and actionable. We have high standards for what can be cited within our articles. Acceptable sources include government agencies, universities and colleges, scholarly journals, industry and professional associations, and other high-integrity sources of mental health journalism. Learn more by reviewing our full editorial policy.
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Landén, M., Eriksson, E., Agren, H., & Fahlén, T. (1999). Effect of buspirone on sexual dysfunction in depressed patients treated with selective serotonin reuptake inhibitors. Journal of clinical psychopharmacology, 19(3), 268–271. https://doi.org/10.1097/00004714-199906000-00012
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Buspirone hydrochloride tablet. (June 28, 2024). DailyMed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
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Smucny, J., & Park, M. S. (2004). Which antidepressant is best to avoid sexual dysfunction?. American family physician, 69(10), 2419–2420. Retrieved from https://pubmed.ncbi.nlm.nih.gov/15168963/
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Cho, J. W., & Duffy, J. F. (2019). Sleep, Sleep Disorders, and Sexual Dysfunction. The world journal of men’s health, 37(3), 261–275. Retrieved from https://pmc.ncbi.nlm.nih.gov/articles/PMC6704301/
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Khera, M., Bhattacharyya, S., & Miller, L. E. (2023). Effect of aerobic exercise on erectile function: systematic review and meta-analysis of randomized controlled trials. The journal of sexual medicine, 20(12), 1369–1375. https://doi.org/10.1093/jsxmed/qdad130
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Stanton, A. M., Handy, A. B., & Meston, C. M. (2018). The Effects of Exercise on Sexual Function in Women. Sexual medicine reviews, 6(4), 548–557. https://doi.org/10.1016/j.sxmr.2018.02.004
We regularly update the articles on ChoosingTherapy.com to ensure we continue to reflect scientific consensus on the topics we cover, to incorporate new research into our articles, and to better answer our audience’s questions. When our content undergoes a significant revision, we summarize the changes that were made and the date on which they occurred. We also record the authors and medical reviewers who contributed to previous versions of the article. Read more about our editorial policies here.
Author: No Change
Reviewer: No Change
Added “Key Takeaways”. Condensed “What is Buspirone (Buspar) & How Is It Used?” and moved to FAQs. Added sections “How Soon Will I Start Feeling the Sexual Effects of Buspirone?”, “How Long Do Sexual Side Effects of Buspirone Last?”, “What If My Side Effects Persist?”. Added new sections “Can You Reduce Sexual Side Effects of Buspirone?”, “When Should I Call My Doctor About Buspirone Sexual Side Effects?”, “How to Cope With Sexual Side Effects of Buspirone“ and several subsections. Added section “When to Seek an Alternative to Wellbutrin Due to Side Effects”, “How to Get a Prescription for Wellbutrin or an Alternative”. Retitled sections “Questions to Ask Your Health Team” to “Questions to Ask Your Provider”. Retitled and expanded “In My Experience” section to “Prescriber’s Tips”. Removed “For Further Reading”, Added FAQs.
Author: Diana Rangaves, PharmD, RPh
Reviewer: Heidi Moawad, MD
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