*An off-label use of a medication is a use that is not FDA-approved. Prescribers can decide to use a medication off-label because, in their professional judgment, they believe it may offer a benefit to someone.
Common buspirone side effects include dizziness, nausea, and headache. Serious side effects, such as chest pain and allergic reactions, are rare and require medical attention.
Unwanted side effects are among the top reasons people stop taking a medication. If buspirone side effects persist beyond the first few weeks, a prescriber can help you determine next steps. This may include a change in dosage, the timing, or switching to a different medication.
If you are considering buspirone or want to discuss your current medication treatment with a provider, online psychiatry platforms, such as Talkiatry and Brightside Health are a good place to start. Their providers offer assessments and prescription consultation, and can answer any questions you have about buspirone’s side effects.
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Key Takeaways
Buspirone causes common side effects such as dizziness, nausea, and a headache. These effects are often temporary, but some side effects may be serious and require medical attention.
If buspirone side effects persist longer than a few weeks, your provider can help you navigate next steps. Your provider may suggest a change in dosage, timing of dosage, or medication.
There are several ways to cope with buspirone side effects, including small changes in daily habits, medication adjustments, and therapy.
If you are considering buspirone or an alternative, start with an evaluation from a medical provider. Many online psychiatry platforms offer online assessments and medication management, such as Talkiatry, or Circle Medical.
Popular Choices for Online Psychiatry
Talkiatry – Safe, virtual mental health care from doctors who take insurance. Most psychiatry visits cost patients $30 or less* Take a short assessment.
Circle Medical – anxiety and depression treatment. Meet with an online doctor today! All prescriptions are based on necessity determined by a medical professional. Diagnosis and prescription over video. Insurance accepted. No membership or hidden fees. Same day appointments. Visit Circle Medical
*Includes copayment, deductible, coinsurance, and $0 Visits. Excludes no shows. **On average. Actual appointment times vary by state and individual patient.
Common Buspirone Side Effects
Common buspirone side effects can cause digestive problems, dizziness, and other discomforts. While these are often temporary, seek medical care for side effects that become severe or don’t go away on their own.
Common side effects of buspirone may include:*1
- Dizziness
- Nausea
- Headache
- Nervousness
- Lightheadedness
- Excitement
- Chest pain
- Disturbing dreams
- Tinnitus (ringing in the ears)
*All medications, including buspirone, can cause side effects that can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and understand the potential side effects and benefits of any medication.
Serious Buspirone Side Effects
Some side effects may be severe or persistent. Call your healthcare provider right away if you experience any of the following side effects.
Serious side effects of buspirone that require immediate medical attention include:*1
- Unpredictable effects on the central nervous system (CNS), making it risky to drive or do activities requiring you to be fully alert
- Increased risk of side effects for those with liver or kidney impairment
- Chest pain
- Increased blood pressure
- Serotonin syndrome
- Severe allergic or hypersensitivity reactions
*All medications, including buspirone, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.
What Are the Risks & Warnings for Buspirone?
Unpredictable Effects on the Central Nervous System
Buspirone is thought to be less sedating than other anxiety medications. But it is still important to be cautious when driving or doing activities that require being fully alert. Avoid these activities until you know how buspirone negatively affects your ability to function.
Liver Impairment
Having an impaired liver means it can take longer for buspirone to leave your body. This condition can increase its effects or the risk of side effects.
Kidney Problems
Having an impaired kidney means it can take longer for buspirone to leave your body. This condition can increase its effects or the risk of side effects.
Possible Risks During Pregnancy
There may be risks when taking anti-anxiety medications while pregnant. Although it has not been well studied, buspirone is not recommended during pregnancy.
Possible Risks While Breastfeeding
It is unclear if buspirone passes into the breast milk and is therefore not recommended for mothers when breastfeeding.
Serotonin Syndrome
This rare condition occurs when there is too much serotonin or serotonin-like chemicals in the body. Symptoms can include agitation, hallucinations, rapid heartbeat, fever, muscle stiffness, and loss of coordination.
Irregular Facial & Body Movements
Because of how it interactions with receptors for the body chemical dopamine, buspirone may cause irregular, uncontrollable movements of the face or body.
Allergic Reactions
As with any medication, buspirone may cause allergic reactions in some individuals. Some individuals may be more susceptible to allergic reactions to the drug. While allergic reactions are typically rare, they can be serious and require immediate attention.
Allergic reactions to buspirone include:
- Skin rash or hives
- Itching or swelling, especially of the face, tongue, or throat
- Severe dizziness or trouble breathing
Seek medical help immediately if you suffer any of these symptoms. Allergic responses can be severe and may need quick medical attention to stop future problems
Drug Interactions
Taking certain medications, herbs, or supplements alongside Wellbutrin XL can change how it works in your body or increase the risk of serious side effects. Do not start, stop, or change the dosage of any medicines without your provider’s approval.
Substances you should avoid using while taking Wellbutrin XL include:
- Drugs broken down by the enzyme CYP2D6 (certain antidepressants, antipsychotics, beta blockers, anti-arrhythmia medications)
- Drugs that speed up the activity of the enzyme CYP3A4 (faster drug breakdown)
- Monoamine oxidase inhibitors (MAOIs)
- Selective serotonin reuptake inhibitors (SSRIs)
- Serotonin norepinephrine reuptake inhibitors (SNRIs)
- Tricyclic antidepressants
- Other drugs that affect serotonin levels in the body
- Drugs that affect dopamine (levodopa, amantadine)
- Grapefruit juice
- Alcohol
This is not a comprehensive list of medications and substances that interact with Zoloft. Be sure to talk with your doctor or pharmacist about any prescription or over the counter medications you take, as well as supplements, herbs, and teas.
*This is not a comprehensive list of all warnings and precautions for buspirone. You should talk with your doctor about any questions you have and to understand the potential warning and precautions of any medication.
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Important Things to Know About Taking Buspirone
Your prescriber will discuss what you can expect when starting buspirone. They will talk with you about your dosage and the proper way to take your medication. They will also cover precautions, potential side effects, and what to do if these become a problem.
How Long Does It Take for Buspirone to Work?
It typically takes 2-4 weeks for buspirone to become fully effective, though some may notice a difference after two weeks. Each person’s body may respond differently, which can affect how long it takes to start working.
Can Buspirone Make You Feel Worse at First?
Yes, some taking buspirone may experience uncomfortable side effects at first like a dizziness, headache, or nausea.1 These typically go away after a few weeks as your body adjusts.
What Happens If I Miss a Dose?
If you forget to take your buspirone dose, take it as soon as you remember. If your next dose is due soon, skip the missed one and take the next one. Never take two doses at once. Keep taking your medication consistently unless your prescriber gives you different instructions.1
Who Experiences Side Effects More?
Some may experience more side effects from buspirone than others. While predicting who may be more sensitive to buspirone is difficult, certain patients should be cautious.
Those Taking Other Medications
Combining buspirone with other medications can increase the risk of side effects and other complications. For example, monoamine oxidase inhibitors (MAOIs) can cause dangerously high blood pressure in some people. Because buspirone has a similar risk, taking these with buspirone should be avoided. Taking buspirone with certain antidepressants can cause elevated serotonin levels, leading to a rare but potentially life-threatening condition called serotonin syndrome. Antidepressants to avoid include selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and tricyclic antidepressants.
Those With Certain Health Risks
Buspirone may not be safe for those with certain health risks or conditions. Discussing your health history with your healthcare provider can help avoid these and other complications.
Those with a higher risk of side effects from buspirone include anyone who:1
- Is breastfeeding or plans to breastfeed
- Is pregnant or may become pregnant
- Has a history of liver problems
- Has a history of kidney problems
- Has had prior allergic reactions to buspirone
- A history of substance misuse
How to Cope With Common Buspirone Side Effects
There are ways to cope with the most common buspirone side effects*. Many may go away on their own during the first few weeks. If side effects persist or worsen, tell your provider as soon as possible.
Headaches
A headache is a commonly reported side effect of buspirone. These often go away after the first few weeks as your body adjusts to buspirone. Getting enough rest, being physically active, and drinking plenty of water can help in the meantime. Taking an over-the-counter pain medication may help, but ask your provider if this is safe for you.
Nausea
Some people feel nauseous when taking buspirone. To minimize this, follow meal timing recommendations for your medication. Also, drink plenty of water, eat smaller, more frequent meals, and avoid spicy foods.
Ginger or peppermint teas may help, but talk with your healthcare provider first. Prescription medication can interact with over-the-counter medications, herbal remedies, and even tea.
Dizziness
Buspirone may cause dizziness for some, especially during the first few weeks. This can negatively affect your ability to drive safely, operate machinery, or do other activities that require steadiness. Avoid these activities until you understand how dizziness impacts your daily functioning. Talk to your provider if this worsens or interferes with daily life.
*All medications, including buspirone, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.
More Ways to Manage Buspirone Side Effects
Here are more ways to cope with and reduce the impact of buspirone side effects.
Practice Good Sleep Habits
Regular sleep can improve your energy levels and keep your mood stable as you adjust to taking buspirone. Try waking up and going to bed about the same time each day. A comfortable and relaxing sleep environment is also important.
If buspirone makes you feel drowsy or interferes with your sleep, talk to your provider for guidance. They may advise you to avoid driving or other activities that require you to be fully alert until you understand buspirone’s impact on your sleep.
Healthy Lifestyle Activities
A balanced diet, regular exercise, and proper rest can help your body handle medication adjustments more smoothly. These activities support your brain functioning, energy levels, and can help you recover from side effects.
Follow a Daily Routine
Following your regular daily routine when starting buspirone can reduce stress. This can be especially helpful when your medication hasn’t started working yet. Take it as prescribed and at the same time each day. Once you fit taking your medication into your daily schedule, you’re more likely to remember it and have a consistent daily dose.
Consider Therapy
Psychotherapy can help you cope with side effects in addition to supporting your mental health. Your healthcare provider or insurance company can connect you with an in-person therapist. Friends and family may also recommend a therapist to work with.
To find an online therapist, an online therapist directory is a great starting point. Many online psychiatry platforms, such as Talkiatry and Brightside Health, also offer therapy services.
Should I Stop Taking Buspirone If I Start Feeling Side Effects?
No, do not stop taking buspirone without talking with your provider first. If you notice side effects while taking buspirone, report them to your provider right away. They can adjust your treatment or help you consider other options. If you need to stop taking buspirone, they will provide a plan to gradually reduce your dose.
When Should I Call My Doctor About Buspirone Side Effects?
Side effects can cause people to stop taking their medication, or at least consider doing so. Many side effects are manageable or may go away on their own. But some may continue until the medication is stopped. Side effects can happen even when you take your medication correctly.
Contact your provider as soon as possible if side effects persist for more than a few weeks or if they get worse. Although rare, serious side effects can happen and may require emergency medical care. Some may even be life-threatening. If you notice any of the serious side effects listed above, seek medical care right away.
When Should I Seek an Alternative to Buspirone Due to Side Effects?
Buspirone’s initial side effects often get better after a few weeks. But if they persist or worsen, a provider can help you explore alternatives to buspirone.
SNRIs and SSRIs are often a first choice as an alternative for buspirone. They are primarily known as depression treatments, but are also effective for reducing anxiety symptoms.
Beta-blockers are medications typically used for heart conditions but some are also used for anxiety symptoms as a non-FDA-approved treatment.2,3 They affect the physical symptoms of anxiety but do not impact the emotional symptoms.
Benzodiazepines are approved as short-term treatments for anxiety symptoms. But they are controlled substances with risks and may not be the right medication for everyone.
How to Get a Prescription for Buspirone or Alternative Medications
To get a prescription for buspirone or an alternative in person, your first step is to get your symptoms evaluated. Your primary care provider, who may be a physician, nurse practitioner, or physician assistant can get the process started. And they may refer you to a psychiatrist or specialist for further assessment, which may include considering medication.
For an online prescription, you’ll also start with an evaluation from an online psychiatric provider. We have carefully reviewed platforms that prescribe anxiety medication, such as Brightside Health, Talkiatry and Circle Medical. Due to special regulations for controlled substances such as benzodiazepines, Talkiatry is one provider that can and will prescribe these medications.
Questions to Ask Your Provider
Before starting buspirone, have a conversation about potential side effects with your provider, psychiatrist, or therapist. They will review possible side effects and what to do if they get worse or don’t go away.
Online psychiatry services offer convenient treatment options for anxiety. Your provider will evaluate your symptoms, provide a diagnosis, and create a personalized treatment plan. And many platforms allow the flexibility to change providers, if needed.
Questions to ask your care team about buspirone side effects may include:
- How long will it take for my body to get used to taking buspirone?
- How quickly do side effects from buspirone typically start?
- What do the first days of buspirone side effects feel like?
- Is there a starting dose that reduces the risk of side effects, especially in the first week?
- When should I reach out if I notice side effects?
- If I can’t tolerate side effects, are there buspirone alternatives to consider?
- What are some strategies for coping with side effects?
- What can I do if side effects don’t improve after a few weeks?
- Is it safe to skip or lower a dose to avoid the side effects?
- Can I switch medications if side effects last longer or get worse?
- What can I do if I have serious side effects?
Prescriber’s Tips Text
Your prescriber will go over all the important points about your buspirone prescription. They will explain how to take it, how to store it, and what to avoid when using it. They will also discuss possible side effects and what to do about them. Follow these tips for safe and effective use of buspirone.
- Take your medication as prescribed. Do not change your dose or stop taking it unless your prescriber tells you to.
- Take your medication at the same time of day each day. Keep a consistent schedule to reduce the chance of unwanted side effects. Your provider can determine the best timing based on your sleep patterns and how your body responds to buspirone.
- Tell your provider right away if any of your mental health symptoms get worse.
- Ask your provider whether it is safe to drink alcohol while taking buspirone.
- Tell your provider all the medications, supplements, and over-the-counter treatments you take. Many over-the-counter products can interact with prescription medications.
Frequently Asked Questions
What Is Buspirone & What Is It Used to Treat?
Buspirone is an anti-anxiety medication and is not chemically related to benzodiazepines, barbiturates, or other sedative drugs . Buspirone is FDA-approved to treat for the management of anxiety disorders or the short-term relief of the symptoms of anxiety.1
How Does Buspirone Work?
Buspirone is thought to work by mimicking serotonin in the brain, resulting in improved anxiety symptoms.. Unlike anti-anxiety medications such as benzodiazepines, buspirone does not have sedative effects and is considered non-addictive.1
How Does Buspirone Make You Feel During the First Week?
During the first week of taking buspirone, the medication is building up in your body. This may trigger side effects for some people like headache or dizziness. Some who take buspirone may start noticing their symptoms improving in the first couple of weeks. But medication affects everyone differently and it may take longer for some people.1
How Long Do Buspirone Side Effects Last?
Most people find that common buspirone side effects improve within the first few days or weeks. But side effects from buspirone can be different for everyone. The way your body reacts, the dosage, and the length of treatment can affect how long your side effects last.
Does Buspirone Cause Anger or Other Emotional Side Effects?
Rarely, buspirone may cause some emotional side effects such as anger, hostility, irritability, or agitation. These side effects are more likely to occur when starting the medication and may decrease over time. If you experience any of these side effects while taking buspirone, talk to your doctor about adjusting your dose or switching to another medication.
Which Anxiety Medications Cause the Fewest Side Effects?
SNRIs and SSRIs are antidepressants that cause few side effects for most people. Buspirone also has a shorter list of side effects and warnings than some anxiety medications.
Which Anxiety Medications Cause the Most Side Effects?
Benzodiazepines have more side effects for most people, the potential for physical dependence, and other risks. These are controlled substances and are not safe or appropriate for everyone with anxiety symptoms.
Should I Stop Taking Buspirone If I Experience Side Effects?
Do not stop taking buspirone unless you have been advised to do so by your provider. If you need to stop taking buspirone, your provider will give instructions for stopping it safely.
Choosing Therapy strives to provide our readers with mental health content that is accurate and actionable. We have high standards for what can be cited within our articles. Acceptable sources include government agencies, universities and colleges, scholarly journals, industry and professional associations, and other high-integrity sources of mental health journalism. Learn more by reviewing our full editorial policy.
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Buspirone Hydrochloride tablet. (June 28, 2024). DailyMed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
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Propranolol Hydrochloride Tablet. (December 30, 2023). DailyMed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
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Noyes, R., Jr, Anderson, D. J., Clancy, J., Crowe, R. R., Slymen, D. J., Ghoneim, M. M., & Hinrichs, J. V. (1984). Diazepam and propranolol in panic disorder and agoraphobia. Archives of general psychiatry, 41(3), 287–292. Retrieved from https://doi.org/10.1001/archpsyc.1984.01790140077009
We regularly update the articles on ChoosingTherapy.com to ensure we continue to reflect scientific consensus on the topics we cover, to incorporate new research into our articles, and to better answer our audience’s questions. When our content undergoes a significant revision, we summarize the changes that were made and the date on which they occurred. We also record the authors and medical reviewers who contributed to previous versions of the article. Read more about our editorial policies here.
Author: No Change
Reviewer: No Change
Primary updates: Added “Key Takeaways” feature. Edited for clarity. Condensed “What is Buspirone & How Is It Used?” and moved to FAQs. Revised and condensed “Serious Side Effects” section. Revised and moved content from “Allergic Reactions”, “Interactions With Buspirone?”, and “Other Warnings & Precautions for Taking Buspirone” sections with new “What Are the Warnings & Risks of Buspirone?” feature. Revised and expanded “Who Experiences Side Effects More?” Added new section “Important Things to Know About Taking Buspirone”. Revised and moved FAQ section to the end. Added new sections “How to Manage Side Effects” to “How to Cope With Common Buspirone Side Effects”, added “More Ways to Manage Buspirone Side Effects”, “Should I Stop Taking Buspirone If I Start Feeling Side Effects?”, “When Should I Seek an Alternative to Buspirone Due to Side Effects?”, “How to Get a Prescription for Buspirone or Alternative Medications” and all included subsections. Retitled “Questions to Ask Your Health Team” to “Questions to Ask Your Provider”. Replaced “Final Thoughts” with “Prescriber’s Tips” feature. Removed “For Further Reading”
Author: Max Ruvinov, PharmD, MBA
Medical Reviewer: Heidi Moawad, MD
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Online psychiatry, sometimes called telepsychiatry, platforms offer medication management by phone, video, or secure messaging for a variety of mental health conditions. In some cases, online psychiatry may be more affordable than seeing an in-person provider. Mental health treatment has expanded to include many online psychiatry and therapy services. With so many choices, it can feel overwhelming to find the one that is right for you.
