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  • What Is Celexa?What Is Celexa?
  • Delivery MethodsDelivery Methods
  • FDA-Approved TreatmentFDA-Approved Treatment
  • Off-Label UsesOff-Label Uses
  • Dosing ConsiderationsDosing Considerations
  • OverdoseOverdose
  • Missing a DoseMissing a Dose
  • QuestionsQuestions
  • In My ExperienceIn My Experience
  • Additional ResourcesAdditional Resources
  • SourcesSources

Celexa (Citalopram) Dosage Guide

Diana Rangaves, PharmD, RPh

Author: Diana Rangaves, PharmD, RPh

Diana Rangaves, PharmD, RPh

Diana Rangaves PharmD, RPh

Diana Rangaves is an accomplished pharmacist and expert in behavioral health pharmacology. Her areas of expertise include patient education, medication cost-reduction, and patient-centered treatment.

See My Bio Editorial Policy
Headshot of Dena Westphalen, Pharm. D.

Medical Reviewer: Dena Westphalen, Pharm.D Licensed medical reviewer

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Dena Westphalen PharmD

Dr. Dena Westphalen is a pharmacist with expertise in clinical research and drug information. She has interests in neurology, oncology, and global health.

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Published: April 26, 2023
  • What Is Celexa?What Is Celexa?
  • Delivery MethodsDelivery Methods
  • FDA-Approved TreatmentFDA-Approved Treatment
  • Off-Label UsesOff-Label Uses
  • Dosing ConsiderationsDosing Considerations
  • OverdoseOverdose
  • Missing a DoseMissing a Dose
  • QuestionsQuestions
  • In My ExperienceIn My Experience
  • Additional ResourcesAdditional Resources
  • SourcesSources
Brand name:
Celexa
Generic name:
Citalopram
Is the generic available:
Yes
Class of drug:
SSRI
Boxed warning:
Yes
FDA-approved treatments:
Major Depression
Common Off-label Uses (non-FDA approved):
Generalized Anxiety Disorder, OCD, Panic Disorder, Premenstrual Dysphoric Disorder (PMDD), Social Anxiety Disorder, PTSD
Common alternatives:

Lexapro, Zoloft, Paxil

View Drug Class, FDA-Approved Uses, Off-Label Uses, and more

*An off-label use of a medication is a use that is not FDA-approved. Prescribers can decide to use a medication off-label because, in their professional judgment, they believe it may offer a benefit to someone.

The Celexa dosage for adults is typically 20 mg daily. Your prescriber give you a smaller dose at the start and work up to a maximum daily dose of 40 mg. Take the missed dose of this medication as soon as you remember. If your next dose is approaching, skip the missed one and resume your regular dosing regimen. Never take two doses at once to make up for a missed one.

Your prescriber can answer questions about dosages and how to take Celexa. If you’re considering Celexa or want to discuss your current medication treatment with a provider, online psychiatry platforms such as Talkiatry and Brightside Health are a good place to start. They can connect you to a provider quickly, who can answer any questions you have about taking your medication and provide new prescriptions as appropriate. 

Boxed Warning: Citalopram (Celexa) - Risk of suicidal thoughts and behaviors in certain people

Click here to open and close the box warning container.

Citalopram, the active ingredient in Celexa, has a black box warning. These are the most serious types of warnings from the Food and Drug Administration (FDA).  Citalopram can increase the risk of suicidal thoughts and behaviors in children, adolescents, and young adults. Regardless of your age, you should talk with your doctor about serious risks with citalopram and any other medications before starting treatment.

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What Is Celexa (Citalopram) & How Is it Used?

Celexa, also known as citalopram, is an antidepressant and is approved as a medication for depression in adults.1 The pharmaceutical known by its brand name, Celexa, comprises the generic substance citalopram. Off-label uses of Celexa (citalopram) include treating symptoms comparable to those seen in illnesses such as anxiety, obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD). An off-label use is when a medication is used to treat a condition that is not FDA-approved based on the professional judgment of the prescriber.

Celexa is not approved for use in children under the age of 18. Celexa is an antidepressant medication classified as a member of the group known as selective serotonin reuptake inhibitors (SSRIs). 2 The antidepressant effects of SSRIs are attributed to an increase in serotonin production in the brain.

Celexa may be prescribed off-label for the treatment of:

  • Obsessive-compulsive disorder (OCD)
  • Panic disorder
  • Generalized anxiety disorder (GAD)
  • Social anxiety disorder
  • Alcohol use disorder
  • Coronary arteriosclerosis
  • Postmenopausal flushing
  • Premenstrual dysphoric disorder

Celexa Delivery Methods

Celexa forms and strengths are varied. While generic citalopram is offered as an oral solution, capsule, and an orally disintegrating tablet, Celexa is exclusively provided as a tablet. Celexa comes in 10 mg, 20 mg, and 40 mg tablets. For adults under 60 years old, the usual dose is 20 mg per day with a maximum of 40 mg per day. For people over 60, the maximum dose is 20 mg per day. The prescriber may choose a dosage of Celexa and form over another based on age and efficacy.

To get the most benefit from this medication and to improve your health, only take it as prescribed by your doctor. The dosage of this medication will vary depending on the patient. Observe your doctor’s instructions or the label’s instructions. You can take Celexa with or without food. Follow your doctor’s instructions if they specify a certain time for you to take it.

Celexa Dosages for FDA-Approved Treatment

The Food and Drug Administration (FDA) of the US Government reviews and approves medications as treatments for many health conditions. This means that the benefits of a medication outweigh the potential risks. As an FDA-approved medication, Celexa dosages vary by the disorder and the individuals taking them.

Celexa Dosage for Major Depressive Disorder (MDD)

The FDA has authorized a dosage of Celexa to treat major depressive disorder (MDD). 3 The first two weeks may see some improvement in sleep, energy, or appetite. These physical depression symptoms becoming better can be a crucial early sign that the drug is working. It may take 6 to 8 weeks for a depressed mood and lack of interest in activities to improve completely. Celexa is typically taken once daily for depression treatment. You can take it any time, but it is better to stick to the same time every day.

Celexa dosages for depression in adults include:

  • Typical starting dosage: 20 mg once daily.
  • Dosage increases: After at least a week, the dosage may be increased to 40 mg once daily.
  • Maximum dosage: 40 mg once daily.

Celexa Dosage for Non-FDA-Approved (Off-Label) Uses

In addition to its FDA-approved uses, prescribers may use Celexa as an off-label treatment for various conditions.4
Possible off-label uses for Celexa may include:

  • Obsessive-compulsive disorder (OCD)
  • Panic disorder
  • Social anxiety disorder
  • Premenstrual dysphoric disorder (PMDD)
  • Generalized anxiety disorder (GAD)
  • Alcoholism

If you are interested in using Celexa for off-label use, you should talk with your health care professional. They can help to determine if it is safe for you to use Celexa and what dose of Celexa you should take.

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Celexa Dosing Considerations

Inform your doctor or pharmacist about your medical history before using this drug, especially if you have or have had glaucoma; liver disease; seizures; low sodium levels in the blood; bleeding issues; or a personal or family history of bipolar/manic-depressive disorder. 5 Angle-closure glaucoma, a disease that develops when iris bulges obstruct the drainage angle, is one of the effects of alcohol and Celexa.

Conditions that may require a different medication than Celexa or require close monitoring include:

  • Bipolar disorder: Celexa is not recommended for the treatment of bipolar disorder. Long-term use can aggravate manic symptoms.
  • Kidney problems: If you have kidney disease, discuss Celexa use with your doctor before starting. This medication may accumulate in those with severe kidney illness and have greater negative effects.
  • Bleeding problems: Before taking Celexa, talk to your doctor if you have bleeding issues. According to certain research, SSRIs may increase the risk of bleeding.
  • Heart problems: It is best to speak with your doctor before taking Celexa if you have cardiac issues. The electrical activity of the heart may be altered fatally by this medication.
  • Glaucoma: If you have glaucoma, an eye ailment, Celexa may worsen the pressure within your eye, potentially impairing your vision.
  • Seizures: Celexa may raise the chance of seizures.

Can You Overdose on Celexa?

The symptoms are typically not severe. However, you should call the poison hotline (1-800-222-1222) or go to a hospital if you take too much Celexa. An overdose of Celexa can cause severe symptoms, such as an irregular heart rate and seizures.

What if I Miss a Dose of Celexa?

You should not stop taking Celexa suddenly. Talk with your health care professional if you would like to stop taking your medication as they can help you taper to reduce the chance of any side effects with antidepressant discontinuation syndrome. Antidepressant discontinuation syndrome can result in muscle aches and mood swings, which might lead to a return of depression, hence the necessity for this cautious taper.6

Prescribers may occasionally advise patients to discontinue the drugs if negative effects like decreased arousal or loss of sexual desire outweigh the therapeutic benefits. Besides these factors, your physician would advise you to continue taking the medications even after your symptoms improve. This form of therapy, known as continuation therapy, is essential for stopping the recurrence of depressive symptoms.

Questions to Ask Your Health Team

Discuss the risks and advantages of the drugs with your doctor before beginning treatment. You can inquire with your doctor about Celexa’s suitability for treating your disease or the drug’s potential adverse effects. Questions to ask your care team about Celexa dosages include:

  • Is it safe to take Celexa with my other medications?
  • Will Celexa be covered by my insurance?
  • Does my medical history indicate a need to adjust my dosage?
  • How long will it take before my symptoms improve?
  • Should I let my therapist know I am taking this medication?
  • What should I do if I want to stop taking Celexa?

In My Experience

In my experience, Celexa’s side effects, including suicidal thoughts, serotonin syndrome, and sleep issues, can range from mild to severe. As a result, patients should use this drug carefully and under the guidance of a clinician. To reduce the hazards of Celexa interactions and other antidepressants, this antidepressant shouldn’t be taken with other SSRIs or SNRIs. Consult with your therapist if you require more help while taking Celexa.

Additional Resources

To help our readers take the next step in their mental health journey, ChoosingTherapy.com has partnered with leaders in mental health and wellness. ChoosingTherapy.com is compensated for marketing by the companies included below.

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For Further Reading

  • How to Get a Celexa (Citalopram) Prescription: Everything You Need to Know
  • Celexa (Citalopram) Withdrawal: Symptoms, Duration, & How to Cope
  • Citalopram (Celexa) Side Effects: Rare, Common, & Severe
  • Does Celexa Cause Weight Gain? Everything You Need to Know
  • Celexa & Alcohol: Understanding the Risks
  • Trintellix Dosage: Strengths, Form, How to Take, & More

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Sources

ChoosingTherapy.com strives to provide our readers with mental health content that is accurate and actionable. We have high standards for what can be cited within our articles. Acceptable sources include government agencies, universities and colleges, scholarly journals, industry and professional associations, and other high-integrity sources of mental health journalism. Learn more by reviewing our full editorial policy.

  • Keller, M. B. (2000). Citalopram therapy for depression: a review of 10 years of European experience and data from US clinical trials. Journal of Clinical Psychiatry, 61(12), 896-908. Retrieved from https://www.psychiatrist.com/read-pdf/2675/

  • Bezchlibnyk-Butler, K., Aleksic, I., & Kennedy, S. H. (2000). Citalopram–a review of pharmacological and clinical effects. Journal of Psychiatry and Neuroscience, 25(3), 241. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1407724/

     

  • Garriock, H. A., Kraft, J. B., Shyn, S. I., Peters, E. J., Yokoyama, J. S., Jenkins, G. D., … & Hamilton, S. P. (2010). A genomewide association study of citalopram response in major depressive disorder. Biological psychiatry, 67(2), 133-138. Retrieved from https://www.sciencedirect.com/science/article/pii/S000632230901049X

  • Chen, H., Reeves, J. H., Fincham, J. E., Kennedy, W. K., Dorfman, J. H., & Martin, B. C. (2006). Off-label use of antidepressant, anticonvulsant, and antipsychotic medications among Georgia Medicaid enrollees in 2001. Journal of Clinical Psychiatry, 67(6), 972-982. Retrieved from https://www.psychiatrist.com/read-pdf/13083/

  • Ghaemi, S. N., Whitham, E. A., Vohringer, P. A., Barroilhet, S. A., Amerio, A., Sverdlov, O., & Patkar, A. A. (2021). Citalopram for acute and preventive efficacy in bipolar depression (CAPE-BD): a randomized, double-blind, placebo-controlled trial. The Journal of clinical psychiatry, 82(1), 6067. Retrieved from https://www.psychiatrist.com/jcp/bipolar/depression/efficacy-of-citalopram-treatment-in-bipolar-depression/

  • Haddad, P. M., & Anderson, I. M. (2007). Recognising and managing antidepressant discontinuation symptoms. Advances in Psychiatric Treatment, 13(6), 447-457. Retrieved from https://www.cambridge.org/core/journals/advances-in-psychiatric-treatment/article/recognising-and-managing-antidepressant-discontinuation-symptoms/

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