Latuda (Lurasidone): Uses, Side Effects, Dosage, & More

Does Latuda Reduce Anxiety?

Yes, Latuda (lurasidone) can be prescribed off-label for the treatment of anxiety, among other conditions.² While it is primarily FDA-approved for schizophrenia and bipolar disorder, research and clinical practice have explored its potential in addressing various off-label uses, including anxiety.

Is Latuda a Mood Stabilizer or Antidepressant?

Latuda is classified as an atypical antipsychotic, not a mood stabilizer or an antidepressant. It works by altering the levels of neurotransmitters in the brain to manage conditions like schizophrenia and bipolar disorder. While it can help stabilize mood in some cases, it is not primarily intended for this purpose and should be used as prescribed by a healthcare professional.¹

Is Latuda the Same as Abilify?

Latuda and Abilify are not the same medication. Latuda is the brand name for lurasidone and is typically available in oral form, and used to treat conditions like schizophrenia and bipolar disorder.¹ Abilify, the brand name for aripiprazole, is available in both oral and injectable forms. It is used to treat schizophrenia and as a maintenance treatment for bipolar I disorder in adults, often given by healthcare providers via injection.³ While they may have some similar uses, they are different drugs with distinct characteristics.

Is Latuda the Same as Seroquel?

Seroquel (Quetiapine) and Latuda (Lurasidone) are both categorized as atypical antipsychotic medications used to treat conditions like schizophrenia. However, they have some differences in their FDA-approved uses.

Seroquel is approved for schizophrenia in individuals aged 13 and older, as well as for major depression and bipolar disorder in adults.⁴ In contrast, Latuda is approved for schizophrenia in adults and adolescents (13 to 17 years) and for the treatment of depressive episodes associated with Bipolar I Disorder in adults and pediatric patients (10 to 17 years). While they share similarities, they are not the same medication and may have distinct indications and uses.

How Does Latuda Work?

Latuda works by helping to regulate the balance of certain chemicals in the brain. This can improve symptoms associated with conditions like bipolar disorder and major depressive disorder. It helps stabilize mood and reduce symptoms by acting on these brain chemicals. This balancing effect can lead to a reduction in mood swings, depressive episodes, and other symptoms of these disorders, making it easier for individuals to manage their condition and lead a better quality of life.

What Is Latuda Used to Treat?

Latuda (Lurasidone) is an FDA-approved medication for the following conditions:¹

• Schizophrenia in adults and adolescents (13 to 17 years)
• Depressive episodes associated with bipolar I disorder in adults and pediatric patients (10 to 17 years) as both monotherapy and adjunctive therapy with lithium or valproate.

However, Latuda can also be used off-label for the following conditions:⁵

• Bipolar mania
• Irritability and anger in autism spectrum disorder
• anxiety

Off-label use means Latuda is prescribed for conditions or purposes not officially approved by the FDA, based on the healthcare provider’s professional judgment and available evidence.

Common Side Effects of Latuda

Common side effects of Latuda can vary by age and condition. In adults, these may include sleepiness, restlessness, difficulty moving, and nausea. Children may experience similar side effects, with some additional symptoms like runny nose, vomiting, weight gain, or insomnia. If side effects become severe or persistent, consult your healthcare provider for guidance.¹

Common side effects of Latuda include:¹

• Sleepiness or drowsiness
• Restlessness and feeling like you need to move around (akathisia)
• Difficulty moving, slow movements, muscle stiffness, or tremor
• Nausea
• Runny nose (in children)
• Vomiting (in children)
• Weight gain (in children)
• Problems sleeping (insomnia) (in children)

*All medications, including Latuda, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.

Serious Side Effects of Latuda

Latuda can lead to serious side effects, including stroke, neuroleptic malignant syndrome, uncontrolled body movements (tardive dyskinesia), metabolic issues, and more. These require immediate medical attention. Contact your healthcare provider if you experience any of these severe side effects while using Latuda.

Serious side effects of Latuda include:¹

• Stroke
• Neuroleptic malignant syndrome (a life-threatening condition)
• Tardive dyskinesia (uncontrolled body movements)
• High blood sugar (hyperglycemia) and diabetes
• Increased fat levels in the blood
• Low white blood cell count
• Decreased blood pressure (orthostatic hypotension)
• Falls
• Seizures

*All medications, including Latuda, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.

Latuda Warnings & Precautions

It’s important to be cautious when taking Latuda. Elderly patients with dementia-related psychosis have a higher risk of stroke. Watch out for severe conditions like neuroleptic malignant syndrome and tardive dyskinesia.

Regular check-ups are needed to monitor metabolic changes, high blood sugar, and elevated prolactin levels. Blood tests help check for low white blood cell counts. Be careful if you have heart issues, as you may experience sudden drops in blood pressure and fainting.

Avoid taking Latuda if you:¹

• Are an elderly patient with dementia-related psychosis: There’s a higher risk of cerebrovascular adverse events, including stroke, for these individuals.
• Are diagnosed with neuroleptic malignant syndrome: This is a serious condition that requires immediate discontinuation and close monitoring.
• Have a history of allergic reactions to Latuda: Latuda’s components, or similar medications, may lead to severe allergic responses.
• Are diagnosed with severe heart conditions: Heart conditions such as orthostatic hypotension and syncope (fainting) may occur.
• Have a history of low white blood cell counts: Low white blood cell count can be caused by leukopenia, neutropenia, or agranulocytosis. Using Latuda may worsen these conditions.
• Experience significant metabolic changes: This includes high blood sugar, dyslipidemia, and substantial weight gain, which need regular monitoring during Latuda treatment.
• Develop signs of elevated prolactin levels: Females may experience irregular menstrual cycles or breast milk secretion.
• Show signs of tardive dyskinesia: Symptoms such as uncontrolled body movements should be addressed by discontinuing Latuda if clinically appropriate

Latuda Dosages for FDA-Approved Treatment

Latuda dosages are individualized, with typical ranges varying by age and condition. For FDA-approved use, the starting dose for adults with schizophrenia is usually 40 mg daily, while doses for bipolar disorder can range from 20 mg to 120 mg daily.

Adolescents with schizophrenia often begin with lower doses. Age and the specific condition influence dosages, so healthcare providers consider these factors when prescribing. Latuda is approved for adults and adolescents (13 to 17 years) for schizophrenia and adults and pediatric patients (10 to 17 years) for bipolar disorder. Off-label dosages can vary broadly, and consultation with a healthcare provider is crucial.

Latuda Forms & Strengths

Latuda comes in tablet form with strengths ranging from 20 to 120 mg. The choice of the appropriate form and strength depends on factors like the patient’s condition, age, and symptom severity.¹ It is an immediate-release medication, acting relatively quickly after ingestion.

Dosing is tailored to each individual’s needs, and healthcare providers may start with lower doses, adjusting as necessary to achieve the desired therapeutic effect.

Latuda is available in the following forms and strengths:¹

• 20 mg oral tablet
• 40 mg oral tablet
• 60 mg oral tablet
• 80 mg oral tablet
• 120 mg oral tablet

How Should I Take Latuda?

To take Latuda effectively, follow your healthcare provider’s instructions precisely. It’s crucial not to change the dose or discontinue Latuda without consulting your healthcare provider. Latuda should be taken by mouth with food, specifically at least 350 calories to ensure optimal absorption.¹

Complying with these directions ensures the medication works as intended. If you accidentally take too much Latuda, contact your healthcare provider or seek immediate medical attention at a hospital emergency room to address potential concerns. Always remember that taking medications as directed by your prescriber is essential for your well-being.

What Happens If I Miss a Dose of Latuda?

If you miss a dose of Latuda, take it as soon as you remember, unless it’s close to the time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take extra doses to compensate for the missed one. It’s essential to maintain a consistent dosing routine, so consult your healthcare provider if you have concerns about missed doses or need further guidance.

Can You Overdose on Latuda?

Yes, an overdose of Latuda is possible and should be taken seriously. Signs of overdose may include heart rhythm issues, low blood pressure, and other severe symptoms.

If an overdose happens, seek immediate medical attention.

What Should You Do If You Take Too Much Latuda?

If you take too much Latuda, seek immediate medical help. It’s crucial to act promptly in cases of overdose to ensure proper evaluation and treatment.

Healthcare providers will provide supportive care, closely monitor your condition, and consider treatments like gastric lavage and activated charcoal to remove the drug from your system. If you experience an overdose, contact a Certified Poison Control Center for guidance.

What to Avoid When Taking Latuda

When taking Latuda, be cautious of potential interactions with certain medications, like strong CYP3A4 inhibitors and inducers. Avoid consuming grapefruit or grapefruit juice during Latuda treatment, as they can affect Latuda’s effectiveness.

5 substances you should avoid while taking Latuda include:¹

• Medications that strongly inhibit CYP3A4 enzymes: These can make Latuda more potent, so avoid using them together.
• Medications that strongly induce CYP3A4 enzymes: These can make Latuda less effective, so it’s best not to use them alongside Latuda.
• Alcohol: It can interact with Latuda, so be cautious when drinking.
• Herbal supplements or medications that affect CYP3A4 enzymes: These can impact how well Latuda works.
• Substances that make you drowsy: They can intensify Latuda’s sedative effects, so check with your healthcare provider before using them with Latuda.

How to Get a Prescription for Latuda

To obtain a Latuda prescription, consult a healthcare provider like a psychiatrist or primary care physician. They will evaluate your condition, medical history, and symptoms to decide if Latuda is suitable. Since Latuda is prescription-only, you must follow their guidance and take it as directed.

How Much Does Latuda Cost?

The cost range for Latuda (lurasidone) can vary, with the brand version typically priced higher. The brand Latuda can cost around $1,373.41 out of pocket, while the generic lurasidone is generally more affordable. If a person has insurance coverage for Latuda, their policy may pay for all or most of the cost.⁶

Prices can fluctuate based on various factors, including your location and the specific pharmacy you choose.

Questions to Ask Your Healthcare Provider About Latuda

If considering Latuda, consult your psychiatrist or therapist. Ask about benefits, side effects, and tailored treatment. Online psychiatry services can offer a convenient option if changing prescribers is necessary.

Questions to ask your care team about Latuda include:

• How safe is Latuda?
• What’s the expected adjustment period when starting Latuda?
• Are there risks of more serious symptoms when taking Latuda alongside other medications?
• What’s the optimal dosage to minimize side effects?
• Can I consume grapefruit or drink grapefruit juice while on Latuda?
• What should I do if I miss a dose?
• Are there any known interactions between Latuda and my current health conditions?
• What signs of improvement should I expect, and when?
• How often should I schedule follow-up appointments to monitor my progress?
• Are there specific lifestyle changes I should make while on Latuda?
• Is it safe to take Latuda during pregnancy or while breastfeeding?
• How can I access resources or support for managing my condition alongside Latuda treatment?
• Are there any specific dietary restrictions I should be aware of while taking Latuda?
• Can I continue my current exercise routine while on Latuda?
• Could Latuda be considered as an Abilify alternative?

In My Experience

In my experience, open communication with your healthcare provider is essential when considering Latuda. Some clients have found success with Latuda in managing conditions like bipolar disorder and schizophrenia, though challenges and side effects can vary.

Remember that medication is just one part of a comprehensive mental health plan. Seeking support from a healthcare team and exploring therapy alongside medication can offer a holistic approach to mental health. Your doctor’s guidance is invaluable in shaping your treatment journey. Stay engaged in your care, share your experiences, and be an active participant in your mental health path.