ProCentra: Uses, Side Effects, Warnings, & More

What Is ProCentra?

ProCentra is a liquid medication whose active ingredient is dextroamphetamine sulfate. This is a stimulant medication that increases norepinephrine and dopamine in the brain.¹ These chemicals play a major role in attention and impulse control. By increasing the levels of these chemicals, individuals can have enhanced focus and decreased hyperactivity.

ProCentra is FDA-approved for the treatment of attention-deficit/hyperactivity disorder (ADHD) and narcolepsy. The focus of this article will be on its use for ADHD. Stimulant medications such as ProCentra have also been used off-label for the treatment of treatment-resistant depression.² Off-label use means that the medication is prescribed for a condition not specifically approved by the FDA. Healthcare providers may choose to use these medications off-label if, in their professional opinion, they believe the medication will still benefit an individual.

Is There a Generic for ProCentra?

Yes, there are generic versions of this available. The active ingredient in ProCentra is dextroamphetamine sulfate. These generic versions come in liquid formulations like ProCentra. Generic tablet formulations containing dextroamphetamine sulfate are also available.

How Does ProCentra Work?

ProCentra works by increasing the levels of norepinephrine and dopamine in the brain. These chemicals are involved in regulating attention control and impulsivity. It’s thought that dysregulation of these chemicals may cause symptoms of ADHD. By increasing these chemicals in the brain, individuals with ADHD will see improved focus, reduced hyperactivity, and decreased impulsive behaviors.

How Effective Is ProCentra?

ProCentra has shown effectiveness in managing ADHD symptoms, with studies showing improvements in attention, focus, and behavior. Several studies have shown that dextroamphetamine sulfate, the active ingredient in ProCentra, led to significant improvement in children and adults.^3,4Individual responses, however, will vary. Some individuals may respond better to ProCentra.

How Long Does ProCentra Last?

ProCentra is an immediate-release formulation of dextroamphetamine sulfate. The drug lasts for approximately 3-6 hours, though the timeframe will vary from person to person. Because of this shorter duration, the medication often needs to be taken once in the morning and again after 4-6 hours.

How Long Does it Take for ProCentra to Work?

Effects from stimulant medications, such as ProCentra, can often be seen within the first dosing. However, it can take several weeks to reach maximum benefit from the medication.

How Long Do I Need to Keep Taking ProCentra?

The duration of ProCentra treatment varies for each individual and depends on factors such as the severity of ADHD symptoms, treatment response, and the healthcare provider’s recommendations. In many cases, ProCentra is used as a long-term treatment to effectively manage symptoms of ADHD. Your healthcare provider will regularly assess your progress and adjust the treatment as needed.

Side Effects of ProCentra

ProCentra can cause various side effects that vary from person to person. Most side effects, such as headaches and abdominal pain, are mild and will resolve over time. Other common side effects, such as decreased appetite, can last as long as someone is taking the medication.

Common Side Effects of ProCentra

The most common side effects of ProCentra are mild and resolve over time as you adjust to the new medication. These side effects typically don’t require immediate medical attention. However, if the side effects are severe or persistent, notify your healthcare provider to receive recommendations.

Common side effects of ProCentra include:^1,5

• Abdominal pain
• Headache
• Decreased appetite
• Weight loss
• Insomnia
• Dry mouth
• Changes in sex drive

*All medications, including ProCentra, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.

Serious Side Effects of ProCentra

Although rare, ProCentra may potentially cause severe side effects similar to other stimulant medications. Side effects may include impacts on the heart, lungs, and nervous system. These side effects may require immediate medical attention. Seek medical attention immediately if you are experiencing difficulty breathing, chest pain, or psychotic episodes.

Serious side effects of ProCentra include:^1,5

• Allergic reactions
• Chest pain
• Irregular heart rate
• Difficulty breathing
• Seizures
• Hallucinations
• Abnormal movements

*All medications, including ProCentra, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.

ProCentra Warnings & Precautions

When taking ProCentra, be aware of the several warnings and precautions associated with its use. Some individuals may be at a higher risk for severe negative effects from the medication, and they may need to take caution when starting this medication.

Warnings and precautions for taking ProCentra include:¹

• Abuse, misuse, and addiction: Stimulant medications have a high potential for misuse and addiction. Individuals with a history of drug abuse may need to avoid taking ProCentra.
• Risk to those with heart disease: ProCentra can increase the risk for serious heart problems in individuals with a history of heart disease.
• Elevated blood pressure: Stimulant medications such as ProCentra can increase blood pressure and heart rate. Individuals with a history of hypertension will need to be closely monitored for blood pressure changes when taking ProCentra.
• Psychiatric reactions: ProCentra may cause a worsening of behaviors and thought patterns in individuals with a history of psychotic episodes.
• Seizures: ProCentra and other stimulants may increase the risk of seizures in those with a history of seizure episodes.
• Serotonin syndrome: Taking ProCentra with medications that increase serotonin can increase the risk of serotonin syndrome. This is a potentially life-threatening reaction that causes mental status changes, rapid heart rate, blood pressure changes, and seizures.
• Tics: Stimulant medications can worsen tic-like behaviors in individuals with Tourette’s syndrome.
• Allergic reactions: Although rare, allergic reactions to ProCentra can occur. Symptoms of an allergic reaction may include hives, swelling of the face and throat, vomiting, and difficulty breathing.
• Raynaud’s phenomenon: ProCentra and other stimulants can cause Raynaud’s phenomenon. This is a condition in which reduced blood flow to the hands and feet causes numbness, tingling, or pain.
• Suppression of growth: Stimulant medications have been associated with weight loss and a slowing of growth in children

Drug Interactions With ProCentra

ProCentra can interact with various foods, medications, substances, and herbs, potentially leading to harmful effects. Individuals taking ProCentera should be aware of these possible interactions and consult their healthcare provider if there are concerns.

Five substances you should avoid while taking ProCentra include:¹

• Monoamine oxidase inhibitors (MAOIs): Taking MAOIs with ProCentra can increase the risk of elevated blood pressure. MAOIs include isocarboxazid, phenelzine, and selegiline.
• Antidepressants: Medications that increase serotonin can increase the risk of serotonin syndrome. These drugs include selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and tricyclic antidepressants.
• Antihypertensive medications: ProCentra may decrease the effectiveness of medications used to treat high blood pressure.
• St. John’s Wort: St. John’s Wort is an herb that can increase serotonin in the brain. Taking this with ProCentra may increase the risk of serotonin syndrome.
• Anti-seizure medications: Some anti-seizure medications may be less effective when taken with ProCentra. This includes phenobarbital, phenytoin, and ethosuximide.

This is not a comprehensive list of the possible interactions with ProCentra. You should talk with your healthcare provider and your pharmacist about all prescription and over-the-counter medications, herbs, and supplements you take before starting ProCentra.

ProCentra Dosages for FDA-Approved Treatment

ProCentra dosages will vary depending on factors such as age, the condition being treated, response to the medication, and medical history. ProCentra is approved for use in individuals 3 years and older. For those aged 3-5 years, the starting dose is often 2.5 mg per day. For individuals aged 6 or older, the starting dose is often 5 mg, taken once or twice per day. This dose can be increased by 2.5-5 mg each week based on the response to the medication. The maximum dose is typically 40 mg total per day.¹

ProCentra Form & Strengths

The active ingredient of ProCentra is dextroamphetamine sulfate. While this active ingredient is available in tablet or capsule form, the brand name ProCentra is only available as a liquid solution. This solution is an immediate-release formulation.

How to Take ProCentra

ProCentra should be taken as soon as possible upon waking in the morning. It is usually taken twice per day, with the second dose taken 4-6 hours after the first dose. It can be taken with or without food. ProCentra should not be taken in the evening as it can impact the ability to fall asleep.

Can You Become Addicted to ProCentra?

Stimulant medications, such as ProCentra, come with a high risk of addiction if taken inappropriately. Because of this risk, there are often limits to how much can be prescribed at one time. Your healthcare provider will also require frequent follow-up visits to assess this risk. The risk for addiction is low for individuals who follow the recommendations of their healthcare provider and pharmacist.

Can You Overdose on ProCentra?

You can overdose on ProCentra if too much is taken at one time or if the medication is taken with other stimulant medications. There are many possible symptoms of overdose. Some symptoms of overdose are restlessness, aggressive behavior, hallucinations, fast heartbeat, and fast breathing.

What Should You Do If You Take Too Much ProCentra?

If too much ProCentra is taken at one time, call the poison control helpline at 1-800-222-1222. Seek immediate medical attention if an overdose leads to seizures, difficulty breathing, or coma.

How to Get ProCentra

To obtain a prescription for ProCentra, first consult with a qualified healthcare provider, such as a psychiatrist, pediatrician, or primary care physician. These healthcare providers can assess your symptoms and medical history to determine if ProCentra is appropriate for your needs. ProCentra is only available through a prescription. This prescription can be obtained through online psychiatry services or in-person office visits.

How Much Does ProCentra Cost?

Without insurance or coupons, ProCentra can cost as much as $250 for a prescription.⁶ This is the cash cost of ProCentra without insurance. Your out-of-pocket costs may vary depending on your insurance coverage. Coupons and discounts are available through the manufacturer or online platforms, such as GoodRx and SingleCare.

How to Know if ProCentra Is Right for You

When considering if ProCentra is the right treatment for you, there are many factors to consider under the guidance of a qualified healthcare provider. Begin by discussing your symptoms and medical history with your psychiatrist or physician. Based on your individual needs, a healthcare provider can offer treatment options and explain the potential risks and benefits.

FAQs About ProCentra

Frequently asked questions about ProCentra often revolve around its safety during pregnancy and breastfeeding, alternative treatment options, and safe storage.

Can You Take ProCentra While Pregnant or Breastfeeding?

The effects of ProCentra during pregnancy have not been well studied, but there are possible risks to the developing fetus. The decision to continue taking ProCentra during pregnancy should be made in conjunction with your healthcare provider. ProCentra is excreted in breast milk, and mothers taking ProCentra should avoid breastfeeding.

What Are Some Alternatives to ProCentra?

There are many alternatives to ProCentra for managing ADHD symptoms. These include other stimulant ADHD medications, such as Adderall and Vyvanse. Non-stimulant medication options include Strattera and Intuniv. Additionally, therapy has also been shown to be effective in managing ADHD symptoms.

How Should ProCentra be stored?

ProCentra should be stored at room temperature, away from moisture and heat. Keep it tightly closed in its original container. The medication should be kept out of the reach of children. To dispose of unneeded medications, talk to your pharmacist or local garbage department to learn about take-back programs in your community. Never flush the medication down the toilet.

Questions to Ask Your Healthcare Provider About ProCentra

When planning your initial evaluation by your healthcare provider, be prepared with a list of questions you might have about ProCentra. These questions may include what to expect when starting the medication and what to do if side effects appear.

Questions to ask your care team about ProCentra include:

• How safe is ProCentra?
• How long will it take for me to adjust to taking ProCentra?
• Am I at risk for more serious symptoms if I am already taking other medications?
• What lifestyle or behavioral strategies can complement ProCentra treatment for ADHD in children?
• Is it possible to maintain long-term medication adherence with ProCentra, and are there alternatives to consider?
• Are there any long-term effects I should be aware of when taking ProCentra?
• What steps should I take if I experience unexpected or concerning side effects?
• What are the signs that ProCentra may not be working effectively for me?
• How long is ProCentra typically prescribed for?
• Will taking ProCentra affect my ability to drive or operate machinery?