*An off-label use of a medication is a use that is not FDA-approved. Prescribers can decide to use a medication off-label because, in their professional judgment, they believe it may offer a benefit to someone.
*An off-label use of a medication is a use that is not FDA-approved. Prescribers can decide to use a medication off-label because, in their professional judgment, they believe it may offer a benefit to someone.
Quviviq and Ambien are both FDA-approved medications for insomnia, but they work differently. Quviviq contains daridorexant, while Ambien contains zolpidem, a sedative-hypnotic. Quviviq targets orexin, a neurotransmitter involved in sleep regulation, which may promote better sleep quality. Ambien acts on the neurotransmitter GABA to induce sleep. Both medications have unique mechanisms and may vary in side effects and efficacy for individual patients.1, 2
Quviviq is a controlled substance, which means that it’s more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
Boxed Warning: Zolpidem (Ambien/Ambien CR)
Zolpidem, the active ingredient in Ambien, has a black box warning. These are the most serious types of warnings from the Food and Drug Administration (FDA). Zolpidem can cause dangerous sleep behaviors like sleep-walking and sleep-driving. These behaviors can lead to serious injury and possibly death. Talk with your doctor about any sleep behaviors you have had or that you have while taking zolpidem to determine if the medication is safe for you to take.
Ambien is a controlled substance, which means that it’s more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
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What Is Quviviq (Daridorexant)?
Quviviq, containing the active ingredient daridorexant, is FDA approved as a treatment for insomnia. FDA approval means a medication has been deemed by the FDA to be safe and effective for a specific use based on data from clinical trials. This medication falls under the class of drugs known as orexin receptor antagonists, which work by regulating wakefulness and sleep.
The generic version of Quviviq is not available due to the relatively recent FDA approval of this medication. Only the brand name version Quviviq is available in the United States at this time.1
What Is Ambien?
Ambien, containing the active ingredient zolpidem, is FDA-approved to treat insomnia, a condition characterized by difficulty falling asleep or staying asleep. Additionally, Ambien is sometimes prescribed for off-label (non-FDA-approved) uses, such as a treatment for restless leg syndrome or as a pre-anesthetic sedative.3 Off-label use refers to the practice of prescribing medication for purposes other than those approved by the FDA.
Ambien belongs to the class of drugs known as sedative-hypnotics, which work by affecting the activity of the neurotransmitter GABA to induce sleep. As of the latest update, generic versions of Ambien are available, and there have been no reports of brand names being discontinued.2
Key Differences Between Quviviq Vs Ambien
Quviviq and Ambien are both FDA-approved medications for insomnia, yet they differ in how they promote improved sleep and their potential side effects. Ambien, containing zolpidem, affects levels of GABA in the brain, while Quviviq, with daridorexant, affects the brain chemical orexin.
While Ambien is available in generic form, Quviviq remains available only as a brand name medication. Additionally, individual responses and side effect profiles may differ, necessitating careful consideration with healthcare providers when selecting the appropriate medication. Both medications have the potential to alter sleep behavior and affect mood.
Here are the key differences between Quviviq versus Ambien:1, 2
Key Components | Quviviq | Ambien |
What is the generic name? | Daridorexant (generic not available) | Zolpidem (generic available) |
What is the active ingredient? | Daridorexant | Zolpidem |
What forms does it come in? | Tablets | Tablets, extended-release tablets, and oral spray |
What are the typical dosages? | Dosages may vary, but common doses include 25 mg and 50 mg tablets taken once daily, usually before bedtime. | The typical dosage for immediate-release tablets is 5 mg for women and either 5 mg or 10 mg for men, taken once nightly before bedtime. Extended-release tablets are available in doses of 6.25 mg and 12.5 mg, usually taken once per night before bedtime. |
Who is approved to take it? | Quviviq is approved for adults suffering from insomnia, specifically those looking to improve sleep quality. | Ambien is approved for the treatment of insomnia in adults. |
Additional Information | Compared to Ambien, Quviviq targets orexin receptors rather than GABA receptors, potentially offering a different mechanism for addressing sleep issues. However, being a newer medication, long-term safety and efficacy data may still be emerging. | Unlike Quviviq, Ambien has been available for a longer time and has established efficacy and safety profiles. Its availability in generic form may offer a more cost-effective option for some patients. However, Ambien's mechanism of action, targeting GABA receptors, may lead to different side effect profiles compared to Quviviq. |
How Do Ambien Vs Quviviq Work?
Ambien and Quviviq work differently to help improve sleep. Ambien contains the active ingredient, which is thought to work by affecting levels of the neurotransmitter GABA in your brain. When these levels change, they may help calm down brain activity, making it easier for you to fall asleep.
Quviviq has daridorexant as its active ingredient, which targets a different brain chemical called orexin. By affecting orexin levels in the brain, Quviviq may help regulate the sleep-wake cycle, promoting better overall sleep quality. So, while both medications help you sleep, they do it in slightly different ways.
How Are Quviviq & Ambien the Same?
Quviviq and Ambien share similarities as FDA-approved medications that can treat insomnia, a common sleep disorder affecting many individuals. Both drugs aim to improve sleep quality by helping users fall asleep faster and stay asleep longer. Despite their differing active ingredients and mechanisms of action—Quviviq targeting orexin receptors while Ambien acts on GABA receptors—both medications ultimately work toward achieving the common goal of promoting restful sleep.
Additionally, they are typically prescribed for short-term use and may carry similar potential side effects such as dizziness, drowsiness, and headache. While there are distinctions between the two, both Quviviq and Ambien are valuable options for individuals seeking relief from sleep difficulties under the guidance of a healthcare professional.1, 2
What Are Quviviq Vs Ambien Used to Treat?
Quviviq and Ambien are medications primarily used to treat insomnia, a sleep disorder characterized by difficulty falling asleep or staying asleep. Additionally, Ambien is sometimes prescribed off-label for conditions such as restless leg syndrome or as a pre-anesthetic sedative.
The table below compares the medical and mental health conditions Quviviq and Ambien are used to treat:1, 2
Condition | Quviviq (daridorexant) | Ambien (zolpidem) |
Insomnia | FDA-approved | FDA-approved |
Restless leg syndrome | No | Off-label |
Pre-anesthetic sedative | No | Off-label |
Post-brain injury recovery3 | No | Off-label |
Which Is Better for Insomnia, Quviviq or Ambien/Ambien CR?
Determining which medication, Quviviq or Ambien, is better for insomnia depends on various factors including individual response, cost, side effect profile, and healthcare provider recommendation. Clinical studies have shown both medications to be effective reducing the time it takes to fall asleep and duration. Quviviq, with its unique mechanism targeting orexin receptors, offers a novel approach to treating insomnia, potentially providing improved sleep quality.4
However, Ambien and its extended-release formulation, Ambien CR, have been widely used for decades and have established efficacy and safety profiles. Ultimately, the choice between Quviviq and Ambien/Ambien CR should be made in consultation with a healthcare provider, taking into consideration individual needs and preferences.5
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Quviviq Vs Ambien Dosages
Quviviq and Ambien have different dosages and formulations tailored to the individual needs of patients. While Quviviq typically comes in 25 mg and 50 mg tablets, Ambien is available in various strengths including 5 mg and 10 mg for immediate-release tablets and 6.25 mg and 12.5 mg for extended-release formulations. Dosages can vary depending on the disorder being treated, the patient’s age, and other individual factors.
Quviviq Form & Dosages
Quviviq is only available in tablet form. The dosages typically range from 25 mg to 50 mg. By working closely with a healthcare professional, patients can ensure they receive the most suitable treatment regimen for their unique circumstances, optimizing the potential benefits of Quviviq therapy.1
Ambien Form & Dosages
Ambien is available in various formulations, including immediate-release tablets, extended-release tablets, and an oral spray, providing flexibility in treatment options for individuals with insomnia. The typical dosages for immediate-release tablets are 5 mg for women and either 5 mg or 10 mg for men, taken once before bedtime. Ambien is not intended to be taken every night.
Extended-release tablets are available in doses of 6.25 mg and 12.5 mg, usually taken once before bedtime. The oral spray formulation offers an alternative method of administration for those who may have difficulty swallowing tablets.
Side Effects of Quviviq Vs Ambien
Quviviq and Ambien may cause similar side effects, including dizziness, drowsiness, headache, and nausea. While these side effects are commonly experienced and often mild, some individuals may require medical attention if they persist or worsen. Additionally, both medications may carry the risk of more serious side effects such as allergic reactions or abnormal behaviors during sleep, although these are less common.
Common side effects from taking Quviviq may include:*1
- Headache
- Dizziness
- Drowsiness
- Fatigue
- Nausea
Serious side effects from taking Quviviq may include:*1
- Sleepwalking
- Allergic reactions such as swelling of the tongue or throat, trouble breathing, or severe rash
- Complex sleep behaviors like sleep-driving or preparing and eating food while asleep
- Severe drowsiness
- Abnormal thinking or behavioral changes
Common side effects from taking Ambien may include:*2
- Drowsiness
- Dizziness
- Headache
- Nausea
- Fatigue
- Disorientation
- Confusion
- Anxiety
Serious side effects from taking Ambien may include:*2
- Complex sleep behaviors like sleep-driving or preparing and eating food while asleep
- Severe allergic reactions such as swelling of the tongue or throat, trouble breathing, or severe rash
- Abnormal thinking or behavioral changes
- Memory loss or amnesia
- Depressed mood or worsening of depression
*All medications, including Ambien and Quviviq, have a risk of side effects, including serious side effects. This is not a complete list of side effects. You should talk with your healthcare professional about the benefits and risks of any medication before starting treatment.
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Warnings & Precautions for Ambien & Quviviq
Both Ambien and Quviviq come with important warnings and precautions that users should be aware of, as outlined in their respective Prescribing Information (PI). These warnings include the potential for complex sleep behaviors such as sleep-driving, abnormal thinking, and behavioral changes, as well as the risk of severe allergic reactions and memory loss or amnesia.
Additionally, both medications advise against consuming alcohol while taking them due to the potential for increased drowsiness and impairment.1, 2
Risks to consider when taking Quviviq include:1
- Allergic reactions: While allergic reactions to Quviviq are rare, they can occur. Symptoms may include difficulty breathing, hives, swelling of the face, lips, tongue, or throat. If any signs of an allergic reaction are experienced, seek immediate medical care.
- Central nervous system effects and daytime impairment: This medication may impair daytime wakefulness even when used correctly. It is important to not do any tasks that require focus such as operating vehicles until it is known how it affects each individual.
- Worsening of depression/suicidal ideation: Patients with psychiatric disorders, including insomnia, are at increased risk of suicide. In primarily depressed patients treated with hypnotics, worsening of depression and suicidal thoughts and actions (including completed suicides) have been reported.
- Worsening of sleep related conditions/behaviors: Complex sleep behaviors, including sleepwalking, sleep driving, and engaging in other activities while not fully awake (e.g., preparing and eating food, making phone calls, having sex), have been reported to occur with the use of Quviviq.
- Sleep paralysis: Sleep paralysis, an inability to move or speak for up to several minutes during sleep-wake transitions, and hypnagogic/hypnopompic hallucinations, including vivid and disturbing perceptions, can occur.
- Patients with compromised respiratory function: The effects of Quviviq on respiratory function should be considered if prescribed to patients with compromised respiratory function.
There may be additional warnings or precautions with this medication. Talk with your healthcare provider about all risks before you start taking this medication.
Risks to consider when taking Ambien include:2
- Complex sleep behaviors: Ambien may cause activities such as sleep-driving, preparing and eating food while asleep, or making phone calls while not fully awake. Patients should be cautious and report any unusual behaviors to their healthcare provider.
- Severe allergic reactions: While rare, Ambien may lead to severe allergic reactions such as swelling of the tongue or throat, trouble breathing, or severe rash. Immediate medical attention is necessary if any signs of an allergic reaction occur.
- Central nervous system effects and daytime impairment: Ambien can cause central nervous system depression, leading to drowsiness, dizziness, and impaired coordination, which may persist into the following day. Patients should avoid activities requiring mental alertness until they know how Ambien affects them.
- Risk of dependency and withdrawal: Ambien has the potential for addiction or physical dependence, particularly with prolonged use or high doses. Abrupt discontinuation may lead to withdrawal symptoms. Gradual tapering of your dosage by your prescriber is recommended to minimize these effects.
- Mental health effects: Ambien may worsen depression or lead to the emergence of suicidal thoughts, particularly in individuals with pre-existing mental health conditions. Patients should monitor their mood or behavior for these changes and seek medical help if necessary.
There may be additional warnings or precautions with this medication. Talk with your healthcare provider about all risks before you start taking this medication.
Can You Take Quviviq or Ambien While Pregnant?
It is generally not recommended to take Quviviq or Ambien during pregnancy unless the potential benefits outweigh the risks. Pregnant individuals should consult with their healthcare provider to discuss the potential risks and benefits of using these medications during pregnancy. Alternative non-pharmacological approaches for managing insomnia should be explored whenever possible, especially during the first trimester when fetal development is most vulnerable.1, 2
Is it Safe to Take Quviviq or Ambien Every Night?
Both Quviviq and Ambien are generally recommended for short-term use due to the risk of tolerance, dependence, and potential adverse effects with long-term use. Regular nightly use may lead to decreased effectiveness over time, as the body can develop tolerance to the medication’s effects. Additionally, dependence and withdrawal symptoms may occur if the medications are suddenly stopped after prolonged use.1, 2
Potential Drug Interactions With Ambien & Quviviq
Both Ambien and Quviviq have the potential to interact with various substances, including other medications, alcohol, and certain foods. These interactions can alter the effectiveness of the medications or increase the risk of side effects. For example, combining Ambien or Quviviq with other central nervous system depressants, such as opioids or benzodiazepines, may promote sedation and respiratory depression.
Avoid consuming alcohol while taking Ambien or Quviviq, as it can increase drowsiness and impair cognitive function. Additionally, certain foods, such as grapefruit juice, may interfere with the metabolism of these medications, leading to increased blood levels and potentially adverse effects. It is crucial for individuals to inform their healthcare provider about all medications, supplements, and substances they are taking to minimize the risk of interactions and ensure the safe and effective use of Ambien or Quviviq.1, 2
Disclaimer: Taking certain medications, herbs, or supplements alongside Ambien and Quviviq can change how these medications work in your body or increase the risk of serious side effects. This article does not consider all the possible interactions. Please let your doctor, psychiatrists, and pharmacists know about all the products you currently use, such as prescription medication, nonprescription drugs, and herbal supplements. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.
Can You Take Ambien or Quviviq With Alcohol?
It is not recommended to take Ambien or Quviviq with alcohol. Both medications are central nervous system depressants, and combining them with alcohol can increase the risk of severe drowsiness, impaired cognitive function, and respiratory depression. Alcohol can increase the sedative effects of Ambien and Quviviq, making it more difficult to wake up and increasing the likelihood of accidents or injuries.
Quviviq Vs Ambien Cost
The average cost of Quviviq and Ambien can vary depending on factors such as dosage, formulation, and pharmacy location. Without insurance, Quviviq tends to be far more expensive than Ambien. A month’s supply of Quviviq can range from approximately $300 to $600, while Ambien typically costs between $20 and $100 per month. It’s important to note that insurance coverage for these medications may vary, and some insurance plans may not cover them at all.
Additionally, some pharmacies offer generic versions of Ambien at a lower cost, which can be a more affordable option for individuals looking to save on their medication expenses. Patients should explore all available options and consult with their healthcare provider to find the most cost-effective solution for their specific needs.
Do you have sleep apnea? Find out with at-home sleep study.
Find out if a sleep study is right for you! Do a sleep study from the comfort of your own bed. Circle Medical will send you a small WESPER sleep monitoring device, which pairs with an app on your phone. After a two-night study, you can discuss the results with your provider at Circle Medical. The cost with insurance ranges from $0 to $250.
Which Is Right for You: Ambien or Quviviq?
Determining whether Ambien or Quviviq is the right medication for your needs requires careful consideration of various factors, including your health history, specific sleep issues, and individual response to treatment. Consulting with a healthcare provider is crucial in making this decision, as they can evaluate your medical history and recommend the most appropriate medication based on your unique circumstances.
If seeing a doctor in person isn’t feasible, online pharmacy services can offer convenient alternatives for discussing your options and obtaining prescriptions. These services can help you weigh the benefits and risks of each medication, explore potential cost-saving options, and provide guidance on how to effectively manage your sleep concerns.
How to Get a Prescription for Quviviq or Ambien
To obtain a prescription for Ambien or Quviviq, individuals must first consult with a licensed healthcare provider, such as a primary care physician, psychiatrist, or sleep specialist. These medications are only available by prescription due to their potential for misuse and side effects. During a medical appointment, the healthcare provider will conduct a thorough evaluation of the patient’s medical history, sleep patterns, and any underlying health conditions to determine the most appropriate treatment option.
They will discuss the benefits and risks of Ambien and Quviviq, taking into account factors such as the severity of insomnia, potential drug interactions, and the patient’s preferences. Based on this assessment, the healthcare provider will then issue a prescription for the recommended medication, providing instructions on how to take it safely and effectively.
Questions to Ask Your Health Team About Ambien & Quviviq
When considering medications like Ambien and Quviviq for the treatment of insomnia, you may have questions. Before your appointment, take some time to reflect on your sleep patterns, concerns, and any questions or apprehensions you may have regarding these medications.
Questions to ask your prescriber about Ambien and Quviviq include:
- What are the potential side effects of taking this medication, and how common are they?
- How long does it typically take for the medication to start working, and how long will the effects last?
- Are there any lifestyle changes or habits I should consider adopting to improve the effectiveness of the medication?
- Are there any specific precautions I should be aware of when taking this medication, such as avoiding certain activities or substances?
- What is the recommended dosage for this medication, and how should I take it? Should I take it with or without food?
- Are there any potential drug interactions I should be aware of, including with over-the-counter medications or supplements?
- How often will I need to follow up with you to monitor my response to the medication and adjust the treatment plan if necessary?
- What are the risks of dependency or withdrawal associated with this medication, and how can I minimize these risks?
- Can you provide information about any discounts, coupons, or savings programs that may help reduce the cost of the medication?
- Is this medication the best option for my specific sleep issues, or are there alternative treatments we should consider?
- Are there any long-term effects or concerns I should be aware of if I continue taking this medication for an extended period?
- What steps should I take if I experience any unusual or concerning symptoms while taking this medication?
- What are some other alternatives to Ambien?
In My Experience
Choosing Therapy strives to provide our readers with mental health content that is accurate and actionable. We have high standards for what can be cited within our articles. Acceptable sources include government agencies, universities and colleges, scholarly journals, industry and professional associations, and other high-integrity sources of mental health journalism. Learn more by reviewing our full editorial policy.
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DailyMed – Quviviq, Daridorexant tablet, film coated. (2023). Dailymed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
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DailyMed – Ambien CR – Zolpidem tablet. (2019). Dailymed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
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Zolpidem StatPearls. (2022). National Library of Medicine, NIH. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK442008/
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Robinson, C. L., Supra, R., Downs, E., Kataria, S., Parker, K., Kaye, A., Viswanath, O., & Urits, I. (2022). Daridorexant for the Treatment of Insomnia. Health psychology research, 10(3), 37400. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425279/
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Greenblatt, D. J., & Roth, T. (2012). Zolpidem for insomnia. Expert opinion on pharmacotherapy, 13(6), 879–893. Retrieved from https://pubmed.ncbi.nlm.nih.gov/22424586/
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