Zurzuvae (Zuranolone) Side Effects

Important Things to Know About Taking Zurzuvae

Before starting Zurzuvae, it’s important to understand what to expect during your course of treatment. Your prescriber will discuss your dosage, how to take your medication, precautions for the medication, potential side effects you may experience, and what to do if side effects become a problem.

How Do I Take Zurzuvae?

Zurzuvae is taken once daily in the evening for 14 days. It should be taken every evening as directed for the full course of treatment unless otherwise instructed by your provider. It is recommended to take Zurzuvae with fat-containing food.¹

How Long Does It Take for Zurzuvae to Work?

Zurzuvae is taken as a single 14-day course of treatment, and symptoms typically improve by the end of this timeframe, and sometimes sooner.² Each person may have a different response time based on how their body absorbs and processes the medication.

Can Zurzuvae Make You Feel Worse at First?

Yes, some people starting Zurzuvae may experience drowsiness, dizziness, and other potential side effects.¹ If you experience worsened symptoms or side effects of any kind, contact your provider immediately.

What Happens If I Miss a Dose?

If you forget to take your Zurzuvae dose, take it as soon as you remember. If your next dose is due soon, skip the missed one and take your next scheduled dose. Never take two doses at once, and continue taking your medication as prescribed unless your prescriber directs you to do otherwise.¹

Who Experiences Side Effects More?

Some patients may experience side effects from Zurzuvae more than others. While predicting who will respond poorly is difficult, specific patient populations should be cautious with Zurzuvae.

Patients taking other medications or substances that can slow the central nervous system, including alcohol, are at risk of serious side effects This can include excessive drowsiness, slow thinking, and trouble walking. Those taking medications affecting the enzyme CYP3A4 are at an increased risk of side effects from Zurzuvae.¹

Populations who are at an increased risk for experiencing side effects include those who:¹

• Are pregnant or are planning to become pregnant
• Are breastfeeding or are planning to breastfeed
• Have liver problems
• Have kidney problems
• Have a history or risk of dependence on prescription medication or alcohol
• Drink alcohol

How to Cope With Common Zurzuvae Side Effects

There are ways to cope with the most common Zurzuvae side effects*. Many may go away on their own during the first few weeks, but others may become hard to tolerate. Contact your provider if side effects persist or worsen.

Drowsiness

Drowsiness is a common side effect of Zurzuvae that can manifest as excessive sleepiness or a general lack of alertness. This drowsiness might impair your ability to concentrate, perform tasks, or drive safely. It’s important to avoid activities that require mental focus or physical coordination until you understand how Zurzuvae affects you.

If drowsiness becomes problematic, consider taking the medication at bedtime to minimize its impact on daytime activities. However, if drowsiness persists or worsens, contact your provider as soon as possible. They may suggest changes to your dosage or timing, or recommend other strategies to help you manage it. Because of the risks, patients should not drive or activities requiring alertness for at least 12 hours after taking Zurzuvae.³

Headaches

Headaches are a possible side effect of taking Zurzuvae and can range from mild discomfort to more severe pain. These headaches may occur because of the changes in brain chemicals or other physiological responses as your body adjusts to the medication. While they may be manageable, frequent or severe headaches can become disruptive to your daily routine.

Staying hydrated, maintaining a regular sleep schedule, and managing stress can help reduce the likelihood of headaches. Over-the-counter pain relievers may offer relief for mild cases, but consult your healthcare provider before using any new medications while taking Zurzuvae.

Diarrhea & Nausea

To reduce diarrhea and nausea, follow meal timing recommendations with Zurzuvae and eat smaller, more frequent meals. Also, drinking plenty of water and reducing spicy or rich foods may help.

You may also try ginger or peppermint teas, but talk with your healthcare provider before taking any prescription or over-the-counter medicine or using supplements such as tea. If diarrhea and nausea persist or get worse, consult your provider as soon as possible.¹

Urinary Tract Infections

Urinary tract infections (UTIs) are a potential side effect associated with Zurzuvae. UTIs can start as discomfort or pain while urinating, increased frequency of urination, and a persistent urge to urinate. These infections occur when bacteria enter the urinary tract and can lead to discomfort, pain, and potential complications if left untreated.¹

To manage and prevent UTIs, maintain good hygiene practices, drink plenty of fluids, and urinate after sexual activity. If you experience symptoms of a UTI, reach out to your healthcare provider right away. They can diagnose the infection, prescribe appropriate antibiotics if necessary, and offer guidance on strategies to prevent future occurrences.

*It’s important to remember that individual experiences with Zurzuvae can vary, and the list of potential side effects provided may not encompass every possibility. Before starting any medication, including Zurzuvae, it’s crucial to have an open discussion with your healthcare provider.

More Ways to Manage Zurzuvae Side Effects

Here are more ways to cope with and reduce the impact of Zurzuvae side effects.

Practice Good Sleep Hygiene

Following good sleep hygiene practices can help you feel rested while your body adjusts to the medication. Try to wake up and go to bed about the same time each day, and make sure your sleeping environment is relaxing and comfortable to you. If you experience drowsiness, avoid doing activities that require alertness, such as driving or operating machinery.

Healthy Lifestyle Activities

Eating well, sleeping enough, and getting adequate exercise are all parts of a healthy lifestyle. These activities are important for all aspects of your physical and mental health and can help you endure the impact of side effects.

Follow a Daily Routine

Following your normal routine is important whether or not the medication is working yet. Doing your regular daily activities can keep life more predictable and reduce stress as you adjust to the medication. Also, be sure you are taking your medication as prescribed and at a consistent time each day.

Consider Therapy

Psychotherapy can support you by addressing the impact of side effects and helping you develop strategies to manage them. For in-person treatment, your primary care provider or insurance company can provide a referral, or you may get one from family or friends.

To find an online therapist, an online therapist directory is a great starting point. Many online psychiatry platforms, such as Talkiatry and Brightside Health, also offer therapy services.

Should I Stop Taking Zurzuvae If I Start Feeling Side Effects?

Do not stop taking Zurzuvae unless you have been advised to do so by your provider. Doing so can cause uncomfortable symptoms, including insomnia, palpitations, decreased appetite, nausea, and excessive sweating.

If you are experiencing side effects from your medication, tell your provider. They will help you determine the best course for continued treatment, which may include changing your dosage, the time for your dosage, or your medication. If your doctor determines discontinuing your medication is the best option, they will provide a plan for stopping your medication gradually, which can minimize your risk of developing withdrawal symptoms.

When Should I Call My Doctor About Zurzuvae Side Effects?

Side effects are one of the most common reasons people choose to stop taking medication. While some effects can be managed and may fade away, some do not go away unless a person stops taking the medication. Side effects can occur even if you are taking your medication correctly.

If side effects persist or become hard to tolerate, contact your provider as soon as possible so you can consider your treatment options. While not common, some people taking Zurzuvae may experience serious side effects. These effects often require immediate medical care and some may be life-threatening. If you notice any of the serious side effects listed above, seek medical care immediately.

How to Get a Prescription for Zurzuvae or Alternative Medications

When getting a prescription for Zurzuvae or an alternative in person, start with an evaluation of your symptoms by your primary provider. A physician, nurse practitioner, or physician assistant can help you start this process. If needed, they may refer you to a psychiatrist or specialist to determine if a prescription for Zurzuvae alternatives should be included in your treatment plan.

To get an online prescription for a Zurzuvae or an alternative, you will also start by completing an evaluation with an online psychiatric provider. Because Zurzuvae is a controlled substance, you must do your evaluation with a provider that can and will prescribe these types of medications.

We have thoroughly reviewed platforms like Talkiatry that prescribe controlled substances, such as Zurzuvae. They also prescribe non-controlled substances such as antidepressants if your provider determines they may be a better option for you.