Mounjaro (tirzepatide) is an FDA-approved medication to help lower high blood sugar with type 2 diabetes, along with diet and exercise. It works by targeting two important substances in our gut, GLP-1 and GIP. It helps control blood sugar levels and may promote weight loss. Mounjaro is also used off-label for obesity. The most common side effects are nausea and diarrhea. It’s important to talk to your provider or pharmacist to determine if Mounjaro is right for you.1
What Is Mounjaro & How Is it Used?
Mounjaro, with the active ingredient tirzepatide, belongs to a drug class called unimolecular dual agonists of GLP-1 and GIP receptors. This special class of medications is designed to help people with type 2 diabetes. Mounjaro works in a unique way by targeting specific receptors in your gut, helping to control your blood sugar levels and manage your weight. One thing to keep in mind is that Mounjaro doesn’t have a generic version available, so it may be costly.
Mounjaro may also be used off-label for treating obesity.1,2 An off-label use of a medication is a use that is not FDA-approved. Prescribers can decide to use a medication off-label because, in their professional judgment, they believe it may offer a benefit to someone.
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Common Side Effects of Mounjaro
Mounjaro can lead to common stomach-related side effects, including abdominal pain, indigestion, nausea, vomiting, and heartburn. While most side effects are mild and temporary, it’s important to monitor your health. If any of these side effects become severe or persist, seeking medical attention is advised. Always consult your healthcare provider or pharmacist to discuss any concerns and ensure the best treatment plan for you.1,2
Common side effects of Mounjaro can include:*1,2
- Abdominal pain
- Constipation
- Decreased appetite
- Diarrhea
- Indigestion
- Nausea
- Vomiting
- Heartburn
*All medications, including Mounjaro, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your provider or pharmacist about any questions you have and to understand the potential side effects and benefits of any medication.
Mild Side Effects of Mounjaro
Mounjaro may cause mild side effects in some people. These can include sinus tachycardia (a slightly faster heartbeat), abdominal distention (feeling bloated), eructation (burping), flatulence (passing gas), gastroesophageal reflux disease (acid reflux), hypersensitivity reaction, and injection-site reaction. These effects are usually not serious and often go away on their own. Talk to your provider or pharmacist if you notice any changes or discomfort, as they can help you manage these issues and ensure your treatment continues smoothly.1,2,3
In addition to the common side effects listed above, other mild side effects of Mounjaro can include:*1,2,3
- Sinus tachycardia (a slightly faster heartbeat)
- Abdominal distention (feeling bloated)
- Eructation (burping)
- Flatulence (passing gas)
- Gastroesophageal reflux disease (acid reflux)
- Injection-site reaction, such as itching at the injection site
- Mild allergic reaction
*All medications, including Mounjaro, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your provider or pharmacist about any questions you have and to understand the potential side effects and benefits of any medication.
Serious Side Effects of Mounjaro
While it’s uncommon, certain individuals could experience severe and potentially life-threatening reactions. Alert your doctor or seek immediate medical attention if you experience any of these serious side effects. It is crucial to follow your provider’s guidance closely. Report any unusual symptoms immediately. Your healthcare provider will monitor you carefully to minimize these risks.1,2,3
Serious side effects of Mounjaro include:*1,2,3
- Hypoglycemia (low blood sugar)
- Increased risk of certain thyroid tumors**
- Gallbladder disease
- Pancreatitis (inflammation of the pancreas)
- Kidney problems
- Serious allergic reaction
*All medications, including Mounjaro, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your provider or pharmacist about any questions you have and to understand the potential side effects and benefits of any medication.
**This medication carries a black box warning for this serious risk.
How to Manage Mounjaro Side Effects
Managing Mounjaro’s side effects involves various steps depending on their severity. For mild effects like stomach discomfort or bloating, over-the-counter remedies might help. In contrast, for severe symptoms like hypoglycemia or acute kidney injury, immediate medical attention is crucial. Always consult your healthcare provider or pharmacist for guidance.1,4,5
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Allergic Reactions
Allergic reactions to Mounjaro can vary from mild to serious. In cases of serious allergic reactions, it’s crucial to discontinue Mounjaro immediately and seek immediate medical assistance if you experience symptoms like facial swelling, difficulty breathing or swallowing, severe rash or itching, fainting, or a very rapid heartbeat. Always prioritize your safety and promptly report any concerning symptoms to your healthcare provider.1,3
What you can do
If someone encounters allergic reactions to Mounjaro, it’s essential to seek medical assistance promptly. Your healthcare provider will evaluate the reaction’s seriousness and decide if discontinuing Mounjaro is necessary. Depending on your health condition and requirements, alternative medications or treatment approaches can be considered.1,3
Digestive Problems
Digestive problems associated with Mounjaro can vary in intensity, spanning from mild discomfort to more serious issues. Mild symptoms like occasional stomach upset or changes in appetite may improve on their own. However, if you experience severe digestive problems such as persistent abdominal pain, severe diarrhea, or vomiting, it’s important to consult your healthcare provider promptly. They can help determine the appropriate steps to manage these symptoms.1,2,5
What you can do
If you’re experiencing digestive problems while taking Mounjaro, it’s crucial to contact your provider immediately for guidance. They can assess your symptoms and recommend appropriate steps, which may include adjusting your medication or treatment plan to alleviate these issues effectively. 1,4,5
Pancreas Inflammation
Experiencing symptoms of pancreatitis while on Mounjaro requires prompt action. If you encounter severe, unrelenting abdominal pain, possibly radiating from your abdomen to your back, along with or without vomiting, discontinue Mounjaro immediately and contact your healthcare provider right away. They will provide necessary guidance and assess your condition to ensure the best steps are taken to manage inflammation of the pancreas and prioritize your health.1,3,5
What you can do
If you experience any symptoms of pancreas inflammation, severe abdominal pain, or any other concerning side effects while taking Mounjaro, it’s crucial to contact your prescriber right away for guidance. They can assess your symptoms, address pancreatitis or other issues promptly, and recommend appropriate steps to ensure your health and safety are prioritized throughout your treatment.1,4
Boxed Warning: Risk of Thyroid Cancer
Patients should know the potential risk of thyroid C-cell tumors associated with Mounjaro. If you or your family have a history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2), Mounjaro is not recommended for you.
Your healthcare provider should counsel you about the potential risk of MTC linked to Mounjaro use and inform you about symptoms like neck masses, difficulty swallowing, breathing problems, or persistent hoarseness. If you experience any concerning symptoms or have a history of thyroid issues, consult your healthcare provider for appropriate guidance and monitoring.5,6
What you can do
If you have any concerns or symptoms related to thyroid problems, such as neck masses, swallowing difficulties, breathing issues, or persistent hoarseness while taking Mounjaro, it’s crucial to contact your healthcare provider or pharmacist immediately. They can assess your symptoms and provide tailored guidance, which may include further evaluation or monitoring to ensure your health and well-being are prioritized throughout your treatment.5,6
Low Blood Sugar (Hypoglycemia)
It’s important to be aware of the possibility of low blood sugar while using Mounjaro, especially if you’re also taking another medication that can lower blood sugar, like insulin. Signs of low blood sugar may range from mild to severe and can include dizziness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, rapid heartbeat, anxiety, hunger, weakness, or mood changes. If you experience any of these symptoms, contact your healthcare provider promptly for guidance on how to manage and prevent low blood sugar episodes while using Mounjaro.4,5,6
What you can do
If you experience low blood sugar while taking Mounjaro, it’s crucial to treat your hypoglycemia with glucose tablets or another form of sugar or contact 911 and seek emergency treatment. You should talk with your prescriber if you experience hypoglycemia. Your prescriber may consider adjusting your Mounjaro dosage, modifying your diet, or making changes to your activity levels. Consulting your healthcare provider promptly ensures that you receive personalized care and safeguards your well-being while using Mounjaro.4,5,6
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5 Ways to Avoid Mounjaro Side Effects
To minimize the risk of Mounjaro side effects, communication with your healthcare provider and pharmacist is paramount. Follow the prescribed dosage and administration schedule diligently. Attend regular check-ups for monitoring and treatment adjustments if needed. Maintain a balanced diet, stay hydrated, and rotate injection sites if applicable to manage digestive issues and skin irritation.
Recognize and report any concerning symptoms, especially low blood sugar or thyroid-related concerns. Be cautious when using Mounjaro alongside other medications affecting blood sugar levels, and always consult your healthcare provider to address potential interactions.1,4,5
Here are 5 ways to reduce the risk of Mounjaro side effects:1,3,5
- Rotate injection sites: If applicable, alternate the locations where you administer injections to reduce the risk of skin irritation or discomfort.
- Drink a lot of water: Ensure proper hydration, especially if you experience digestive problems like diarrhea.
- Regular monitoring: Attend scheduled check-ups to allow your healthcare provider to monitor your progress and adjust your treatment plan as needed.
- Dietary awareness: Maintain a balanced diet and discuss any dietary changes with your healthcare provider to manage digestive issues and blood sugar fluctuations.
- Alcohol awareness: Limit or avoid alcohol consumption, as it can interact with Mounjaro and potentially worsen side effects.
Frequently Asked Questions (FAQ) About Mounjaro Side Effects
You may have questions about the side effects of Mounjaro. Here are several frequently asked questions some people have about the medication.
Can Mounjaro Cause Kidney Problems?
While this isn’t very common, there is a chance of Mounjaro causing issues with kidney function. It’s important to know that regular check-ups with your healthcare provider are crucial, especially if you already have kidney concerns or are taking other medications that might impact your kidneys. If you notice any changes in how you urinate or if you feel like you’re retaining fluids, it’s important to let your healthcare providers know promptly. By staying in touch with your healthcare team and keeping them informed, you can ensure that any potential kidney problems are identified and managed properly.5,6
What Are the Long-term Side Effects of Mounjaro?
While Mounjaro is generally effective in managing blood sugar levels, prolonged use might lead to issues such as digestive problems like stomach discomfort, changes in appetite, or low blood sugar, which can cause dizziness, sweating, and shakiness.
Additionally, there’s a need to watch out for more serious concerns like thyroid C-cell tumors, although these are less common. It’s essential to maintain open communication with your healthcare provider, who can monitor your health and help manage any potential long-term side effects, ensuring that your treatment remains safe and effective over time.5,6
What Happens if I Stop Taking Mounjaro?
When you discontinue Mounjaro, the impact on your blood sugar levels can vary depending on factors like your use of other diabetes medications, your diet, and your exercise routine during treatment. It’s possible that your blood sugar levels may revert to the levels they were at before starting the medication, indicating a continued need for treatment. Since Mounjaro remains in your system for a few weeks after your last dose, any changes in your blood sugar levels may occur gradually.
If you experience a reduced appetite while using Mounjaro, it should return to normal within a few weeks after discontinuation. Follow up with your healthcare provider or pharmacist a few weeks after stopping Mounjaro to assess your blood sugar levels and determine the next steps in your medication management plan.1,4,6
What Should I Do if I Experience Low Blood Sugar While Taking Mounjaro?
If you experience low blood sugar while taking Mounjaro, it’s essential to take prompt action to raise your blood sugar levels. You can start by consuming a quick-acting source of sugar, such as glucose tablets or a small glass of fruit juice. Follow this with a longer-lasting source of carbohydrates like a granola bar or a piece of fruit. It’s crucial to avoid overtreating low blood sugar, as this can lead to high blood sugar levels later on. Additionally, inform your healthcare provider about the episode, as they can adjust your treatment plan to prevent future occurrences and ensure your treatment remains effective and safe.6
Can Alcohol Cause Side Effects While Taking Mounjaro?
Yes, alcohol consumption while using Mounjaro may potentially result in side effects and complications. Alcohol can interact with Mounjaro and heighten the risk of low blood sugar. This interaction may lead to symptoms such as dizziness, confusion, sweating, and shakiness. Alcohol’s impact on judgment can make it more challenging to identify and address low blood sugar promptly. It’s recommended to consider limiting or avoiding alcohol intake while taking Mounjaro. 5,6
Questions to Ask Your Healthcare Provider About Mounjaro Side Effects
When considering Mounjaro, it’s essential to discuss potential side effects with your healthcare provider and pharmacist, especially if you have concerns about how the medication may affect you. You can ask your prescriber and pharmacist about the common side effects, how to manage them, and any signs of more serious side effects. Ask about any lifestyle adjustments, such as diet or alcohol consumption, that might impact Mounjaro’s effectiveness or interactions. Open communication ensures that you have a clear understanding of the medication and can work together with your healthcare team to manage side effects effectively.1,5,6
Weight Loss With Circle Medical
Medically Managed Weight Loss. Our expert team of online weight loss doctors and providers has only one goal: helping you find a way to live your healthiest life in a way that actually works for you. Most Insurance Accepted. Same day online appointments available.
Questions to ask your care team about Mounjaro side effects:1,5,6
- How long will it take for me to adjust to taking Mounjaro?
- Am I at risk for more serious side effects if I am already taking other medications?
- What is the best dosage to ensure fewer side effects?
- What are the common side effects of Mounjaro, and how can I manage them effectively?
- Are there any dietary considerations or restrictions I should be aware of while taking Mounjaro to minimize side effects?
- Can alcohol be consumed in moderation while on Mounjaro?
- How can I recognize and address low blood sugar symptoms while taking Mounjaro?
- What are the signs of kidney-related issues that may occur with Mounjaro, and how frequently should I have my kidney function monitored?
- Are there any long-term side effects associated with Mounjaro, and what steps can I take to prevent or manage them?
- Can Mounjaro interact with other medications I am currently taking, and should I be concerned about potential drug interactions?
- What precautions should I take to ensure the safe and effective use of Mounjaro in my medication management plan?
- Is Mounjaro safe to use during pregnancy?
- How do side effects compare to other weight loss medications, such as Mounjaro vs Ozempic?
In My Experience
In my experience, openly discussing the potential side effects of Mounjaro is essential. This dialogue enables personalized care, allowing patients to address both common and rare side effects effectively. By following medical guidance, engaging in regular monitoring, and making necessary lifestyle adjustments, individuals can confidently navigate their treatment journey while minimizing potential challenges.
Maintaining consistent communication with your prescriber and pharmacist, attending check-ups, and seeking their guidance when needed are essential steps to achieve the best outcomes with treatment. It’s crucial to remember that managing your medications is a collaborative effort, and with the right support, it can be effectively controlled, ensuring a healthier and more fulfilling life.
Additional Resources
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For Further Reading
Semaglutide: Uses, Side Effects, Interactions, & More
Understanding the complexities of medications like semaglutide is crucial for anyone seeking effective treatment. It’s important to acknowledge that semaglutide is extensively used in managing type 2 diabetes and obesity, with potential benefits in weight loss and cardiovascular risk reduction.
Mounjaro Weight Loss: Safety, Side Effects, & More
Mounjaro is a relatively new medication that is within a class of medications known for their control of blood sugar and potential for managing weight. It’s unique in that it has two different ways of working in the body. It is generally recommended that patients make lifestyle choices alongside any medications used for weight management.