Trulicity Vs Mounjaro Comparison

What Is Trulicity?

Trulicity, containing the active ingredient dulaglutide, is a prescription medication used primarily for the management of type 2 diabetes. It belongs to a class of drugs known as GLP-1 receptor agonists. Trulicity works by mimicking the action of the GLP-1 hormone, which is naturally produced in the body. This hormone is involved in regulating blood sugar levels by increasing insulin release from the pancreas when blood sugar levels are high.

Additionally, Trulicity slows down the digestion process in the stomach, which helps decrease the rate at which glucose enters the bloodstream after eating. It also reduces the liver’s production of glucose. These actions combined help to lower blood sugar levels and, over time, may contribute to weight loss in some patients. Trulicity is administered through a subcutaneous injection (between the skin and muscle), typically once a week. It is recommended to be used in conjunction with diet and exercise to improve glycemic control in adults with type 2 diabetes.

Trulicity is an FDA-approved medication for:¹

• Helping control blood sugar in adults and kids (10 years and older) with type 2 diabetes.
• Reducing the chances of heart issues in adults with type 2 diabetes who have heart problems or several risk factors.

Doctors might also prescribe Trulicity “off-label” to help with weight loss in people dealing with excess weight or obesity. “Off-label” means doctors use it for something not specifically approved by the FDA, based on their judgment and the patient’s needs.

What Is Mounjaro?

Mounjaro, containing the active ingredient tirzepatide, is another injectable prescription medication that works somewhat differently. It is designed for the treatment of type 2 diabetes and has shown promise in weight management. Mounjaro is unique because it acts as a dual agonist, meaning that two chemical actions occur to improve blood sugar control and promote weight loss.

By stimulating both the GLP-1 and GIP receptors, Mounjaro enhances insulin secretion, reduces the liver’s glucose production, and slows gastric emptying (how long it takes for food to leave the stomach). Both actions work together for improved control over blood sugar levels, which may lead to significant weight loss for patients with type 2 diabetes. Mounjaro is administered via injection, typically once a week, similar to Trulicity.

Mounjaro is an FDA-approved medication for the following condition:²

• Type 2 diabetes

The FDA approval means it’s been carefully checked for safety and effectiveness. It falls into the category of medicines that work on the GLP-1 receptor, designed to improve blood sugar control when used alongside a healthy diet and exercise.

It is also used as an off-label use for the following conditions:

• Weight loss in individuals with excess weight or obesity

Key Differences Between Trulicity & Mounjaro

Mounjaro and Trulicity, both used for type 2 diabetes, differ in their drug classes and limitations. Trulicity is a GLP-1 receptor agonist, while Mounjaro combines GIP and GLP-1 agonists. Mounjaro is not for type 1 diabetes and has use restrictions in pancreatitis cases, setting it apart from Trulicity.

Here are the key differences between Trulicity and Mounjaro:^{1, 2}

How Do Mounjaro Vs. Trulicity Work?

Mounjaro and Trulicity are medications that may help with weight loss, although their primary focus is managing type 2 diabetes. They belong to a class of drugs that influence certain hormones involved in blood sugar and appetite control. Mounjaro, a GIP and GLP-1 receptor agonist, sends signals that help regulate blood sugar and can contribute to weight loss.

Trulicity, on the other hand, also a GLP-1 receptor agonist, not only helps with blood sugar but has the added benefit of reducing cardiovascular risks. Both medications, in their ways, can promote weight loss as a part of their broader impact on diabetes management.

Are Mounjaro & Trulicity the Same Thing?

No, Mounjaro and Trulicity aren’t the same, even though they both help with type 2 diabetes. They belong to different groups of medications. Mounjaro is a GIP and GLP-1 receptor agonist, while Trulicity is just a GLP-1 receptor agonist. They work in similar ways but have some differences, and your healthcare provider may choose one over the other based on your specific needs.

Can You Switch Between Trulicity & Mounjaro?

Switching between Trulicity and Mounjaro is a decision that should be made in consultation with your healthcare provider. While both medications aim to manage type 2 diabetes, they have different mechanisms of action. Your doctor may consider factors such as your response to the medication, overall health, and treatment goals when determining if a switch is appropriate.

Talk with your healthcare provider about any concerns or issues you may be experiencing, as they can guide you on the most suitable treatment plan for your specific needs.

Which Is More Effective, Trulicity or Mounjaro?

Determining whether Trulicity or Mounjaro is more effective depends on the individual. Both are approved to help manage type 2 diabetes, but what works best can vary from person to person.

Your response to the medication, overall health, age, and treatment goals all play a role. It’s important to talk openly with your healthcare provider about your experiences and concerns. They can guide you to the most effective treatment plan tailored to your specific needs.

Trulicity Vs Mounjaro Dosages

Trulicity and Mounjaro have different recommended dosages, and the appropriate dose can vary for each individual based on factors such as their response to the medication and overall health. While sometimes used off-label for weight loss, neither medication has standardized dosages for this purpose.

Taking medication as prescribed by your healthcare provider is essential for achieving optimal results and managing potential side effects. Always follow your healthcare provider’s guidance to ensure safe and effective use of these medications in your specific case.

Trulicity Form & Dosages

Trulicity is available as a self-injected solution pen with various dosages to cater to individual needs.

Trulicity dosages are available in the following amounts:¹

• 0.75 mg/0.5 mL
• 1.5 mg/0.5 mL
• 3 mg/0.5 mL
• 4.5 mg/0.5 mL

Mounjaro Form & Dosages

Mounjaro is available as a self-injected solution pen or vials with various dosages.

Trulicity dosages are available in the following amounts per .5mL:²

• 2.5 mg
• 5 mg
• 7.5 mg
• 10 mg
• 12.5 mg
• 15 mg

Side Effects of Trulicity Vs. Mounjaro

The side effects of Trulicity and Mounjaro share similarities, including commonly reported effects. These side effects are often mild, and many individuals tolerate the medications well. However, if any side effects persist or worsen, medical attention may be necessary.

For a comprehensive understanding of Mounjaro side effects, refer to specific information on Mounjaro side effects provided by healthcare professionals. Always consult with your healthcare provider for personalized guidance on potential side effects and appropriate management.

Common side effects from taking Trulicity may include:¹

• Nausea
• Diarrhea
• Vomiting
• Stomach (abdominal) pain
• Decreased appetite

Serious side effects from taking Trulicity may include:¹

• Inflammation of the pancreas (pancreatitis)
• Low blood sugar (hypoglycemia)
• Serious allergic reactions
• Kidney problems
• Severe stomach problems
• Changes in vision
• Gallbladder problems

Common side effects from taking Mounjaro may include:²

• Nausea
• Diarrhea
• Decreased appetite
• Vomiting
• Constipation
• Indigestion
• Stomach (abdominal) pain

Serious side effects from taking Mounjaro may include:²

• Inflammation of the pancreas (pancreatitis)
• Low blood sugar (hypoglycemia)
• Serious allergic reactions
• Kidney problems (kidney failure)
• Severe stomach problems
• Vision changes
• Gallbladder problems

*All medications, including Mounjaro and Trulicity, have a risk of side effects, including serious side effects. This is not a complete list of side effects. You should talk with your healthcare professional about the benefits and risks of any medication before starting treatment.

Warnings & Precautions for Mounjaro & Trulicity

Both Mounjaro and Trulicity, containing semaglutide, carry warnings about serious side effects and allergic reactions. Seek immediate medical care if you experience any of the following symptoms.^{1, 2}

Risks to consider when taking Trulicity include:¹

• Allergic reactions: Serious allergic reactions, though rare, may occur. Symptoms include difficulty breathing and hives. If experienced, seek immediate medical care.
• Pancreatitis: Pancreatitis has been reported for some patients taking these medications. Consult your healthcare provider promptly.
• Kidney impairment: Impaired kidney functioning has been reported for some taking these medications.
• Gastrointestinal disease: Severe gastrointestinal adverse reactions may occur, and the medication is not recommended for those with severe gastrointestinal disease.
• Diabetic retinopathy: Some people with diabetic retinopathy (retina disease related to diabetes) have reported complications when taking these medications.
• Gallbladder disease: Some with gallbladder disease may need additional follow-up to check on their condition while taking these medications.

Risks to consider when taking Mounjaro include:²

• Thyroid tumor risks: If you or your family have a history of certain thyroid tumors, Mounjaro isn’t recommended. Watch for symptoms like a neck mass and inform your doctor.
• Pancreatitis: Keep an eye out for severe belly pain; if suspected, stop taking Mounjaro.
• Low blood sugar with insulin: If you’re using Mounjaro with insulin, there’s a higher risk of low blood sugar. Learn the signs and symptoms.
• Allergic reactions: If you have a serious allergic reaction, seek medical care and stop Mounjaro immediately.
• Kidney issues: Dehydration from Mounjaro can lead to kidney problems. Watch for severe belly issues and report them to your doctor.
• Stomach problems: Mounjaro may not be suitable for severe stomach conditions.
• Eye issues in diabetes: If you have a history of eye issues with diabetes, keep an eye on your condition.
• Gallbladder problems: If you suspect gallbladder problems, get checked with tests and follow up with your doctor.

There may be additional warnings or precautions with this medication. Talk with your healthcare provider about all risks before you start taking this medication.

Potential Drug Interactions With Mounjaro Vs. Trulicity

Both Trulicity and Mounjaro can affect how your body absorbs oral medications by slowing down stomach emptying. For Trulicity, this effect lessens with subsequent doses, so be cautious, especially with drugs like warfarin. Keep an eye on drug levels for medications with a narrow therapeutic range.^{1, 2}

If you’re starting Trulicity or Mounjaro with insulin or insulin secretagogues, think about reducing their doses to lower the risk of low blood sugar. Mounjaro users should also switch to non-oral contraceptives or add a barrier method for a specific time.

Disclaimer: Taking certain medications, herbs, or supplements alongside Mounjaro and Trulicity can change how these medications work in your body or increase the risk of serious side effects. This article does not consider all the possible interactions. Please let your doctor, psychiatrists, and pharmacists know about all the products you currently use, such as prescription medication, nonprescription drugs, and herbal supplements. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Trulicity Vs. Mounjaro Cost

The average retail price of Trulicity is $1096.16, with the lowest GoodRx price of $805.25 (saving 26.54%).³ On the other hand, Mounjaro has an average retail price of $1214.47, and the lowest GoodRx price is $1000.06 (saving 17.65%).⁴ Utilizing manufacturer coupons for Mounjaro and Trulicity can also help cut costs.

It’s worth noting that these figures represent the cost without insurance, and while insurance coverage may not be complete, patients may explore various discounts and savings options to manage the expenses associated with these medications.

Which Is Right for You: Mounjaro or Trulicity?

Determining whether Mounjaro or Trulicity is the right medication for you involves considering several factors. Your healthcare provider can offer personalized guidance based on your specific health conditions, medical history, and treatment goals. If in-person consultations are challenging, online pharmacy services may be a convenient alternative.

These platforms can connect you with healthcare professionals who can assess your needs and provide insights into the benefits and risks of each medication. It’s essential to weigh factors such as individual health requirements, potential side effects, and financial considerations to make an informed decision that aligns with your overall well-being.

How to Get a Prescription for Trulicity or Mounjaro

To learn how to get Mounjaro or Trulicity, consult with a qualified healthcare professional. These medications are only available through a prescription, and your healthcare provider will assess your health condition, medical history, and treatment goals to determine their suitability for you.

Reach out to healthcare professionals such as primary care physicians, endocrinologists, or other specialists who are authorized to prescribe these medications. During your consultation, they will discuss your health needs, potential benefits, and risks of the medications, helping you make an informed decision.

Questions to Ask Your Health Team About Mounjaro & Trulicity

Clear communication with your healthcare team is vital when considering Mounjaro or Trulicity. Come to your appointment prepared with questions or concerns. Open dialogue ensures you and your provider are aligned on your treatment plan, fostering informed decision-making about your health.

Questions to ask your prescriber about Mounjaro and Trulicity include:

• Is it safe to take Mounjaro or Trulicity with my other medications?
• Will Mounjaro or Trulicity be covered by my insurance?
• Which one has the best results for weight loss?
• Does my medical history increase the risk of side effects for either?
• How long can I expect side effects to last?
• How often should I have checkups while taking Mounjaro or Trulicity?
• What should I do if unsure about weight loss medications?
• Are there lifestyle changes I should make while on Mounjaro or Trulicity?
• Can I take these medications if I have other health conditions?
• What are the potential interactions with over-the-counter supplements?
• How soon can I expect to see results in terms of weight loss?
• Are there specific diet or exercise recommendations to enhance effectiveness?
• Can these medications be adjusted if I experience side effects?
• What should I do if I miss a dose?
• Are there long-term considerations or limitations with these medications?
• Can I drink alcohol while taking Trulicity with Ozempic or Mounjaro?
• Are there alternative weight loss treatments or approaches to consider?
• How will these medications affect my overall health and well-being?