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  • What Is Evekeo?What Is Evekeo?
  • Used to TreatUsed to Treat
  • Side EffectsSide Effects
  • Warnings & PrecautionsWarnings & Precautions
  • InteractionsInteractions
  • Use to TreatUse to Treat
  • How to TakeHow to Take
  • Addiction RiskAddiction Risk
  • OverdoseOverdose
  • Questions to AskQuestions to Ask
  • In My ExperienceIn My Experience
  • ResourcesResources

Evekeo: Uses, Side Effects, & Risks

Headshot Max Ruvinov PharmD MBA

Written by: Max Ruvinov, PharmD, MBA

Heidi-Moawad-MD-Headshot

Reviewed by: Heidi Moawad, MD

Published: September 21, 2023

Evekeo is a central nervous system (CNS) stimulant prescribed for treating attention-deficit hyperactivity disorder (ADHD) in children aged 3 to 17 years. It helps manage ADHD symptoms, enhancing focus and reducing impulsivity. While it may help improve attention, be aware of potential side effects and risks.

Boxed Warning: Evekeo

Boxed Warning: Amphetamine (Evekeo) – Risk of medication misuse or abuse
Amphetamine, the active ingredient in Daytrana, has a black box warning. These are the most serious types of warnings from the Food and Drug Administration (FDA). Amphetamine has a risk of misuse (abuse) which can lead to dependence on the medication.

What Is Evekeo?

Evekeo is a medication used to treat attention-deficit hyperactivity disorder in children aged 6 to 17 years.1 This ADHD medication belongs to the class of stimulants, which work by increasing certain chemicals in the brain that help with focus and impulse control. It can cause side effects like decreased appetite and insomnia.

How Does Evekeo Work?

Evekeo works by affecting certain brain chemicals, helping improve ADHD symptoms. It boosts the activity of these chemicals responsible for attention, focus, and controlling impulses.2 This balance in brain activity can lead to better concentration and reduced hyperactivity.

How Is Evekeo Different from Adderall?

Evekeo and Adderall are both medications used to manage ADHD symptoms in individuals. However, there are some differences between them. While Adderall can also be used for patients three years and older and is used for narcolepsy, Evekeo is specifically indicated for ADHD in pediatric patients aged 6 to 17 years.3

Adderall comes in tablet form, while Evekeo is available as orally disintegrating tablets. Regarding dosing, Adderall can be taken multiple times daily, while Evekeo is usually taken once or twice in the morning.3 It’s important to consult a healthcare professional to determine which medication is most suitable based on individual needs and medical history.

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What Is Evekeo Used to Treat?

Evekeo has received approval from the FDA to treat attention-deficit hyperactivity disorder (ADHD) in kids aged 6 to 17. This FDA approval signifies that the medication has undergone strict testing to ensure it’s safe and effective for this particular purpose.

Side Effects of Evekeo

Evekeo can bring about various side effects due to its direct action. Some of these, like headache, upset stomach, trouble sleeping, and nervousness, may linger as long as the medication is taken. There are also temporary effects that people might experience while their body adapts, such as decreased appetite, weight loss, and nervousness.

More serious effects, although rare, can include hypersensitivity reactions, cardiovascular issues, high blood pressure, psychiatric reactions, seizures, and potential growth suppression. While Evekeo can be beneficial, it’s important to be mindful of these possible effects and consult a healthcare professional if any concerns arise.

Common Side Effects of Evekeo

Common side effects of Evekeo may include headaches, upset stomach, trouble sleeping, decreased appetite, weight loss, dry mouth, and nervousness. While these effects are not unusual, they should be monitored. It’s important to consult a healthcare provider if any concerns arise or if these effects persist or worsen over time.

Common side effects of Evekeo include:1

  • Insomnia
  • Diarrhea
  • Constipation
  • Dizziness
  • Headache
  • Irritability
  • Fatigue
  • Loss of appetite

*All medications, including Evekeo, can cause side effects that can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and understand the potential side effects and benefits of any medication.

Serious Side Effects of Evekeo

While Evekeo can be beneficial for treating ADHD, it’s important to be aware of potentially serious side effects that may require immediate medical attention. These include risks such as hypersensitivity reactions, cardiovascular issues, increased blood pressure and heart rate, psychiatric adverse reactions, and more. If any of these serious side effects are experienced, it’s crucial to consult a healthcare provider.

Serious side effects of Evekeo may include:1

  • Cardiovascular problems
  • Abuse and dependence
  • Psychiatric issues
  • Increased heart rate and blood pressure
  • Seizures
  • Hypersensitivity
  • Long-term suppression of growth

*All medications, including Evekeo, can cause side effects that can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and understand the potential side effects and benefits of any medication.

Allergic Reactions to Evekeo

Some individuals might experience allergic reactions to Evekeo, which can manifest as skin issues like hives and rashes, along with hypersensitivity reactions such as swelling (angioedema) and severe allergic reactions (anaphylaxis). If any signs of allergic reactions occur, it’s important to seek medical attention promptly.

Allergic reactions to Evekeo may include:2

  • Urticaria (hives)
  • Rash
  • Hypersensitivity reactions
  • Angioedema (swelling, often around the eyes and lips)
  • Anaphylaxis (severe allergic reaction)
  • Serious skin rashes like Stevens-Johnson Syndrome
  • Toxic epidermal necrolysis (peeling of the skin)
  • Itching
  • Difficulty breathing

If an allergic reaction is confirmed, alternative treatment options may need to be explored, considering the individual’s medical history and specific needs. Your healthcare provider can guide you in finding a suitable alternative medication if necessary.

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Evekeo Warnings & Precautions

When it comes to using Evekeo, it’s essential to have a clear understanding of the associated warnings and precautions. If any of these potential concerns come to your attention, it’s important to seek medical attention promptly.

Precautions for taking Evekeo’s address:1

  • Potential for abuse and dependence: Evekeo, like other CNS stimulants, carries a risk of abuse and physical or psychological dependence. Monitoring for signs of abuse and dependence is essential throughout treatment.
  • Serious cardiovascular reactions: There have been reports of sudden death, stroke, and heart attacks (myocardial infarction). These risks are higher in adults and children who already have heart conditions.
  • Blood pressure and heart rate Increases: CNS stimulants can lead to higher blood pressure and heart rate. Regular monitoring is advised, and any potential issues should be addressed.
  • Psychiatric adverse reactions: Evekeo can worsen symptoms of behavior disturbance and thought disorder in individuals with pre-existing psychotic conditions. It might also induce manic or mixed episodes in those with bipolar disorder.
  • Long-term suppression of growth: Pediatric patients treated with CNS stimulants, including Evekeo, might experience weight loss and slowed growth.
  • Seizures: Stimulants could lower the seizure point, so it’s important to discontinue Evekeo if seizures occur.
  • Peripheral vasculopathy: Some ADHD stimulants have been connected to troubles in blood vessels outside the heart. This includes a condition called Raynaud’s phenomenon.
  • Serotonin syndrome: This is a serious reaction that affects the body’s serotonin system. It’s important to avoid certain drug combinations to prevent this potentially life-threatening situation.

Interactions With Evekeo

Evekeo can have potentially harmful interactions with other medications, substances, and herbs. It’s crucial to be aware of these interactions, as they can affect how Evekeo works or cause unwanted side effects.

6 substances you should avoid while taking Evekeo include:1

  • MAO Inhibitors (MAOI): MAOI antidepressants can interact with Evekeo, leading to dangerous increases in blood pressure and severe neurological effects. Do not take Evekeo if you are currently taking or have taken MAOIs within the last 14 days.
  • Serotonergic drugs: Combining Evekeo with drugs that affect serotonin levels can increase the risk of serotonin syndrome, a potentially life-threatening condition. This includes medications like certain antidepressants, pain relievers, and herbal supplements.
  • Alkalinizing agents: Certain medications that increase the pH of your stomach or urine can affect how your body processes Evekeo. Caution should be taken if you are using gastrointestinal or urinary alkalinizing agents.
  • Acidifying agents: Conversely, some medications that make your stomach or urine more acidic can lower the effectiveness of Evekeo. Your dose may need adjustment in this case.
  • Tricyclic antidepressants: Combining Evekeo with tricyclic antidepressants can enhance their effects and potentially lead to increased d-amphetamine concentrations in the brain. This can cause cardiovascular effects, so careful monitoring and dose adjustment may be necessary.
  • CYP2D6 inhibitors: Using Evekeo with medications that inhibit the CYP2D6 enzyme can increase the risk of serotonin syndrome. These inhibitors can affect how Evekeo is processed in your body.

Evekeo Dosages for FDA-Approved Treatment

Evekeo dosages for FDA-approved treatment can vary based on individual needs and factors. The medication is approved for treating pediatric patients aged 6 to 17 with ADHD. Factors influencing dosages include the patient’s age, weight, overall health, and individual response to the medication.

It’s important for healthcare providers to carefully assess and monitor patients to find the right dosage that effectively manages ADHD symptoms while minimizing potential side effects.

Evekeo Forms & Strengths

Evekeo is available in orally disintegrating tablet (ODT) form, known as EVEKEO ODT. This form comes in various strengths: 5 mg, 10 mg, 15 mg, and 20 mg. Each tablet is marked with strength on one side and “EVI” on the other. The choice of form and strength is determined by the prescribing healthcare provider based on individual patient characteristics and needs.

EVEKEO ODT is not an extended-release or delayed-release formulation; it’s designed to dissolve quickly in the mouth without needing water. The effects of Evekeo typically begin within 30 to 60 minutes after administration.

Evekeo is available in the following forms and strengths:1

  • 5 mg: white to off-white, round, flat-faced radius-edged tablet with “5” on one side and “EVI” on the other.
  • 10 mg: white to off-white, round, flat-faced radius-edged tablet with “10” on one side and “EVI” on the other.
  • 15 mg: white to off-white, round, flat-faced radius-edged tablet with “15” on one side and “EVI” on the other.
  • 20 mg: white to off-white, round, flat-faced radius-edged tablet with “20” on one side and “EVI” on the other.

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How Should I Take Evekeo?

For effective use of Evekeo, take it in the morning with or without food or liquid.2 Don’t substitute Evekeo with other amphetamine products based on milligrams due to different compositions and effects.

To take the tablet from its blister pack, use dry hands to push it through the foil-lined back.  When taking Evekeo, put the tablet on your tongue and let it dissolve in saliva before swallowing. Do not chew or crush. After opening, put the tablet on your tongue to dissolve—no need for liquid. Following your healthcare provider’s guidance is crucial for effectiveness and well-being.

What Happens If I Miss a Dose of Evekeo?

If you miss a dose of Evekeo, take it as soon as you remember unless it’s close to your next scheduled dose. It’s crucial not to double the dose to catch up or suddenly stop taking it. Abruptly stopping or altering your dose can disrupt the effectiveness of the medication and affect your ADHD symptoms. If you have concerns about missed doses or your treatment plan, consult your healthcare provider for guidance.

Can You Become Addicted to Evekeo?

Yes, there’s a risk of dependence on Evekeo and similar CNS stimulants. These drugs can be abused or cause addiction due to their effects. Signs of abuse include increased heart rate, restlessness, insomnia, and severe symptoms like anxiety or aggression.1

Healthcare providers assess risks, educate patients, and monitor use to prevent abuse. Continued use of Evekeo can lead to physical dependence, with withdrawal symptoms if stopped abruptly, and tolerance, where effects reduce over time. It’s best to seek professional advice from your healthcare provider before taking Evekeo.

Can You Overdose on Evekeo?

Yes, you can overdose on Evekeo. Signs of an overdose may include restlessness, tremors, rapid breathing, confusion, hallucinations, panic, high body temperature, and muscle breakdown. Other symptoms can involve abnormal heart rhythms, blood pressure changes, nausea, vomiting, and more. If you suspect an overdose, seek medical help immediately. (FN2)

What Should You Do If You Take Too Much Evekeo?

If you take too much Evekeo, seek immediate medical help. Contact your healthcare provider or go to the nearest emergency room. Be sure to share all relevant information about the amount of medication taken and any symptoms you’re experiencing. It’s important to address potential overdose situations promptly to ensure your safety.

Questions to Ask Your Healthcare Provider About Evekeo

If you’re considering starting Evekeo or have been prescribed it, there are important questions to discuss with your doctor, psychiatrist, and therapist. Inquire about any precautions or interactions with other medications you’re taking. If you need to change prescribers, online psychiatry services can be a helpful option, allowing you to connect with a qualified psychiatrist remotely for evaluations, adjustments, and ongoing care.

Questions to ask your care team about Evekeo include:

  • How long does it usually take to adjust to taking Evekeo?
  • Are there any risks or interactions with my current mental health medications?
  • What’s the recommended dosage to minimize side effects?
  • How should I address sexual side effects if they occur?
  • Can you explain the benefits of Evekeo for my condition?
  • What common side effects of Evekeo should I be aware of?
  • How should I handle missed doses or accidental overdoses?
  • Can you provide information about online psychiatry services for remote consultations or changing prescribers?

In My Experience

In my experience, discussing topics like Evekeo is vital for those considering or undergoing treatment. Seeking support for mental health concerns is a positive step. By asking informed questions and understanding potential risks and benefits, you’re taking control of your journey toward better health.

I encourage open dialogue with their healthcare team. It’s essential to share concerns and preferences to tailor treatment to their needs. While Evekeo offers benefits, considering side effects and interactions is crucial. Working closely with professionals ensures a well-informed approach.

The outlook for clients facing these issues can be positive with the right guidance. Each person’s response to treatment is unique. If this concerns you, gather information, ask questions, and collaborate with your care team. Seeking help and staying informed contribute to your well-being. Your healthcare provider supports you, and your commitment to health is a step forward.

Additional Resources

Education is just the first step on our path to improved mental health and emotional wellness. To help our readers take the next step in their journey, Choosing Therapy has partnered with leaders in mental health and wellness. Choosing Therapy may be compensated for marketing by the companies mentioned below.

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For Further Reading

  • 10 Tips for Healthy Living With ADHD as an Adult
  • Stimulant vs Non-Stimulant ADHD Meds: Key Differences
  • Side Effects of ADHD Medication

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Sources

Choosing Therapy strives to provide our readers with mental health content that is accurate and actionable. We have high standards for what can be cited within our articles. Acceptable sources include government agencies, universities and colleges, scholarly journals, industry and professional associations, and other high-integrity sources of mental health journalism. Learn more by reviewing our full editorial policy.

  • National Institutes of Health. (2022). DailyMed – EVEKEO ODT- amphetamine sulfate tablet, orally disintegrating. U.S. National Library of Medicine. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm 

  • Access Data. (2022). EVEKEO – HIGHLIGHTS OF PRESCRIBING INFORMATION. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/209905s003lbl.pdf

  • Medicaid.gov. (2019). OptumRx – Therapeutic Class Overview Attention-Deficit/Hyperactivity Disorder (ADHD) Agents. Retrieved from https://www.medicaid.nv.gov/Downloads/provider/ADHD_2019-06.pdf

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  • What Is Evekeo?What Is Evekeo?
  • Used to TreatUsed to Treat
  • Side EffectsSide Effects
  • Warnings & PrecautionsWarnings & Precautions
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