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Is BPD Genetic? Causes & Risk Factors

Published: December 3, 2021 Updated: June 29, 2022
Published: 12/03/2021 Updated: 06/29/2022
Headshot of Lydia Angelica Antonatos, LMHC
Written by:

Lydia Antonatos

LMHC
Headshot of Trishanna Sookdeo, MD, MPH, FAAFP
Reviewed by:

Trishanna Sookdeo

MD, MPH, FAAFP
  • Is Borderline Personality Disorder Caused by Genetics?Is It Genetic?
  • Components in the Development of BPD3 Causes
  • Genetic Factors: Looking at the ResearchCurrent Research
  • Will Children of a Borderline Parent Inherit BPD?Heritability
  • Borderline Personality Disorder TreatmentTreatment
  • Final Thoughts on the Impact of Genetics on BPDConclusion
  • Additional ResourcesResources
Headshot of Lydia Angelica Antonatos, LMHC
Written by:

Lydia Antonatos

LMHC
Headshot of Trishanna Sookdeo, MD, MPH, FAAFP
Reviewed by:

Trishanna Sookdeo

MD, MPH, FAAFP

Borderline personality disorder (BPD) is a psychiatric condition marked by persistent patterns of intense emotions and severe mood swings often resulting in impulsive behaviors and difficulty with interpersonal relationships. Precise causes for BPD are unclear; however, many experts agree that BPD emerges from a combination of genetics, biological factors, and early life adverse environmental influences.

Would like to someone to talk to about BPD? BetterHelp has over 20,000 licensed therapists who provide convenient and affordable online therapy. BetterHelp starts at $60 per week. Complete a brief questionnaire and get matched with the right therapist for you.

Choosing Therapy partners with leading mental health companies and is compensated for referrals by BetterHelp

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Is Borderline Personality Disorder Caused by Genetics?

As with most mental health conditions, there isn’t one specific reason to account for the emergence of borderline personality disorder. While existing research suggests that genetics are a strong precursor for the development of BPD, there is a scientific consensus that BPD is likely a byproduct of an interaction of underlying vulnerabilities that include genetics, brain anomalies, and environmental triggers.1,2,3

What Does It Mean For Something to Be Genetic or Hereditary?

Hereditary refers to the transmission of certain qualities from one generation to the next. Birth parents pass on a combination of genes that influence how children look, behave, or whether they develop a type of illness. The closer you are in the family tree to the person with the condition, the more likely you are to get it.6

3 Components in the Development of BPD

Note that while having one or a mixture of contributing elements or risk factors (genetics, environmental triggers, and brain anomalies) can increase the chances of developing BPD, it doesn’t necessarily mean you’re going to have it. Similarly, there are incidences where individuals who lack these predispositions still develop BPD in their lifespan.

Here are three key components that factor into the development of BPD:

1. Genetics

Family history is a compelling predictor for BPD. This personality disorder is about five times more common among first-generation biological relatives with BPD as compared to the general population. That means that individuals with a close family member like a sibling or parent with BPD have a higher probability of developing this mental illness. Additionally, BPD is generally more often diagnosed in females than males.

2. Environment

Certain types of toxic, stressful environments are linked to BPD. In fact, most BPD cases are connected to childhood trauma with individuals reporting a history of sexual, emotional, and/or physical abuse, neglect, and/or separation from an important adult or parent. Other conditions associated with BPD include growing up in a hostile and invalidating family environment or with a relative who has a mental illness or substance use issues.

3. Brain Anomalies

Clinical brain examinations of individuals with BPD reveal structural and functional variations thought to be potential contributing factors. These findings have helped to bring clarity into the reasons why those with BPD have symptoms like intense emotional reactions, mood instability, and poor impulse control.

Moreover, alterations in certain neurotransmitters like serotonin have also been identified and linked with BPD. However, these findings are inconclusive in showing whether brain anomalies lead to BPD or if these occur because of the condition itself.

Genetic Factors: Looking at the Research

Although studies are scarce and outcomes vary, there is moderate evidence linking genetics with BPD. Most of these studies, however, cannot conclusively determine if genetic vulnerability is a cause. Instead, genetics is deemed a strong predictor for development. The majority of scientific research is typically inclined toward the theory of “nature” and “nurture,” meaning BPD evolves from a combination of genetics and environmental influences.

Here are several examples of research around BPD and genetics:

  • Early 2000’s twin studies: Two twin studies had moderate evidence for the genetic transmission and heritability of BPD. The findings revealed a higher rate of BPD between identical twins in comparison to fraternal twins. However, a third twin study indicated that environmental factors outweigh genetics in the development of BPD.2
  • A 2014 scientific review: This review found genetic predisposition to be a strong underlying influence in the development of BPD. Nevertheless, it suggested that the onset of BPD was likely caused by a gene and environment interaction.4
  • A 2019 twin study: Perhaps a more compelling comprehensive study in 2019 examined identical twins and concluded that BPD would have likely developed even if the identical twins were raised in different environments.5

Would like to someone to talk to about BPD? BetterHelp has over 20,000 licensed therapists who provide convenient and affordable online therapy. BetterHelp starts at $60 per week. Complete a brief questionnaire and get matched with the right therapist for you.

Choosing Therapy partners with leading mental health companies and is compensated for referrals by BetterHelp

Visit BetterHelp

Will Children of a Borderline Parent Inherit BPD?

Although children born to BPD parents may be at a greater genetic risk for developing this condition, only a small percentage will. However, inserting your genetically predisposed child into a dysfunctional, traumatic environment will likely result in the development of BPD. Many studies conclude that early life chronic exposure to trauma and maltreatment are the most influential risk factors for BPD.1,2

Negative childhood experiences linked to BPD include:

  • Separation from or the loss of a parent/caregiver at an early age
  • Sexual, physical, and/or emotional abuse
  • Neglect
  • Inadequate parenting
  • Invalidating family backgrounds
  • Unstable and conflictive relationships

As a parent with BPD, you may worry about how it could affect your parenting or passing on the disorder. Since the environment plays a significant role in your child’s development, you can put your worries to rest. There are many things you can do to create a nurturing, stable, safe, and validating atmosphere and reduce your child’s risk of developing BPD.

Take the following actions to create a healthy environment for your child:

  • Get psychological help (individual or group therapy)
  • Seek family therapy
  • Join an in-person/online parenting-focused support group
  • Take a course on effective parenting skills
  • Grow your support network and reach out to close friends, family, and professionals

Borderline Personality Disorder Treatment

Seeking treatment for BPD is of utmost importance. It can help you develop the necessary skills for building a validating and stable family environment.7 Begin your recovery process by searching an online directory and finding a mental health professional who is experienced with personality disorders, uses evidenced-based techniques, and you can bond with. Evidence shows that psychotherapy is the most effective treatment path for those with BPD.

Is BPD Curable?

People who are invested in their treatment plan can expect significant improvement and sustainable mental and emotional wellness over time. In addition, approaching the treatment of BPD in a multimodal fashion by complementing your individual treatment with family therapy, group therapy, and/or other supportive programs or services that address endeavors outside of therapy can lend remarkable results and long-term benefits.7

Final Thoughts on the Impact of Genetics on BPD

Borderline personality disorder has often been misunderstood and stigmatized. Luckily, decades of diligent research have advanced our understanding about this multifaceted disorder. As the research on BPD continues, more specific causes will likely be uncovered. This can pave the way for a more comprehensive level of care.

Additional Resources

Education is just the first step on our path to improved mental health and emotional wellness. To help our readers take the next step in their journey, Choosing Therapy has partnered with leaders in mental health and wellness. Choosing Therapy may be compensated for referrals by the companies mentioned below.

BetterHelp (Online Therapy) – BetterHelp has over 20,000 licensed therapists who provide convenient and affordable online therapy. BetterHelp starts at $60 per week. Complete a brief questionnaire and get matched with the right therapist for you. Get Started

Online-Therapy.com – Receive help for BPD. The Online-Therapy.com standard plan includes a weekly 45 minute video session, unlimited text messaging between sessions, and self-guided activities like journaling. Recently, they added Yoga videos. Get Started

Brightside Health (Online Psychiatry) – If you’re struggling with Borderline Personality Disorder (BPD), finding the right medication can make a difference. Brightside Health treatment plans start at $95 per month. Following a free online evaluation and receiving a prescription, you can get FDA approved medications delivered to your door. Free Assessment

Choosing Therapy’s Directory – Find an experienced therapist specialising in BPD. You can search for a therapist by specialty, availability, insurance, and affordability. Therapist profiles and introductory videos provide insight into the therapist’s personality so you find the right fit. Find a therapist today.

Choosing Therapy partners with leading mental health companies and is compensated for referrals by BetterHelp, Online-Therapy.com, and Brightside

For Further Reading

  • Borderline Personality Disorder Resource Center
  • National Education Alliance for Borderline Personality Disorders
  • National Institute of Mental Health (NIMH)
  • MentalHealth.gov
7 sources

Choosing Therapy strives to provide our readers with mental health content that is accurate and actionable. We have high standards for what can be cited within our articles. Acceptable sources include government agencies, universities and colleges, scholarly journals, industry and professional associations, and other high-integrity sources of mental health journalism. Learn more by reviewing our full editorial policy.

  • Chapman, J., Jamil, R. T., & Fleisher, C. (2021, August). Borderline Personality Disorder. Nih.gov; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK430883/

  • Kulacaoglu, F., & Kose, S. (2018). Borderline Personality Disorder (BPD): In the Midst of Vulnerability, Chaos, and Awe. Brain Sciences, 8(11), 201. https://doi.org/10.3390/brainsci8110201

  • NIMH» Borderline Personality Disorder. (2017). Nih.gov. https://www.nimh.nih.gov/health/topics/borderline-personality-disorder

  • Amad, A., Ramoz, N., Thomas, P., Jardri, R., & Gorwood, P. (2014). Genetics of borderline personality disorder: Systematic review and proposal of an integrative model. Neuroscience & Biobehavioral Reviews, 40, 6–19. https://doi.org/10.1016/j.neubiorev.2014.01.003

  • Skoglund, C., Tiger, A., Rück, C., Petrovic, P., Asherson, P., Hellner, C., Mataix-Cols, D., & Kuja-Halkola, R. (2019). Familial risk and heritability of diagnosed borderline personality disorder: a register study of the Swedish population. Molecular Psychiatry, 26(3), 999–1008. https://doi.org/10.1038/s41380-019-0442-0

  • NIMH» Looking at My Genes: What Can They Tell Me About My Mental Health? (2020). Nih.gov. https://www.nimh.nih.gov/health/publications/looking-at-my-genes

  • Choi-Kain, L. W., Finch, E. F., Masland, S. R., Jenkins, J. A., & Unruh, B. T. (2017). What Works in the Treatment of Borderline Personality Disorder. Current Behavioral Neuroscience Reports, 4(1), 21–30. https://doi.org/10.1007/s40473-017-0103-z

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Headshot of Lydia Angelica Antonatos, LMHC
Written by:

Lydia Antonatos

LMHC
Headshot of Trishanna Sookdeo, MD, MPH, FAAFP
Reviewed by:

Trishanna Sookdeo

MD, MPH, FAAFP
  • Is Borderline Personality Disorder Caused by Genetics?Is It Genetic?
  • Components in the Development of BPD3 Causes
  • Genetic Factors: Looking at the ResearchCurrent Research
  • Will Children of a Borderline Parent Inherit BPD?Heritability
  • Borderline Personality Disorder TreatmentTreatment
  • Final Thoughts on the Impact of Genetics on BPDConclusion
  • Additional ResourcesResources
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