Qsymia Side Effects: Common, Serious, & Long Term

What Is Qsymia & How Is it Used?

Qsymia is an FDA-approved medication containing phentermine and topiramate extended-release to assist adults and children aged 12 and older in managing weight, especially for those dealing with obesity or weight-related medical conditions.¹

While FDA-approved, its impact on the risk of heart problems or stroke is not fully understood. Classified as a federally controlled substance due to its phentermine component, Qsymia requires secure storage to prevent misuse, and sharing or selling it is against the law.

Common Side Effects of Qsymia

Qsymia may cause common side effects such as numbness, dizziness, and dry mouth in adults. Children may experience depression, joint pain, and flu-like symptoms. Some side effects may require medical attention, so it’s important to consult a healthcare provider if symptoms persist or worsen.

Common side effects of Qsymia include:¹

• Numbness or tingling in the hands, arms, feet, or face
• Dizziness
• Changes in taste or loss of taste
• Trouble sleeping
• Constipation
• Dry mouth
• Depression (in children aged 12 and older)
• Joint pain (in children aged 12 and older)

*All medications, including Qsymia, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.

Serious Side Effects of Qsymia

Qsymia may cause serious side effects requiring urgent medical attention. These include an elevated risk of birth defects, increased heart rate, and potential for suicidal thoughts or actions related to the ingredient topiramate. If pregnant or experiencing symptoms like chest discomfort or emotional distress, immediate medical consultation is essential.

Serious side effects of Qsymia include:¹

• Birth defects
• Increased heart rate
• Potential for suicidal thoughts or actions
• Chest discomfort
• Emotional distress
• Severe allergic reactions

*All medications, including Qsymia, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.

Qsymia Long-Term Side Effects

Using Qsymia for an extended period may impact cardiovascular health, though specific long-term effects are not fully known. Regular monitoring, including heart rate checks, is crucial for those on long-term Qsymia. Healthcare providers will also track sustained weight loss and address any concerns that arise. It’s important for individuals to stay in touch with their healthcare team, reporting any changes in health or unexpected symptoms during extended use.

Qsymia Warnings & Precautions

Qsymia should be used with the awareness of several warnings and precautions. While the following serious effects are rare, patients should remain aware of symptoms and seek immediate medical care if they develop.

Warnings and precautions for taking Qsymia include:¹

• Increased risk of birth defects: Qsymia may increase the risk of birth defects, particularly cleft lip and cleft palate if used during pregnancy. Regular pregnancy tests and effective contraception are strongly recommended for individuals at reproductive risk.
• Increased heart rate: It’s crucial to monitor heart rate, especially for individuals with pre-existing heart conditions, as Qsymia may cause an elevation in heart rate. Close observation and assessment of any significant changes in heart rate during treatment is advised.
• Suicidal thoughts and depression: Patients taking Qsymia should be monitored for signs of suicidal thoughts or other depression symptoms. Discontinuation of Qsymia is recommended if these symptoms emerge, and immediate medical attention should be sought.
• Risk of eye adverse reactions: Qsymia users should be vigilant for potential Qsymia side effects impacting the eyes. Acute myopia (extreme nearsightedness) and secondary angle closure glaucoma (vision change due to abnormal blood vessel growth in the eye) are severe symptoms. Stop taking Qsymia immediately if these problems occur.
• Pediatric growth monitoring– Pediatric patients using Qsymia should have their growth regularly monitored. If concerns arise regarding slowed growth, healthcare providers may consider dosage adjustment or discontinuation.
• Attention and memory disturbances: Qsymia may cause attention, memory, or speech/language disturbances. Patients should be cautious when operating machinery or vehicles. Any persistent cognitive issues should be reported to healthcare providers.
• Metabolic and renal monitoring – Qsymia can affect your kidney function and the levels of minerals in your body. Regular blood tests might be recommended to monitor these effects, and you might need a dose adjustment or discontinuation of this medication if you have persistent or significant changes in blood minerals.
• Serious skin reactions: Qsymia should be promptly discontinued at the first sign of a rash, unless it is clearly unrelated to the medication. Serious skin reactions should be reported to healthcare providers for evaluation and management.

Allergic Reactions to Qsymia

Although rare in the general population, these reactions may include hives and, in more severe cases, dermatologic issues like bullous skin reactions. Other potential allergic responses involve the cardiovascular system and central nervous system. Recognizing these symptoms is vital, and immediate medical attention is necessary for those experiencing any allergic reactions.

Allergic reactions to Qsymia include:¹

• Hives
• Elevated blood pressure
• Bullous skin reactions (fluid-filled blisters)

If someone experiences allergic reactions to Qsymia, prompt medical attention is crucial. Allergic responses, including hives, elevated blood pressure, psychiatric effects,or severe skin issues, require immediate evaluation by healthcare professionals. It’s vital to seek medical help promptly to address and manage any potential complications associated with these allergic reactions.

Interactions That May Exacerbate Qsymia Side Effects

Certain medications and dietary factors can interact with Qsymia, potentially intensifying its side effects. When used alongside oral contraceptives, there may be changes in progestin and estrogen exposure, possibly causing irregular bleeding. It’s advised not to discontinue oral contraceptives solely due to spotting.¹

CNS depressants, including alcohol, can enhance the central nervous system depressant effects of Qsymia, emphasizing the importance of avoiding excessive alcohol use. When combined with diuretics (water pills) that are classified as non-potassium sparing, it can cause low potassium. Blood tests can monitor for this side effect. Being mindful of these interactions is essential for safe and effective Qsymia use.

How to Manage Qsymia Side Effects

Common side effects of Qsymia, like numbness, dizziness, and taste changes, often improve with continued use. Establishing a regular sleep routine helps with insomnia, and staying hydrated eases constipation. For dry mouth, frequent water intake and sugarless gum are helpful.

Contact your child’s healthcare provider right away if they experience side effects from Qsymia. Monitoring heart rate is crucial, and any persistent or concerning symptoms should be reported immediately to their prescriber.

Dry Mouth

For dry mouth, a possible Qsymia side effect, drink water regularly to stay hydrated. Consider using sugarless gum or candies for added relief. Limiting caffeine and alcohol can also help. Dry mouth typically occurs early in treatment and often lessens over time.

Sleep Problems

If trouble sleeping arises while taking Qsymia, establishing a consistent sleep routine can help. Creating a calming bedtime environment, avoiding stimulants close to bedtime, and using relaxation techniques may improve the quality of your sleep.

Constipation

For constipation, a common side effect of Qsymia, increasing dietary fiber through fruits, vegetables, and whole grains can promote regular bowel movements. Staying hydrated by drinking plenty of water and engaging in regular physical activity can also help with constipation.

Changes in Taste

Changes in taste may be managed by experimenting with different foods and flavors to find what is most enjoyable. Maintaining good oral hygiene and staying hydrated can also help when adjusting to altered taste.

Joint Pain

Joint pain can be managed with over-the-counter pain relievers, such as acetaminophen or ibuprofen, as directed. Applying ice or heat to affected areas and engaging in gentle exercises may also provide relief.

Individual responses to Qsymia may vary, and the provided list may not encompass all potential side effects. If considering Qsymia, consult with your healthcare provider to understand your unique risk profile and potential side effects.

Lifestyle Tips to Reduce Qsymia Side Effects

Adopting certain lifestyle modifications can minimize potential side effects while taking Qsymia. Prioritize a well-balanced, nutritious diet rich in fruits, vegetables, and whole grains to support overall health and potentially mitigate digestive issues. Regular physical activity, such as brisk walking or other low-impact exercises, can enhance the effectiveness of Qsymia and alleviate some side effects.

Staying hydrated is key, particularly for dry mouth. Consulting with your healthcare provider to tailor these lifestyle adjustments to your individual needs ensures a holistic approach to managing potential side effects while on Qsymia.

Questions to Ask Your Healthcare Provider About Qsymia Side Effects

Discuss Qsymia side effects with your psychiatrist or other healthcare provider if considering or using the medication. Ask about common and rare side effects, their duration, and potential lifestyle adjustments. Inquire about warning signs requiring immediate attention to make informed decisions about your treatment.

Questions to ask your care team about Qsymia side effects:

• How long is the typical adjustment period when starting Qsymia?
• Will the side effects of Qsymia go away on their own?
• Are there potential interactions between Qsymia and other medications I am currently taking?
• What signs indicate more serious side effects that require immediate attention?
• Is there a recommended time of day to take Qsymia for optimal effectiveness and minimal side effects?
• How might Qsymia affect my existing medical conditions, if any?
• Are there specific dietary considerations to enhance the medication’s effectiveness and minimize side effects?
• Can adjustments in dosage help reduce the likelihood of side effects?
• What lifestyle changes can I incorporate to mitigate common side effects?
• Are there any activities or substances I should avoid while on Qsymia to prevent adverse reactions?
• How frequently should I schedule follow-up appointments to monitor side effects and overall progress?
• What steps can I take to manage specific side effects like dry mouth or trouble sleeping?
• Is Qsymia safe to use while pregnant or breastfeeding?
• Are there alternative medications or strategies if I experience intolerable side effects with Qsymia?
• Can you provide resources or educational materials about Qsymia and its potential side effects for further understanding?
• How will Qsymia impact routine blood pressure and heart rate monitoring?
• Does Qsymia cause hair loss?