Saxenda Vs Ozempic: What’s the Difference?

What Is Saxenda?

Saxenda is an FDA-approved injectable weight loss medication for adults with obesity or excess weight-related medical problems and for adolescents aged 12 to 17 with obesity. It helps in weight loss and maintenance.¹

“FDA-approved” signifies it’s been rigorously tested and deemed safe and effective. Saxenda belongs to the GLP-1 receptor agonist class. As of record, there are limited to no off-label uses, which involve prescribing a medication for purposes beyond its approved indications. Another liraglutide injection called Victoza is FDA-approved for managing blood sugar in people with type 2 diabetes, but this article will not be discussing Victoza.

What Is Ozempic?

Ozempic is an FDA-approved injectable prescription medicine, with the active ingredient semaglutide, used to improve blood sugar levels in adults with type 2 diabetes mellitus. FDA-approved indicates that the U.S. Food and Drug Administration has thoroughly evaluated and approved the medication for specific uses, ensuring its safety and effectiveness.

Ozempic is also FDA-approved for the following conditions:²

• Reduce the risk of major cardiovascular events, such as heart attack or stroke
• Help adults with type 2 diabetes and known heart disease

Off-label use refers to prescribing a medication for purposes other than its FDA-approved uses. Ozempic can be used to reduce blood sugar resulting in weight loss and management.³ Another semaglutide injection known as Wegovy is FDA-approved for weight loss and management but this article will not discuss Wegovy.

Key Differences Between Saxenda & Ozempic

Saxenda and Ozempic, both injectable medications, differ primarily in their approved uses. Saxenda is FDA-approved for weight management in adults and children aged 12 and older with obesity or excess weight, while Ozempic is indicated for adults with type 2 diabetes to improve blood sugar control. Although both belong to the same class, their distinct focuses on weight management and diabetes treatment set them apart

Here are the key differences between Saxenda and Ozempic:^{1, 2}

Key Components	Saxenda	Ozempic
What is the generic name?	Liraglutide	Semaglutide
What is the active ingredient?	Liraglutide	Semaglutide
What forms does it come in?	Injectable solution	Injectable solution
What are the typical maintenance dosages?	3 mg injected once daily	1 mg to 2 mg injected once weekly
Who is approved to take it?	Adults and children (12 and older) for weight management	Adults with type 2 diabetes for blood sugar control
Relevant comparisons	Saxenda is specifically approved for chronic weight management, addressing obesity in both adults and children.	Ozempic is specifically approved for adults with type 2 diabetes to enhance blood sugar control.
Administration frequency	Daily	Weekly
Off-Label Use	None	Off-label use for weight loss observed due to associated weight reduction effects
Common Side Effects	Nausea, diarrhea, constipation, headache	Nausea, vomiting, diarrhea, abdominal pain

How Do Saxenda Vs. Ozempic Work?

Saxenda and Ozempic work to aid weight loss in different ways but are very similar as they both belong to the same class of medications known as GLP-1 agonists. Saxenda signals your brain to feel full, helping control appetite and reduce food intake. Ozempic, designed for managing blood sugar in type 2 diabetes, also leads to weight loss as a side effect by regulating blood sugar levels and promoting a sense of fullness. Both medications enhance the body’s natural mechanisms for weight management.

Are Saxenda & Ozempic the Same Thing?

Saxenda and Ozempic are not the same active ingredient but share similarities. Both are injectable medications in the GLP-1 receptor agonist class. Saxenda, with liraglutide, is FDA-approved for chronic weight management in adults and adolescents. Ozempic, containing semaglutide, is approved for treating Type 2 diabetes in adults. Saxenda is also given as a daily injection, while Ozempic is a weekly injection.

While their class and mechanisms align, their primary purposes differ—Saxenda for weight loss and Ozempic for diabetes control. It’s crucial to use each medication as prescribed for its specified condition, as they are distinct in their approved uses and dosage recommendations.

Can You Switch From Ozempic to Saxenda?

It is not common to switch between these two, but a switch may be made to another medication with the same active ingredient. Switching from Ozempic to Saxenda or vice versa, or to any other medication, should be done under the guidance of a healthcare professional. The decision to switch depends on individual health needs, and adjustments in dosage and monitoring may be necessary.

Which Is More Effective, Ozempic or Saxenda?

The effectiveness of Ozempic and Saxenda hinges on individual health objectives. Ozempic, used to treat blood sugar in people who have type 2 diabetes has been shown to be effective in controlling blood sugar levels.

Meanwhile, Saxenda is approved for weight management and has been shown to be effective in weight loss and management. The decision between the two depends on whether the primary focus is diabetes control or weight loss.

Is Saxenda Better Than Ozempic for Weight Loss?

These two medications cannot be compared for weight loss since Ozempic has not been studied and FDA-approved for weight loss. If you have questions about using a GLP-1 agonist for weight loss, talk with your healthcare professional. They will be able to help determine what medication is the best option for you.

Saxenda Vs. Ozempic Dosages

Saxenda and Ozempic have different dosages and formulations. Saxenda is available in a pre-filled pen delivering doses ranging from 0.6 mg to 3 mg. Ozempic comes in disposable pens with doses of 0.25 mg, 0.5 mg, 1 mg, and 2 mg per injection, each with varying concentrations. It’s important to note that dosages are not standardized for weight loss, and individual responses may vary. Healthcare providers tailor doses based on specific health needs.

Saxenda Form & Dosages

Saxenda is available in a pre-filled pen formulation, containing a clear, colorless solution at a concentration of 6 mg/mL. The pen allows for convenient and precise delivery of doses ranging from 0.6 mg to 3 mg.¹

For adults and children, the starting dosage of Saxenda is 0.6 mg per day for one week, and the dose is increased in weekly intervals until the maintenance dosage of 3 mg injected once weekly is reached. If children have side effects, their maintenance dosage may be reduced to 2.4 mg injected once daily.

The appropriate form and dosage of Saxenda for an individual are determined by various factors, including the specific disorder being treated, the patient’s age, and other individual health considerations. Healthcare professionals tailor the prescription to the unique needs of each patient, emphasizing the importance of consulting with a healthcare provider for personalized guidance on Saxenda usage.

Ozempic Form & Dosages

Ozempic is administered through pre-filled, disposable pens containing a clear, colorless solution. The available dosages include 0.25 mg, 0.5 mg, 1 mg, and 2 mg per injection, each with varying concentrations per mL.²

The starting dosage of Ozempic is 0.25 mg, injected once weekly. The dose should be increased to 0.5 mg once weekly after 4 weeks. Depending on the blood sugar control that is needed, the dose may be increased to 1 mg or even 2 mg once weekly in 4-week intervals.

Determining the appropriate form and dosage of Ozempic is based on factors such as the specific disorder being treated, the patient’s age, and other individual health considerations. It’s essential to consult with a healthcare provider for personalized guidance on Ozempic usage.

Side Effects of Saxenda Vs.Ozempic

Side effects from Saxenda or Ozempic may occur for some people, including nausea, vomiting, diarrhea, abdominal pain, and constipation. These side effects are often mild, and many individuals tolerate the medications well. However, it’s essential to notify your healthcare provider if any side effects persist.

Common side effects from taking Saxenda may include:¹

• Nausea
• Diarrhea
• Constipation
• Vomiting
• Injection site reaction
• Low blood sugar (hypoglycemia)
• Headache
• Upset stomach (dyspepsia)
• Tiredness (fatigue)
• Dizziness
• Stomach pain
• Change in enzyme (lipase) levels in your blood

Serious side effects from taking Saxenda may include:¹

• Inflammation of the pancreas (pancreatitis)
• Gallbladder problems
• Increased risk of low blood sugar (hypoglycemia)
• Increased heart rate
• Kidney problems
• Serious allergic reactions
• Depression or thoughts of suicide

Common side effects from taking Ozempic may include:²

• Nausea
• Vomiting
• Diarrhea
• Abdominal (stomach) pain
• Constipation

Serious side effects from taking Ozempic may include:²

• Inflammation of the pancreas (pancreatitis)
• Changes in vision
• Low blood sugar (hypoglycemia)
• Kidney problems (kidney failure)
• Serious allergic reactions
• Gallbladder problems

*All medications, including Saxenda and Ozempic, have a risk of side effects, including serious side effects. This is not a complete list of side effects. You should talk with your healthcare professional about the benefits and risks of any medication before starting treatment.

Warnings & Precautions for Saxenda & Ozempic

Warnings and precautions for Saxenda and Ozempic, both containing GLP-1 agonists semaglutide and liraglutide, include the risk of thyroid C-cell tumors, acute pancreatitis, and gallbladder issues. It’s vital for users to be aware of these warnings, and consultation with healthcare providers is crucial for personalized guidance and monitoring based on individual health conditions.

Risks to consider when taking Saxenda and Ozempic include:^{1, 2}

• Thyroid C-cell tumors: Both Saxenda and Ozempic carry a potential risk of thyroid C-cell tumors. Look out for symptoms like a lump in the neck or difficulty swallowing and seek immediate medical attention if noticed.
• Pancreatitis: There is a risk of acute pancreatitis with both medications. Watch for persistent severe abdominal pain and consult your healthcare provider promptly if such symptoms occur.
• Gallbladder issues: Saxenda and Ozempic may lead to acute gallbladder disease. Seek medical attention if you experience pain in the upper stomach, fever, jaundice, or clay-colored stools.
• Hypoglycemia: Both medications pose a risk of low blood sugar. Monitor for symptoms like dizziness, sweating, and confusion, especially if taking other anti-diabetic medications. Seek prompt medical attention if hypoglycemia occurs.
• Heart rate increase (Saxenda): Saxenda may cause an increase in heart rate. Notify your healthcare provider if you experience sustained rapid heartbeats.
• Kidney issues: Both Ozempic and Saxenda may contribute to kidney problems. Monitor for symptoms like changes in urine output and seek medical attention if noticed.
• Diabetic retinopathy complications (Ozempic): Ozempic users with diabetic retinopathy may face complications. Schedule regular eye check-ups and report any vision changes promptly.
• Hypersensitivity reactions: Both medications carry a risk of hypersensitivity reactions. Watch for symptoms like swelling, difficulty breathing, and severe rash. Seek immediate medical attention if these reactions occur.
• Suicidal ideation (Saxenda): Saxenda may cause suicidal ideation or experience worsening of depression. If you experience thoughts of suicide or feel depressed while taking Saxenda, tell your healthcare provider or seek emergency treatment immediately.

Potential Drug Interactions With Saxenda & Ozempic

When using Saxenda or Ozempic, it’s important to know how they might interact with other medications. Saxenda could slow down how quickly your stomach empties, which might affect how other oral medications are absorbed. While studies show this impact is usually minimal, it’s a good idea to keep an eye out for any changes in how your medications work together.

Both Saxenda and Ozempic, when combined with insulin or certain other medications, may raise the risk of low blood sugar, so adjusting the insulin dose might be necessary. Both drugs could also affect how your body absorbs oral medications, even though it’s usually not a big issue.^{1, 2}

Disclaimer: Taking certain medications, herbs, or supplements alongside Saxenda and Ozempic can change how these medications work in your body or increase the risk of serious side effects. This article does not consider all the possible interactions. Please let your doctor, psychiatrists, and pharmacists know about all the products you currently use, such as prescription medication, nonprescription drugs, and herbal supplements. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Saxenda Vs Ozempic Cost

The average cost of Saxenda without insurance is around $1,310.91 for a month’s supply.⁵ On the other hand, Ozempic, without insurance, has an average cost of approximately $916.02.⁶ The ultimate price you will pay will be determined by a number of factors, such as insurance coverage (if you have it) and the pharmacy you use.

It’s important to note that insurance coverage for these medications may vary, and some plans may not include them in their formulary. However, various Saxenda coupons, discounts, and savings programs are available to help offset the costs for individuals without insurance coverage.

Which Is Right for You: Saxenda or Ozempic?

Choosing between Saxenda and Ozempic depends on various factors, such as your health needs and lifestyle. Consulting with a healthcare provider is essential for personalized advice considering your medical history, potential risks, and benefits.

If in-person visits are challenging, online pharmacy services can connect you with professionals who can provide remote guidance. Considerations like cost, side effects, and administration method should be weighed. Both medications have unique features, and your healthcare provider can help you decide which one aligns best with your circumstances and health goals.

How to Get a Prescription for Saxenda or Ozempic

To get a prescription for Saxenda or Ozempic, you need to consult with a healthcare professional such as your primary care physician, an endocrinologist, or an obesity medicine specialist. They’ll discuss the potential benefits and risks of these medications based on your individual situation. If suitable, your healthcare provider will then provide a prescription and offer guidance on how to incorporate these medications into your overall treatment plan.

Questions to Ask Your Health Team About Saxenda & Ozempic

Open communication with your healthcare team is crucial when considering medications like Saxenda and Ozempic. Before your appointment, take a moment to jot down any questions or concerns you may have about these medications. Remember, your healthcare team is there to support you, so don’t hesitate to bring up any uncertainties or seek clarification during your appointment.

Questions to ask your prescriber about Saxenda and Ozempic include:

• Is it safe to take Saxenda or Ozempic with my other medications?
• Will Saxenda or Ozempic be covered by my insurance?
• Which one has the best results as a treatment for weight loss?
• Does my medical history increase my risk of side effects for either?
• How long can I expect side effects to last?
• How can I prevent Ozempic face or appearance changes due to rapid weight loss?
• How often should I see you for checkups while taking Saxenda or Ozempic?
• What should I do if I am unsure whether weight loss medications are right for me?
• Are there any lifestyle changes or dietary considerations I should be aware of while taking these medications?
• What are the potential interactions with alcohol or other substances?
• Can you provide more information about the expected timeline for seeing results with Saxenda or Ozempic?
• How does the cost of Saxenda and Ozempic compare, and are there any patient assistance programs available?
• Will these medications interact with any over-the-counter supplements or herbal remedies I am currently using?
• Is there any additional lifestyle advice, such as exercise recommendations, that could complement the effects of Saxenda or Ozempic?
• Are there circumstances under which I should discontinue these medications, and what is the process for doing so?
• Can you explain the expected mechanism of action of Saxenda or Ozempic in simple terms?
• How does Ozempic differ from compounded semaglutide?
• Are there alternatives to Ozempic I can consider?
• What is the risk of taking Saxenda or Ozempic while pregnant?
• What other peptides for weight loss may be effective?