Zurzuvae (Zuranolone): Uses, Side Effects, & More

What Is Zurzuvae?

Zurzuvae is a new postpartum depression medication from the class of drugs known as neuroactive steroids and contains the active ingredient zuranolone. It acts on the brain’s GABA receptors, enhancing the inhibitory neurotransmitter’s effects and reducing feelings of anxiety and depression. Unlike traditional antidepressants, Zuranolone has a rapid onset of action, providing potential relief within days of treatment initiation.¹

Is Zurzuvae FDA-Approved?

Yes. The FDA has approved Zurzuvae for treating postpartum depression. Zurzuvae was also evaluated in clinical trials for treating major depressive disorder (MDD), but the FDA decided that the clinical results were not complete and did not approve Zurzuvae for treating MDD. It is unclear if Zurzuvae will continue being investigated as a treatment for MDD.

How Does Zurzuvae Work?

Zurzuvae works by interacting with a specific receptor in the brain called GABA-A receptor. This receptor is part of the brain’s major inhibitory system, which helps control brain function and communication. As a once-daily, 14-day treatment, Zurvuae acts on the GABA-A receptor, part of the many pathways that carry signals in the brain. This property holds the potential to provide quick relief in postpartum depression (PPD) symptoms. ¹

Zurzuvae Forms & Strengths

Zurzuvae is available in a single form: a rapid-acting, once-daily, 14-day oral capsule. Zurzuvae is available in three strengths: 20 milligrams (mg), 25 mg, and 30 mg capsules. Patients are typically instructed to take one capsule daily for the prescribed 14-day duration. The drug is currently only available as a brand name and has no generic version.³

What Is Zurzuvae Used to Treat?

Zurzuvae is FDA-approved to treat postpartum depression (PPD).² FDA approval signifies that the drug has successfully met rigorous safety and efficacy standards, indicating its potential to become a valuable treatment option for individuals facing specific conditions.⁴

Zurzuvae’s use in treating postpartum depression (PPD) provides a rapid-acting, once-daily, 14-day oral treatment option for PPD. Women experiencing PPD have unique needs as they navigate the challenges of motherhood. ^{1, 3} PPD is a severe and time-sensitive condition that can significantly impact a woman’s mental health during a critical phase of her life. ¹

Common Side Effects of Zurzuvae

In clinical trials, Zurzuvae has been associated with common side effects, including gastrointestinal discomfort, headache, dizziness, fatigue, sleep disturbances, and dry mouth. It’s important to note that individual responses may vary, and some people may not experience side effects from Zurzuvae. If you encounter any concerning symptoms, seeking medical attention is crucial for proper evaluation and management.

Common side effects of Zuranolone include:¹

• Nausea
• Headache
• Dizziness
• Fatigue
• Insomnia
• Dry mouth

Serious Side Effects of Zurzuvae

Zurzuvae may lead to significant side effects that demand urgent medical attention. These include the risk of suicidal thoughts or behavior, depression symptoms getting worse, agitation, seizures, and potential allergic reactions.¹ If these adverse effects occur while using Zurzuvae, seek immediate medical care to ensure your safety and well-being.

Serious side effects of Zurzuvae include:

• Suicidal thoughts or behavior
• Worsening depression symptoms
• Agitation or restlessness
• Changes in mood or behavior
• Unusual or severe thoughts or behaviors
• Uncontrolled movements
• Seizures
• Allergic reactions
• Severe drowsiness and confusion
• Impaired ability to drive or engage in hazardous activity

*All medications, including Zurzuvae, can cause side effects that can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and understand the potential side effects and benefits of any medication.

Zurzuvae Warnings & Precautions

Before taking Zurzuvae, be aware of potential warnings and precautions. These include monitoring for suicidal thoughts, restlessness, and sleep disturbances.¹ Additionally, being watchful for signs of allergic reactions is essential. Seek medical attention promptly if any concerning symptoms arise.

Precautions for taking Zurzuvae include:

• Suicidal thoughts & behavior: Be vigilant for any signs of worsening depression, suicidal thoughts, or unusual mood changes. Learn how to spot warning signs of suicide as a precautionary measure. Promptly seek medical assistance or contact emergency services if you do spot these signs.
• Agitation & Restlessness: Monitor for increased irritability or restlessness while using Zurzuvae and report any concerning symptoms to your healthcare provider.
• Sleep Disturbances: Be aware of sleep disturbances, such as insomnia or changes in sleep patterns, and discuss them with your doctor for appropriate management.
• Sedation and Confusion: Zurzuvae may cause drowsiness, sedation, and confusion; avoid operating heavy machinery or driving until you know how the drug affects you.
• Allergic Reactions: Watch for signs of allergic reactions, such as rash, itching, swelling, severe dizziness, or difficulty breathing, and seek immediate medical attention if they occur.

Interactions With Zurzuvae

Zurzuvae may interact adversely with some medications, leading to increased risks of drowsiness, dizziness, impaired judgment, and respiratory depression.⁶ To be safe, please discuss any medicines or substances you take with a healthcare provider while receiving treatment with Zurzuvae.

5 substances to avoid while taking Zurzuvae include:

• Alcohol: Taking alcohol with Zurzuvae may increase the risk of drowsiness, dizziness, and impaired judgment.
• Benzodiazepines: Combining Zurzuvae with benzodiazepines can lead to excessive sedation and respiratory depression.
• Antidepressants: Using Zurzuvae with other antidepressants may heighten the risk of serotonin syndrome, a potentially serious condition.
• Antipsychotics: Using antipsychotics alongside Zurzuvae may result in increased sedation and drowsiness.
• Opioids: Taking opioids with Zurzuvae can intensify respiratory depression and central nervous system depression, leading to potential life-threatening effects.

Questions to Ask Your Healthcare Provider About Zurzuvae

When consulting your psychiatrist, therapist, or doctor about Zurzuvae, inquire about its potential benefits and side effects. Ask if it’s right for your mental health needs and discuss any concerns. Additionally, consider exploring online psychiatry services as a convenient option if you need to change prescribers or seek specialized care.

Questions to ask your care team about Zurzuvae, a potentially transformative treatment for depression, include:

• How long does it take to adjust to Zurzuvae?
• Are there risks if I’m already on anxiety/depression medications?
• What’s the optimal Zurzuvae dosage for fewer side effects?
• When should I seek help for sexual side effects?
• What information should I share with my therapist about this medication?
• Are there alternatives to consider?
• How can online psychiatry services assist me with medication management?
• What lifestyle changes can complement Zurzuvae effectiveness?
• Are there any foods, drinks, or supplements to avoid while taking Zurzuvae?
• What symptoms require immediate medical attention?

In My Experience

In my experience, I think Zurzuvae shows great promise in transforming the lives of individuals battling postpartum depression. It offers hope and healing quickly and timely for women, especially during a challenging stage in their lives facing an adjustment to motherhood. As a healthcare professional, I strongly recommend discussing Zurzuvaeand its potential side effects with your doctor, psychiatrist, or therapist. FDA approval signifies that the drug has met safety and efficacy standards.

For women experiencing postpartum depression, rapid treatment is highly important, as PPD is a severe and time-sensitive condition. If left untreated, PDD significantly impacts their mental health during a critical life where everything constantly changes. This period is when they need quick relief the most.

Let’s say you’re considering Zurzuvae as a treatment option. In that case, it’s essential to consult your healthcare provider to make sure it’s the right choice, considering your specific needs and circumstances. Remember that your care team, including online psychiatry services, can provide valuable support and guidance throughout your journey to wellness.