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  • What Is Depression?What Is Depression?
  • Neurotic DepressionNeurotic Depression
  • SignsSigns
  • SymptomsSymptoms
  • TreatmentTreatment
  • HistoryHistory
  • ConclusionConclusion
  • InfographicsInfographics
  • Additional ResourcesAdditional Resources
Depression Articles Depression Depression Treatments Types of Depression Online Therapy for Depression

Neurotic Depression: Signs, Symptoms, & Treatments

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Author: Julia Chamberlain, LMHC

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Julia M. Chamberlain MS, INHC, LMHC

Julia offers holistic therapy for individuals and families, specializing in family stabilization and mental health counseling, fostering wellness through compassionate care.

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Medical Reviewer: Kristen Fuller, MD Licensed medical reviewer

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Kristen Fuller MD

Kristen Fuller, MD is a physician with experience in adult, adolescent, and OB/GYN medicine. She has a focus on mood disorders, eating disorders, substance use disorder, and reducing the stigma associated with mental health.

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Published: February 9, 2023
  • What Is Depression?What Is Depression?
  • Neurotic DepressionNeurotic Depression
  • SignsSigns
  • SymptomsSymptoms
  • TreatmentTreatment
  • HistoryHistory
  • ConclusionConclusion
  • InfographicsInfographics
  • Additional ResourcesAdditional Resources

Depression is characterized by a group of symptoms that include general unhappiness, hopelessness, low energy, low mood, apathy, fatigue, and slow motor function.1 Neurotic depression is a unique type of depression determined by pre-existing patterns of emotional instability. However, it has been removed from major diagnostic publications such as the ICD and the DSM.2,3,4

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What Is Depression?

Depression is a common mental health ailment that affects approximately 16 million American adults annually, but it is treatable with professional help.1,2

What Is Neurotic Depression?

Neurotic depression is a type of depression distinguished by depressive symptoms in someone who is emotionally unstable. Neurotic depression presents as depression, but with the added discomfort of a ruminative loop of negative and anxious thoughts. These thoughts then influence someone’s behavior, perception, and processing of emotions and experiences, often leading to general chaos, anxious avoidance, internalization, and disorientation.5

This form of depression is often exhibited in individuals suffering from major personality disorders, neuroticism, and substance use disorders.3

A Professional Will Not Diagnose Someone With Neurotic Depression

Neurotic depression is not considered one of the major subtypes of depression, as it is not included in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). It was also removed from the 10th edition of the international classification of diseases (ICD-10).1,2,4 Neurotic depression was replaced by persistent depressive disorder (dysthymia) and major depressive disorder, but there are nuanced differences in these presentations versus neurotic depression.4 These complex distinctions as well as overlap with other mental disorders create difficulty in pinpointing signs that are specific to neurotic depression.

Neurotic depression is unique to other mental health diagnoses in that it is intertwined with life circumstances and how these circumstances are processed.3 These issues may result in difficulty with daily tasks, heightened emotional reactivity and avoidance, substance abuse, fixation on negative experiences, and catastrophizing.3,4,5,6 But these symptoms are exhibited in other diagnoses as well, including anxiety, depression, personality disorders, and high neuroticism. This is what makes neurotic depression difficult to pinpoint, and it may be the reasoning for its omission in more recent versions of the ICD and DSM.

Signs of Neurotic Depression

In general, the signs that someone is dealing with neurotic depression include a blended presentation of depressive and neurotic behaviors.3,5,6 However, neurotic depression holds similarities and differences from non-neurotic depression, also known as melancholic depression.

Neurotic depression is similar to other types of depression in that the individual is experiencing sadness, hopelessness, and despair. However, it differs in that individuals are generally younger in age, more likely to attempt suicide, and demonstrate lower levels of melancholia, memory issues, and delusional thinking.3,5 Individuals with neurotic depression are more likely to display anxiousness and less likely to show melancholic symptoms.4,5

Typical signs that an individual is struggling with neurotic depression vs. melancholic depression include:1

  • General negative attitude and self-perception
  • Increased suicidality in comparison to non-neurotic counterparts
  • Emotional reactivity and maladaptive coping
  • Comorbid diagnoses such as a personality disorder, mood disorder, and/or substance use disorder
  • General life instability such as issues with relationships, finances, and work

Symptoms of Neurotic Depression

Neurotic depression involves a ruminative loop that can paralyze individuals and inhibit their ability to utilize coping skills and solution-focused thought processes. Long-term depression & anxiety and can yield neurotic symptoms.5

Common neurotic depression symptoms include:3,4,5,6

  • Anxiousness/anxiety
  • Suicidality
  • Internalization
  • Heightened emotional reactivity
  • Rumination
  • Fixation on negative experiences/memories
  • Maladaptive coping such as substance abuse
  • Self-blame and ‘other’ blame
  • Catastrophizing
  • Negative/low mood
  • Avoidance of triggering stimuli
  • Life problems (relationships, finances, sense of purpose)
  • Low self-esteem
  • General life dissatisfaction
  • Identity issues

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Getting Treatment For Neurotic Depression

Treatment specific to neurotic depression consists of clinical therapy to help stop being neurotic, holistic intervention, and medication management. Presumably, due to the deterrence from the neurotic depression diagnosis, there is more research on treatment that dates prior to its omission.

Therapy

Anyone who is experiencing a negative thought loop and notices that their function is being impacted should talk to a therapist to help them learn emotional regulation. Whether it is neurotic depression or another mental health issue, it is essential to prioritize treatment and wellness.

There are many access points to professional support and depression therapy. One of the main distinguishing factors of neurotic depression is the higher levels of suicidal ideation (SI), so when you’re looking for a therapist, it is essential to find a provider who is experienced in treating and managing it.3

Medication

Medication management for depression can be highly effective. Multiple studies dating back to the 1970’s discuss the efficacy of medications such as benzodiazepines and trazodone being effective for the treatment of neurotic depression. Interestingly, a 1979 study found that medication intervention was effective on both the placebo group and the control group in relieving depression and anxiety symptoms.

Coping Mechanisms

Knowing how to treat depression is vital. These finding above suggest that neurotic symptoms may be soothed by belief and mindset changes, since the placebo group also improved.1 Additionally, the implementation of exercise, specifically yoga, is shown to decrease the negative symptoms associated with both neuroticism and depression.10,11,12

The History of the Term “Neurotic Depression”

A 1978 study identified six different meanings for the term neurotic depression and suggested that the diagnosis be retired due to its vagueness.7 This form of depression relies heavily on the presence of maladaptive processing and general life chaos, which may be the result of a comorbid diagnosis such as a personality disorder or a substance use disorder.

Furthermore, the argument is made that an individual who grows up in adverse circumstances would also fit the criteria for this diagnosis, creating doubt around its validity as a stand-alone diagnosis.3 More recently, however, researchers have circled back to the idea of neurotic depression and hypothesize that it may be the ‘missing link’ between depression and anxiety.5

A 2020 study that examined the connection between neuroticism and depression in Chinese adolescents found that there was a significant relationship between the two, and that high levels of neuroticism were a predictive factor in the manifestation of depressive symptoms.6,8

Additionally, recent research has suggested that emotional regulation is the mediator between neuroticism and depression, highlighting that individuals who can access adaptive coping strategies to foster emotional regulation tend to experience lower levels of neuroticism and depression. These findings also highlight that maladaptive coping is linked to higher levels of neuroticism and depression.6,8,9

Since neurotic depression is deeply linked to life circumstances and the processing of life experiences, individuals who experience adversity are not able to develop adaptive coping skills and maintain emotional regulation.3 They are more likely to engage in thoughts and behaviors that lead to chaos and instability, triggering more emotional dysregulation. This cycle showcases the symptoms and patterns associated with neurotic depression.

Final Thoughts on Neurotic Depression

Depression is a common mental health condition characterized by a group of symptoms that include general unhappiness, hopelessness, low energy, apathy, and fatigue.1,2 Neurotic depression is a type of depression that includes depressive symptoms plagued by the addition of emotional instability, anxious and ruminative thoughts that result in impaired function.

Neurotic Depression Infographics

What Is Neurotic Depression? Symptoms of Neurotic Depression Getting Treatment for Neurotic Depression

Additional Resources

To help our readers take the next step in their mental health journey, ChoosingTherapy.com has partnered with leaders in mental health and wellness. ChoosingTherapy.com is compensated for marketing by the companies included below.

Personalized Treatment for Depression

Talkiatry – can match you with an actual psychiatrist. Talkiatry psychiatrists can evaluate you for depression and other issues that may be impacting your mood then implement a personalized treatment plan. Insurance accepted. Get started with a short online assessment.

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For Further Reading

  1. The Depression Code: Deciphering the Purposes of Neurotic Depression by Roger Di Pietro
  2. “Exploring depression” Free Course 
  3. Neurotics Anonymous Support Groups
  4. Best Books for Living With Depression

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Sources Update History

ChoosingTherapy.com strives to provide our readers with mental health content that is accurate and actionable. We have high standards for what can be cited within our articles. Acceptable sources include government agencies, universities and colleges, scholarly journals, industry and professional associations, and other high-integrity sources of mental health journalism. Learn more by reviewing our full editorial policy.

  • NIMH. Depression. Retrieved from: https://www.nimh.nih.gov/health/topics/depression

  • High Watch Recovery. 8 Subtypes of Depression. Retrieved from: https://highwatchrecovery.org/8-subtypes-of-depression/

  • Winokur, G., Black, D. W., & Nasrallah, A. (1987). Neurotic depression: a diagnosis based on preexisting characteristics. European archives of psychiatry and neurological sciences, 236(6), 343–348. https://doi.org/10.1007/BF00377423

  • Hoffmann S. O. (2003). Die neurotische Depression–Eine Krankheit ohne Diagnose oder eine Diagnose ohne Glossar? [Neurotic depression–a disease without a diagnosis or a diagnosis without a glossary? ]. Zeitschrift fur Psychosomatische Medizin und Psychotherapie, 49(4), 346–362. https://doi.org/10.13109/zptm.2003.49.4.346

  • Nierenberg, A., & Ellard, K. (2015). Neurotic depression as the missing link: Old wine with a new twist on anxiety and major depressive disorder. Epidemiology and Psychiatric Sciences, 24(3), 230-232. doi:10.1017/S2045796015000323

  • Liu C, Chen L and Chen S (2020) Influence of Neuroticism on Depressive Symptoms Among Chinese Adolescents: The Mediation Effects of Cognitive Emotion Regulation Strategies. Front. Psychiatry 11:420. doi: 10.3389/fpsyt.2020.00420

  • Klerman, G. L., Endicott, J., Spitzer, R., & Hirschfeld, R. M. (1979). Neurotic depressions: a systematic analysis of multiple criteria and meanings. The American journal of psychiatry, 136(1), 57–61. https://doi.org/10.1176/ajp.136.1.57

  • Guo WB, Yao SQ, Lu YH, Zhu XZ, Wu DX. (2003) Study on life events and social support characteristics of patients with depression. Chin. J Men. Health (2003) 17(10):693–5. doi: CNKI:SUN:ZXWS.0.2003-10-014

  • Kathleen Lira Yoon, John Maltby & Jutta Joormann (2013) A pathway from neuroticism to depression: examining the role of emotion regulation. Anxiety, Stress & Coping, 26:5,558-572, DOI: 10.1080/10615806.2012.734810

  • Grover, Poonam & Varma, V & Pershad, Dwarka & Verma, Savita Kumari. (1994). Role of Yoga in the treatment of neurotic disorders: current status and future directions. Indian journal of psychiatry. 36. 153-62.

  • Kurland M. L. (1976). Neurotic depression an empirical guide to two specific drug treatments. Diseases of the nervous system, 37(8), 424–431.

  • Goldberg, H. L., & Finnerty, R. J. (1980). Trazodone in the treatment of neurotic depression. The Journal of clinical psychiatry, 41(12 Pt 1), 430–434.

  • Rickels, K., Downing, R., & Stein, M. (1979). The differentiation between neurotic depression and anxiety and drug treatment. In Neuro-psychopharmacology (pp. 467-472). Pergamon.

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We regularly update the articles on ChoosingTherapy.com to ensure we continue to reflect scientific consensus on the topics we cover, to incorporate new research into our articles, and to better answer our audience’s questions. When our content undergoes a significant revision, we summarize the changes that were made and the date on which they occurred. We also record the authors and medical reviewers who contributed to previous versions of the article. Read more about our editorial policies here.

February 9, 2023
Author: No Change
Reviewer: No Change
Primary Changes: Updated for readability and clarity. Reviewed and added relevant resources.
December 14, 2021
Author: Julia Chamberlain, MS, INHC, LMHC
Reviewer: Kristen Fuller, MD
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