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  • What Is Depression?What Is Depression?
  • Endogenous DepressionEndogenous Depression
  • Exogenous DepressionExogenous Depression
  • Endogenous Vs. ExogenousEndogenous Vs. Exogenous
  • Endogenous Depression SymptomsEndogenous Depression Symptoms
  • Exogenous Depression SymptomsExogenous Depression Symptoms
  • DiagnosisDiagnosis
  • TreatmentTreatment
  • How to CopeHow to Cope
  • ConclusionConclusion
  • InfographicsInfographics
  • Additional ResourcesAdditional Resources
Depression Articles Depression Depression Treatments Types of Depression Online Therapy for Depression

Endogenous & Exogenous Depression: Definition, Symptoms, & Treatment

Headshot of Nicole Arzt, LMFT

Author: Nicole Arzt, LMFT

Headshot of Nicole Arzt, LMFT

Nicole Arzt LMFT

Nicole specializes in psychodynamic and humanistic therapy.  She’s  an expert in complex trauma, substance use disorder, eating disorders, anxiety, depression, imposter syndrome, narcissistic abuse, and relationships and intimacy.

See My Bio Editorial Policy
Rajy Abulhosn, MD

Medical Reviewer: Rajy Abulhosn, MD Licensed medical reviewer

Published: March 6, 2023
  • What Is Depression?What Is Depression?
  • Endogenous DepressionEndogenous Depression
  • Exogenous DepressionExogenous Depression
  • Endogenous Vs. ExogenousEndogenous Vs. Exogenous
  • Endogenous Depression SymptomsEndogenous Depression Symptoms
  • Exogenous Depression SymptomsExogenous Depression Symptoms
  • DiagnosisDiagnosis
  • TreatmentTreatment
  • How to CopeHow to Cope
  • ConclusionConclusion
  • InfographicsInfographics
  • Additional ResourcesAdditional Resources

Although the terms aren’t commonly used when discussing mental health anymore, it can be helpful to understand the concepts of endogenous and exogenous depression. Endogenous depression refers to depression that presents as biological or genetic. There are no specific or apparent external variables. Exogenous depression, on the other hand, appears to be triggered by specific factors like stress or trauma.

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What Is Depression?

Depression is a serious mental health condition and is classified as a mood disorder. Those who struggle with depression experience many symptoms such as changes in sleep, weight, appearance, motivation, joy, and sociability. Those who struggle often report having such a low mood that they have no motivation to properly care for themselves.

What Is Endogenous Depression?

Endogenous depression refers to a type of depression that was once diagnosed as a distinct disorder. Today, it’s best understood as major depressive disorder (MDD), a mood disorder characterized by pervasive negative feelings without an apparent cause.1

Causes of Endogenous Depression

While researchers have not identified a specific cause, it is likely that endogenous depression manifests from a combination of genetic and psychological factors, including:

  • Life stressors
  • Biological predisposition
  • Genetic predisposition
  • Family history and general exposure to depression
  • Physical manifestation of depression

What Is Exogenous Depression?

Exogenous depression is a type of reactive depression, meaning that it results from a specific, external cause. Also called situational depression, the symptoms of reactive depression can mimic those of MDD.

Cause of Exogenous Depression

Exogenous depression often mimics situational depression, in that the individual experiences depression as a result of a particular event like a divorce, financial hardship, or medical issue like depression ater surgery or depression after stroke. Exogenous depression can occur quickly after the challenging event.

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Endogenous Depression Vs. Exogenous Depression

Endogenous depression means the depression does not have a specific cause. Exogenous depression means the depression resulted from an identified stressor.2 Mental health experts used to distinguish endogenous depression from exogenous depression by assessing whether a stressor occurred before MDD symptoms emerged. Today, this is no longer applicable. Instead, practitioners will typically diagnose someone with depression based on a set criterion of symptoms.

Endogenous Depression Symptoms

Because endogenous depression does not have a specified cause, depression symptoms can occur suddenly and without warning.3 Symptoms may present as mild at first, but they can progress quickly. With that in mind, the average age at onset is during one’s mid-twenties, and women are nearly twice as likely to experience depression than men.4

Symptoms of endogenous depression include:5

  • Pervasive feelings of hopelessness or helplessness
  • Apathy – losing interest in usual hobbies or relationships
  • Difficulty with focus or concentration
  • Suicidal ideation or making attempts to hurt yourself
  • Isolating yourself from others
  • Depression & weight changes
  • Body pain (headaches, gastrointestinal distress, muscle tightness)
  • Lack of motivation

Exogenous Depression Symptoms

Exogenous depression can arise in response to an upsetting event or stressor. For example, you might experience this depression after losing your job, breaking up with your significant other, or relocating to a new city. Symptoms can occur anytime after the event, and they may be either short-lived or persistent, depending on the situation.

Symptoms of exogenous depression are the same as endogenous depression, with the addition of intense regret or rumination to go back to the way things were before the stressful event.

Diagnosis of Endogenous Vs. Exogenous Depression

The biggest difference in the diagnosis process between endogenous and exogenous depression is determining stress levels before the onset of major depression. Those with endogenous depression tend to develop this type of depression organically, not due to previous stress or trauma. Exogenous depression onsets following a stressful or traumatic event. That is the biggest differentiator when coming up with one of these diagnoses.

Treatment of Endogenous & Exogenous Depression

Knowing how to treat depression is often multifaceted and customized to an individual’s specific situation and needs. Treatment may consist of a combination of psychotherapy, medication, and lifestyle habits. In crippling depression instances, such as in the presence of suicidal ideation, crisis support is imperative. Get immediate help by contacting your therapist, reaching out to the suicide prevention hotline at 800-273-TALK, or calling 9-1-1.6

Medication

Medication for depression can be extremely beneficial in managing and treating depression symptoms. For example, selective serotonin reuptake inhibitors (SSRIs), such as Prozac, Lexapro, Celexa, and Paxil, work by stabilizing serotonin levels in the brain. This process can help support mood and emotional regulation.

Therapy

Psychotherapy can help you understand your depression triggers and learn healthier skills for managing your symptoms. If medication is prescribed, it is highly recommended that you also regularly see a therapist. Therapy and lifestyle changes can greatly influence and enhance medication outcomes.

Different therapeutic modalities address treatment of depression variously:

  • Cognitive behavioral therapy (CBT): cognitive therapy models, such as CBT for depression or dialectical behavioral therapy (DBT), often focus on recognizing how certain beliefs affect feelings and behaviors
  • Psychodynamic therapy: psychodynamic therapy explores how past issues and experiences affect current areas of functioning
  • Experiential therapies: experiential therapies may integrate concepts of art, writing, dance, or other forms of expression to help with mood regulation

How to Find a Therapist

It can be helpful to explore the process of finding a therapist through an online therapist directory. While the origin of your depression likely won’t impact how your provider supports you, a good therapist can help you understand the thoughts, feelings, or experiences that may be maintaining your distressing symptoms.

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How to Cope With Endogenous & Exogenous Depression

Coping with depression can be challenging, but it is possible to reduce your distress and overcome your struggles. Keep in mind that different coping skills may work better at some times than others. That’s why it’s important to have several skills you can refer to when you’re struggling. The more you practice them, the more second nature they will become.

Here are ways to cope with endogenous and exogenous depression:

  • Meditate: meditation for depression can help you feel more grounded and present in everyday life. There are many ways to meditate, including taking several deep breaths in a row, completing a guided imagery exercise, focusing on single-task mindfulness, or taking an intentional nature walk.
  • Spend time outside: research shows clear benefits of nature on mental health.7 Commit to taking a morning walk, eating lunch outside, or spending the afternoon at the park.
  • Exercise: exercise can release feel-good hormones that decrease depression symptoms. Find an activity you enjoy and participate in it several times a week.
  • Spend time with supportive loved ones: it’s important to make meaningful connections in your life. Laughing, seeking support, and feeling validated by others can lessen the intensity of your depression.
  • Reflect on your gratitude: gratitude can help keep “the big picture” into perspective. Try to commit to incorporating a regular gratitude exercise in your daily routine.
  • Limit numbing behaviors: try to be mindful of your intake of nicotine, caffeine, alcohol, or mood-altering drugs. Limit excess time spent on social media or watching TV. Instead, try to focus on being more active and engaged with your everyday life.
  • Cuddle your pets: connecting with animals can be extremely helpful in boosting your mood or self-esteem. If you don’t have your own animals, consider volunteering at a local rescue.
  • Plan something fun and exciting: having something to look forward to can instill a sense of hope and joy. This will give you something to focus on even when life feels challenging.
Depression Workbook

Depression Workbook

Our workbook contains our best depression worksheets to help you understand your depression, develop effective coping skills, and manage challenging moments.

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Final Thoughts On Endogenous & Exogenous Depression

Endogenous and exogenous depression can be challenging to deal with, but you can overcome your symptoms and live a meaningful life. Treatment is available, and reaching out for support now can make a tremendous difference in how you feel.

Endogenous & Exogenous Depression Infographics

Endogenous Depression vs. Exogenous Depression What is Exogenous Depression? What is Endogenous Depression?

Additional Resources

To help our readers take the next step in their mental health journey, ChoosingTherapy.com has partnered with leaders in mental health and wellness. ChoosingTherapy.com is compensated for marketing by the companies included below.

Online Therapy

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Therapy for Depression & Medication Management

Brightside Health – If you’re struggling with depression, finding the right medication can make a difference. Brightside Health treatment plans start at $95 per month. Following a free online evaluation and receiving a prescription, you can get FDA approved medications delivered to your door. Free Assessment

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For Further Reading

  • American Psychiatric Association: Help With Depression
  • NAMI Hotline
  • National Suicide Prevention Lifeline
  • Depression Center: Helpful Mental Health Resources

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Sources Update History

ChoosingTherapy.com strives to provide our readers with mental health content that is accurate and actionable. We have high standards for what can be cited within our articles. Acceptable sources include government agencies, universities and colleges, scholarly journals, industry and professional associations, and other high-integrity sources of mental health journalism. Learn more by reviewing our full editorial policy.

  • The endogenous and reactive depression subtypes revisited: integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder (2014, May). BMC Medicine. Retrieved from: https://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-12-73.

  • The doctrine of the two depressions in historical perspective (2007). Acta Psychiatrica Scandinavica. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712975/.

  • Endogenous Depression (1998). Comprehensive Clinical Psychology. Retrieved from: https://www.sciencedirect.com/topics/medicine-and-dentistry/endogenous-depression

  • Mental Health Disorder Statistics (2022). John Hopkins Medicine. Retrieved from: https://www.hopkinsmedicine.org/health/wellness-and-prevention/mental-health-disorder-statistics

  • Depression: major depressive disorder (2018, February). Mayo Clinic. Retrieved from: https://www.mayoclinic.org/diseases-conditions/depression/symptoms-causes/syc-20356007.

  • Are you thinking about suicide? How to stay safe and find treatment (2018, January). Mayo Clinic. Retrieved from: https://www.mayoclinic.org/diseases-conditions/suicide/in-depth/suicide/art-20048230.

  • Nurtured by nature (2020, April). American Psychological Association. Retrieved from: https://www.apa.org/monitor/2020/04/nurtured-nature.

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We regularly update the articles on ChoosingTherapy.com to ensure we continue to reflect scientific consensus on the topics we cover, to incorporate new research into our articles, and to better answer our audience’s questions. When our content undergoes a significant revision, we summarize the changes that were made and the date on which they occurred. We also record the authors and medical reviewers who contributed to previous versions of the article. Read more about our editorial policies here.

May 7, 2025
Author: No Change
Reviewer: No Change
Primary Changes: Added Depression Workbook with nine worksheets.
March 6, 2023
Author: No Change
Reviewer: No Change
Primary Changes: Updated for readability and clarity. Reviewed and added relevant resources. Added “What Is Depression?”, “Causes of Endogenous Depression”, and “Diagnosis of Endogenous Vs. Exogenous Depression”. New material written by Silvi Saxena, MBA, MSW, LSW, CCTP, OSW-C and reviewed by Dena Westphalen, PharmD.
March 10, 2022
Author: Nicole Arzt, LMFT
Reviewer: Rajy Abulhosn, MD
Show more Click here to open the article update history container.

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