Levitra (Vardenafil) Vs. Cialis (Tadalafil): Differences, Similarities, & Which Is Better?

What Is Levitra (Vardenafil)?

Levitra was an FDA-approved medication designed to treat erectile dysfunction (ED), a condition affecting the ability to achieve and maintain an erection. FDA-approved signifies that the U.S. Food and Drug Administration has rigorously evaluated the drug’s safety and efficacy for its intended use.¹ Levitra is no longer available, but generic vardenafil is available.

Off-label use refers to instances where a medication is prescribed for purposes beyond its approved indications. While off-label use is not uncommon, it should be approached with caution. In the case of vardenafil, some healthcare providers may prescribe it off-label for conditions such as premature ejaculation or to enhance sexual performance. However, such uses lack official FDA endorsement. Vardenafil belongs to the phosphodiesterase type 5 (PDE5) inhibitor drug class, working by increasing blood flow to the penis to facilitate and maintain an erection.

What Is Cialis (Tadalafil)?

Cialis, containing the active ingredient tadalafil, is FDA-approved to treat erectile dysfunction (ED), a condition marked by difficulty achieving and sustaining an erection. The designation “FDA-approved” signifies that the U.S. Food and Drug Administration has extensively evaluated Cialis for safety and efficacy in addressing ED.² It is also FDA-approved to treat benign prostatic hyperplasia (BPH) with or without ED.

While off-label use involves the prescription of a medication for purposes outside its approved indications, Cialis is primarily indicated for ED and benign prostatic hyperplasia. However, some healthcare providers may prescribe it off-label for conditions such as pulmonary arterial hypertension. Cialis falls under the phosphodiesterase type 5 (PDE5) inhibitor drug class, functioning by enhancing blood flow to the penile region and facilitating improved erectile function.

What Are the Differences Between Levitra & Cialis?

Levitra and Cialis are both FDA-approved medications designed to treat erectile dysfunction, but they differ in key aspects. While Levitra, containing vardenafil, tends to have a quicker onset, Cialis, with its active ingredient tadalafil, offers a longer duration of action. Their choice often hinges on individual preferences regarding onset time and duration.

Here are the key differences between Levitra and Cialis:^{1, 2}

*Refers to individuals assigned male at birth.

Are Vardenafil & Cialis the Same?

No, Vardenafil and Cialis are not the same. Although both are FDA-approved medications used to treat erectile dysfunction, they differ in their active ingredients and characteristics. Vardenafil is a generic medication that used to be known as the brand Levitra, while Cialis contains tadalafil. The main distinctions lie in their onset time and duration of action, with Levitra often acting more quickly and Cialis offering a longer window of effectiveness.

How Do Vardenafil & Cialis Work?

Vardenafil and Cialis share a common goal of helping men* with erectile dysfunction achieve and maintain an erection, and both medications are a type of phosphodiesterase type 5 (PDE5) inhibitor. These medications work by relaxing the muscles in the blood vessels of the penis, allowing increased blood flow within the penis when sexual stimulation occurs. However, there are subtle differences in how they achieve this effect.

Vardenafil often acts more quickly, making it a preferred choice for those seeking a faster response. At the same time, Cialis is known for its longer duration of action, providing a more extended window of opportunity for intimacy. Choosing between them may involve considering factors such as how quickly one wants the medication to take effect and how long one wants its effects to last.^{1, 2}

*Refers to individuals assigned male at birth.

Can Cialis & Vardenafil Be Used Together?

Using Cialis and vardenafil together is generally not recommended without explicit guidance from a healthcare professional. Both medications belong to the same drug class, phosphodiesterase type 5 (PDE5) inhibitors, and combining them may increase the risk of side effects such as low blood pressure, dizziness, and headaches.

What Are Vardenafil & Cialis Used to Treat?

Vardenafil and Cialis are medications for erectile dysfunction (ED), a condition characterized by the inability to achieve or sustain an erection for satisfactory sexual activity.

The table below compares the medical and mental health conditions vardenafil and Cialis are used to treat:^{1, 2}

Is Vardenafil More Effective Than Cialis?

Vardenafil and Cialis, both effective treatments for erectile dysfunction (ED), exhibit distinct profiles of efficacy. Vardenafil is known for its relatively rapid onset, often providing a quicker response than Cialis. On the other hand, Cialis, containing tadalafil, distinguishes itself with a longer duration of action, allowing for a more extended window of effectiveness.

Is Vardenafil Stronger Than Cialis?

The strength of vardenafil compared to Cialis is not solely determined by potency but rather by individual responses and preferences. While both medications are effective in treating erectile dysfunction, they differ in characteristics such as onset time and duration. Vardenafil often acts more quickly, providing a faster response. Conversely, Cialis, containing tadalafil, is known for its prolonged duration of action.

Does Cialis or Vardenafil Last Longer?

The notable difference between vardenafil and Cialis lies in the duration of their effects. Vardenafil typically has a relatively short duration of action, providing effectiveness for about four to five hours. In contrast, Cialis, containing tadalafil, stands out for its notably prolonged duration, with effects lasting up to 36 hours.

This extended window of opportunity has earned Cialis the nickname “the weekend pill,” making it a popular choice for those seeking a longer duration of erectile support. The choice between the two often hinges on individual preferences regarding the desired time for effectiveness.^{1, 2}

Does Cialis or Vardenafil Work Faster?

The onset times of Cialis and vardenafil, both medications designed to treat erectile dysfunction, differ noticeably. Vardenafil has a relatively quick onset, with effects often manifesting within 30 minutes to 2 hours after injection.

In contrast, Cialis, featuring tadalafil, has a more gradual onset, typically taking effect within 30 minutes to 6 hours. This distinction in onset times may influence an individual’s choice between the two, depending on their preferences and the spontaneity of their sexual activity.

Vardenafil & Cialis Dosages for FDA-Approved Treatment

The dosages of Cialis and vardenafil vary to cater to individual needs, reflecting people’s diverse responses to these medications. Individuals must adhere strictly to the prescribed dosage provided by their healthcare professional, as these recommendations are tailored based on factors such as overall health, existing medical conditions, and potential interactions with other medications.

Vardenafil is available in the following forms and strengths:¹

• Tablets
• 2.5 milligrams (mg)
• 5 mg
• 10 mg
• 20 mg
• Orally disintegrating tablet (ODT)
  • 10 mg

Cialis is available in the following forms and strengths:²

• Tablets
  • 2.5 milligram (mg)
  • 5 mg
  • 10 mg
  • 20 mg

Side Effects of Vardenafil & Cialis

Vardenafil and Cialis both contain phosphodiesterase type 5 (PDE5) inhibitors and have similar potential side effects. However, individual reactions may vary. It’s important to note that while these side effects are usually well-tolerated, some individuals may experience more severe reactions or interactions with other medications. Any persistent or severe side effects should be promptly reported to a healthcare provider.

Common side effects from taking vardenafil may include:¹

• Headache
• Flushing
• Nasal congestion
• Indigestion
• Sinusitis
• Flu symptoms
• Dizziness
• Increased creatine kinase
• Nausea
• Back pain

Serious side effects from taking vardenafil may include:¹

• Priapism (prolonged, painful erection)
• Sudden vision loss
• Hearing loss
• Allergic reactions
• Irregular heartbeat
• Severe dizziness or fainting
• Chest pain
• Nausea or vomiting
• Severe difficulty breathing or swallowing

Common side effects from taking Cialis may include:²

• Headache
• Indigestion
• Back pain
• Muscle pain
• Nasal congestion
• Flushing
• Pain in limbs

Serious side effects from taking Cialis may include:²

• Priapism
• Sudden vision loss
• Hearing loss
• Allergic reactions
• Irregular heartbeat.
• Severe dizziness or fainting
• Chest pain
• Nausea or vomiting
• Severe headache
• Difficulty breathing or swallowing

*All medications, including Cialis and Viagra, have a risk of side effects, including serious side effects. This is not a complete list of side effects. You should talk with your healthcare professional about the benefits and risks of any medication before starting treatment.

Warnings & Precautions for Vardenafil & Cialis

Vardenafil and Cialis belong to the same drug class and have similar warnings and precautions. Promptly reporting any concerning symptoms to healthcare providers and regular consultation with them is crucial for the safe and responsible use of these medications.

Risks to consider when taking vardenafil and Cialis include:^{1, 2}

• Hypotension (low blood pressure): Both vardenafil and Cialis can cause a sudden drop in blood pressure, especially when taken with nitrates or alpha-blockers. This may lead to dizziness, fainting, or other complications.
• Cardiovascular issues: Individuals with a history of heart problems or cardiovascular diseases should use vardenafil and Cialis cautiously, as these medications can exert an additional strain on the heart.
• Vision changes: Some users may experience changes in vision, such as blurred vision or a blue tint. This side effect is rare but should be reported to a healthcare provider if it occurs.
• Priapism risk: Priapism, a prolonged and painful erection lasting more than four hours, is a rare but serious side effect. Prompt medical attention is required to prevent potential damage to the penis.
• Drug interactions: Vardenafil and Cialis may interact with other medications, including those containing nitrates, alpha-blockers, and certain antifungal or antibiotic drugs. These interactions can result in adverse effects and should be discussed with a healthcare professional.
• Hearing loss: There have been rare reports of sudden hearing loss associated with the use of these medications. Individuals experiencing any hearing changes should seek medical attention promptly.
• Allergic reactions: Some people may be allergic to the active ingredients in vardenafil or Cialis, leading to allergic reactions. Seek immediate medical attention if you experience rash, itching, swelling, severe dizziness, or difficulty breathing.
• Liver and kidney issues: Patients with pre-existing liver or kidney problems may require dose adjustments or close monitoring when using vardenafil or Cialis, as these conditions can affect drug metabolism and clearance.
• Grapefruit interaction: Both medications can interact with grapefruit or grapefruit juice, potentially increasing the risk of side effects. It is advisable to avoid grapefruit products when using vardenafil or Cialis.
• Contraindication in certain health conditions: Individuals with certain health conditions, such as severe heart failure, recent stroke, or uncontrolled high blood pressure, may be advised against using vardenafil or Cialis due to potential risks. Consultation with a healthcare professional is crucial in such cases.

Potential Drug Interactions With Vardenafil & Cialis

Both vardenafil and Cialis can interact with certain substances, and users must be aware of potential interactions to ensure their safety and the effectiveness of the medications. Notably, both drugs should not be taken concurrently with nitrates, commonly prescribed for chest pain, as the combination can lead to a dangerous drop in blood pressure. Additionally, the consumption of grapefruit or grapefruit juice should be avoided while using these medications, as it can affect the metabolism of the drugs in the body, potentially altering their effectiveness.^{1, 2}

Disclaimer: Taking certain medications, herbs, or supplements alongside vardenafil and Cialis can change how these medications work in your body or increase the risk of serious side effects. This article does not consider all the possible interactions. Please let your doctor, psychiatrists, and pharmacists know about all the products you currently use, such as prescription medication, nonprescription drugs, and herbal supplements. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Vardenafil & Cialis Cost

The average cost of vardenafil and Cialis without insurance can vary depending on the dosage and the pharmacy. A 30-day supply of brand-name Cialis can cost up to $400 and is not typically covered by insurance. The generic version of Cialis, tadalafil, costs around $17 for a 30-day supply of 10 mg pills.³ These are prices without insurance.

On the other hand, the generic version, vardenafil, costs around $240 for a 30-day supply of 10 mg pills. However, discounts, coupons, and savings are available that may help reduce the cost of these medications, and it’s advisable to check with the pharmacy or use savings cards to lower the expenses.⁴ These are prices without insurance.

Lifestyle Considerations

Lifestyle factors, including the desire for spontaneity and the preferred duration of action, play a crucial role in choosing between Cialis and vardenafil for managing erectile dysfunction. If spontaneous intimacy is a priority, the quicker onset of action provided by vardenafil may be favored.

On the other hand, individuals seeking a more extended window of opportunity may opt for Cialis, offering up to 36 hours of effectiveness. Considering these lifestyle preferences ensures a more tailored approach to treatment, emphasizing the importance of open communication with healthcare providers to make an informed decision that aligns with individual needs and enhances overall satisfaction.

Personal Tolerance to Side Effects

Personal tolerance to medication and side effects is a key factor influencing the choice between erectile dysfunction medications such as Cialis and vardenafil. Individuals may have varying responses to each drug, with some experiencing side effects more acutely than others.

Factors like headaches, flushing, or digestive issues can influence the decision, prompting patients to choose one medication over the other based on their specific tolerance and comfort with potential side effects.

How to Get a Prescription for Vardenafil & Cialis

Obtaining a prescription for Vardenafil and Cialis involves consulting with a healthcare provider, as these medications are exclusively available by prescription. Primary care physicians, urologists, and other qualified healthcare professionals can prescribe these drugs after a comprehensive evaluation of the patient’s health, medical history, and potential contraindications. During the consultation, the healthcare provider will discuss the patient’s symptoms, lifestyle factors, and preferences, helping them decide on the most suitable medication.

Questions to Ask Your Health Team About Vardenafil & Cialis

When discussing medications like vardenafil or Cialis, preparing for your appointment with any questions or concerns is essential. Your healthcare provider is there to address your specific needs, provide guidance on treatment options, and ensure your well-being.

Questions to ask your prescriber about vardenafil and Cialis include:

• Is it safe to take vardenafil and Cialis with my other medications?
• Will vardenafil and Cialis be covered by my insurance?
• Which one has the best results as a treatment for erectile dysfunction?
• Does my medical history increase my risk of side effects for either?
• How long can I expect side effects to last?
• How often should I see you for checkups while taking vardenafil and Cialis?
• What should I do if I am unsure whether erectile dysfunction medications are right for me?
• Are there discounts or coupons available for Cialis to help me save on my prescription?