Stendra (Avanafil): Uses, Dosage, Side Effects, & More

What Is Stendra?

Stendra, also known as avanafil, is a medication approved by the FDA to help men with erectile dysfunction (ED). FDA approval means it has undergone rigorous evaluation for safety and efficacy. It works by blocking an enzyme called PDE5 in the body, which helps increase blood flow in the penis, allowing for better erections.¹

However, it can cause serious side effects, including prolonged erections, vision loss, and hearing issues, so consult a healthcare provider before use. Common side effects include headaches, flushing, nasal congestion, sore throat, and back pain.¹

Is Stendra Available as a Generic Medication?

No, Stendra is not available as a generic medication at this time.

How Does Stendra Work?

Stendra is a prescription medication primarily used to help adult men with erectile dysfunction (ED) achieve and maintain erections. It works by increasing blood flow in the penis, helping with some of the physical aspects of sexual function.

Its safety and effectiveness for women remain uncertain, so it should only be used as prescribed for its approved purpose in men with ED. The recommended starting dose is 100 mg, to be taken about 15 minutes before sexual activity, with adjustments based on individual response and tolerability.¹

What Is Stendra Used to Treat?

Stendra is FDA-approved specifically for the treatment of erectile dysfunction (ED) in adult men. FDA approval signifies that after rigorous clinical trials, the medication has been deemed safe and effective for this specific condition.

It’s important to note that Stendra is not approved for use in women or children, and there are no recognized off-label uses for this medication. Off-label use refers to the practice of using a medication for a purpose not approved by the FDA but deemed suitable by a healthcare provider based on their professional judgment.

How Effective is Stendra?

Stendra is a newer medication approved by the US FDA to treat erectile dysfunction (ED). Clinical trials studied Stendra with over 1300 patients, including those with diabetes and those who had prostate surgery. Stendra was more effective than a non-active placebo pill for all men who were given the medication in the randomized group. Stendra works faster and is more specific for ED compared to other similar drugs like sildenafil and tadalafil.²

While Stendra is effective and safe, its role in the market is changing. Generic sildenafil may become available in some places, which could make Stendra seem less appealing due to its higher cost. Deciding which medication to use should be discussed with a healthcare provider, considering your health and preferences.

Is Stendra Better Than Viagra?

In one small study comparing Stendra (Stendra) and sildenafil (Viagra) for treating erectile dysfunction (ED) in 220 patients, Stendra was more effective. The study measured participants’ ability to achieve and maintain an erection. Participants taking Stendra reported a faster response to the medication than those taking Viagra.³

Additionally, Stendra had a safer profile with fewer common side effects like headaches and flushing than sildenafil. While both drugs can help with ED, these findings suggest that Stendra may offer quicker and more effective relief for those experiencing ED. However, it’s important to discuss the best treatment option with a healthcare provider based on individual needs.

Pros & Cons of Taking Stendra

Taking Stendra for erectile dysfunction (ED) has both risks and benefits. The advantage is that it works quickly, often within 15 minutes, which is great for spontaneous intimacy. It also tends to cause fewer common side effects like headaches and flushing compared to some other ED drugs.

On the downside, it can be pricier, especially when cheaper generic ED drugs are available. Its effectiveness can vary from person to person, and it may not be as well-known as other ED meds like Viagra. Remember, you’ll need a prescription and should use it as your healthcare provider recommends. Discuss these factors with your healthcare provider to decide if Stendra is right for you.

Stendra Warnings & Precautions

When considering taking Stendra for erectile dysfunction (ED), it’s important to be aware of some important warnings and precautions. Stendra, like other ED medications, should not be used by men for whom sexual activity is medically advised against due to pre-existing cardiovascular issues. Stendra may also affect vision, and if there is a sudden loss of vision in one or both eyes, it’s crucial to seek medical help promptly.

Avoid taking Stendra if you:¹

• Have cardiovascular risks: Stendra should not be used by individuals with pre-existing cardiovascular disease, especially those who are advised against sexual activity due to their heart condition.
• Have allergic reactions: Allergic reactions can vary in severity and may affect anyone sensitive to the drug’s components.
• Have a history of priapism: Use Stendra cautiously if you’ve had priapism (painful, prolonged erections lasting more than 6 hours) in the past or if you have anatomical penile deformities, as these factors can increase the risk of priapism.
• Combining with CYP3A4 inhibitors: Don’t use Stendra if you use potent CYP3A4 inhibitors. These medications can boost the levels of Stendra (the active ingredient in Stendra) in your blood, which may result in unwanted side effects. You can ask your pharmacist if any fo the medications you take (even over-the-counter medications) are in this category.
• Potential effects on vision: Stendra users should stop its use and seek medical attention if they experience a sudden loss of vision in one or both eyes.
• Sudden hearing loss: Individuals experiencing sudden hearing loss or accompanying symptoms like tinnitus or dizziness should cease using the medication and seek prompt medical attention.

Common Side Effects of Stendra

Common side effects of Stendra include headaches, flushing, nasal congestion, sore throat, and back pain. While these side effects are generally mild and don’t typically require medical attention, individuals experiencing severe or persistent discomfort should consult a healthcare provider for guidance.

Common side effects of Stendra include:¹

• Headache
• Facial flushing
• Nasal congestion (stuffy or runny nose)
• Sore throat
• Back pain

*All medications, including Stendra, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and understand the potential side effects and benefits of any medication.

Serious Side Effects of Stendra

Stendra can have serious side effects that need immediate medical attention. These include priapism, a painful and prolonged erection lasting over four hours, which can damage the penis if not treated quickly. Another concern is sudden vision loss in one or both eyes, which may indicate a severe eye condition.

While it’s not clear if Stendra directly causes vision loss, any sudden vision problems should be reported to a healthcare provider right away. Some users may also experience sudden hearing decrease or loss, along with symptoms like ringing in the ears or dizziness, requiring prompt medical attention.

Serious side effects of Stendra include:¹

• Priapism (prolonged and painful erection)
• Sudden vision loss in one or both eyes
• Sudden hearing decrease or loss
• Chest pain or heavy feeling
• Pain spreading to the arm or shoulder
• Irregular heartbeat
• Swelling in your hands, ankles, or feet
• Shortness of breath
• Seizures (convulsions)
• Feeling light-headed, fainting

*All medications, including Stendra, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.

Stendra Dosages for FDA-Approved Treatment

Stendra, an FDA-approved medication for erectile dysfunction (ED) in adult men from 18 years and above, comes in different dosages to accommodate individual needs. The typical dosage ranges from 50 mg to 200 mg.¹ The appropriate dosage can vary depending on factors such as age, overall health, and individual response to the medication.

Stendra Forms & Strengths

Stendra is available in tablet form with three different strengths: 50 mg, 100 mg, and 200 mg. Typically, the starting dose is 100 mg, taken about 15 minutes before anticipated sexual activity, on an as-needed basis. It’s important not to take Stendra more than once a day. The dose can be increased to 200 mg if needed or decreased to 50 mg for those who experience better results with a lower dose.

Stendra is available in the following forms and strengths:¹

• 50 mg tablets
• 100 mg tablets
• 200 mg oval tablets

What’s the Most Effective Dose of Stendra?

The most effective dose of Stendra can vary from person to person and is typically determined based on individual response and tolerability. The starting dose is often 100 mg, taken approximately 15 minutes before sexual activity.¹ Depending on how well it works and any side effects experienced, the dose may be adjusted to 200 mg for some individuals or decreased to 50 mg for others. It’s important for individuals to work closely with their healthcare provider to determine the most suitable dose for their specific needs.

How to Take Stendra

To take Stendra, follow your healthcare provider’s instructions. Generally, it’s taken approximately 15 minutes before sexual activity, but the specific timing and dosage can vary depending on your needs and tolerability.

Here are the steps to taking Stendra effectively:¹

1. Carefully read the instructions: It’s crucial to understand how and when to take Stendra as prescribed by your healthcare provider to ensure safe and effective use.
2. Follow your healthcare provider’s recommendations: They will determine the appropriate dosage and timing for your specific needs. This may be Stendra 100 mg or 200 mg, to be taken approximately 15 minutes before sexual activity, or Stendra 50 mg taken about 30 minutes before sexual activity.
3. Do not exceed one dose a day: Taking more than one dose within a 24-hour period can lead to health risks and side effects.
4. Engage in sexual stimulation: Keep in mind that sexual arousal is necessary for Stendra to be effective. It doesn’t provide an automatic erection; it enhances your body’s natural response.
5. Adjust dosage if necessary: Your healthcare provider may modify your dose to achieve the best results with the lowest effective amount.
6. Take with or without food: Stendra can be taken with or without a meal, depending on your preference.
7. Seek immediate medical attention if you overdose: If you accidentally take too much Stendra, contact your healthcare provider or visit the nearest hospital emergency room right away.

Can I Take Avanafil Daily?

Yes, you can take Avanafil (Stendra) daily, but it should not be taken more than once a day. The typical recommended timing is about 15 minutes before engaging in sexual intercourse. However, it’s essential to follow your doctor’s advice and prescribed dosage instructions to ensure safe and effective use.

What Happens If I Miss a Dose of Stendra?

While you can take Stendra daily, it is an as-needed medication. Not taking it every day is not the same as missing a dose. Ideally, take Stendra about 15 minutes before anticipated sexual activity. However, do not double the dose or take more than one dose within 24 hours.

It’s essential to follow your prescribed dosing schedule to avoid potential side effects or complications. If you have any concerns or questions about your medication, consult your healthcare provider for guidance.

How Long Does Stendra Last?

Stendra typically lasts for about 6 hours after taking it. The duration of its effects may vary slightly among individuals, so it’s essential to follow your healthcare provider’s guidance on when to take Stendra for the best results.

How Long Does it Take for Stendra to Kick in?

The time it takes for Stendra to take effect can vary depending on the dosage. If you’re taking a lower dose, like the 50 mg dose, it may take approximately 30 to 45 minutes for the medication to start working. However, higher doses like 100 mg or 200 mg can have a faster onset of action, often within 15 minutes.

Can You Overdose on Stendra?

Yes, it is possible to overdose on Stendra, and doing so can lead to serious health risks. Taking more than the prescribed dose can increase the likelihood of experiencing severe side effects and complications. Symptoms of a Stendra overdose may include severe headache, dizziness, nausea, vomiting, changes in vision, irregular heartbeat, and a prolonged and painful erection (priapism) lasting longer than four hours. If you suspect that you or someone you know has taken an excessive amount of Stendra, it is crucial to seek immediate medical attention.

What Should You Do If You Take Too Much Stendra?

If you take too much Stendra, it’s essential to seek immediate medical attention. Contact your healthcare provider or go to the nearest hospital emergency room right away. Timely medical intervention is crucial to address potential overdose symptoms and manage any complications that may arise.

What to Avoid When Taking Stendra

When taking Stendra, it’s important to avoid certain substances and medications that can interact negatively with the drug. These interactions can potentially lead to adverse effects or decreased effectiveness. Specifically, you should avoid excessive alcohol consumption, nitrates, and antihypertensive medications.

7 substances you should avoid while taking Stendra include:¹

• Excessive alcohol: Consuming too much alcohol, such as three glasses of wine or three shots of whiskey, in combination with Stendra can increase the risk of adverse effects like an increased heart rate, lowered blood pressure, dizziness, and headaches.
• Nitrates: The use of any form of organic nitrates while taking Stendra is contraindicated due to the potential for a life-threatening drop in blood pressure. Nitrate administration should be avoided for at least 12 hours after the last dose of Stendra.
• Alpha-blockers: Combining Stendra with alpha-blockers may lead to hypotension, resulting in symptoms like dizziness, lightheadedness, and fainting.
• Other antihypertensives: Stendra can make your blood vessels relax a bit, and when you take it with other medicines that lower blood pressure, it can make your blood pressure drop.
• Strong CYP3A4 inhibitors: These drugs can significantly increase Stendra exposure, potentially causing serious side effects.
• HIV Protease Inhibitor (Ritonavir): Ritonavir, a strong CYP3A4 inhibitor, can also increase Stendra exposure. Patients should avoid taking Stendra if they are using ritonavir.
• Moderate CYP3A4 inhibitors: Medicines such as erythromycin, amprenavir, and fluconazole, which can moderately slow down the way Stendra is processed in your body, may change how Stendra works.

How to Get a Prescription for Stendra

To obtain a prescription for Stendra, you will need to consult with a licensed healthcare provider, typically a physician. These healthcare professionals can evaluate your specific medical history, current health condition, and any underlying causes of erectile dysfunction. They may also discuss your lifestyle, the medications you are currently taking, and any potential risks or contraindications.

During the evaluation, your healthcare provider will assess whether Stendra is an appropriate and safe treatment option for you. If they determine that it is, they can write a prescription for the appropriate dosage.

Questions to Ask Your Healthcare Provider About Stendra

If you are considering Stendra as a treatment for erectile dysfunction, it’s essential to have an open and honest conversation with your healthcare provider, whether it’s a primary care physician, urologist, or psychiatrist. You may want to discuss the medication’s potential benefits, side effects, and interactions with other medications you may be taking. If you need to change prescribers or prefer a more convenient option, online psychiatry services can also provide guidance and prescriptions, making it easier to access the medication while ensuring your questions are addressed.

Questions to ask your care team about Stendra include:

• How does Stendra work, and what benefits can I expect from taking it?
• What are the potential side effects of Stendra, and how common are they?
• Are there any specific lifestyle changes or precautions I should consider while taking Stendra?
• Can Stendra interact with other medications I’m currently taking?
• Is there a particular dosage of Stendra that is most suitable for my condition?
• How quickly should I expect to see results when taking Stendra?
• Are there any alternative treatments for erectile dysfunction that I should explore?
• What should I do if I experience severe side effects or an erection lasting longer than four hours?
• Will my medical history or pre-existing conditions affect my ability to take Stendra safely?
• Are there any foods or substances I should avoid while using Stendra?
• Can I take Stendra with alcohol, or should I abstain from drinking when using this medication?
• Is there a generic version of Stendra available that may be more cost-effective?

In My Experience

In my experience, discussing erectile dysfunction and treatments like Stendra is crucial. It’s a common concern, and seeking help from a healthcare provider is essential. Open and honest conversations with your doctor are vital for personalized guidance tailored to your needs, ensuring the most suitable treatment plan.

Stendra and similar medications offer promising solutions for erectile dysfunction, but their effectiveness varies from person to person. Patience and ongoing communication with your healthcare provider are key. I advise clients to reach out to a medical professional, ask questions, and work together to find effective solutions for a satisfying and healthy sex life. You’re not alone in facing this issue, and help is available.