Vardenafil (Levitra): Dosage, Side Effects, How Long it Lasts, & More

What Is Vardenafil?

Vardenafil belongs to the drug class known as phosphodiesterase type 5 (PDE5) inhibitors. This medication is specifically designed to address erectile dysfunction (ED) in men*, a condition characterized by the inability to achieve or sustain an erection suitable for sexual intercourse. As a PDE5 inhibitor, vardenafil blocks the enzyme phosphodiesterase-PDE5, leading to increased cyclic guanosine monophosphate (cGMP) levels.²

This biochemical process relaxes smooth muscles in the penile area, facilitating improved blood flow during sexual stimulation. FDA approval signifies that vardenafil has undergone thorough testing to ensure its safety and effectiveness in treating ED.

*Disclaimer: The use of the term men refers to people who were assigned male at birth.

Is Vardenafil Available as a Brand Medication?

Vardenafil is a generic medication. Previously, brand versions of vardenafil were available, but they have been discontinued. These brands were Levitra and Staxyn. Vardenafil is only available as a generic medication.³

What Is Vardenafil Used to Treat?

Vardenafil is approved by the FDA to treat Erectile Dysfunction (ED), a prevalent condition affecting men. Vardenafil belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors, which enhance blood flow to the genital area, aiding in achieving and maintaining an erection during sexual stimulation.

Besides its application in ED, vardenafil may be used off-label for other conditions, such as pulmonary arterial hypertension. In this context, it may work by relaxing the blood vessels in the lungs, facilitating improved blood flow. Off-label use refers to prescribing a medication for a purpose not officially approved by the FDA. Medical professionals may choose to use vardenafil off-label based on their judgment, believing it might provide benefits in certain situations.²

How Effective is Vardenafil?

Vardenafil has been shown in clinical trials to be effective in treating erectile dysfunction (ED). The trials showed significant improvement in erectile function with the use of vardenafil. The trials assessed the Erectile Function (EF) Domain score of the International Index of Erectile Function (IIEF) Questionnaire, along with the Sexual Encounter Profile (SEP) questions related to the ability to achieve vaginal penetration (SEP2) and maintain an erection for successful intercourse (SEP3).

In all four clinical trials that enrolled 2431 men aged 20-83, vardenafil exhibited clinically meaningful and statistically significant improvements in EF Domain, SEP2, and SEP3 scores compared to placebo. The effectiveness was observed across different doses of vardenafil, including 5 mg, 10 mg, and 20 mg, and the positive impact was maintained for up to 6 months in some trials.²

Vardenafil Warnings & Precautions

Vardenafil comes with important warnings and precautions that individuals should know before taking it. Medical attention may be necessary to address these concerns.

You should consult with your healthcare provider and may need to avoid taking vardenafil if you have:²

• Kidney or Liver issues: You may need to avoid using vardenafil if you have kidney or liver issues or are undergoing renal dialysis. Talk with your healthcare provider about any issues you’ve had with your kidneys or liver.
• History of priapism or are at risk for prolonged erections: Individuals with a history of priapism or conditions predisposing them to prolonged erections, such as sickle cell anemia, multiple myeloma, or leukemia, should exercise caution when using vardenafil. Immediate medical assistance is required if an erection persists for more than 4 hours, as priapism can lead to penile tissue damage and permanent problems with the penis.
• Anatomical deformations of the penis: Caution should be exercised when using vardenafil in patients with anatomical deformations of the penis, including angulation, cavernosal fibrosis, or Peyronie’s disease. Such conditions may elevate the risk of priapism.
• History of eye problems: If you have had issues with your eyes, it’s possible that it is not safe for you to take vardenafil. PDE5 inhibitors have a risk of causing you to suddenly lose your vision. Talk with your healthcare provider about any issues with your eyes that you have had.
• Certain medications: Before using vardenafil, individuals taking nitrates, guanylate cyclase stimulators such as riociguat, alpha-blockers, or potent CYP3A4 inhibitors should consult their healthcare providers. The concomitant use of these medications may have adverse effects, and caution is advised to ensure safe use.
• History of allergic reactions to vardenafil or PDE5 inhibitors: Individuals with a history of allergic reactions to vardenafil or PDE5 inhibitors should exercise caution when considering vardenafil. This precaution is particularly important for those who have experienced allergic responses to similar medications.
• History of cardiovascular diseases: Patients with a history of cardiovascular diseases should be aware of potential risks when using vardenafil. Caution is advised, and consultation with healthcare providers is recommended to ensure the safe use of the medication.

Common Side Effects of Vardenafil

Common side effects of vardenafil may manifest in some individuals. While these reactions can range from mild to severe, not everyone experiences them. It’s essential to be aware of potential side effects and discuss any concerns with your healthcare provider.

Common side effects of vardenafil include:¹

• Headaches
• Dizziness
• Flushing
• Indigestion
• Nasal congestion
• Back pain
• Muscle aches

*All medications, including vardenafil, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.

Serious Side Effects of Vardenafil

Individuals may sometimes experience more severe side effects with vardenafil, requiring immediate medical attention. Serious side effects can affect various body areas, and their severity varies. It’s crucial to recognize and address these effects promptly. Serious side effects include but are not limited to:

Serious side effects of vardenafil can include:¹

• Priapism (prolonged and painful erection)
• Sudden vision loss
• Hearing loss
• Irregular heartbeat
• Severe dizziness
• Fainting
• Allergic reactions (rash, itching, swelling)
• Difficulty breathing
• Chest pain
• Seizures

*All medications, including vardenafil, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.

Vardenafil Dosages for Treating Erectile Dysfunction

Individual responses to vardenafil dosages can vary, influenced by age, overall health, and the specific treatment condition. Vardenafil is approved for use in adults only. The typical dosage range spans from 5 to 20 milligrams (mg).²

Prescribers carefully consider various factors in determining the appropriate dosage, including the patient’s age and the nature of their condition. Notably, the severity of symptoms is not directly correlated with the dosage prescribed.

Vardenafil Forms & Strengths

Vardenafil is available in diverse forms and strengths, offering flexibility in treatment. These forms may include oral tablets, and while it doesn’t come in extended-release or sustained-release versions, the choice of form and strength is pivotal.

Prescribers consider criteria such as the patient’s ability to swallow, preference, and the urgency of symptom relief. Dosages may vary, ensuring a tailored approach to each patient’s needs. The onset of action is relatively rapid, typically within 30 to 60 minutes, highlighting its efficacy in providing timely relief.

Vardenafil is available in the following forms and strengths:⁴

• 2.5 milligram (mg) oral tablet
• 5 mg oral tablet
• 10 mg oral tablet
• 10 ml orally disintegrating tablet
• 20 mg oral tablet

How to Take Vardenafil

To take vardenafil for the treatment of erectile dysfunction, it is generally recommended to start with a dose of 10 mg, taken orally approximately 60 minutes before engaging in sexual activity. The dosage can be adjusted based on individual response and tolerability, with a maximum recommended dose of 20 mg or a minimum of 5 mg. Sexual stimulation is essential for the medication to be effective.

One notable aspect of vardenafil is its flexibility in terms of administration with or without food. This offers convenience to users, allowing them to take the medication without strict dietary restrictions. However, it may be advisable to avoid high-fat meals or excessive alcohol consumption, as these may potentially impact the onset and effectiveness of the medication.

Consistency in following the prescribed regimen ensures effectiveness and minimizes the likelihood of side effects. Always consult your healthcare professional for personalized guidance on taking vardenafil.²

What Happens If I Miss a Dose of Vardenafil?

Vardenafil is only taken as needed, 60 minutes before sexual activity. You should not double up on doses of vardenafil. If you have questions on how to take vardenafil, talk with your healthcare provider or your pharmacist.

How Long Does Vardenafil Last?

The duration of action for vardenafil typically lasts for up to 6 hours with the greatest effects in the first 2 hours.. Individual variations may occur, influencing how long the medication remains effective. It’s essential to recognize that sexual stimulation is necessary for the medication to produce the desired effects.²

How Long Does Vardenafil Take to Work?

The onset of action for vardenafil is usually observed within 30 to 60 minutes after ingestion. This timeframe may vary among individuals, influenced by factors such as metabolic rate and individual responsiveness. Users are advised to plan their activities accordingly, ensuring they take the medication well before the anticipated sexual activity.²

Can You Overdose on Vardenafil?

Taking more than the recommended dose of vardenafil can lead to an overdose. An overdose of vardenafil can result in adverse effects on the cardiovascular system, such as a drop in blood pressure, rapid heartbeat, and dizziness. Additionally, it can intensify common side effects of Levitra, including headaches, flushing, and nausea.¹

What Should You Do If You Take Too Much Vardenafil?

If you suspect you have taken too much vardenafil, it is essential to seek immediate medical attention. Overdosing the medication can increase the risk of adverse effects, such as low blood pressure and other serious complications.²

What to Avoid When Taking Vardenafil

When taking vardenafil, being aware of potential interactions with other medications, substances, and herbs is crucial. These interactions can lead to adverse effects or reduce the effectiveness of the medication. It’s essential to consult with a healthcare professional before starting vardenafil or any other medication to ensure your safety and well-being.

13 substances you may need to avoid while taking vardenafil include:²

• Nitroglycerin: Nitroglycerin and other nitrate medications can cause a dangerous drop in blood pressure when taken alongside vardenafil.
• Alpha-blockers: These medications used for high blood pressure or prostate issues can interact with vardenafil, leading to dizziness and a sudden drop in blood pressure.
• Ritonavir and indinavir: These HIV protease inhibitors may increase the levels of vardenafil in the body, potentially leading to an increased risk of side effects.
• Ketoconazole and itraconazole: These antifungal medications can also increase the levels of vardenafil in the body, increasing the risk of side effects.
• Grapefruit juice: Consuming grapefruit or its juice can interfere with the absorption of vardenafil, making it less effective.
• Erythromycin: This antibiotic can increase the levels of vardenafil in the blood, potentially causing side effects or reduced effectiveness.
• Rifampin: An antibiotic used to treat tuberculosis, rifampin can decrease the effectiveness of vardenafil.
• Herbal supplements: Some herbal supplements, such as St. John’s Wort, can interact with vardenafil, potentially leading to adverse effects.
• Alcohol: Excessive alcohol consumption can increase the risk of experiencing side effects like dizziness or low blood pressure when taking vardenafil.
• High-fat meals: Consuming high-fat meals before taking vardenafil can delay its absorption and potentially reduce its effectiveness.

This is not a comprehensive list of the possible interactions with vardenafil. You should talk with your healthcare provider and your pharmacist about all prescription and over-the-counter medications, herbs, and supplements you take before starting vardenafil.

How to Get a Prescription for Vardenafil

Obtaining a prescription for vardenafil involves a careful evaluation by a qualified healthcare professional. Since vardenafil is a prescription-only medication, it’s crucial to consult with a licensed healthcare provider who can assess your medical history, overall health, and any pre-existing conditions. The process typically begins with a visit to a primary care physician or a specialist, such as a urologist, who can prescribe medications like vardenafil.

During the consultation, your healthcare provider will conduct a thorough examination to determine the underlying causes of your condition and assess whether vardenafil is a suitable and effective treatment for you. It’s essential to discuss any existing medications, potential contraindications, and any history of cardiovascular issues to ensure the safe use of the medication. The prescription will specify the appropriate dosage, and your healthcare provider will offer guidance on its proper usage.⁵

How Much Does Vardenafil Cost?

The cost of vardenafil can vary depending on several factors, such as the dosage, the pharmacy you choose, if you have insurance, and whether you can access coupons or discounts. On average, the price for a 10 mg tablet of vardenafil can range from $1 to $5 per pill, while the 20 mg dosage may cost between $2 to $10 per tablet. Prices may be lower when purchasing a larger quantity.⁶

To save on the cost of vardenafil, you can look for coupons or discounts offered by pharmacies or online retailers. Additionally, some healthcare insurance plans may cover the cost of vardenafil or offer co-pay assistance programs. Be sure to consult with your healthcare provider to discuss your options and find the most cost-effective solution for your needs.

Vardenafil Alternatives

When seeking alternatives to vardenafil, individuals may explore various options within the same class of medications. Additionally, patients may consider alternative phosphodiesterase type 5 (PDE5) inhibitors like sildenafil (Viagra) and tadalafil (Cialis). These alternatives enhance blood flow to the penis, aiding in the treatment of erectile dysfunction.

Which Is Better: Viagra, Cialis, or Vardenafil?

While vardenafil shares a common mechanism with its counterparts Viagra and Cialis, each medication has unique characteristics. Vardenafil is known for its relatively rapid onset of action compared to Viagra, with effects lasting up to 6 hours. Conversely, Cialis stands out for its prolonged duration of action, up to 36 hours. The choice between these medications depends on individual preferences, response to treatment, and considerations such as how quickly one wants the medication to take effect. Talk with your healthcare provider to learn which one may be the best choice for you.

Is Vardenafil Stronger than Cialis?

When comparing vardenafil to Cialis, it’s important to note that Cialis contains tadalafil, another PDE5 inhibitor like vardenafil. Strength can vary from person to person based on individual responses, but there is no clear evidence suggesting that vardenafil is inherently stronger than Cialis. Cialis is known for its extended duration of action, often providing effectiveness for up to 36 hours.⁵

Is Vardenafil Stronger than Viagra?

Examining the strength of vardenafil compared to Viagra involves considering their active ingredients. Viagra contains the active ingredient sildenafil. Both vardenafil and sildenafil are effective PDE5 inhibitors, facilitating increased blood flow to the penis. While the strength of these medications is comparable, individual responses may vary. Some individuals may find one medication more effective or better tolerated than the other due to differences in onset time, duration of action, and potential side effects.

Questions to Ask Your Healthcare Provider About Vardenafil

If someone is considering using vardenafil, they should discuss it with their healthcare providers, including their doctor, psychiatrist, and therapist. It’s important to have an open and informed conversation about this medication. Online psychiatry services can also be a good option if you need to change prescribers, as they can provide remote consultations and prescriptions.

Questions to ask your care team about vardenafil include:

• How safe is vardenafil, and are there any specific health conditions or medications that may pose a risk when taking it?
• What is the typical adjustment period for someone starting vardenafil, and what side effects might be expected?
• If I take other medications, is there a risk of more serious symptoms or interactions with vardenafil?
• How long does it usually take for the effects of vardenafil to become noticeable, and what factors can influence this?
• What is the recommended dosage for vardenafil to ensure effectiveness with minimal side effects?
• Are there lifestyle changes, such as diet or alcohol consumption, that may impact the effectiveness of vardenafil?
• Can vardenafil be taken alongside other treatments for sexual health or underlying medical conditions?
• How frequently should I follow up with my healthcare provider once I start taking vardenafil?
• How do I consider medications, such as comparing vardenafil vs tadalafil?