*An off-label use of a medication is a use that is not FDA-approved. Prescribers can decide to use a medication off-label because, in their professional judgment, they believe it may offer a benefit to someone.
Cymbalta (duloxetine) is a medication commonly used to treat depression and anxiety. For some people, Cymbalta may also cause sexual side effects, such as low libido and problems with orgasm. If you are considering Cymbalta or want to discuss your current medication treatment with a provider, online psychiatry platforms, such as Talkiatry and Brightside Health are a good place to start. Their providers offer assessments and prescription consultation, and can answer any questions you have about Cymbalta’s sexual side effects.
What is Cymbalta (Duloxetine) & How is it Used?
Duloxetine, commonly known by its brand name Cymbalta is a medication from the SSRIs classification. It is a prescription with a black box warning from the Food and Drug Administration (FDA). The FDA warns of an increased risk of suicidal thoughts and behavior in children, adolescents, and young adults. It is, therefore, important to closely monitor for worsening and the emergence of suicidal thoughts and behaviors. Be sure you seek expert advice regarding duloxetine medication from your doctor before starting the medication.1
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Cymbalta is commonly used as an FDA-approved medication to treat:2
- Major depressive disorder (MDD)
- Generalized anxiety disorder (GAD)
- Fibromyalgia
- Diabetic peripheral neuropathy
- Chronic musculoskeletal pain
Cymbalta can also be used off-label (non-FDA-approved) for treating:2
- Chemotherapy-induced peripheral neuropathy
- Stress urinary incontinence
Cymbalta belongs to the class of drugs called serotonin and norepinephrine reuptake inhibitors (SNRIs). This medication works by increasing the amounts of serotonin and norepinephrine – natural substances in the brain – that help maintain mental balance and prevent the movement of pain signals. Taking Cymbalta can have specific physiological effects on the body, such as nausea, dry mouth, or increased sweating.
However, your doctor may prescribe duloxetine as part of a treatment plan for several health conditions. This includes if you have depression, anxiety disorders, or chronic pain. Your doctor may consider prescribing Cymbalta as part of your treatment after a thorough evaluation of your symptoms, medical history, and other factors. Cymbalta is also commonly prescribed as a medication for anxiety and medication for depression.
What Causes Cymbalta Sexual Side Effects?
Like other antidepressants, Cymbalta can cause sexual side effects such as decreased libido and erectile dysfunction. While the exact cause of the side effect is not fully understood, some medical experts believe the antidepressant’s impact lies in its mechanism of action. High serotonin levels may lead to decreased sexual desire and difficulty achieving orgasm, while increased norepinephrine levels can lead to erectile dysfunction.
Does Cymbalta Have Sexual Side Effects?
Cymbalta’s sexual side effects are believed to be due to the antidepressant effect on serotonin and norepinephrine levels in the brain, which can lead to changes in sexual function. Studies have revealed that 35 to 50% of people with untreated MDD and 64% with depression experience some sexual dysfunction.3 Duloxetine, sexual side effects, are the most commonly reported side effects along with other side effects of Cymbalta, such as nausea and headache.
Research suggests that duloxetine’s sexual side effects can affect both men and women. However, the nature and prevalence of the side effects may vary between genders. In clinical trials of Cymbalta, both men and women reported some differences in side effects. The trial established that certain sexual side effects, including decreased libido and delayed orgasm, were reported in men and women. Men also reported erectile dysfunction and delayed ejaculation. The clinical trial established that Cymbalta’s sexual side effects were more common in men than women.4
Sexual Side Effects of Cymbalta in Women
Duloxetine’s sexual side effects affect women’s sexual functioning. Women with symptoms of depression experience decreased sex drive. Additionally, women can experience vaginal dryness due to delayed lubrication making sex quite unpleasant. These symptoms can have a negative impact on relationships and may lead to feelings of frustration, guilt, and shame. Cymbalta’s sexual side effects can vary from person to person. If you are experiencing post-SSRI sexual dysfunction or other unwanted Cymbalta side effects, talk to your doctor to discuss potential treatment options.
Common duloxetine sexual side effects in women include:
- Discomfort during intercourse
- Delayed orgasm
- Decreased libido
- Lack of desire for sex
Sexual Side Effects of Duloxetine in Men
The most common duloxetine sexual side effects in men are erectile dysfunction, ejaculatory dysfunction, and difficulty reaching orgasm. These side effects are unpleasant, so many patients struggle to find medical help. The symptoms of duloxetine sexual side effects can affect relationships by causing frustration and dissatisfaction. Also, the duration of Cymbalta’s sexual side effects can vary from person to person.
Common negative duloxetine side effects in men include:
- Decreased libido
- Erectile dysfunction
- Orgasms problems
- Ejaculatory dysfunction
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How to Cope with Sexual Side Effects of Cymbalta
Sexual side effects can be distressing, but they can be managed. Some people may also struggle to talk to their doctor about the condition. Cymbalta’s sexual side effects can affect relationships with feelings of frustration due to a lack of satisfaction during sexual activity. However, there are many options for treating or reducing symptoms.
Adjust Your Dose
Antidepressants like Cymbalta can affect your sex drive at any dose. If you are experiencing sexual side effects from taking Cymbalta, talk to your doctor about whether a lower dose would be right for you. A lower Cymbalta dose may potentially decrease the impact of the antidepressant on sexual function. Do not adjust your dose on your own. Your healthcare provider will give you guidance to help you avoid antidepressant withdrawal symptoms or other complications.
Consider Switching Antidepressants
Adjusting the Cymbalta dose can be a practical strategy for managing sexual side effects, but only under the guidance of your healthcare provider. Your doctor can help determine the best course of action for adjusting your medication which includes gradual tapering off the medication or switching to a different antidepressant.
Switching from Cymbalta to another antidepressant with fewer sexual side effects can be an effective option for managing sexual side effects, especially if other strategies, such as adjusting Cymbalta dosage, have not been successful. However, switching to a different antidepressant should be done under the guidance of your doctor, as changing medication can lead to adverse effects and withdrawal symptoms.
Consider Therapy
You may consider therapy to cope with Cymbalta’s sexual side effects if they impact your life or relationships. Psychotherapy can help address psychological or relational factors that may be contributing to duloxetine’s sexual side effects and develop ways for managing symptoms.
Online therapy options can be beneficial for you to consider because they offer greater flexibility and convenience, especially if you have challenges accessing in-person therapy. However, it’s important to find the right therapist for your needs so the therapy received is safe, effective, and delivered by a licensed therapist. Additionally, it can be beneficial to seek out a therapist who specializes in sexual health.
Talk to Your Partner
It can be challenging to deal with Cymbalta’s sexual side effects, especially if you are in a relationship, because Cymbalta can affect your sex drive. However, it’s important to talk to your partner about your condition. You can work with our partner on solutions that can help address your mental health and sexual needs.
Practice Self-care
Practicing self-care activities such as exercise and a healthy diet can help reduce anxiety and stress, which can contribute to sexual side effects. Additionally, relaxation and adequate rest or sleep can help improve your overall physical and emotional well-being, which may improve your sexual functioning. You can also try natural remedies for anxiety, like lavender or chamomile.5
Questions to Ask Your Health Team
Before starting any antidepressant medication, it’s always important to talk to your healthcare provider to understand the benefits and risks of the medication. After properly evaluating your condition and symptoms, your doctor will determine the best action or the right antidepressant. You can ask your doctor how long it will take you to adjust to the antidepressant or when you should reach out if you are experiencing sexual side effects. If you struggle to manage your symptoms or are in crisis, can you call 911 for immediate medical help?
Questions to ask your care team about the sexual side effects of Cymbalta include:
- How long will it take for me to adjust to taking Cymbalta?
- Am I at risk for more severe symptoms if I am already taking other anxiety /depression medications?
- What is the best dosage to ensure fewer side effects?
- When should I reach out to you if I am experiencing sexual side effects?
- Is there anything I should tell my therapist about this new medication?
- Does Cymbalta cause erectile dysfunction?
- Does Cymbalta affect libido?
- Does Cymbalta have sexual side effects?
- What are the best online therapy options?
In My Experience
Cymbalta (duloxetine), like other antidepressants, can have side effects. Therefore, individuals may need to combine medication with talk therapy and proper guidance from a healthcare provider. It’s important to speak to your healthcare practitioner about Cymbalta’s sexual side effects or other side effects caused by the medication. They can best determine the next step and any action after properly evaluating your condition and symptoms. Cymbalta can help manage symptoms of several health conditions, such as depression and anxiety. However, you must consult your doctor before starting the medication. Remember, seek a credentialed therapist to get the most from your talk therapy sessions.
Additional Resources
To help our readers take the next step in their mental health journey, Choosing Therapy has partnered with leaders in mental health and wellness. Choosing Therapy is compensated for marketing by the companies included below.
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For Further Reading
- Cymbalta Weight Gain: Everything You Need to Know
- Cymbalta (Duloxetine) Withdrawal: Symptoms, Duration, & How to Cope
- Cymbalta For Anxiety: Effectiveness, Dosage, & More
- How to Get a Cymbalta (Duloxetine) Prescription: Everything You Need to Know
- Paxil (Paroxetine) Sexual Side Effects: What They Are & How to Manage Them
- Which Antidepressants Are Without Sexual Side Effects?
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Best Online Psychiatry Services
Online psychiatry, sometimes called telepsychiatry, platforms offer medication management by phone, video, or secure messaging for a variety of mental health conditions. In some cases, online psychiatry may be more affordable than seeing an in-person provider. Mental health treatment has expanded to include many online psychiatry and therapy services. With so many choices, it can feel overwhelming to find the one that is right for you.