Addyi (Flibanserin): Uses, Dosage, Side Effects & Warnings

What Is Addyi (Flibanserin)?

Addyi (Flibanserin) is a medication for premenopausal women with female sexual arousal disorder (FSAD). It falls under the drug class of selective serotonin receptor agonists and works in the brain to boost sexual desire.¹ The FDA has approved it to treat FSAD, meaning it’s officially recognized as effective for this condition. However, it’s essential to know that Addyi is not available in a generic form. It is not approved for other conditions, relationship issues, or for use in men.

How Does Addyi Work?

Addyi acts as both a serotonin agonist and antagonist. In simpler terms, it influences the levels of a brain chemical called serotonin. As an agonist, it boosts serotonin in some parts of the brain, which can enhance sexual desire. As an antagonist, it reduces serotonin activity in other areas, which helps reduce inhibitions and improve sexual responsiveness. This dual action on serotonin aims to rebalance brain chemistry, ultimately addressing the symptoms of hypoactive sexual desire disorder (HSDD).

How Long Does it Take for Addyi to Work?

Typically, Addyi starts to work within a few days. When taken as recommended, it reaches a steady level in the body after about 3 days of daily use.¹. This means that the effects of the medication on sexual desire may become noticeable after this initial period. It’s important to follow the prescribed dosage and be patient for the best results.

Addyi Vs Viagra

Addyi and Viagra are two medications with different approaches to addressing sexual concerns. Addyi, recommended to be taken once daily at bedtime, is intended for premenopausal women with hypoactive sexual desire disorder (HSDD). It works gradually by affecting brain chemistry to boost sexual desire over time, not just as needed.

Doctors do not typically prescribe Viagra for women. Viagra is typically used by men to treat erectile dysfunction and is taken as needed before sexual activity.². It works by enhancing blood flow to specific areas of the body, which can help with achieving and maintaining an erection. While both medications aim to improve sexual experiences, their mechanisms, recommended dosages, and timing of use vary significantly.

How Effective is Addyi?

Studies suggest Addyi (flibanserin) can boost sexual desire in premenopausal women with HSDD, adding about half an extra satisfying sexual event per month.³ However, it’s important to consider that these benefits are relatively small but statistically significant

The long-term usefulness is still uncertain, and its suitability varies among individuals. It may be most beneficial for those who haven’t responded to other treatments, are willing to accept the risks, and can refrain from alcohol use during treatment.⁴

Addyi Warnings & Precautions

Addyi (Flibanserin) comes with important warnings and precautions. It should not be taken within two hours of alcohol consumption, as this can lead to low blood pressure and fainting.¹ Combining Addyi with certain medications can also increase the risk of these side effects, necessitating caution. These precautions are vital for the safe and responsible use of Addyi.

Avoid taking Addyi if you:¹

• Are pregnant or breastfeeding: Pregnant or breastfeeding individuals should avoid Addyi, as its safety during pregnancy and its potential effects on nursing infants are not well established. It’s crucial to consult with a healthcare provider for alternative options in these situations.
• Are diagnosed with hepatic impairment (liver problem): People with liver problems should avoid Addyi because it can significantly increase their concentration in the body, which can lead to hypotension and loss of consciousness. This warning is particularly important for individuals with hepatic impairment.
• Have allergic reactions: If you’ve had severe allergic reactions in the past, like swelling, itching, or hives, be careful with Addyi. Watch for any signs of allergies, and stop using it if you have a reaction.
• Have a fainting or low blood pressure history: If you’ve fainted or have had low blood pressure before, use Addyi cautiously. It might make these issues worse, so keep an eye on them and get medical help if needed.
• Take strong medications (CYP3A4 inhibitors): Mixing Addyi with strong medicines that affect how your body processes drugs can be risky. It can make the side effects of Addyi worse, like low blood pressure and fainting. If your doctor prescribes a strong medicine, stop taking Addyi for at least two days before starting it.

Side Effects of Addyi

Side effects of Addyi may persist for some who take it, such as dizziness, nausea, tiredness, difficulty sleeping, and dry mouth. Additionally, temporary effects like sleepiness can occur, particularly if taken during waking hours.¹ These temporary effects typically subside as your body adapts to the medication, but caution is essential, especially when starting Addyi.

Furthermore, serious side effects such as low blood pressure and fainting may happen, even without alcohol or other medications.

Common Side Effects of Addyi

Common side effects of Addyi include dizziness, nausea, tiredness, difficulty falling asleep or staying asleep, and dry mouth. While these side effects are generally manageable and may not require immediate medical attention, it’s important to consult a healthcare provider if they persist or worsen. Follow recommended guidelines to minimize the risk of more serious side effects.

Common side effects of Addyi include:¹

• Dizziness
• Nausea
• Fatigue
• Insomnia
• Dry mouth

*All medications, including Addyi, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.

Serious Side Effects of Addyi

Serious side effects of Addyi necessitating immediate medical attention can include sleepiness, low blood pressure, and fainting. While these side effects can occur irrespective of alcohol or other medications, they should not be taken lightly. It’s essential to be cautious and seek medical help promptly if you experience these symptoms.

Serious side effects of Addyi include:¹

• Sleepiness
• Low blood pressure
• Fainting
• Hypersensitivity reactions (e.g., severe allergies, swelling of lips, face, and mouth)

*All medications, including Addyi, can cause side effects which can be mild or serious. This is not a comprehensive list of all possible side effects. You should talk with your doctor about any questions you have and to understand the potential side effects and benefits of any medication.

What to Avoid When Taking Addyi

While using Addyi, it’s crucial to avoid certain substances and medications to prevent harmful interactions. These include refraining from drinking alcohol close to the time you take Addyi, as it can significantly increase the risk of severe low blood pressure and fainting.

Additionally, consult your doctor before using herbal supplements or certain over-the-counter medicines, as they may increase the risk of low blood pressure, fainting, and sleepiness when combined with Addyi.

5 substances you should avoid while taking Addyi include:¹

• Alcohol: Combining Addyi with alcohol increases the risk of low blood pressure, fainting, and drowsiness.
• CNS depressants: Taking medications like sleep aids and certain pain relievers with Addyi can make you even sleepier.
• Strong CYP2C19 inhibitors: Combining Addyi with these inhibitors might cause low blood pressure, fainting, and make you feel sleepy.
• CYP3A4 inducers: Using Addyi with herbal supplements like St. John’s Wort or ginkgo can reduce the amount of flibanserin in your body a lot, and that’s not a good idea.
• Digoxin or other p-glycoprotein substrates: Digoxin is a medication that helps your heart beat stronger and slower, and having too much of it can cause issues. If you’re taking medicines that P-glycoprotein moves around in your body, it’s wise to keep an eye on those levels.

Addyi Dosages for FDA-Approved Treatment

Addyi dosages vary between individuals and depend on factors like age and the condition being treated. The typical dosage is 100 mg, taken once daily at bedtime. Addyi is approved for premenopausal women within a specific age range. Dosage adjustments based on symptom severity are generally not required. It’s crucial for individuals to follow their healthcare provider’s recommended dosage to achieve the desired results while minimizing side effects.

Addyi Forms & Strengths

Addyi is supplied as 100 mg oval, pink, film-coated tablets, typically available in bottles of 30 tablets. There is no variation in forms or strengths for this medication, simplifying the prescription process. The onset of action may vary slightly among individuals, but it typically takes a few weeks of consistent use to achieve its full effect. Addyi is available as a 100mg oral tablet.¹

How Should I Take Addyi?

To take Addyi effectively, follow your doctor’s instructions closely. Typically, you’ll take one Addyi tablet at bedtime, and it should only be taken at this time. Taking Addyi at any other time can increase the risk of side effects like low blood pressure, fainting, drowsiness, and accidental injury. If you accidentally miss a dose, skip it and take the next one at bedtime the following day. Always adhere to your doctor’s recommendations regarding medication use for the best results.

What Happens If I Miss a Dose of Addyi?

If you accidentally miss a dose of Addyi, the best course of action is to simply take your next scheduled dose at bedtime the following day. It’s crucial not to take Addyi in the morning or double up on your next dose to compensate for the missed one. Attempting to catch up with extra doses can lead to potential health risks and side effects. Don’t hesitate to contact your doctor for guidance and support.¹

Can You Overdose on Addyi?

Overdosing on Addyi can lead to an increased risk of side effects, including drowsiness, sedation, low blood pressure, and fainting. If an overdose occurs, seek immediate medical attention. Treatment should focus on managing the specific symptoms and providing necessary support since there is no known antidote for flibanserin, the active ingredient in Addyi.

What Should You Do If You Take Too Much Addyi?

If you accidentally take too much Addyi, seek immediate medical attention. Contact your healthcare provider or go to the nearest emergency room. It’s crucial to address any potential overdose promptly to manage symptoms and receive appropriate medical care.

Questions to Ask Your Healthcare Provider About Addyi

If you’re considering Addyi as a treatment option, it’s essential to have an open and informed discussion with your healthcare provider, particularly your psychiatrist. Ask questions about the potential benefits, side effects, and how it may specifically address your condition. If you need to change prescribers, online psychiatry services can provide a convenient and accessible way to continue your care while maintaining regular consultations and medication management.

Questions to ask your care team about Addyi include:

• How safe is Addyi, and what are the common side effects?
• How long does it typically take to adjust to taking Addyi?
• Are there potential interactions between Addyi and other medications I’m currently taking?
• What dosage of Addyi is recommended for me to minimize side effects while effectively treating my condition?
• Are there any lifestyle changes or dietary restrictions I should be aware of while taking Addyi?
• Can you provide guidance on the best time to take Addyi to maximize its effectiveness?
• What should I do if I miss a dose of Addyi?
• How often will I need follow-up appointments to monitor my progress and discuss any concerns?
• Are there any specific warning signs or symptoms I should watch out for while taking Addyi?
• Is it safe to drink alcohol or use herbal supplements while on Addyi?
• Are there alternative treatments or therapies I should consider alongside Addyi?
• Can you recommend resources or support groups for individuals with my condition to help manage it effectively?

In My Experience

In my experience, discussing topics related to Addyi and its impact on individuals dealing with Hypoactive Sexual Desire Disorder (HSDD) is crucial. It’s important to remember that everyone’s experience with HSDD can vary, and seeking professional guidance from a healthcare provider, psychiatrist, or therapist is key.

Treatment and support for HSDD often involve a holistic approach, which may include medications like Addyi, therapy, lifestyle changes, and communication with your partner. The outlook for clients experiencing HSDD can be positive, especially when a tailored treatment plan is in place.

My advice to someone facing this issue would be to not hesitate in reaching out to healthcare professionals who specialize in sexual health. Addressing HSDD is a significant step towards improving one’s quality of life and overall well-being. Remember, you’re not alone in this journey, and there are effective ways to manage and overcome these challenges with the guidance of a dedicated care team.

For Further Reading

• Anxiety & Weight Loss: Causes & How to Cope
• Depression & Weight Gain: Connection & Management
• Premenstrual dysphoric disorder (PMDD)