Levitra Vs Viagra: Similarities, Differences, & Which Is Best for You

What Is Levitra (Vardenafil)?

Levitra (vardenafil) is a medication FDA-approved for the use of erectile dysfunction.¹ The drug’s effect has been reviewed and determined to provide benefits that outweigh its known and potential risks for the population it is intended for. This medication belongs to the phosphodiesterase 5 inhibitor family of medications, also known as PDE-5 inhibitors.

Levitra may also have off-label uses, defined as a use that is not FDA-approved where a physician, using their professional judgment, decides that there is a clinical benefit to using it for a different purpose. Some off-label uses for Levitra are pulmonary hypertension and treatment for premature ejaculation.^{1, 2, 3}

What Is Viagra (Sildenafil)?

Viagra (sildenafil) is similar to Levitra in that it is also FDA-approved for the treatment of erectile dysfunction. Viagra is one of the oldest erectile dysfunction medications in use, and it also belongs to the PDE5 inhibitor class of medications. Like Levitra, this medication has similar off-label uses, with the difference being that the active ingredient, sildenafil, is FDA-approved in the use of pulmonary hypertension. Viagra, like Levitra, is taken as needed before sex and does not need to be taken regularly each day.^{4, 5, 6}

What Are the Differences Between Generic Levitra & Viagra?

Levitra and Viagra are medications belonging to the same class of medications. They are both available as their generics, vardenafil and sildenafil, respectively, but Levitra is no longer sold as its brand since it has been discontinued. They both come as oral tablets, but their dosages do differ. They should both be taken an hour before sexual activity, although Viagra has some leeway with being taken just 30 minutes or 4 hours before sexual activity.

Here are the key differences between generic Levitra versus Viagra:^{2, 5}

How Do Levitra & Viagra Work?

Levitra and Viagra work by relaxing the blood vessels in the penis, which can affect blood flow within the penis. Their active ingredients, vardenafil and sildenafil, are both within the same category of medication called phosphodiesterase-5 inhibitors, or known as PDE5 inhibitors, so they were in similar ways. The relaxing of the muscles of the penis allows blood to flow normally within the penis, which may help an erection occur. You still need sexual stimulation to promote an erection, and PDE5 inhibitors have no effect without this stimulation.^{2, 5}

What Are Levitra & Viagra Used to Treat?

Levitra and Viagra are both medications used for erectile dysfunction, but sometimes they are used for other purposes. This is called an off-label use which is when a doctor uses the medication for a purpose that is not FDA-approved. For the purpose of the chart, we will focus on the generic versions of the medications.

The table below compares the medical and mental health conditions generic Levitra and Viagra are used to treat:^{2, 3, 5, 6, 7, 8, 9}

Is Levitra or Viagra More Effective?

Both medications have similar efficacy levels. Regardless of age and race, they were effective in providing temporary relief to those with erectile dysfunction. They work for a similar amount of time. Viagra can work up to 4 hours, but the erectile response was diminished compared to the first 2 hours. Levitra saw peak concentrations in the body between 30 minutes and 2 hours in healthy volunteers during clinical trials. Which medication may be right for you depends on individual factors and must be discussed with a doctor.

How Long Do Levitra & Viagra Last?

Levitra and Viagra both last for a similar amount of time, but you shouldn’t see an erection lasting longer than 4 hours. They are both intended to provide short-term relief for those with erectile dysfunction. How long the medication’s effects last for you depends on several factors. For example, your dosage, age, diet and lifestyle, other medications you take, and your overall health can affect how long they work in your body.

Levitra & Viagra: Which One Works Faster?

Levitra and Viagra are fast-acting medications. You do not have to wait long after taking either drug to engage in sexual activity. In general, it is recommended to take both medications about 60 minutes before sex, but Viagra can be taken just 30 minutes before or as early as 4 hours before sexual activity. For best results, take either medication 60 minutes before sex. ^{2, 5}

Levitra Vs. Viagra Dosages for FDA-Approved Treatment

Levitra and Viagra are provided as oral tablets that are swallowed whole. Typically, those on Levitra will start with 10 mg, and Viagra will start with 50 mg. The dosage can go higher or lower depending on your response. Dosages can vary for each individual. It is important to take medication as prescribed and to not change your dosage unless directed by a medical professional.

Levitra is available in the following forms and strengths:^{1, 2}

• 2.5 milligrams (mg) oral tablet
• 5 milligrams (mg) oral tablet
• 10 milligrams (mg) oral tablet
• 20 milligrams (mg) oral tablet

Viagra is available in the following forms and strengths:^{4, 5}

• 25 milligrams (mg) oral tablet
• 50 milligrams (mg) oral tablet
• 100 milligrams (mg) oral tablet

Side Effects of Generic Levitra & Viagra

These two medications share similar side effect profiles, given that they share the same class of medication. Both Levitra and Viagra have side effects which are often mild, though some may require medical attention. If you experience any changes to your senses, have changes in your heart rhythm, or have signs of an allergic reaction, then seek immediate medical care.

Common side effects from taking Levitra may include:*^{1, 2}

• Headache
• Flushing
• Dizziness
• Nasal congestion
• Indigestion
• Back pain
• Flu syndrome

Serious side effects from taking generic Levitra may include:*^{1, 2}

• Prolonged erection (Priapism)
• Serious vision changes, including vision loss
• Sudden Hearing loss
• Low blood pressure
• Long QT syndrome (a heart rhythm condition)
• Allergic reaction
• Cardiovascular problems, including heart attack

*All medications, including generic Levitra and Viagra, have a risk of side effects, including serious side effects. This is not a complete list of side effects. You should talk with your healthcare professional about the benefits and risks of any medication before starting treatment.

Common side effects from taking Viagra may include:*^{4, 5}

• Headache
• Flushing
• Dizziness
• Nasal congestion
• Indigestion
• Abnormal vision
• Rash
• Muscle pain

Serious side effects from taking Viagra may include:*^{4, 5}

• Priapism
• Sudden hearing loss
• Vision changes, including vision loss
• Low blood pressure
• Allergic reaction
• Cardiovascular problems, including heart attack

*All medications, including generic Levitra and Viagra, have a risk of side effects, including serious side effects. This is not a complete list of side effects. You should talk with your healthcare professional about the benefits and risks of any medication before starting treatment.

Warnings & Precautions for Generic Levitra & Viagra

Levitra and Viagra belong to the same class of medications, meaning that they contain the same warnings to be aware of. The concern with these medications is that they affect your blood pressure, so in combination with other conditions or substances, they may cause an unintended side effect that could be serious. If you experience any of these warnings, then you must seek immediate medical care. If you have any concerns with these warnings prior to taking Levitra or Viagra, talk with your doctor to assess whether the medications are right for you.

Risks to consider when taking generic Levitra and Viagra include:^{1, 2, 4, 5}

• Allergic reactions: If you are sensitive to the medication or components of the medication, do not take them. Signs and symptoms of an allergic reaction include slow heart rate; hives; difficulty breathing; and swelling of the lips, face or throat.
• Severe drop in blood pressure Levitra and Viagra can lower the blood pressure in patients, which is of little consequence in most patients. But those with underlying cardiovascular disease could be affected adversely. Certain combinations of medications or substances with Viagra and Levitra may also worsen these effects.
• Those with cardiovascular problems: There is a certain degree of cardiac risk associated with sexual activity. Those with underlying cardiac statuses should avoid taking Levitra and Viagra.
• People who take alpha-blockers: Patients on alpha-blockers should be cautioned with the use of Levitra or Viagra. In some patients, blood pressure can be lowered significantly and lead to problems like fainting.
• QT prolongation: Patients with congenital QT syndrome or are taking antiarrhythmics should avoid taking Levitra due to the risk of changing their heart rhythm.
• Effects on the eye: There is a risk of developing an eye condition called NAOIN. Patients on Levitra or Viagra should seek immediate medical care should they experience a sudden loss of vision in one or both eyes.
• Risk of Priapism: There is a risk of an erection becoming prolonged while on Levitra or Viagra. In the event that an erection lasts for more than 4 hours, the patient should seek immediate medical care.
• Sudden hearing loss: If a patient experiences sudden hearing loss, sometimes accompanied by tinnitus and dizziness, they should seek immediate medical care and stop taking Viagra or Levitra.
• Sexually transmitted infections: Levitra and Viagra do not offer protection against sexually transmitted diseases. Patients should be counseled on using protective measures to guard against STIs.

Potential Drug Interactions With Generic Levitra & Viagra

Levitra and Viagra both affect your blood pressure and, combined with other substances, may cause an adverse event where your blood pressure can become too low. This may result in symptoms such as becoming dizzy or fainting, sometimes requiring medical intervention.

Substances, when combined with Levitra or Viagra, that may trigger a drop in blood pressure include: nitrates, alpha-blockers, amlodipine, and other medications meant to control high blood pressure. You cannot take Viagra or Levitra with GC stimulators such as riociguat, or take nitrates, including the recreational drug “poppers”, as this can lead to a dangerous and sudden drop in blood pressure.

Some medications, like ritonavir, some antifungals, and other CYP3A4 inhibitors, may require a dosage adjustment to Levitra. While taking Levitra and Viagra, you should let your physician and other medical professionals know you are on it to avoid potential interactions.^{1, 2, 4, 5}

Disclaimer: Taking certain medications, herbs, or supplements alongside generic Levitra and Viagra can change how these medications work in your body or increase the risk of serious side effects. This article does not consider all the possible interactions. Please let your doctor, psychiatrists, and pharmacists know about all the products you currently use, such as prescription medication, nonprescription drugs, and herbal supplements. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Are Generic Levitra and Viagra Affected by Food?

Both Viagra and Levitra can be taken with or without food, but there is a concern in regards to Viagra. If Viagra is taken after a high-fat meal, such as a cheeseburger and fries, Viagra may take a little longer to start working. If the timing is a concern and you take Viagra, do not eat high-fat meals around the time that you intend to take Viagra.^{2, 5}

Generic Levitra Vs Viagra Cost

Generic medications will be a more affordable option. According to Optum, the price without insurance or coupons can be over $100 depending on which medication, its dosage strength, and the pharmacy you use.¹⁰ Keep in mind that your insurance may not cover these medications, but there are other options available to help cover the cost, such as discounts and coupons.

Viagra has a manufacturer coupon that can help you save 50% off the amount of your co-pay or your out-of-pocket cost, whichever is less, and if you are eligible. This is available once every 30 days with a maximum savings of $350 per month.¹¹ Brand name Levitra is no longer available, but the generic version is still on the market. You may also use discount cards that you can find online in order to save money. The price of the drug will vary depending on what strength is prescribed, the quantity you are receiving, and which pharmacy you are filling the medication with.

Which Is Right for You: Generic Levitra or Viagra?

No two people are the same, so what may look right for one person may not be appropriate for another. Which medication is best for your needs depends on many factors. A doctor can help you consider the benefits and risks of each medication and how they interact with factors like side effects, drug interactions, and preexisting conditions. Cost, lifestyle choices like your diet, the timing of these medications, and warnings associated with both medications may impact whether you choose Levitra or Viagra. If seeing a doctor in person is a barrier for you, you may need to consider online psychiatry services.

How to Get a Prescription for Generic Levitra & Viagra

Both medications require a prescription which you must obtain from a licensed physician or a provider who has an agreement with a licensed physician to prescribe medications, such as a physician’s assistant. Your doctor will assess whether these medications are appropriate for what you are trying to treat and whether it will be beneficial to you if you take them. Once it is confirmed that the medication is appropriate, they will either give you a paper prescription to bring to a pharmacy or they will send an electronic copy directly to your pharmacy of choice.

Questions to Ask Your Health Team About Generic Levitra & Viagra

Good communication with your provider is key to receiving the best treatment for your diagnosis. You must advocate for yourself regarding your own healthcare, and knowing what questions to ask can help you make a more informed decision. Personal factors like your lifestyle and current medical condition can impact what therapy would be best for you. You should also listen to medical advice given by your physician. Following instructions and attending follow-up appointments can help your doctor gauge whether this therapy works for you, and it gives you the opportunity to ask more questions.

Questions to ask your prescriber about generic Levitra and Viagra include:

• Is it safe to take generic Levitra or Viagra with my other medications?
• Will generic Levitra or Viagra be covered by my insurance?
• Which one has the best results as a treatment for erectile dysfunction?
• Does my medical history increase my risk of side effects for either?
• How long can I expect side effects to last?
• How often should I see you for checkups while taking generic Levitra or Viagra?
• What should I do if I am unsure whether erectile dysfunction medications are right for me?
• Which medication will work best with my lifestyle?

In My Experience

In my experience, erectile disfunction is fairly common. This issue impacts confidence as well as potentially social and romantic life. Those with erectile dysfunction should seek out advice and knowledge from healthcare professionals, educating themselves on what they can to help manage their condition. Patients should also be aware that not all erectile dysfunction medications are taken the same way and that timing may vary depending on the medication prescribed. Some medications take very little time, while others, like Viagra, may take around an hour before sexual activity to work as intended.