Paxil (Paroxetine) Weight Gain: Everything You Need to Know

What Is Paxil (Paroxetine)?

Paxil, the brand name for paroxetine, is an effective and commonly prescribed medication for managing symptoms of depression, anxiety, and other mental health disorders. It belongs to the selective serotonin reuptake inhibitors (SSRIs) class of drugs that play an important role in regulating serotonin levels in the brain. Paxil blocks the reabsorption of serotonin which is believed to improve one’s overall mood.¹

Why Does Paxil Cause Weight Gain?

Antidepressants have been associated with weight gain because they alter the levels of serotonin. While this neurotransmitter influences one’s mood and emotions, it also regulates appetite and metabolism. Therefore, an increase in serotonin levels can sometimes lead to possible weight gain.

Paxil weight gain is possible, especially if you take the medication for a longer period. Taking Paxil can result in appetite increase or cravings for food. Additionally, the medication can slow a person’s metabolism, further contributing to weight gain.

Depression itself can also influence a person’s weight as this condition can affect their motivation and energy levels. Eating excessively while engaging in minimal physical activity can lead to weight gain.

Do Other Antidepressants Cause Weight Gain?

Other antidepressants work similarly to Paxil and therefore can result in similar side effects, including weight gain. However, medications such as tricyclic antidepressants and monoamine oxidase inhibitors (MAOIs) are believed to pose a greater potential for weight gain than other antidepressants.² Some research suggests that Paxil is more likely to cause weight gain than other SSRI medications, especially if taken for more than six months.³

Short-Term vs. Long-Term Impacts

There is limited research regarding how Paxil affects weight gain in both the short- and long-term. However, one study found that Paxil weight gain may be more common in those who take the antidepressant for periods of six months or more. Therefore, taking Paxil as a part of long-term treatment increases one’s risk for weight changes as opposed to those who take it short-term.¹

Other Reasons for Gain Weight After Starting Medications

Weight gain can be a side effect of Paxil depending on how long a person is on the medication. However, this may not be the sole contributor to their weight gain. Those with depression or anxiety may engage in binge eating and emotional eating when with symptoms. These behaviors can greatly influence a person’s weight.

Water retention is also possible when taking medication. Some SSRIs may block the effects of hormones that play an important role in controlling sodium and fluid, resulting in water retention. Water buildup in the body can cause bloating in the legs and arms, making your weight fluctuate. It is also important to note that severe water retention can be a symptom of kidney disease.

Ways to Manage Paxil Weight Gain

While Paxil can be an effective part of one’s treatment plan, it can result in unwanted side effects. If you experience weight gain while taking Paxil, you can consider speaking with your doctor about possible alternatives. Otherwise, maintaining healthy eating habits and exercise routines can help you manage your weight.

Below are ways to manage weight gain while taking Paxil:

• Eat nutritious foods: Eating a diet rich in fruits and vegetables can help you maintain a steady body weight.
• Stay active: Regular physical activity will increase your total energy expenditure, which can help you avoid weight gain.⁵
• Work with a dietician: A dietician can recommend healthy foods and meal plans to try when managing weight gain.
• Adjust the dose: If you are experiencing weight gain, your doctor might consider adjusting your Paxil dose.
• Request another medication: Paxil may not be the best option for you; your physician can recommend other medications should you be interested in alternatives.

Other Side Effects of Paxil

Side effects of Paxil are generally mild, but can become severe depending on various factors such as one’s age and overall health. Seek immediate medical attention if you experience serious adverse reactions. Weight gain is only one possibility in a more extensive list of side effects.

Common side effects of Paxil include:¹

• Weight changes
• Drowsiness
• Headache
• Dizziness
• Restlessness
• Dry mouth
• Diarrhea or constipation
• Sweating
• Indigestion
• Nausea
• Sleeping problems
• Appetite issues
• Sexual problems

Side effects that may require immediate medical attention include:¹

• Bone fractures
• Seizures
• Serotonin syndrome
• Discontinuation syndrome
• Angle-closure glaucoma
• Bleeding problems
• Manic episodes
• Anxiety symptoms
• Suicidal thoughts and behaviors
• Irregular heartbeat
• Hyponatremia

Alternatives to Paxil for Weight Gain

Paxil can lead to weight gain. If this concerns you, talk with your doctor about how the medication has been affecting you. Your physician can offer suitable alternatives that better suit your needs. Alternatives to Paxil may include Prozac and Effexor.

Questions to Ask Your Health Team

Before starting Paxil, be sure to go over the associated risks thoroughly with your doctor. This will ensure you are safe while taking the medication.

Questions to ask your care team about Paxil include:

• How can I tell if Paxil is causing my weight gain?
• How long does weight gain last while taking Paxil?
• Am I at risk for increased weight gain if I am taking other medications?
• Will a previous history of weight gain make me more susceptible?
• What is the best dosage to limit weight gain?
• When should I reach out to you about any weight gain?
• Are there other medications that will impact my weight less?
• How soon am I likely to experience weight gain after my initial dosage?
• Are there other factors that can contribute to weight gain?

Final Thoughts

Paroxetine can be an effective option for relieving symptoms of depression and anxiety. While everyone responds to medications differently, taking antidepressants like Paxil may result in weight gain. If the possible side effects of Paxil concern you, discuss other options with your doctor to ensure you find the best suitable treatment option.