*An off-label use of a medication is a use that is not FDA-approved. Prescribers can decide to use a medication off-label because, in their professional judgment, they believe it may offer a benefit to someone.
Trintellix coupons and discount programs can help reduce the cost of your medication, and some patient assistance programs might provide additional savings. Without insurance, the average cost of Trintellix ranges from $487-$576 for a 30-day supply. And for those who qualify, a Trintellix savings card may bring the cost down to $10. Using a mail order pharmacy, getting a 90-day supply, or considering alternative medications may reduce costs as well.
If you’re considering Trintellix, online psychiatry platforms can be a good place to start. Talkiatry works with many major insurance plans and Brightside Health takes cash payments. Both platforms can connect you with a provider quickly for psychiatric assessments and prescription consultation.
Boxed Warning: Vortioxetine (Trintellix) – Risk of suicidal thoughts and behaviors
Vortioxetine, the active ingredient in Trintellix, has a black box warning. This is the most serious type of warning from the Food and Drug Administration (FDA). Vortioxetine can increase the risk of suicidal thoughts and behaviors in children, adolescents, and young adults. Regardless of your age, you should talk with your doctor about serious risks with vortioxetine and any other medications before starting treatment.
Online Psychiatry and Medication Management Covered by Insurance
Talkiatry can match you with a real psychiatrist who takes your insurance and is seeing new patients. They’re in-network with major insurers and offer medication management. Get started with a short online assessment
How Much Is Trintellix Without Insurance?
The cost of Trintellix without insurance may be affected by the pharmacy you choose, any coupons or discounts you use, and the specific dosage prescribed by your provider.
Trintellix Prices
The cost of Trintellix currently ranges from $487-$576 for a 30-day supply of 5 milligrams without insurance. Your Trintellix prescription may cost much less with insurance depending on your plan and coverage. The cost of Trintellix will also vary based on the dosage and amount prescribed. Coupons for Trintellix are often available and may reduce your out-of-pocket costs.
Note: Cash prices listed are derived from multiple sources. The prices listed are an estimate only and cannot be guaranteed. For exact prices, please contact the pharmacy.
Walmart
$555
Walgreens
$487
CVS / Target
$544
RiteAid
$487
Kroger
$512
Costco
$576
Hy-Vee
$523
Publix
$578
Albertsons
$492
How Much Does Trintellix Cost With Insurance?
The cost of Trintellix with insurance can vary based on your coverage type. Insurance companies may offer different copayments or coinsurance rates for Trintellix, affecting out-of-pocket expenses. Your deductible, copay, and coinsurance can also influence your final Trintellix cost.
Commercial Insurance
The cost of Trintellix with insurance can vary depending on copayments, deductibles, and coinsurance rates. Some plans may even provide discounts or preferred pricing for certain medications. Your insurance company may offer other benefits and savings, such as using mail-order pharmacy options or prescription savings programs.
Medicare
At this time, 100% of Medicare prescription drug plans cover Trintellix, providing potential cost savings. Be aware that coverage may change, so it’s important to check your Medicare plan before filling your prescription.1
Medicaid
Trintellix is classified as an “NP” or Non-preferred drug under Medicaid, which means it may not be prioritized over the cheaper alternatives within the formulary. Due to this classification, prior authorization is necessary before filling the prescription. With prior approval, Medicaid may provide coverage for Trintellix.2 Additionally, Medicaid recipients may explore state-specific prescription assistance programs or other cost-saving initiatives.
TRICARE
Trintellix may be covered by your TRICARE plan. The TRICARE website has a lookup tool, so check there to verify whether Trintellix is covered by your plan. Be aware that generics may be preferred or the only version available for some medications.3
Trintellix Coupons, Savings Cards, & Discounts
A Trintellix coupon is available from the drug manufacturer as part of the tAccess Support Program. This Trintellix $10 coupon may be used at most pharmacies. Even without prior authorization, eligible patients may pay as little as $10 for a month’s supply of Trintellix. 4
Here are the eligibility criteria for the Trintellix savings card:
- Must be age 18 or older
- Must have a valid prescription for Trintellix
- Not eligible if part of the prescription is covered by government-funded healthcare programs (e.g., Medicare, Medicaid, TRICARE)
- Not eligible if covered by the Medicare Prescription Drug Program (Part D) or currently in the coverage gap
- Not eligible if insurance is paying the entire cost of the prescription. Individuals paying with cash for their prescriptions are not eligible.
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Talkiatry – Safe, virtual mental health care from doctors who take insurance. Most psychiatry visits cost patients $30 or less* Take a short assessment.
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*Includes copayment, deductible, coinsurance, and $0 Visits. Excludes no shows. **On average. Actual appointment times vary by state and individual patient.
Trintellix Cost Savings Programs
Trintellix cost savings programs are available from organizations such as SimpleFill, NeedyMeds, and savings from the manufacturer. Some organizations provide information about cost savings programs. Others assist with the application and enrollment process. Individuals need to apply for each program and meet certain criteria to qualify for savings.
Takeda Help at Hand
The Takeda Help at Hand program can reduce the cost of Trintellix and other medications made by the same manufacturer. Individuals need to meet certain criteria to be eligible for savings.5
Here are the eligibility criteria for the Takeda Help at Hand Program:
- If your doctor has prescribed Trintellix (vortioxetine) and you live in the US or its territories, you may be eligible for the program.
- The program is designed to assist patients who don’t have enough insurance coverage, are struggling to afford Trintellix, or have no health insurance.
- Your annual household income should be equal to or less than $72,900 for a single-person household, $98,600 for two people, $124,300 for three people, $150,000 for four people, or meet specific criteria for households with five or more members to qualify for the program.
SimpleFill
SimpleFill offers a Trintellix copay card to those who qualify for their patient assistance program. To find out if you are eligible for their assistance program, complete the online application to find out if you qualify for this discount. You should anticipate a response within 24 hours about whether you qualify for a Trintellix copay card.6
NeedyMeds
NeedyMeds is a nonprofit organization dedicated to helping individuals with limited financial resources have access to prescription medications, such as Trintellix. To be eligible for their assistance program, consider the following criteria:7
- Your income falls at or below 500% of the federal poverty level.
- You are a US resident.
- Please check if you have Part D prescription coverage, and if you do, reach out to NeedyMeds Customer Support to apply for eligibility.
Other Ways to Find Trintellix Coupons & Discount Cards
Trintellix coupons and discount cards are available online, at pharmacies, and via the mail. These and other options may help save money when filling your prescription for Trintellix.
Pharmacy Discounts and Savings Cards
Pharmacy chains and retailers may offer discount cards for Trintellix, although this availability is not guaranteed. Talk with your local pharmacist about discounts and, if so, what Trintellix costs with their discount applied. Sometimes, pharmacies require an active prescription for them to check if they have a discount card within their system, but this may vary depending on the retailer.
Online Resources and Apps
Some websites help connect patients with discount cards and coupons for Trintellix. Several of these sites have mobile apps to make it easier to use these discounts. GoodRx, RxSaver, and WellRx are some examples of these sites. Note that the cost of Trintellix on these discount cards can fluctuate day to day, depending on when you fill your medication.
HSA Accounts
A health savings account (HSA) is a part of high-deductible health insurance plans. With an HSA, you can set aside pre-tax money from your paycheck to pay for certain health expenses. This means the money you contribute to this account is not subject to federal taxes, leaving the full amount available for use. Contact your company directly to learn if your Trintellix prescription is eligible.8
Ask Your Prescriber for Samples
Your prescriber may have samples of Trintellix available, which would provide a short-term supply of medication. Using samples allows you to try a medication without the expense of a full prescription.
Ask About Getting a 90-day Supply
If you and your prescriber determine that Trintellix may work for you, getting a 90-day supply can save money. Refilling every three months is often less expensive and more convenient than refilling every month. This also lessens the chance of running out before a refill is needed. Mail-order pharmacies typically offer 90-day supplies to cut down on the cost of shipping and operating local pharmacies.
Fill Your Prescription by Mail-order
Using a mail-order pharmacy is another way to get your medication at a lower price. Your provider calls in the prescription directly and your medication is typically delivered to your home within two weeks. Mail-order prescriptions are ideal for medications that are not temperature sensitive and are used as long-term treatments.9
How to Get a Trintellix Prescription
To get a prescription for Trintellix, you will first need a psychiatric evaluation. Begin by consulting your primary provider, who may be a physician, nurse practitioner, or physician assistant. They may refer you to a psychiatrist to further evaluate your depression symptoms. A provider doing an evaluation will consider your medical history, any medications or substances you are using, and other factors. With this information, they will then determine whether Trintellix is a suitable treatment for you.
To get prescribed Trintellix online, you will also start by getting evaluated by an online psychiatric provider. We have thoroughly reviewed platforms like Talkiatry or Circle Medical that prescribe antidepressants like Trintellix, and found them each to be a good place to get started with an evaluation. If your provider feels Trintellix is a good fit for your depression symptoms, they may offer you an online prescription for the medication.
Online Psychiatry and Medication Management Covered by Insurance
Talkiatry can match you with a real psychiatrist who takes your insurance and is seeing new patients. They’re in-network with major insurers and offer medication management. Get started with a short online assessment
Trintellix Alternatives
For some individuals, Trintellix alternatives may need to be considered. It may take several weeks before you feel the full effects of antidepressant medication. Everyone responds in a unique way to medication, and your age, health history, and previous experience with side effects can have an impact. Your doctor will help to decide which medication may work best for you.
Prescriber’s Tips
Frequently Asked Questions
What Is Trintellix?
Trintellix, containing the active ingredient vortioxetine, is a brand name antidepressant medication. Trintellix is approved for treating major depressive disorder in adults. Trintellix is not approved for use in children and adolescents.10
How Does Trintellix Work?
Trintellix works by helping to regulate the chemicals in the brain that play a role in mood and emotions. It’s thought to enhance the transmission of certain signals between nerve cells. For some, this activity may lead to an improvement in depressive symptoms.11
Why Is Trintellix So Expensive?
Brand name medications like Trintellix undergo costly research for safety and effectiveness under the patent. Generics have the same active ingredient and don’t require the same level of testing to sell it, making it a less expensive option.12
Is There a Generic Version of Trintellix?
No, currently a generic version of Trintellix is not available.
Can You Use a Trintellix Coupon With Insurance?
It depends, some savings programs may allow it while others may not. Check with the program you are applying to understand their restrictions on using insurance.
How Can I Lower My Long-Term Prescription Trintellix Costs?
Getting a 90-day supply, filling your prescription via mail order, and using generics are all ways to lower long-term drug costs. For those who qualify, patient assistance and discount programs can also help you save money on your medication.
Can I Use Coupons for Trintellix at My Pharmacy?
Yes, you can use Trintellix coupons at many pharmacies.
Is There a Trintellix Manufacturer Coupon Available?
Yes, there is a Trintellix manufacturer coupon available as well as a Trintellix savings card.
Does the Cost of Trintellix Vary Depending on the Strength?
It’s possible. Costs may also vary depending on your insurance and the pricing at various pharmacies. The dosage of your prescription may also be a factor.
Choosing Therapy strives to provide our readers with mental health content that is accurate and actionable. We have high standards for what can be cited within our articles. Acceptable sources include government agencies, universities and colleges, scholarly journals, industry and professional associations, and other high-integrity sources of mental health journalism. Learn more by reviewing our full editorial policy.
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Medicare and Trintellix. (n.d.). GoodRx.com. Retrieved from https://www.goodrx.com/trintellix/medicare-coverage
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Medicaid List of Covered Drugs (Formulary). (June, 2024). HealthPartners.com. Retrieved from https://www.healthpartners.com/ucm/groups/public/@hp/@public/documents/
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TRICARE Formulary Search. (n.d.). Express-Scripts.com. Retrieved from https://www.express-scripts.com/frontend/open-enrollment/tricare/fst/#/
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Savings Card & Patient Support | TRINTELLIX (vortioxetine). (n.d.). US.trintellix.com. Retrieved from https://us.trintellix.com/savings-support
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Takeda Help at Hand Eligibility. (n.d.). HelpatHandPAP.com. Retrieved from https://www.helpathandpap.com/Eligibility.aspx
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Trintellix Patient Assistance Programs. (n.d.). SimpleFill.com. Retrieved from https://simplefill.com/patient-assistance-program/trintellix/
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Trintellix. (n.d.). NeedyMeds.org. Retrieved from https://www.needymeds.org/brand-drug/name/Trintellix
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What Are HSA-eligible Plans? (n.d.). Healthcare.gov. Retrieved from (https://www.healthcare.gov/high-deductible-health-plan/hdhp-hsa-information/
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Getting a Prescription Filled. (July 8, 2023). MedlinePlus.gov. Retrieved from https://medlineplus.gov/ency/article/001956.htm
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TRINTELLIX- vortioxetine tablet, film coated. (March 5, 2025). DailyMed.nlm.nih.gov. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm
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D’Agostino, A., English, C. D., & Rey, J. A. (2015). Vortioxetine (brintellix): a new serotonergic antidepressant. P & T : a peer-reviewed journal for formulary management, 40(1), 36–40. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296590/
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Generic Drugs: Questions & Answers. (March 16, 2021). FDA.gov. Retrieved from https://www.fda.gov/drugs/frequently-asked-questions-popular-topics/generic-drugs-questions-answers
We regularly update the articles on ChoosingTherapy.com to ensure we continue to reflect scientific consensus on the topics we cover, to incorporate new research into our articles, and to better answer our audience’s questions. When our content undergoes a significant revision, we summarize the changes that were made and the date on which they occurred. We also record the authors and medical reviewers who contributed to previous versions of the article. Read more about our editorial policies here.
Author: No Change
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Primary Changes: Updated the Dailymed resource to the most recent.
Author: No Change
Reviewer: No Change
Primary Changes: Updated cost information in intro paragraph and “Trintellix Prices” section.
Author: No Change
Reviewer: No Change
Primary Changes: Updated cost information in intro paragraph and “Trintellix Prices” section, Updated the Dailymed resource to the most recent.
Author: No Change
Reviewer: No Change
Primary Changes: Updated cost information in intro paragraph and “Trintellix Prices” section.
Author: No Change
Reviewer: No Change
Primary Changes: Added new sections titled “Takeda Help at Hand”, “SimpleFill”, “NeedyMeds”, “HSA Accounts”, “Ask Your Prescriber for Samples”, “Ask About Getting a 90-day Supply”, Fill Your Prescription by Mail-order”, “trintellix Alternatives”, “Prescriber’s Tips”, “FAQs”; Revised introduction and sections titled “How Much Does Trintellix Cost Without Insurance?”, “How Much Does Trintellix Cost With Insurance?”, “Trintellix Cost Savings Programs”, “How to Get a Trintellix Prescription”; Reviewed and added relevant sources. Edited for readability and clarity.
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