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  • Mental Health Issues
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  • What Is Vyvanse & How Is it Used?What Is Vyvanse & How Is it Used?
  • Why Does It Cause Changes in Sex Drive?Why Does It Cause Changes in Sex Drive?
  • How to Cope With Sexual Side Effects?How to Cope With Sexual Side Effects?
  • Questions to AskQuestions to Ask
  • In My ExperienceIn My Experience

Vyvanse & Sex Drive: Everything You Need to Know

Luke Prest, MD headshot

Written by: Luke Prest, MD

Dena Westphalen, Pharm. D.

Reviewed by: Dena Westphalen, Pharm.D

Published: July 17, 2023

Vyvanse is a stimulant medication used to treat attention-deficit hyperactivity disorder (ADHD) and binge eating disorder. While Vyvanse is typically well-tolerated, it can have effects on sex drive. The medication’s influence on brain chemicals can result in either an increase or decrease in sex drive. If you experience these side effects, consult your healthcare provider to discuss treatment options. Your prescriber may suggest adjusting the dosage, stopping the medication, or incorporating psychotherapy into your treatment plan.

Boxed Warning: Vyvanse - Global

Boxed Warning: Lisdexamfetamine dimesylate (Vyvanse) – Risk of medication misuse or abuse
Lisdexamfetamine dimesylate, the active ingredient in Vyvanse, has a black box warning. These are the most serious types of warnings from the Food and Drug Administration (FDA). Lisdexamfetamine dimesylate has a risk of misuse (abuse) which can lead to dependence on the medication.

What Is Vyvanse & How Is it Used?

Vyvanse (lisdexamfetamine dimesylate) is a stimulant medication used for the treatment of attention-deficit hyperactivity disorder (ADHD) and binge eating disorder. A stimulant medication, such as Vyvanse, works by increasing the chemicals norepinephrine, dopamine, and serotonin, in the brain. These chemicals are associated with impulse control and attention regulation.

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Why Does Vyvanse Cause Changes in Sex Drive?

By increasing norepinephrine, dopamine, and serotonin in the brain, Vyvanse can improve focus, reduce impulsivity, and decrease hyperactivity. Although it is not fully understood, the increase in dopamine and serotonin can lead to changes in sex drive. Increasing serotonin is associated with a lowering of the libido, which was experienced in approximately 1.4% of people taking Vyvanse in clinical trials. Additionally, Vyvanse can lead to erectile dysfunction in 2.6% of males in clinical trials. However, by increasing dopamine in the brain, Vyvanse has also been reported to cause increased libido and hypersexuality, although these were not seen in clinical trials.1,2

Vyvanse & Hypersexuality

Vyvanse has been reported to cause hypersexuality, an excessive preoccupation with sexual thoughts, urges, or behaviors.3 This Vyvanse side effect was not reported in clinical trials. Hypersexuality may decrease or resolve over time, even if you continue taking the medication. However, in severe or persistent cases, the dose of the medication may need to be adjusted, or the medication may need to be discontinued.

Symptoms of hypersexuality while taking Vyvanse may include:2,4

  • Preoccupation with sexual thoughts or planning sexual activity
  • Engaging in sexual behavior without regard for risk
  • Increased need for sexual gratification or arousal
  • Difficulty controlling or limiting sexual behaviors
  • Neglecting other responsibilities due to preoccupation with sex
  • Experiencing negative consequences as a result of sexual behavior

Vyvanse Sexual Side Effects in Females

When women begin taking Vyvanse, they may experience sexual side effects as their body adjusts to the medication. Like in men, this can lead to decreased libido, while other women may experience increased libido, although an increase in libido was not seen in clinical trials. Some women may also develop difficulty achieving orgasm. The changes in sexual experiences may lead to frustration, dissatisfaction, or strain in a relationship. It is important to remember that these side effects vary, and not all women experience them. The side effects may resolve over time, while others may experience them until the medication is stopped.

Sexual side effects for women taking Vyvanse may include:1

  • Low libido
  • Difficulty maintaining arousal
  • Difficulty achieving orgasm

Vyvanse Sexual Side Effects in Males

The sexual side effects of Vyvanse in men are similar to the side effects for women. These symptoms include changes in sex drive, erectile dysfunction, and delayed ejaculation. These symptoms can negatively impact a relationship, as sexual intimacy is vital in many relationships. Not all men experience side effects, and these symptoms may resolve with time as the body adjusts to the medication. For some, the side effects may not resolve until the medication is discontinued.

Sexual side effects for men taking Vyvanse may include:1,3,5

  • Changes in libido
  • Erectile dysfunction
  • Delayed ejaculation

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How to Cope With Sexual Side Effects of Vyvanse

Sexual side effects caused by Vyvanse or any other medication can be treated or minimized. While sexual side effects can be unpleasant, seeking help from a healthcare provider can be beneficial.

Psychotherapy can provide some useful skills for coping with sexual side effects and may help address any psychological factors contributing to the difficulties. Online therapy options can be beneficial as they offer convenience, accessibility, and privacy, allowing individuals to receive support from the comfort of their homes. Finding the right therapist for your needs is important as they can provide tailored strategies to address your concerns.

Adjust Your Dose

Adjusting the Vyvanse dose, under the guidance of your healthcare provider, may help reduce or even eliminate sexual side effects. It is crucial to seek professional advice when adjusting your dose to ensure safety and avoid complications such as Vyvanse withdrawal. Your healthcare provider will evaluate your situation and may recommend lowering the dose to strike a balance between managing sexual side effects and effectively treating the underlying disorder. Their expertise will help tailor the dosage adjustment to your needs, optimizing your treatment outcome and minimizing potential negative impacts.

Consider Switching Medications

In some instances, reducing the sexual side effects of Vyvanse may not be possible. Your healthcare provider can help you consider other treatment options, including trying other medications or incorporating psychotherapy into your treatment plan. Do not stop taking Vyvanse or reduce your dosage on your own. Discontinuing Vyvanse should only be done under the supervision of the prescriber to prevent Vyvanse withdrawal.

Give it More Time

For some, the sexual side effects of Vyvanse may reduce or subside with time. It is common for the body to undergo an adjustment period as it adapts to the medication’s effects. During this initial period, sexual side effects may occur. However, as the body becomes accustomed to the medication, these effects on sexual functioning often diminish or resolve with time. Discuss any concerns with your healthcare provider as they can guide whether it is appropriate to give it more time or if other options should be considered.

Talk to a Therapist

Psychotherapy can be a valuable treatment option when addressing the sexual side effects caused by Vyvanse. By working with a qualified therapist, individuals can explore the psychological factors contributing to sexual difficulties. Therapy provides a safe and supportive space to address emotional or relationship-related issues that may impact sexual functioning. By working with a therapist, an individual can develop coping strategies, improve communication between partners, and alleviate anxiety/stress surrounding sexual performance.

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Questions to Ask Your Health Team About Vyvanse Sexual Side Effects

Engaging in open and honest conversations with your health team is essential for making informed decisions about your treatment options and effectively managing any side effects caused by Vyvanse. Your medical team possesses the expertise to provide accurate information and help you set realistic expectations regarding Vyvanse and its potential impact on sexual functioning. By actively involving your healthcare provider in these discussions, you can work together to develop an individualized treatment plan that prioritizes your overall well-being.

Questions to ask your care team about the sexual side effects of Vyvanse include:

  • How likely am I to experience sexual side effects?
  • Does my medical history increase the likelihood of experiencing sexual side effects?
  • How long after starting Vyvanse might I experience side effects?
  • How long will it take for me to adjust to taking Vyvanse?
  • Am I at risk for more severe symptoms if I take other medications, such as antidepressants?
  • What is the best dosage to ensure fewer side effects?
  • When should I contact you if I am experiencing sexual side effects?
  • Are there any lifestyle changes that can reduce the risk of sexual side effects?
  • Is there anything I should tell my therapist about this new medication?
  • Are there any medications or supplements I can take with Vyvanse to address the side effects?

In My Experience

In my experience, Vyvanse remains a highly effective treatment option for conditions like ADHD and Binge Eating Disorder. While it is understandable to feel concerned about potential sexual side effects, the risk of experiencing these side effects is generally low, and many of these side effects diminish or resolve with time. Your medical providers have your best interests and well-being in mind and rely on open communication to understand the specific side effects you may be experiencing. By sharing your concerns and experiences, your medical provider can provide appropriate guidance and support to help safely address and manage potential side effects.

Additional Resources

To help our readers take the next step in their mental health journey, Choosing Therapy has partnered with leaders in mental health and wellness. Choosing Therapy is compensated for marketing by the companies included below.

Online Psychiatry

Plushcare There are many effective medications for ADHD, including Strattera, which a Plushcare doctor can prescribe. In as little as 15 minutes, you can speak with a board-certified doctor from PlushCare to receive ADHD treatment. Plushcare DOES NOT prescribe controlled substances. Visit Plushcare

Grow Therapy enables you to find a psychiatrist or psychiatric nurse practitioner that can diagnose your condition, prescribe appropriate medications, and monitor your reaction to medication. Accepting most major insurances. Find A Provider

Online Therapy

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For Further Reading

  • Treatment for Adult ADHD: Medication, Therapy, & Self-Help Strategies
  • ADHD Medication: Types, Side Effects & Risks
  • Hypersexuality: Definition, Symptoms, & Treatments
  • CDC: Attention-Deficit/Hyperactivity Disorder (ADHD)
  • How Long Does Vyvanse Last?
  • Vyvanse Vs Ritalin: Differences, Similarities, & Which to Take

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Sources

Choosing Therapy strives to provide our readers with mental health content that is accurate and actionable. We have high standards for what can be cited within our articles. Acceptable sources include government agencies, universities and colleges, scholarly journals, industry and professional associations, and other high-integrity sources of mental health journalism. Learn more by reviewing our full editorial policy.

  • DailyMed.nlm.nih.gov (2022). VYVANSE- Lisdexamfetamine Dimesylate capsuleVYVANSE- Lisdexamfetamine Dimesylate Tablet, Chewable. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm

  • Schneider, E., Higgs, S., & Dourish, C. T. (2021). Lisdexamfetamine and binge-eating disorder: A systematic review and meta-analysis of the preclinical and clinical data with a focus on mechanism of drug action in treating the disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 53, 49–78. Retrieved from https://doi.org/10.1016/j.euroneuro.2021.08.001

  • Chou, N. H., Huang, Y. J., & Jiann, B. P. (2015). The Impact of Illicit Use of Amphetamine on Male Sexual Functions. The journal of sexual medicine, 12(8), 1694–1702. Retrieved from https://doi.org/10.1111/jsm.12926

  • ICD-11 for Mortality and Morbidity Statistics. (n.d.). ICD-11 for Mortality and Morbidity Statistics. Retrieved from https://icd.who.int/browse11/l-m/en

  • Haghighi, M., Doostizadeh, M., Jahangard, L., Soltanian, A., Faryadres, M., Dürsteler, K. M., Beatrix Brühl, A., Sadeghi-Bahmani, D., & Brand, S. (2021). Influence of Lisdexamfetamine Dimesylate on Early Ejaculation-Results from a Double-Blind Randomized Clinical Trial. Healthcare (Basel, Switzerland), 9(7), 859. Retrieved from https://doi.org/10.3390/healthcare9070859

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  • What Is Vyvanse & How Is it Used?What Is Vyvanse & How Is it Used?
  • Why Does It Cause Changes in Sex Drive?Why Does It Cause Changes in Sex Drive?
  • How to Cope With Sexual Side Effects?How to Cope With Sexual Side Effects?
  • Questions to AskQuestions to Ask
  • In My ExperienceIn My Experience
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