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Adderall Side Effects in Men: Erectile Dysfunction & Other Sexual Side Effects

Published: October 3, 2022 Updated: January 5, 2023
Published: 10/03/2022 Updated: 01/05/2023
Osama_Tariq_MD Headshot
Written by:

Osama Tariq

MD
Dena Westphalen, PharmD
Reviewed by:

Dena Westphalen

PharmD
  • What Is Adderall & What Are Its Uses?What Is Adderall
  • Why Does Adderall Affect Men Differently?Side Effects in Men
  • Adderall & Erectile DysfunctionErectile Dysfunction
  • Additional Sexual Side Effects of Adderall in MenOther Sexual Effects
  • Impacts of Adderall on Sex LifeImpact On Sex Life
  • How to Talk to Your Doctor About Adverse Side EffectsTalk to your Doctor
  • Questions to Ask Your Health Team About Adderall’s Side Effects On MenQuestions to Ask
  • Final ThoughtsFinal Thoughts
  • Additional ResourcesResources
Osama_Tariq_MD Headshot
Written by:

Osama Tariq

MD
Dena Westphalen, PharmD
Reviewed by:

Dena Westphalen

PharmD

While side effects of Adderall have a broad variation, men specifically can experience erectile dysfunction, inability to orgasm, or even climaxing too quickly. It is essential to understand that all patients may react to Adderall differently, so speaking to your doctor about undesirable side effects is vital. Adderall can benefit many patients but may not be best for all men due to side effects impacting their sex life.

Boxed Warning: Adderall

 Warning: Risk of medication misuse or abuse for amphetamine, dextroamphetamine mixed salts (Adderall)
Adderall has a black box warning. These are the most serious types of warnings from the Food and Drug Administration (FDA). Amphetamines, an active ingredient in Adderall, have a risk of misuse (abuse) which can lead to dependence on the medication, serious heart conditions, and even sudden death.

What Is Adderall & What Are Its Uses?

Stimulant medications such as Adderall are usually the first-line treatment for adult ADHD. Adderall has other benefits for narcolepsy and is sometimes used off-label for other conditions. Despite the benefits, its active ingredients of amphetamine and dextroamphetamine mixed salts make Adderall a controlled substance by the DEA due to its high potential for addiction.1

Even students who do not have ADHD often abuse Adderall to increase their focus and allow them to study for longer. One study found that, of college students in the survey, 43% of those without ADHD took Adderall while in school.2 Despite its increased focus, the GPA of the students not using Adderall was higher than those using the drug.

Prescribers will generally not refill medication unless the patient is seen in the clinic and will discontinue Adderall on any signs of misuse/abuse. Adderall has shown benefits in its treatment of ADHD symptoms. However, it has side effects for all patients taking Adderall, including some unique sexual side effects for men who use it in their treatment.

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Why Does Adderall Affect Men Differently?

Sexual changes are an expected side effect for men with ADHD starting Adderall. In clinical studies of Adderall, changes in sex drive, erectile dysfunction and frequent or prolonged erections were reported.6

One study looked at men who used amphetamines such as Adderall and found a significantly higher percentage of erectile dysfunction than men who did not take amphetamines. The study also saw a decrease in erectile rigidity and sexual satisfaction. However, in this study, half of the men reported no changes in their sexual behaviors.3

It is critical to discuss with your doctor if these changes arise. The connection between amphetamine and erectile dysfunction in men is not well known; however, specialists believe the link has to do with its effects on dopamine and serotonin in the brain.4

Adderall & Erectile Dysfunction

Researchers theorize that Adderall is a constrictor of blood vessels, thus allowing less blood to flow to the penis, which decreases rigidity and causes erectile dysfunction 5. The direct cause of erectile dysfunction in men taking Adderall is not well understood, as sexual dysfunction is variable between men. However, we know that there is a significant effect.

One study found that half of the research patients had no sexual changes when taking amphetamines 3. Users of Adderall can expect the symptoms soon after taking it, as it is a fast-acting medication. Men of all ages seem at risk of experiencing sexual dysfunction of Adderall. It is essential to discuss with your physician if you have these symptoms from Adderall and discuss different treatment options if it negatively affects your life.

When Does Adderall Cause Erectile Dysfunction?

Factors that increase the risk of developing ED with Adderall include having a history of ED, the stress of starting medication in a physical relationship, or even the effect of untreated ADHD on a relationship. Prescribed patients can resolve these symptoms if medication is stopped or the dose decreases. However, you should discuss this with your physician before stopping Adderall abruptly, as it can lead to severe withdrawal effects.

Additional Sexual Side Effects of Adderall in Men

Adderall can have additional sexual side effects in males, with different people having different reactions to their medications. While some may see changes in sex drive, others may encounter more symptoms of ED. It is essential to discuss these and other side effects with your physician if you feel they decrease your quality of life.

Other Adderall side effects in men include:

1. Changes in Sex Drive

Some men will report no changes in sexual drive, while others will have only a significant decrease 3. The reason for this is not well known, but the hypothesis involves constriction of blood vessels, decreasing blood flow to the penis. While a slight decline in sex drive may be acceptable to some men, discussing side effects that reduce your quality of life with your doctor is essential. This is especially important if there is an active desire to have children while taking it.

2. Penile Shrinkage

Penile shrinkage is a known potential side effect of Adderall use. Patients may describe their penis going deeper into their body 5. It can be alarming and cause significant anxiety. Penile shrinkage is a temporary side effect of Adderall and will return to normal. However, it is not well known why penile shrinkage occurs in some patients that take Adderall.

3. Premature Ejaculation

Some may exercise premature or spontaneous ejaculation. Spontaneous ejaculation has been reported at home, school, and even work. This side effect is thought to be due to the effect Adderall has on the neurotransmitter, dopamine. Increases in dopamine are associated with hypersexuality as well as spontaneous ejaculation. These symptoms thankfully resolve themselves after their discontinuation. 4

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Impacts of Adderall on Sex Life

Erectile dysfunction can have a draining effect on sexual self-esteem and confidence in bed. Relationships can significantly suffer due to the lack of sexual intimacy when it makes partners not feel attractive. It can be difficult for men to discuss it with their partners. However, an honest conversation on ED can build trust through vulnerability and give their partners the reassurance they need. Remember that sex is important in a relationship, so being able to openly talk about Adderall’s effects and potentially even switch medication to prevent sexual side effects is worth considering.

How to Talk to Your Doctor About Adverse Side Effects

Talking about sexual side effects with your physician can be uncomfortable for patients. It’s always important to remember that your doctor is there to help with any healthcare concerns you may have. Similarly, doctors are used to hearing all sorts of different problems that patients are going through. Doctors may elect to decrease your dosage of medication or can prescribe other medicines that may help reduce sexual side effects. You should always feel safe and comfortable enough to bring up any health concerns you may have.

Questions to Ask Your Health Team About Adderall’s Side Effects On Men

Talking about the side effects of ED and sexual dysfunction from Adderall can be daunting. However, everyone who is a part of your treatment plan should know the medication’s side effects for you so they can update your treatment profile.

Questions a man should ask his care team before taking Adderall to include:

  • What are my risks for ED?
  • Whom should I speak to if ED does arise?
  • What are my options for treatment with ED?
  • How long should I expect side effects to last from Adderall, if they come at all?
  • What non-sexual side effects should I look out for?
  • How often should I see the doctor for checkups when taking Adderall?
  • Are there ways to reduce sexual side effects while taking Adderall?

Final Thoughts

Adderall can cause several undesirable side effects specific to men that may further impact them in their romantic relationships. Always consult your doctor to determine the best medication for you and how to stop taking Adderall if you need to switch prescriptions safely.

Additional Resources

Education is just the first step on our path to improved mental health and emotional wellness. To help our readers take the next step in their journey, Choosing Therapy has partnered with leaders in mental health and wellness. Choosing Therapy may be compensated for marketing by the companies mentioned below.

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For Further Reading

  • ADDERALL (CII)
  • Prescription Stimulants DrugFacts | National Institute on Drug Abuse (NIDA)
  • Dextroamphetamine and Amphetamine: MedlinePlus Drug Information
  • Health Unlocked: CHADD’s Adult ADHD Support Groups
  • 12 Symptoms & Signs of Adult ADHD
  • Best Books on ADHD
  • Best Podcasts on ADHD
  • Best Youtube Channels on ADHD
  • Best Blogs about ADHD
  • Stimulant vs Non-Stimulant ADHD Meds: Key Differences
6 sources

Choosing Therapy strives to provide our readers with mental health content that is accurate and actionable. We have high standards for what can be cited within our articles. Acceptable sources include government agencies, universities and colleges, scholarly journals, industry and professional associations, and other high-integrity sources of mental health journalism. Learn more by reviewing our full editorial policy.

  • Sharbaf Shoar N, Marwaha R, Molla M. Dextroamphetamine-Amphetamine. [Updated 2022 May 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK507808/

  • Advokat CD, Guidry D, Martino L. Licit and illicit use of medications for Attention-Deficit Hyperactivity Disorder in undergraduate college students. J Am Coll Health. 2008 May-Jun;56(6):601-6. doi: 10.3200/JACH.56.6.601-606. PMID: 18477513. Available from: https://pubmed.ncbi.nlm.nih.gov/18477513/

  • Chou NH, Huang YJ, Jiann BP. The Impact of Illicit Use of Amphetamine on Male Sexual Functions. J Sex Med. 2015 Aug;12(8):1694-702. doi: 10.1111/jsm.12926. Epub 2015 Jul 6. PMID: 26147855. Available from: https://pubmed.ncbi.nlm.nih.gov/26147855/

  • Öncü B, Çolak B, Er O. Methylphenidate-induced spontaneous ejaculation. Ther Adv Psychopharmacol. 2015 Feb;5(1):59-61. doi: 10.1177/2045125314561993. PMID: 25653832; PMCID: PMC4315676. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315676/

  • Bloor RN. Whizz-dick: side effect, urban myth or amfetamine-related koro-like syndrome? Int J Clin Pract. 2004 Jul;58(7):717-9. doi: 10.1111/j.1368-5031.2004.00035.x. PMID: 15311730. Available from: https://pubmed.ncbi.nlm.nih.gov/15311730/

  • ADDERALL- dextroamphetamine saccharate, amphetamine aspartate, dextroamphetamine sulfate, and amphetamine sulfate tablet. DailyMed. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f22635fe-821d-4cde-aa12-419f8b53db81

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Osama_Tariq_MD Headshot
Written by:

Osama Tariq

MD
Dena Westphalen, PharmD
Reviewed by:

Dena Westphalen

PharmD
  • What Is Adderall & What Are Its Uses?What Is Adderall
  • Why Does Adderall Affect Men Differently?Side Effects in Men
  • Adderall & Erectile DysfunctionErectile Dysfunction
  • Additional Sexual Side Effects of Adderall in MenOther Sexual Effects
  • Impacts of Adderall on Sex LifeImpact On Sex Life
  • How to Talk to Your Doctor About Adverse Side EffectsTalk to your Doctor
  • Questions to Ask Your Health Team About Adderall’s Side Effects On MenQuestions to Ask
  • Final ThoughtsFinal Thoughts
  • Additional ResourcesResources
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