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  • DifferencesDifferences
  • How Do They Work?How Do They Work?
  • Used to TreatUsed to Treat
  • Focalin Vs VyvanseFocalin Vs Vyvanse
  • Side EffectsSide Effects
  • Warnings & PrecautionsWarnings & Precautions
  • Drug InteractionsDrug Interactions
  • DosagesDosages
  • CostCost
  • Right For YouRight For You
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Focalin Vs Vyvanse: Differences & Which to Take

Headshot Max Ruvinov PharmD MBA

Author: Max Ruvinov, PharmD, MBA

Headshot Max Ruvinov PharmD MBA

Max Ruvinov PharmD, MBA

Max Ruvinov is an accomplished pharmacist and an expert in medication management for multiple mental health conditions. His areas of expertise include weight loss, sexual health, and mood disorders.

See My Bio Editorial Policy
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Medical Reviewer: Heidi Moawad, MD Licensed medical reviewer

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Heidi Moawad MD

Heidi Moawad, MD is a neurologist with 20+ years of experience focusing on
mental health disorders, behavioral health issues, neurological disease, migraines, pain, stroke, cognitive impairment, multiple sclerosis, and more.

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Published: November 8, 2023
  • DifferencesDifferences
  • How Do They Work?How Do They Work?
  • Used to TreatUsed to Treat
  • Focalin Vs VyvanseFocalin Vs Vyvanse
  • Side EffectsSide Effects
  • Warnings & PrecautionsWarnings & Precautions
  • Drug InteractionsDrug Interactions
  • DosagesDosages
  • CostCost
  • Right For YouRight For You
  • How to GetHow to Get
  • Questions to AskQuestions to Ask
  • In My ExperienceIn My Experience
  • Additional ResourcesAdditional Resources
Brand name:
Focalin
Generic name:
Dexmethylphenidate Hydrochloride
Is the generic available:
Yes
Class of drug:
Stimulant
Boxed warning:
Yes
FDA-approved treatments:
ADHD
Common Off-label Uses (non-FDA approved):
Treatment-resistant depression, narcolepsy
Common alternatives:

Adderall, Ritalin, Vyvanse

View Drug Class, FDA-Approved Uses, Off-Label Uses, and more

*An off-label use of a medication is a use that is not FDA-approved. Prescribers can decide to use a medication off-label because, in their professional judgment, they believe it may offer a benefit to someone.

Brand name:
Vyvanse
Generic name:
Lisdexamfetamine Dimesylate
Is the generic available:
Yes
Class of drug:
Stimulant
Boxed warning:
Yes
FDA-approved treatments:
ADHD, Binge Eating Disorder
Common Off-label Uses (non-FDA approved):
Depression, Schizophrenia, excessive daytime sleepiness, weight loss
Common alternatives:

Adderall, Ritalin, Strattera

View Drug Class, FDA-Approved Uses, Off-Label Uses, and more

*An off-label use of a medication is a use that is not FDA-approved. Prescribers can decide to use a medication off-label because, in their professional judgment, they believe it may offer a benefit to someone.

Focalin and Vyvanse are both central nervous system stimulants used to treat ADHD, but Vyvanse also treats moderate to severe binge eating disorders in adults. The choice between them should be guided by your specific medical condition and your doctor’s recommendation.

If you’re considering Focalin or Vyvanse, or want to discuss your current prescription with a provider, you will be limited in your options. Talkiatry is an online psychiatry platform that can and will prescribe stimulant medications, which are controlled substances. This platform can connect you with a provider quickly and offer assessments and prescription consultation.

Boxed Warning: Dexmethylphenidate (Focalin, Focalin XR) - Risk of misuse and dependence

Click here to open and close the box warning container.

Dexmethylphenidate hydrochloride, the active ingredient in Focalin and Focalin XR, has a black box warning. These are the most serious types of warnings from the Food and Drug Administration (FDA). Dexmethylphenidate hydrochloride has a risk of misuse (abuse) which can lead to dependence on the medication.

Focalin is a controlled substance, which means that it’s more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.

Boxed Warning: Lisdexamfetamine dimesylate (Vyvanse) – Risk of medication misuse or abuse

Click here to open and close the box warning container.

Lisdexamfetamine dimesylate, the active ingredient in Vyvanse, has a black box warning. These are the most serious types of warnings from the Food and Drug Administration (FDA). Lisdexamfetamine dimesylate has a risk of misuse (abuse) which can lead to dependence on the medication.

Vyvanse is a controlled substance, which means that it’s more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.

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What Are the Differences Between Focalin Vs Vyvanse?

Focalin and Vyvanse are both medications used to treat ADHD, but they have some differences. Focalin is available in tablet form, while Vyvanse comes in capsules and chewable tablets. The dosages for these medications can also vary, and the age groups for which they are approved may differ.

Here are the key differences between Focalin versus Vyvanse:1, 2

Key ComponentsFocalinVyvanse
What is the generic name?Dexmethylphenidate hydrochlorideLisdexamfetamine dimesylate
What forms does it come in?Tablets: 2.5 mg, 5 mg, 10 mgCapsules: 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, 70 mg
Chewable tablets: 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg
What are the typical dosages?Varies based on individual needs, but common doses are 5 mg, 10 mg, or 20 mgCommon dosages for Vyvanse range from 30 mg to 70 mg for adults and 20 mg to 70 mg for children
Who is approved to take it?Approved for children (6 years and older) and adults with ADHDApproved for children (6 years and older) and adults with ADHD, as well as adults with binge eating disorder
Side effectsIncreased blood pressure and heart rate, painful erections, and moreGrowth slowdown, increased blood pressure, and heart rate, might have issues with blood vessels

How Do Focalin & Vyvanse Work?

Focalin and Vyvanse are both central nervous system stimulants used to treat ADHD.1, 2 They work by increasing certain neurotransmitters in the brain, like dopamine and norepinephrine, which play a role in attention and impulse control. This helps to enhance attention and reduce impulsiveness and hyperactivity in individuals with ADHD.

In addition to ADHD, Vyvanse is also used to treat binge eating disorder in adults.2 It operates similarly by affecting brain chemicals and can reduce the frequency of binge eating episodes. These medications are typically used as part of a comprehensive treatment plan, which may include counseling or other therapies, to manage the respective conditions effectively. Your healthcare provider will determine the most suitable choice for your specific needs.

What Are Focalin & Vyvanse Used to Treat?

Focalin and Vyvanse are medications for ADHD that help manage symptoms of attention deficit hyperactivity disorder. Focalin is FDA-approved for this purpose, and Vyvanse is also FDA-approved as a treatment for ADHD.

The table below compares the medical and mental health conditions Focalin and Vyvanse are used to treat:1, 2

ConditionFocalinVyvanse
ADHDFDA-approvedFDA-approved
Binge eating disorderOff-labelFDA-approved
ObesityNoOff-label
DepressionNoOff-label
NarcolepsyOff-labelOff-label

Focalin Vs. Vyvanse for ADHD

The study data shows that long-acting medications like Focalin XR and Vyvanse are often preferred for ADHD treatment. They make up a significant portion of prescriptions across different specialities, including primary care, psychiatry, and pediatrics.3

Long-acting medications can be beneficial because they provide a sustained release of the medication throughout the day, helping to maintain symptom control without the need for multiple doses. Both Focalin XR and Vyvanse are long-acting options and have demonstrated efficacy in managing ADHD symptoms. It’s important to consult with a healthcare professional to determine which medication suits an individual’s specific needs.

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Side Effects of Focalin Vs. Vyvanse

Focalin and Vyvanse share similar side effects, as they contain the same active ingredient, methylphenidate. Commonly experienced side effects for both drugs can include appetite changes, nausea, and stomach discomfort. These side effects are often mild and well-tolerated. However, it’s important to note that individual responses may vary, and some people might experience more severe side effects.

Common side effects from taking Focalin include:1

  • Abdominal pain
  • Fever
  • Decreased appetite
  • Nausea

Serious side effects from taking Focalin may include:1

  • Heart problems
  • Painful and prolonged erections (priapism)
  • Circulation problems in fingers and toes, including Raynaud’s phenomenon
  • Unexplained wounds appearing on fingers or toes
  • Slowing of growth (height and weight) in children

*All medications, including Focalin and Vyvanse, have a risk of side effects, including serious side effects. This is not a complete list of side effects. You should talk with your healthcare professional about the benefits and risks of any medication before starting treatment.

Common side effects from taking Vyvanse may include:2

  • Loss of appetite (anorexia)
  • Decreased appetite
  • Diarrhea
  • Dry mouth
  • Trouble sleeping
  • Stomach pain
  • Anxiety
  • Weight loss
  • Dizziness
  • Irritability
  • Nausea
  • Vomiting

Serious side effects from taking Vyvanse may include:2

  • Slowing of growth (height and weight)
  • Circulation problems in fingers and toes
  • Serotonin Syndrome with symptoms of agitation, hallucinations, seizures, and more.

*All medications, including Focalin and Vyvanse, have a risk of side effects, including serious side effects. This is not a complete list of side effects. You should talk with your healthcare professional about the benefits and risks of any medication before starting treatment.

Warnings & Precautions for Focalin & Vyvanse

Both Focalin and Vyvanse, as CNS stimulants in the same drug class, share similar warnings and precautions. These include the potential for abuse and dependence, serious heart risks, increased blood pressure, psychiatric concerns, and the possibility of growth suppression in children.1, 2

Both Focalin and Vyvanse are associated with potential circulation problems in fingers and toes, like Raynaud’s phenomenon, and they could cause a serious reaction called serotonin syndrome when used with certain other drugs. If you experience these issues while taking either medication, it’s crucial to seek immediate medical help.

Risks to consider when taking Focalin and Vyvanse include:1, 2

  • Allergic reactions: While rare, some individuals may experience severe allergic reactions with symptoms like hives, rash, swelling, severe dizziness, and difficulty breathing.
  • Pregnancy and breastfeeding: Consult a healthcare professional if you are pregnant or nursing, as the safety of these medications in these situations may not be well established.
  • Heart conditions: People with known serious heart conditions should avoid Focalin and Vyvanse due to the risk of cardiovascular problems, including heart attack, stroke, and sudden death.
  • High blood pressure: If you have hypertension, monitor your blood pressure while on these medications, as they can elevate it. Consult your doctor to manage this effectively.
  • Psychiatric history: Individuals with a history of psychiatric disorders, such as bipolar disorder or psychotic symptoms, should use Focalin and Vyvanse with caution, as they may exacerbate these conditions.
  • Growth concerns in children: Both medications can slow growth in pediatric patients. Close monitoring of height and weight is necessary, and if inadequate growth occurs, your healthcare provider may need to adjust or interrupt treatment.
  • Peripheral vasculopathy: Be vigilant for signs of circulation problems in fingers and toes, like numbness, color changes, or persistent pain, as these can be linked to both medications.
  • Serotonin syndrome risk: When taking Focalin or Vyvanse along with certain other drugs affecting the serotonergic system, there is a risk of serotonin syndrome. Be aware of symptoms like agitation, hallucinations, or rapid heartbeat, and seek medical attention if these signs appear.

Potential Drug Interactions With Focalin & Vyvanse

Focalin and Vyvanse can interact with other substances, posing risks. For Focalin, avoid combining it with certain antidepressants that can cause high blood pressure and health issues, such as monoamine oxidase inhibitors (MAOIs). It may also affect the effectiveness of some blood pressure drugs. In surgery, Focalin with certain anesthetics can raise heart rate and blood pressure.1

Mixing Focalin with risperidone may cause additional symptoms. For Vyvanse, avoid MAOIs, which can lead to dangerous blood pressure problems. Combining Vyvanse with specific drugs can result in serotonin syndrome, and some may require lower doses. Consult your doctor to manage these interactions safely.2

Disclaimer: Taking certain medications, herbs, or supplements alongside Focalin and Vyvanse can change how these medications work in your body or increase the risk of serious side effects. This article does not consider all the possible interactions. Please let your doctor, psychiatrists, and pharmacists know about all the products you currently use, such as prescription medication, nonprescription drugs, and herbal supplements. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Focalin Vs. Vyvanse Dosages for FDA-Approved Treatment

Focalin and Vyvanse have different dosage forms and strengths. Focalin comes in tablet form with strengths of 2.5 mg, 5 mg, and 10 mg. Vyvanse dosage, on the other hand, is available in capsules and chewable tablets with a wider range of strengths, from 10 mg to 70 mg. The right dosage for each individual can vary based on their specific condition and needs.

Focalin is available in the following forms and strengths:1

  • 2.5 milligrams (mg) oral tablet
  • 5 milligrams (mg) oral tablet
  • 10 milligrams (mg) oral tablet

Vyvanse is available in the following forms and strengths:2

  • Capsules, in milligrams (mg): 10 (mg), 20 (mg), 30 (mg), 40 (mg), 50 (mg), 60 (mg), 70 (mg)
  • Chewable tablets (mg): 10 (mg), 20 (mg), 30 (mg), 40 (mg), 50 (mg), 60 (mg)

Which Is Stronger, Focalin or Vyvanse?

Comparing the strength of Focalin and Vyvanse is not straightforward since they contain different active ingredients. Focalin contains dexmethylphenidate, while Vyvanse contains lisdexamfetamine.

The perceived strength of these medications may vary from person to person, and their effectiveness can depend on individual factors such as metabolism, the specific condition being treated, and the prescribed dosage. Therefore, it’s essential to consult with a healthcare professional to determine which medication is most suitable for your specific needs rather than solely focusing on their relative strength.

Focalin Vs. Vyvanse Cost

The cost of Focalin (dexmethylphenidate) can vary depending on whether you opt for the brand or generic version. The brand-name Focalin is typically more expensive, costing $92.02.4 However, you can save significantly by choosing the generic version, with a GoodRx lowest price of $19.72, allowing you to save 78.96%.

Similarly, Vyvanse (lisdexamfetamine) offers potential cost savings by opting for the generic version. The brand-name Vyvanse has a lowest price of $369.53.5 However, the generic Vyvanse is available at a significantly lower cost, with the lowest price of $92.17, providing a chance to save on your prescription expenses. Insurance coverage may vary, but additional savings options like Vyvanse coupons and discounts can make these medications more affordable for those without insurance.

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Which Is Right for You: Focalin or Vyvanse?

Choosing between Focalin and Vyvanse depends on individual factors such as your specific medical condition, treatment preferences, and any existing health concerns. Consulting with a psychiatrist or healthcare professional is essential to determine the most suitable medication. If in-person visits to a psychiatrist are challenging, you might explore online pharmacy services that can connect you with licensed healthcare providers. These services can help you weigh the benefits and potential risks of each medication, ensuring that you make an informed decision tailored to your unique needs.

How to Get a Prescription for Focalin & Vyvanse?

Focalin and Vyvanse can only be obtained with a prescription from healthcare providers such as psychiatrists, pediatricians, or general practitioners. To start, schedule an appointment with one of these professionals. During your visit, they’ll assess your condition, considering your medical history and symptoms. If they find that Focalin or Vyvanse may be suitable treatments, they will discuss benefits and risks and provide a prescription accordingly. Follow their guidance, attend regular check-ups, and adhere to the prescribed dosage.

Questions to Ask Your Health Team About Focalin & Vyvanse

Open and effective communication with your healthcare team is crucial when considering medications like Focalin and Vyvanse. Before your appointment, it’s essential to be well-prepared with any questions or concerns you might have. This proactive approach ensures that you receive the information you need to make informed decisions about your treatment.

Questions to ask your prescriber about Focalin and Vyvanse include:

  • Is it safe to take Focalin or Vyvanse with my other medications?
  • Will Focalin or Vyvanse be covered by my insurance?
  • Which one has the best results as a treatment for ADHD?
  • Does my medical history increase my risk of side effects for either?
  • How long can I expect side effects to last?
  • How often should I see you for checkups while taking Focalin or Vyvanse?
  • What should I do if I am unsure whether ADHD medications are right for me?
  • Are there specific foods, beverages, or dietary restrictions I should be aware of when taking Focalin or Vyvanse?
  • How do I adjust my dosage if I experience side effects or if the medication is not as effective as expected?
  • Are there any potential long-term effects of taking Focalin or Vyvanse that I should be aware of?
  • Can you provide guidance on how to manage the “comedown” or withdrawal symptoms, if any, associated with these medications?
  • Are there non-pharmacological treatments or therapies I should consider in addition to or instead of medication?
  • What should I do if I miss a dose of Focalin or Vyvanse?
  • Are there any specific lifestyle changes or accommodations that can complement the effects of the medication?
  • How do I know if these medications are working effectively for me, and what signs should I watch for to evaluate their impact?
  • How can I compare ADHD medications, such as Focalin vs Concerta?

In My Experience

In my experience, clients using Focalin and Vyvanse for ADHD have shared diverse perspectives. For some, these medications have been transformative, leading to increased focus, productivity, and better relationships. However, it’s essential to remember that responses can vary. Challenges, such as side effects or dosage adjustments, can occur. The key is individualized treatment plans and ongoing communication with healthcare providers.

Regarding the questions raised in this article, I stress the importance of a holistic approach to ADHD management. Medications are valuable but should be part of a comprehensive strategy involving lifestyle adjustments, therapy, and medical support.

Headshot Max Ruvinov PharmD MBA Max Ruvinov, PharmD, MBA
Sources

ChoosingTherapy.com strives to provide our readers with mental health content that is accurate and actionable. We have high standards for what can be cited within our articles. Acceptable sources include government agencies, universities and colleges, scholarly journals, industry and professional associations, and other high-integrity sources of mental health journalism. Learn more by reviewing our full editorial policy.

  • National Institutes of Health. (2023). DailyMed – focalin- dexmethylphenidate hydrochloride tablet. U.S. National Library of Medicine. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm 

  • National Institutes of Health. (2023b). DailyMed – vyvanse- lisdexamfetamine dimesylate capsule vyvanse- lisdexamfetamine dimesylate tablet, Chewable. U.S. National Library of Medicine. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm 

  • Cascade, E., Kalali, A. H., & Weisler, R. H. (2008). Short-acting versus long-acting medications for the treatment of ADHD. Psychiatry (Edgmont (Pa. : Township). Retrieved from  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695738/ 

  • GoodRx. (n.d.). Focalin (dexmethylphenidate): Uses, side effects, alternatives & more. Retrieved from https://www.goodrx.com/dexmethylphenidate/what-is#cost 

  • GoodRx. (n.d.). Vyvanse (Lisdexamfetamine): Uses, side effects, dosage & reviews. Retrieved from https://www.goodrx.com/vyvanse/what-is#cost

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